Two piperazic acid-containing cyclic hexapeptides from Streptomyces alboflavus 313.

abstract：:A fast and efficient microwave-assisted solid phase peptide synthesis (MW-SPPS) of a 51mer peptide, the main heparin-binding site (60-110) of human pleiotrophin (hPTN), using 2-chlorotrityl chloride resin (CLTR-Cl) following the 9-fluorenylmethyloxycarbonyl/tert-butyl (Fmoc/tBu) methodology and with the standard N,N'-...

journal_title：Amino acids

authors： Friligou I,Papadimitriou E,Gatos D,Matsoukas J,Tselios T

更新日期：2011-05-01 00:00:00

abstract：:We have developed the first operationally simple and environmentally benign protocol for the aqueous asymmetric Michael addition reaction of chiral nickel(II) glycinate with nitroalkenes. The reactions proceeded smoothly in the presence of TBAB (tetrabutyl ammonium bromide) in neat water at room temperature and provid...

journal_title：Amino acids

authors： Wang J,Ji X,Shi J,Sun H,Jiang H,Liu H

更新日期：2012-05-01 00:00:00

abstract：:A growing body of evidence implicates endoplasmic reticulum (ER)-induced cellular dysfunction and apoptosis as important factors to a variety of diseases. In endothelial cells (ECs), the sulfur-containing amino acid homocysteine (Hcy) causes EC apoptosis and reactive oxygen species (ROS) generation through induction o...

journal_title：Amino acids

authors： Kil JS,Jeong SO,Chung HT,Pae HO

更新日期：2017-04-01 00:00:00

abstract：:The mitochondrial branched chain aminotransferase-deficient mouse model (BCATm KO), which exhibits elevated plasma and tissue branched chain amino acids (BCAAs), was used to study the effect of BCAAs on mammalian target of rapamycin complex 1 (mTORC1) regulation of organ size. BCATm is the first enzyme in the BCAA cat...

journal_title：Amino acids

authors： Neishabouri SH,Hutson SM,Davoodi J

更新日期：2015-06-01 00:00:00

abstract：:Among the available protocols, chemically driven approaches to oxidize cysteine may not be required for molecules that, under the native-like conditions, naturally fold in conformations ensuring an effective pairing of the right disulfide bridge pattern. In this contest, we successfully prepared the distinctin, a natu...

journal_title：Amino acids

authors： Calce E,Vitale RM,Scaloni A,Amodeo P,De Luca S

更新日期：2015-08-01 00:00:00

abstract：:Amino acid networks (AANs) are undirected networks consisting of amino acid residues and their interactions in three-dimensional protein structures. The analysis of AANs provides novel insight into protein science, and several common amino acid network properties have revealed diverse classes of proteins. In this revi...

journal_title：Amino acids

authors： Yan W,Zhou J,Sun M,Chen J,Hu G,Shen B

更新日期：2014-06-01 00:00:00

abstract：:A prior knowledge of protein structural classes can provide useful information about its overall structure, so it is very important for quick and accurate determination of protein structural class with computation method in protein science. One of the key for computation method is accurate protein sample representatio...

journal_title：Amino acids

authors： Li ZC,Zhou XB,Dai Z,Zou XY

更新日期：2009-07-01 00:00:00

abstract：:Glucosinolates are amino acid-derived natural plant products found throughout the Capparales order. Glucosinolates and their degradation products have a wide range of biological activities, e.g. in plant defense as deterrents against insect and fungi. The conversion of amino acids to aldoximes is a key step in glucosi...

journal_title：Amino acids

authors： Mikkelsen MD,Petersen BL,Olsen CE,Halkier BA

更新日期：2002-01-01 00:00:00

abstract：:Glutamate is stored in synaptic vesicles in presynaptic neurons. It is released into the synaptic cleft to provide signalling to postsynaptic neurons. Normally, the astroglial glutamate transporters GLT-1 and GLAST take up glutamate to mediate a high signal-to-noise ratio in the synaptic signalling, and also to preven...

journal_title：Amino acids

authors： Persson M,Rönnbäck L

更新日期：2012-01-01 00:00:00

abstract：:Protein and peptide oxidation is a key feature in the progression of a variety of disease states and in the poor performance of protein-based products. The present work demonstrates a mass spectrometry-based approach to profiling degradation at the amino acid residue level. Synthetic peptides containing the photosensi...

