Abstract:
:Reaction between glutathione and ribose was carried out to study the volatiles formed via Maillard reaction and their antioxidant activity as well as their role in inhibition of LDL oxidation. The simultaneous distillation-extraction technique was used for trapping the volatile components followed by GC-MS analysis. Thirty six compounds were identified with the predominance of carbonyls and sulfur-containing compounds in the volatiles of this model system. Sensory evaluation was performed for the model system product according to the International Standard Methods (ISO). The results showed a high decrease in roasted and burnt attributes and remarkable increase in the like-boiled and roasted meat attributes. The sensory results of the model system product were confirmed by the presence of high concentrations of some volatile compounds having meat--like aroma such as 2-methyl-3-furanthiol and 2-furylmethanethiol. The radical scavenging activity of glutathione-ribose model system was quantified spectrophotometrically, using DPPH radical. The activity of the model system product was found to be slightly lower than that of gallic acid and BHA, but it was much higher than that of cinnamic acid (200 ppm. for each). A highly antioxidative activity was recorded by the model system product during the inhibition of LDL-oxidation in comparison with L-ascorbic acid as well as reduced glutathione (as a concentration of 0.5 micromol/L, for each) which may be due to the presence of some compounds such as 2-furylmethanethiol, 2-acetyl thiazole, 4-hydroxy-5-methyl-3(2H)-furanone.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
El-massry K,Farouk A,El-Ghorab Adoi
10.1007/s00726-002-0318-4subject
Has Abstractpub_date
2003-01-01 00:00:00pages
171-7issue
1-2eissn
0939-4451issn
1438-2199journal_volume
24pub_type
杂志文章相关文献
AMINO ACIDS文献大全abstract::The presence of an enzyme activity which hydrolyzes glycyl-D-aspartate was found in the homogenates of pig kidney cortex. The activity was inhibited by metal chelating agents and cilastatin, suggesting that the enzyme was a cilastatin-sensitive metallo-peptidase. Of the two hydrolysis products,D-aspartate was found to...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00806591
更新日期:1996-06-01 00:00:00
abstract::G-protein-coupled receptors (GPCRs) are cell surface receptors. The dynamic property of receptor-receptor interactions in GPCRs modulates the kinetics of G-protein signaling and stability. In the present work, the structural and dynamic study of A(2A)R-D(2)R interactions was carried to acquire the understanding of the...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1218-x
更新日期:2012-10-01 00:00:00
abstract::Antimicrobial peptides (AMPs) with amphipathic β-hairpin structures have been demonstrated to possess potent antimicrobial activities and great cell selectivities. However, our understanding of β-hairpin antimicrobial peptides lags behind that of α-helices, mainly because it is difficult for short peptides to form rob...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2029-7
更新日期:2015-11-01 00:00:00
abstract::Molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression has drawn significant attention because of the unique role of the HER2 gene in diagnosis, therapy and prognosis of human breast cancer. In our previous research, a novel cyclic 2-helix small protein, MUT-DS, was discovered as an anti-...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1096-7
更新日期:2012-07-01 00:00:00
abstract::Effects exerted by heavy isotope substitution in biopolymers on the functioning of whole organisms have not been investigated. We report on the decrease of permissive temperature of nematodes fed with bacteria containing 5,5-D2-lysine. We synthesized 5,5-dideuterolysine and, taking advantage of lysine being an essenti...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2386-5
更新日期:2017-05-01 00:00:00
abstract::In this paper, nanoparticles of Fe3O4 as well as their modified forms with different ionic liquids (IL-Fe3O4) were prepared and used for adsorption of lysozyme. The mean size and the surface morphology of the nanoparticles were characterized by TEM, XRD and FTIR techniques. Adsorption studies of lysozyme were performe...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2033-y
更新日期:2015-12-01 00:00:00
abstract::Animals at the neonatal stage have to eat more to support better growth and health. However, it is difficult to understand the mechanism of feeding during an early stage of life in the brain of the rodent model. Chickens are precocial and they can look for their food by themselves right after hatching. Neonatal chicks...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-019-02762-x
更新日期:2019-08-01 00:00:00
abstract::Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (ischemic disease, such as stroke and myocardial infarction, and arterial and venous thrombotic events) in the general population. We can assume that the association is causal, based on the example of homocystinuria, and on the evidence put ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-003-0026-8
更新日期:2003-12-01 00:00:00
abstract::Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were found in various clinical settings including coronary heart disease. To assess ADMA and SDMA diagnostic validity in patients with different stages of ischemic heart disease, we studied these markers in patie...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1307-x
更新日期:2012-12-01 00:00:00
abstract::Agmatine, a metabolite generated by arginine decarboxylation, has been reported as neuromodulator and neuroactive substance. Several findings suggest that agmatine displays neuroprotective effects in several models of neurodegenerative disorders, such as Parkinson's disease (PD). It has been hypothesized that biogenic...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02759-6
更新日期:2020-02-01 00:00:00
abstract::Epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition are biologic processes responsible for conversion of epithelial cells into a mesenchymal phenotype or viceversa, respectively. They occur during embryo- and foetal-development and, in adult organisms, are involved in wound healing, in the ge...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0995-y
更新日期:2012-02-01 00:00:00
abstract::Numerous indolyl amino acids and their derivatives inhibited arginase activity. The inhibition was found to be non-competitive, - at least partly - allosteric, and independent on manganese ions in the active site, and it cannot be explained by the dissociation of arginase homotrimers. Indole alone is weakly inhibitory...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-006-0470-3
