The gastro-intestinal tract as the major site of biological action of dietary melanoidins.

abstract：:The intestine is not only critical for the absorption of nutrients, but also interacts with a complex external milieu. Most foreign antigens enter the body through the digestive tract. Dietary amino acids are major fuels for the small intestinal mucosa, as well as important substrates for syntheses of intestinal prote...

journal_title：Amino acids

authors： Wang WW,Qiao SY,Li DF

更新日期：2009-05-01 00:00:00

abstract：:We recently reported that dietary supplementation with L-proline (proline) during gestation improved embryonic survival in C57BL/6J mice. The objective of the present study was to test the hypothesis that the effect of maternal proline supplementation on embryonic survival can be carried forward to the first generatio...

journal_title：Amino acids

authors： Liu N,Dai Z,Zhang Y,Jia H,Chen J,Sun S,Wu G,Wu Z

更新日期：2019-05-01 00:00:00

abstract：:High-protein diets have been shown to alleviate detrimental effects of high-fat diets and this effect can be partially mimicked by dietary L-leucine supplementation. Here, we aimed to elucidate the early mechanisms and the specificity of leucine effects. We performed a 1-week trial with male C57BL/6 mice fed ad libitu...

journal_title：Amino acids

authors： Freudenberg A,Petzke KJ,Klaus S

更新日期：2013-02-01 00:00:00

abstract：:Based on ubiquitous presence of large ionic motifs and clusters in proteins involved in gene transcription and protein synthesis, we analyzed the distribution of ionizable sidechains in a broad selection of proteins with regulatory, metabolic, structural and adhesive functions, in agonist, antagonist, toxin and antimi...

journal_title：Amino acids

authors： Parker MS,Balasubramaniam A,Parker SL

更新日期：2012-12-01 00:00:00

abstract：:Prophylactic supplementation of N-acetyl-cysteine (NAC) and epigallocatechin gallate (EGCG) was studied for physiological and cellular changes in skeletal muscle after eccentric muscle contractions. Thirty healthy, active males (20.0 +/- 1.8 years, 160 +/- 7.1 cm, 76.1 +/- 17.0 kg) ingested for 14 days either 1,800 mg...

journal_title：Amino acids

authors： Kerksick CM,Kreider RB,Willoughby DS

更新日期：2010-06-01 00:00:00

abstract：:The lipidicα-amino acids (LAAs) are non-naturalα-amino acids with saturated or unsaturated long aliphatic side chains. LAAs and their derivatives (lipid mimetics) together with the lipidic peptides represent a class of compounds which combine structural features of lipids with those of amino acids and peptides. Racemi...

journal_title：Amino acids

authors： Kokotos G,Martin V,Constantinou-Kokotou V,Gibbons WA

更新日期：1996-09-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are cell surface receptors. The dynamic property of receptor-receptor interactions in GPCRs modulates the kinetics of G-protein signaling and stability. In the present work, the structural and dynamic study of A(2A)R-D(2)R interactions was carried to acquire the understanding of the...

journal_title：Amino acids

authors： Prakash A,Luthra PM

更新日期：2012-10-01 00:00:00

abstract：:Schiff bases represent a class of molecules widely studied for their importance in organic and coordination chemistry. Despite the large amount of studies on the chemical and biological properties of the Schiff bases, the different experimental conditions prevent a useful comparison to search for a correlation structu...

journal_title：Amino acids

authors： Fattuoni C,Vascellari S,Pivetta T

更新日期：2020-03-01 00:00:00

abstract：:In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters ...

journal_title：Amino acids

authors： Inbar E,Canepa GE,Carrillo C,Glaser F,Suter Grotemeyer M,Rentsch D,Zilberstein D,Pereira CA

更新日期：2012-01-01 00:00:00

abstract：:We performed sensory evaluations on 141 bottles of sake and analyzed the relationship between the D-amino acid concentrations, and the taste of the sake using principal component analysis, which yielded seven principal components (PC1-7) that explained 100 % of the total variance in the data. PC1, which explains 33.6 ...