journal_title：Amino acids

authors： Grosvenor AJ,Morton JD,Dyer JM

更新日期：2010-06-01 00:00:00

abstract：:A novel recombinant disintegrin, vicrostatin (VCN), displays high binding affinity to a broad range of human integrins in substantial competitive biological advantage over other integrin-based antagonists. In this study, we synthesized a new 64Cu-labeled VCN probe and evaluated its imaging properties for prostate canc...

journal_title：Amino acids

authors： Jadvar H,Chen K,Park R,Yap LP,Vorobyova I,Swenson S,Markland FS

更新日期：2019-11-01 00:00:00

abstract：:This study investigated the effect of different sampling environments on hemolymph amino acid content of individual Drosophila melanogaster larvae. Hemolymph was collected from individual third instar larvae under cold-anesthetized, awake, and stress conditions. Qualitative and quantitative hemolymph amino acid analys...

journal_title：Amino acids

authors： Piyankarage SC,Augustin H,Featherstone DE,Shippy SA

更新日期：2010-03-01 00:00:00

abstract：:Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were found in various clinical settings including coronary heart disease. To assess ADMA and SDMA diagnostic validity in patients with different stages of ischemic heart disease, we studied these markers in patie...

journal_title：Amino acids

authors： Djordjević BV,Pavlović R,Ćosić V,Deljanin-Ilić M,Ristić T,Krstić N,Jevtović-Stoimenov T

更新日期：2012-12-01 00:00:00

abstract：:The Disrupted-in-schizophrenia 1 (DISC1) gene is involved in vulnerability to neuropsychiatric disorders. Naples high-excitability (NHE) rat model neuropsychiatric problems characterized by an unbalanced mesocortical dopamine system. Here, we assessed behavioral and neurochemical effects of immunization against multim...

journal_title：Amino acids

authors： Ruocco LA,Treno C,Gironi Carnevale UA,Arra C,Boatto G,Pagano C,Tino A,Nieddu M,Michel M,Prikulis I,Carboni E,de Souza Silva MA,Huston JP,Sadile AG,Korth C

更新日期：2015-03-01 00:00:00

abstract：:The cellular amino acid composition of plant cells was analyzed. The callus of carrot (Daucus carota), leaves of Torenia fournieri and protocomb-like body of Cymbidium, s.p. were examined as examples of plant cells. The cellular amino acid compositions differed in the plant cells, but their basic patterns were quite s...

journal_title：Amino acids

authors： Sorimachi K,Okayasu T,Akimoto K,Niwa A

更新日期：2000-01-01 00:00:00

abstract：:Predicting the three-dimensional structure of proteins is a long-standing challenge of computational biology, as the structure (or lack of a rigid structure) is well known to determine a protein's function. Predicting relative solvent accessibility (RSA) of amino acids within a protein is a significant step towards re...

journal_title：Amino acids

authors： Kaleel M,Torrisi M,Mooney C,Pollastri G

更新日期：2019-09-01 00:00:00

abstract：:BE-3-3-3-3 (1,15-(ethylamino)4,8,12-triazapentadecane) is a bis(ethyl)polyamine analogue under investigation as a therapeutic agent for breast cancer. Since estradiol (E(2)) is a critical regulatory molecule in the growth of breast cancer, we examined the effect of BE-3-3-3-3 on estrogen receptor α (ERα) positive MCF-...

journal_title：Amino acids

authors： Nayvelt I,John S,Hsu HC,Yang P,Liu W,Das G,Hyvönen MT,Alhonen L,Keinänen TA,Shirahata A,Patel R,Thomas T,Thomas TJ

更新日期：2012-02-01 00:00:00

abstract：:Functionalized collagen-mimetic peptides (CMPs) have been widely used in the preparation of collagen-related biomaterials. Among the reported results, the induced noncovalent interactions between the implanted functional groups or moieties were frequently the key elements to promote the self-assembly of small CMPs. In...

journal_title：Amino acids

authors： Huang PW,Chang JM,Horng JC

更新日期：2016-12-01 00:00:00

abstract：:Oxidative deamination of norepinephrine (NE) and dopamine (DA) by monoamine oxidase (MAO) generates the catecholaldehydes 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively, and H2O2. Catecholaldehydes are highly reactive electrophiles that have been implicated as cau...

journal_title：Amino acids

authors： Nelson MM,Builta ZJ,Monroe TB,Doorn JA,Anderson EJ

更新日期：2019-01-01 00:00:00

abstract：:For medical use of proteins and peptide-based drugs, it is desirable to have small biologically active sequences because they improve stability, reduce side effects, and production costs. Several plant defensins have their biological activities imparted by a sequence named γ-core. Vu-Def, a Vigna unguiculata defensin,...

