Mcm1p binding sites in the ARG1 promoter positively regulate ARG1 transcription and S. cerevisiae growth in the absence of arginine and Gcn4p.

abstract：:Fibronectin (FN) is a cell adhesion protein that binds integrins in a process also involving the protein-crosslinking enzyme transglutaminase 2 (TG2) as a co-receptor. The cell-adhesive property of TG2 has been linked to a complex formation with FN and to its ability to crosslink and polymerize FN on the cell surface....

journal_title：Amino acids

authors： Forsprecher J,Wang Z,Nelea V,Kaartinen MT

更新日期：2009-04-01 00:00:00

abstract：:Proteins with polybasic clusters bind to negatively charged phosphoinositides at the cell membrane. In this review, I have briefly discussed the types of phosphoinositides naturally found on membrane surfaces and how they recruit protein complexes for carrying out the process of signal transduction. A large number of ...

journal_title：Amino acids

authors： Gokhale NA

更新日期：2013-10-01 00:00:00

abstract：:Breast cancer susceptibility gene 2 (BRCA2) is an important tumor suppressor, which is participated in repair of damaged DNA by its highly conserved BRC repeat motifs regulating RAD51 protein homologous recombination and thereby preventing cell carcinogenesis. In this study, the BRCA2(1524-1548)-RAD51(241-260) complex...

journal_title：Amino acids

authors： Li J,Lu K,Lv M,Liu G,Ma L,Qi J

更新日期：2020-03-01 00:00:00

abstract：:We report the solid phase synthesis and some pharmacological properties of 24 oxytocin (OT) analogues. Basic modifications at position 9 (introduction of L- or D-beta-(2-thienyl)-alanine [L- or D-Thi], or L- or D-3-Pyridylalanine [L- or D-3-Pal]) were combined with D-tyrosine(OEthyl) [D-Tyr(Et)] or D-1-naphthylalanine...

journal_title：Amino acids

authors： Magafa V,Borovicková L,Slaninová J,Cordopatis P

更新日期：2010-05-01 00:00:00

abstract：:The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis). This has been assigned to the known bioenergetic, anti-apoptotic, anti-excitotoxic and anti-oxidant properties of creatine....

journal_title：Amino acids

authors： Klopstock T,Elstner M,Bender A

更新日期：2011-05-01 00:00:00

abstract：:The enzymes Akt, mTOR, p70(S6K), rpS6, GSK3, and glycogen synthase interact in the control of protein and/or glycogen synthesis in skeletal muscle, and each has been found to respond to exercise and nutrient supplementation. In the present study, we tested the hypothesis that nutrient supplementation post exercise, in...

journal_title：Amino acids

authors： Ivy JL,Ding Z,Hwang H,Cialdella-Kam LC,Morrison PJ

更新日期：2008-06-01 00:00:00

abstract：:Enzymes are the most versatile molecules in the biological world. These amazing molecules play an integral role in the regulation of various metabolic pathways and physiology subsequently. Promiscuity of an enzyme is the capacity to catalyze additional biochemical reactions besides their native one. Catalytic promiscu...

journal_title：Amino acids

authors： Verma MK,Pulicherla KK

更新日期：2016-04-01 00:00:00

abstract：:Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic chan...

journal_title：Amino acids

authors： Li Y,Zhang B,Wang X,Yan H,Chen G,Zhang X

更新日期：2011-10-01 00:00:00

abstract：:Schiff bases represent a class of molecules widely studied for their importance in organic and coordination chemistry. Despite the large amount of studies on the chemical and biological properties of the Schiff bases, the different experimental conditions prevent a useful comparison to search for a correlation structu...

journal_title：Amino acids

authors： Fattuoni C,Vascellari S,Pivetta T

更新日期：2020-03-01 00:00:00

abstract：:In a previous research, we have shown that adequate levels of polyamines are required in transformed mouse fibroblasts for the correlated activations of MAPK subtypes (ERK and JNK) and caspases induced by etoposide and leading to apoptosis. We report now that the treatment of fibroblasts with etoposide also elicited a...

journal_title：Amino acids

authors： Tantini B,Pignatti C,Fattori M,Fiumana E,Facchini A,Stefanelli C,Caldarera CM,Pegg AE,Flamigni F