journal_title：Amino acids

authors： Okada K,Gogami Y,Oikawa T

更新日期：2013-02-01 00:00:00

abstract：:Amino acids are potent regulators of muscle protein synthesis and breakdown and have received considerable attention for the treatment of muscle wasting conditions. Arginine is critically involved in numerous physiological functions including providing substrate for the production of creatine, urea and nitric oxide (N...

journal_title：Amino acids

authors： Ham DJ,Caldow MK,Lynch GS,Koopman R

更新日期：2014-12-01 00:00:00

abstract：:The unusual basic amino acid, hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)-lysine], is a modified lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This naturally occurring amino acid is a product of a unique posttranslational modification that occurs in only one cellular protein, euk...

journal_title：Amino acids

authors： Park MH,Nishimura K,Zanelli CF,Valentini SR

更新日期：2010-02-01 00:00:00

abstract：:New bioinorganic complexes of the aspartic acid with the antimony or bismuth triiodide were synthesized by a direct solid-solid reaction at room temperature. The formula of the complex is MI(3)[OOCCH(2)CH(NH(2))CO](2.5) x 2.5H(2)O (M = Sb, Bi). The complex may be a dimer with bridge structure. The crystal structure of...

journal_title：Amino acids

authors： Jia RR,Wu CP,Wu S,Yang YX,Chen YR,Jia YQ

更新日期：2006-07-01 00:00:00

abstract：:Regulated proteolysis plays important roles in cell biology and pathological conditions. A crosstalk exists between apoptosis and the ubiquitin-proteasome system, two pathways responsible for regulated proteolysis executed by different proteases. To investigate whether the apoptotic process also affects the 20S protea...

journal_title：Amino acids

authors： Schmidt F,Dahlmann B,Hustoft HK,Koehler CJ,Strozynski M,Kloss A,Zimny-Arndt U,Jungblut PR,Thiede B

更新日期：2011-07-01 00:00:00

abstract：:We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activitie...

journal_title：Amino acids

authors： Delwing D,Chiarani F,Wannmacher CM,Wajner M,Wyse AT

更新日期：2005-05-01 00:00:00

abstract：:Fibronectin (FN) is a cell adhesion protein that binds integrins in a process also involving the protein-crosslinking enzyme transglutaminase 2 (TG2) as a co-receptor. The cell-adhesive property of TG2 has been linked to a complex formation with FN and to its ability to crosslink and polymerize FN on the cell surface....

journal_title：Amino acids

authors： Forsprecher J,Wang Z,Nelea V,Kaartinen MT

更新日期：2009-04-01 00:00:00

abstract：:The daily requirement of a 70-kg male for creatine is about 2 g; up to half of this may be obtained from a typical omnivorous diet, with the remainder being synthesized in the body Creatine is a carninutrient, which means that it is only available to adults via animal foodstuffs, principally skeletal muscle, or via su...

journal_title：Amino acids

authors： Brosnan ME,Brosnan JT

更新日期：2016-08-01 00:00:00

abstract：:Arginine (Arg) and glutamine (Gln) utilization is greatly increased during catabolic stress. While the supply of both amino acids has been advocated in this situation, arginine administration is possibly associated with deleterious effects. From a metabolic point of view, these two amino acids are reciprocal precursor...

journal_title：Amino acids

authors： Ventura G,Moinard C,Segaud F,Le Plenier S,Cynober L,De Bandt JP

更新日期：2010-11-01 00:00:00

abstract：:Reaction between glutathione and ribose was carried out to study the volatiles formed via Maillard reaction and their antioxidant activity as well as their role in inhibition of LDL oxidation. The simultaneous distillation-extraction technique was used for trapping the volatile components followed by GC-MS analysis. T...

journal_title：Amino acids

authors： El-massry K,Farouk A,El-Ghorab A

更新日期：2003-01-01 00:00:00

abstract：:Immobilization of papain on Sepharose 6B in the presence of different concentrations of cysteine affected the enzyme activity depending on cysteine concentration. The maximum specific activity was observed when papain was immobilized with 200 mM cysteine. The immobilization process brought significant enhancement of s...