journal_title：Amino acids

authors： Souza GS,de Carvalho LP,de Melo EJT,da Silva FCV,Machado OLT,Gomes VM,de Oliveira Carvalho A

更新日期：2019-11-01 00:00:00

abstract：:N-Acetyl-AA(amino acid)-NHtBu derivatives of all 20 naturally occurring amino acids have been synthesized. Syntheses were performed via solution-phase methodology with yields that allow for access to gram quantities of substrates, in most cases. Syntheses include the coupling of a hindered amine, tert-butylamine, with...

journal_title：Amino acids

authors： Ekkati AR,Campanali AA,Abouelatta AI,Shamoun M,Kalapugama S,Kelley M,Kodanko JJ

更新日期：2010-03-01 00:00:00

abstract：:This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson's disease. A...

journal_title：Amino acids

authors： Fisher A,Biggs CS,Starr MS

更新日期：1998-01-01 00:00:00

abstract：:As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on diet...

journal_title：Amino acids

authors： van de Rest O,van der Zwaluw NL,de Groot LC

更新日期：2013-11-01 00:00:00

abstract：:The interaction of antitumor drug, cisplatin (cis-[PtCl2(NH3)2], CDDP) with insulin from porcine pancreas has been investigated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and high resolution hybrid ion trap/time-of-flight mass spectrometry (MALIDI-TOF/TOF-MS and ESI-IT/TOF MS). The...

journal_title：Amino acids

authors： Li J,Yue L,Liu Y,Yin X,Yin Q,Pan Y,Yang L

更新日期：2016-04-01 00:00:00

abstract：:The relationship between taurine concentrations of plasma, whole blood, serum and skeletal muscle during taurine depletion and repletion was investigated in cats, to identify the most useful indicators of taurine status. Sixteen cats were fed a purified diet containing either 0 or 0.15 g/kg taurine for 5 months. Treat...

journal_title：Amino acids

authors： Pacioretty L,Hickman MA,Morris JG,Rogers QR

更新日期：2001-12-01 00:00:00

abstract：:This work proposes a strategy that uses solid-phase peptide synthesis associated with copper(I)-catalyzed azide alkyne cycloaddition reaction to promote the glycosylation of an antimicrobial peptide (HSP1) containing a carboxyamidated C-terminus (HSP1-NH2). Two glycotriazole-peptides, namely [p-Glc-trz-G1]HSP1-NH2 and...

journal_title：Amino acids

authors： Junior EFC,Guimarães CFRC,Franco LL,Alves RJ,Kato KC,Martins HR,de Souza Filho JD,Bemquerer MP,Munhoz VHO,Resende JM,Verly RM

更新日期：2017-08-01 00:00:00

abstract：:Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with magnesium-ammonium ph...

journal_title：Amino acids

authors： Atanassova SS,Panchev P,Ivanova M

更新日期：2010-05-01 00:00:00

abstract：:Delta-amino acids are very attractive in drug discovery, especially in the peptidomimetic area, because of their capability to act as dipeptide isosteres and reverse turn mimetics. Herein we report the synthesis of a rigid delta-amino acid constrained by a 3-aza-6,8-dioxabicyclo[3.2.1]octane-based scaffold, which can ...

journal_title：Amino acids

authors： Trabocchi A,Menchi G,Danieli E,Guarna A

更新日期：2008-06-01 00:00:00

abstract：:The purpose of the present study was to investigate the relationship between plasma carnitine concentration and body composition variation in relation to muscular and fat masses since there is no experimentally proved correlation between plasma carnitine and body masses. We used bioelectric impedance analysis (BIA), t...

journal_title：Amino acids

authors： Gatti R,De Palo CB,Spinella P,De Palo EF

更新日期：1998-01-01 00:00:00

abstract：:In yeast, toxicity of acetaminophen (APAP), a frequently used analgesic and antipyretic drug, depends on ubiquitin-controlled processes. Previously, we showed a remarkable overlap in toxicity profiles between APAP and tyrosine, and a similarity with drugs like rapamycin and quinine, which induce degradation of the ami...

journal_title：Amino acids

authors： Huseinovic A,Dekker SJ,Boogaard B,Vermeulen NPE,Kooter JM,Vos JC

更新日期：2018-10-01 00:00:00