更新日期：2004-10-01 00:00:00

abstract：:Emerging evidence from laboratory researches has highlighted the bioactivity of food melanoidins and melanoproteins. Whilst such studies have been carried out with different in vitro systems, information about melanoidins absorption and bio-availability are scarce. However, they are generally considered as poorly abso...

journal_title：Amino acids

authors： Tagliazucchi D,Bellesia A

更新日期：2015-06-01 00:00:00

abstract：:We determined the alterations in metabolic conversion of cysteine into glutathione and taurine in liver of rats treated with ethanol acutely. Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were s...

journal_title：Amino acids

authors： Ahn CW,Kwon DY,Jun DS,Lee YM,Kim YC

更新日期：2015-06-01 00:00:00

abstract：:Reaction between glutathione and ribose was carried out to study the volatiles formed via Maillard reaction and their antioxidant activity as well as their role in inhibition of LDL oxidation. The simultaneous distillation-extraction technique was used for trapping the volatile components followed by GC-MS analysis. T...

journal_title：Amino acids

authors： El-massry K,Farouk A,El-Ghorab A

更新日期：2003-01-01 00:00:00

abstract：:The effects of metabotropic glutamate receptor (mGluR) activation were studied in medium spiny neurons and large aspiny (LA) interneurons by means of electrophysiological and optical recordings. DCG-IV and L-SOP, agonists for group II and III mGluRs, respectively, produced a presynaptic inhibitory effect on corticostr...

journal_title：Amino acids

authors： Pisani A,Bernardi G,Bonsi P,Centonze D,Giacomini P,Calabresi P

更新日期：2000-01-01 00:00:00

abstract：:Lamin A/C proteins are the major components of a thin proteinaceous filamentous meshwork, the lamina, that underlies the inner nuclear membrane. A few specific mutations in the lamin A/C gene cause a disease with remarkably different clinical features: FPLD, or familial partial lipodystrophy (Dunnigan-type), which mai...

journal_title：Amino acids

authors： Rajendran V,Purohit R,Sethumadhavan R

更新日期：2012-08-01 00:00:00

abstract：:To mutant ddY/DAO(-) mice lacking D-amino-acid oxidase activity and normal ddY/DAO(+) mice, five D-amino acids (D-Asp, D-Ser, D-Ala, D-Leu and D-Pro) were orally administered for two weeks, and the D-amino acid levels were examined in seven brain regions. The levels of D-Asp markedly increased in the pituitary and pin...

journal_title：Amino acids

authors： Morikawa A,Hamase K,Inoue T,Konno R,Zaitsu K

更新日期：2007-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) constitute a diverse class of naturally occurring or synthetic antimicrobial molecules that have potential for use in the treatment of drug-resistant infections. Several undesirable properties of AMPs, however, may ultimately hinder their development as antimicrobial agents. Thus, new syn...

journal_title：Amino acids

authors： Dong N,Zhu X,Lv YF,Ma QQ,Jiang JG,Shan AS

更新日期：2014-09-01 00:00:00

abstract：:Contemporary theoretical models used in describing electrostatic properties of amino acids in polypeptides rely usually on atomic point charges. Recently noted defects of such models in reproducing protein folding originate from the inadequate representation of the electrostatic term, in particular inability of atomic...

journal_title：Amino acids

authors： Sokalski W

更新日期：1994-02-01 00:00:00

abstract：:The extracellular transglutaminases (TGs) in eukaryotes are responsible for the post-translational modification of proteins through different reactions, cross-linking being the best known. In higher plants, extracellular TG appears to be involved in roles similar to those performed by the mammalian counterparties. Sin...

journal_title：Amino acids

authors： Del Duca S,Verderio E,Serafini-Fracassini D,Iorio R,Cai G

更新日期：2014-03-01 00:00:00

abstract：:Glutamine and leucine are abundant constituents of plant and animal proteins, whereas the content of arginine in foods and physiological fluids varies greatly. Besides their role in protein synthesis, these three amino acids individually activate signaling pathway to promote protein synthesis and possibly inhibit auto...