journal_title：Amino acids

authors： Homaei AA,Sajedi RH,Sariri R,Seyfzadeh S,Stevanato R

更新日期：2010-03-01 00:00:00

abstract：:A large series of plasma albumin (ALB, g/dl) and simultaneous blood and clinical measurements were prospectively performed on 92 liver resection patients, and processed to assess the correlations between ALB, other plasma proteins, additional variables and clinical events. The measurements were performed preoperativel...

journal_title：Amino acids

authors： Giovannini I,Chiarla C,Giuliante F,Vellone M,Ardito F,Nuzzo G

更新日期：2006-11-01 00:00:00

abstract：:Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined b...

journal_title：Amino acids

authors： Wei S,Fan L,Wu W,Ji Z

更新日期：2012-11-01 00:00:00

abstract：:Green tea which is widely consumed in China, Japan and India, contains polyphenolic compounds, which account for 30% of the dry weight of the leaves. Most of the polyphenols are flavanols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant. Epidemiological studies revealed that the incidences of stomach a...

journal_title：Amino acids

authors： Bachrach U,Wang YC

更新日期：2002-01-01 00:00:00

abstract：:The extracellular transglutaminases (TGs) in eukaryotes are responsible for the post-translational modification of proteins through different reactions, cross-linking being the best known. In higher plants, extracellular TG appears to be involved in roles similar to those performed by the mammalian counterparties. Sin...

journal_title：Amino acids

authors： Del Duca S,Verderio E,Serafini-Fracassini D,Iorio R,Cai G

更新日期：2014-03-01 00:00:00

abstract：:In this work, we describe the asymmetric synthesis of a series of fluorinated and non-fluorinated quaternary α-amino acid derivatives. This methodology involves the diastereoselective addition of chiral 2-p-tolylsulfinyl benzylcarbanions to either imines containing a 2-furyl moiety or trifluoromethyl α-imino esters. S...

journal_title：Amino acids

authors： Fustero S,Sánchez-Roselló M,Báez C,Del Pozo C,García Ruano JL,Alemán J,Marzo L,Parra A

更新日期：2011-08-01 00:00:00

abstract：:The objective of the study was to test L-methioinine as a possible immune supportive supplement in HIV infected patients by means of a clinical study. A double-blind, placebo-controlled study was designed. The patients (n = 253) from four different trial centres were randomly divided into two groups, active and placeb...

journal_title：Amino acids

authors： Van Brummelen R,du Toit D

更新日期：2007-07-01 00:00:00

abstract：:Vigabatrin is a GABA derivative (gamma-vinyl GABA) which inhibits irreversibly the enzyme activity of GABA transaminase and thus increased indirectly brain GABA concentrations. We have used body temperature assay to examine the effects of Vigabatrin on thermoregulation in intact rats. In order to understand the mechan...

journal_title：Amino acids

authors： Nikolov RP,Yakimova KS

更新日期：2011-05-01 00:00:00

abstract：:Hippocampus trimaculatus is one of the most heavily traded seahorse species for traditional medicine purposes in many countries. In the present study, we showed neuroprotective effects of peptide derived from H. trimaculatus against amyloid-β42 (Aβ42) toxicity which are central to the pathogenesis of Alzheimer's disea...

journal_title：Amino acids

authors： Pangestuti R,Ryu B,Himaya S,Kim SK

更新日期：2013-08-01 00:00:00

abstract：:Over the last few years, consistent data have demonstrated that creatine (Cr) supplementation prevents the accumulation of fat in rat liver as well as the progression of fatty liver disease in different situations. Studies have demonstrated that Cr is effective and prevents fatty liver in high-fat and choline-deficien...

journal_title：Amino acids

authors： Deminice R,de Castro GS,Brosnan ME,Brosnan JT

更新日期：2016-08-01 00:00:00

abstract：:Among many actions assigned to taurine (Tau), the most abundant amino acid in numerous mammalian tissues, it prevents high-fat diet-induced obesity with increasing resting energy expenditure. To sustain this Tau action, the goal of the present study was to explore the acute effects of Tau on baseline and on adrenaline...

journal_title：Amino acids

authors： Piña-Zentella G,de la Rosa-Cuevas G,Vázquez-Meza H,Piña E,de Piña MZ

更新日期：2012-05-01 00:00:00