更新日期:2008-02-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) arise from the interstitial cells of Cajal through gain of function mutations of the oncogene KIT. Imatinib offers the first effective treatment for patients with GISTs, but the therapeutic outcome strongly depends on the type of KIT mutation. We used ProteinChip technology to i...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-004-0140-2
更新日期:2004-12-01 00:00:00
abstract::In plasma and serum, the presence of high-abundance proteins can overwhelm the signals of low-abundance proteins, which then become undetectable either by two-dimensional gels or chromatographic techniques. Therefore, depletion of abundant proteins is a prerequisite to detect low-abundance components. Furthermore, the...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-007-0556-6
更新日期:2008-04-01 00:00:00
abstract::Arginine is a precursor of proteins and employed in urea synthesis. It is also the precursor of many other compounds, such as creatine, nitric oxide, polyamines, agmatine, proline. In this review, its transport and that of other basic amino acids are examined, along with its transformation into nitric oxide, agmatine ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-004-0081-9
更新日期:2004-07-01 00:00:00
abstract::The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protei...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1055-3
更新日期:2012-06-01 00:00:00
abstract::Breast cancer susceptibility gene 2 (BRCA2) is an important tumor suppressor, which is participated in repair of damaged DNA by its highly conserved BRC repeat motifs regulating RAD51 protein homologous recombination and thereby preventing cell carcinogenesis. In this study, the BRCA2(1524-1548)-RAD51(241-260) complex...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02813-3
更新日期:2020-03-01 00:00:00
abstract::The expression of pluripotent stem cell protein markers, self-renewal, the potential to differentiate in cell types of all three germlines and teratoma formation in nude mice form the spectrum of the stringent pluripotency criteria for human stem cells. Currently, intercellular variability is discussed as an additiona...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1599-5
更新日期:2013-12-01 00:00:00
abstract::Factor VIII, the plasma protein deficient or defective in individuals with hemophilia A, is a critical member of the blood coagulation cascade. Recent studies have identified the FVIII light chain region Glu1811-Lys1818 as being involved in FIXa binding and in the assembly of the FX-activating FIXaz-FVIIIa complex. Ba...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0464-z
更新日期:2010-07-01 00:00:00
abstract::Subcellular localization is an important protein property, which is related to function, interactions and other features. As experimental determination of the localization can be tedious, especially for large numbers of proteins, a number of prediction tools have been developed. We developed the PROlocalizer service t...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0724-y
更新日期:2011-03-01 00:00:00
abstract::In this study, we investigated the activating role of Mcm1p at ARG1 during arginine starvation. Our results showed that two Mcm1p binding sites positively contribute to ARG1 transcription and cell growth. Especially, we provide strong evidence that the Mcm1p binding sites play a positive role in ARG1 transcription to ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0687-z
更新日期:2011-02-01 00:00:00
abstract::The discovery of the dipeptide gamma-glutamyltaurine (gamma-GT; glutaurine, Litoralon) in the parathyroid in 1980 and later in the brain of mammals gave rise to studies on intrinsic and synthetic taurine peptides of this type. It was suggested that gamma-glutamyltransferase (GGT; gamma-glutamyltranspeptidase) in the b...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-005-0196-7
更新日期:2005-06-01 00:00:00
abstract::Predicting the three-dimensional structure of proteins is a long-standing challenge of computational biology, as the structure (or lack of a rigid structure) is well known to determine a protein's function. Predicting relative solvent accessibility (RSA) of amino acids within a protein is a significant step towards re...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02767-6
更新日期:2019-09-01 00:00:00
abstract::Protein-DNA interaction plays an important role in many biological processes. The classical methods and the novel technologies advanced have been developed for the interaction of protein-DNA. Recent developments of these methods and research achievements have been reviewed in this paper. ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-012-1377-9
更新日期:2012-09-01 00:00:00
abstract::The hepatitis B core (HBc) protein has been used successfully in numerous experiments as a carrier for heterologous peptides. Folding and capsid formation of the chimeric proteins is not always achieved easily. In silico analyses were performed to provide further comprehension of the feasibility for predicting success...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0365-1
更新日期:2010-05-01 00:00:00
abstract::Anti-tissue transglutaminase (tTG) antibodies are specifically produced in the small-intestinal mucosa of celiac disease (CD) patients. It is now recognized that these antibodies, acting on cell-surface tTG, may play an active role in CD pathogenesis triggering an intracellular response via the activation of different...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1120-y
更新日期:2013-01-01 00:00:00
abstract::The present research has been carried out to elicit the mechanism of antiangiogenic activity of a fusion peptide P2. Peptide P2 was designed by the connection of a heptapeptide MMP inhibitor to ES-2, a fragment of Endostatin. In a previous study, P2 demonstrated strong antiangiogenic and antitumor effect, and the curr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2589-4
更新日期:2018-08-01 00:00:00
abstract::Contemporary theoretical models used in describing electrostatic properties of amino acids in polypeptides rely usually on atomic point charges. Recently noted defects of such models in reproducing protein folding originate from the inadequate representation of the electrostatic term, in particular inability of atomic...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00808443
更新日期:1994-02-01 00:00:00
abstract::We describe six children with tetrahydrobiopterin (BH(4)) responsive phenylalanine hydroxylase (PAH) deficiency. All patients carry two mutant alleles in the PAH gene. Cofactor deficiency was excluded. The effect of BH(4) administration was studied by correlating different oral BH(4) doses with plasma phenylalanine le...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-002-0354-0
更新日期:2003-07-01 00:00:00
abstract::Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling....
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-1113-x
更新日期:2013-01-01 00:00:00