journal_title：Amino acids

authors： Marc Rhoads J,Wu G

更新日期：2009-05-01 00:00:00

abstract：:This study investigated the effect of taurine and β-alanine supplementation on muscle function and muscle taurine transporter (TauT) protein expression in mdx mice. Wild-type (WT) and mdx mice (5 months) were supplemented with taurine or β-alanine for 4 weeks, after which in vitro contractile properties, fatigue resis...

journal_title：Amino acids

authors： Horvath DM,Murphy RM,Mollica JP,Hayes A,Goodman CA

更新日期：2016-11-01 00:00:00

abstract：:Glycation, or non-enzymatic glycosylation, is a common protein modification formed by reactions between reducing sugars (i.e. aldoses and ketoses) with protein amino groups. Resulting Amadori and Heyns compounds, respectively, can be oxidatively degraded yielding a structurally heterogeneous group of advanced glycatio...

journal_title：Amino acids

authors： Greifenhagen U,Frolov A,Hoffmann R

更新日期：2015-05-01 00:00:00

abstract：:Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined b...

journal_title：Amino acids

authors： Wei S,Fan L,Wu W,Ji Z

更新日期：2012-11-01 00:00:00

abstract：:The purpose of this study was to investigate H(e) concentration in plasma from 80 healthy donors in relation to age (6 newborns are also included), sex, daily variation (9, 11 a.m.; 2, 6, 12 p.m.) and a period of 5 subsequent months. A significant correlation (r = 0.63, p < 0.001) was observed between plasma H(e) and ...

journal_title：Amino acids

authors： Fermo I,De Vecchi E,D'Angelo SV,D'Angelo A,Paroni R

更新日期：1993-02-01 00:00:00

abstract：:A procedure for the synthesis of enantiopure beta3-amino acids from proteinogenic alpha-amino acids, developed by our group a few years ago, has been modified to enable the production of C-2 fully deuterated, C-protected beta3-amino acids and, even more important, the synthesis of valuable deuterium labelled N(Boc)-pr...

journal_title：Amino acids

authors： Caputo R,Longobardo L

更新日期：2007-01-01 00:00:00

abstract：:Taurine can protect against cardiovascular diseases, whereas elevated levels of plasma homocysteine are associated with atherosclerotic and thromboembolic cardiovascular diseases. To illustrate the effects of taurine on hyperhomocysteinemia, we observed the myocardial mitochondria dysfunction in the rats with hyperhom...

journal_title：Amino acids

authors： Chang L,Xu J,Yu F,Zhao J,Tang X,Tang C

更新日期：2004-08-01 00:00:00

abstract：:Developmental changes in the levels of the excitatory amino acids L-glutamate (Glu) and L-Aspartate (Asp) and inhibitory amino acids glycine (Gly) and gamma-amino butyric acid (GABA), as well as taurine and its related amino acids L-methionine (Met), L-cysteine (Cys) and L-serine (Ser) in the brain and pectoralis musc...

journal_title：Amino acids

authors： Sato M,Tomonaga S,Denbow DM,Furuse M

更新日期：2009-02-01 00:00:00

abstract：:The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [(3)H]taurine release...

journal_title：Amino acids

authors： Saransaari P,Oja SS

更新日期：2010-05-01 00:00:00

abstract：:Excitotoxicity induced by NMDA receptor stimulation is able to increase the activity of many enzymes involved in neuronal cell death. Primary cultures of rat cerebellar granule cells were used to elucidate the role of transglutaminase reaction in the excitotoxic cell response, and to evaluate the role of glutamate rec...

journal_title：Amino acids

authors： Caccamo D,Currò M,Cusumano G,Crisafulli G,Ientile R

更新日期：2004-03-01 00:00:00

abstract：:The reactions of phosphorus trichloride with various amino acids afford the pentacoordinated spirophosphoranes. The reaction procedures were traced by (31)P NMR spectra techniques. A new crystal structure of alanine derivative was characterized, which is a slightly distorted TBP structure. Besides, this kind of spirop...

journal_title：Amino acids

authors： Yu L,Liu Z,Fang H,Zeng QL,Zhao YF

更新日期：2005-06-01 00:00:00