The gastro-intestinal tract as the major site of biological action of dietary melanoidins.


:Emerging evidence from laboratory researches has highlighted the bioactivity of food melanoidins and melanoproteins. Whilst such studies have been carried out with different in vitro systems, information about melanoidins absorption and bio-availability are scarce. However, they are generally considered as poorly absorbable and bio-available compounds. Therefore, we present a review in which the gastro-intestinal tract is hypothesized to be the main site of action of food melanoidins and melanoproteins biological activity. We described recent data supporting this hypothesis both in vitro model systems and in vivo. Importantly, we focused this review only on the effect of melanoidins and melanoproteins extracted from food. Most of the studies had been carried out using water-soluble carbohydrate-based melanoidins isolated from different food sources (beer, barley coffee, coffee). In bakery products, melanoidins are protein-based structure (melanoproteins) which are largely insoluble in water. Dietary melanoidins and melanoproteins have been demonstrated to exert in vitro antioxidant and metal chelating ability in the gastro-intestinal tract reducing the formation of lipid hydroperoxides and advanced lipid oxidation end products during the digestion of meat. The reduction in the formation of these pro-atherogenic compounds has been shown to be followed by a decrease in their absorption in human volunteers. Food melanoidins have also shown in vitro anti-caries and prebiotic activities. We conclude by underlining the possible role of food melanoidins in the prevention of gastro-intestinal tract cancers. We hope this review will stimulate further research on food melanoidins and their biological activities in the gastro-intestinal tract.


Amino Acids


Amino acids


Tagliazucchi D,Bellesia A




Has Abstract


2015-06-01 00:00:00












  • Amino acids and gut function.

    abstract::The intestine is not only critical for the absorption of nutrients, but also interacts with a complex external milieu. Most foreign antigens enter the body through the digestive tract. Dietary amino acids are major fuels for the small intestinal mucosa, as well as important substrates for syntheses of intestinal prote...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Wang WW,Qiao SY,Li DF

    更新日期:2009-05-01 00:00:00

  • Maternal L-proline supplementation during gestation alters amino acid and polyamine metabolism in the first generation female offspring of C57BL/6J mice.

    abstract::We recently reported that dietary supplementation with L-proline (proline) during gestation improved embryonic survival in C57BL/6J mice. The objective of the present study was to test the hypothesis that the effect of maternal proline supplementation on embryonic survival can be carried forward to the first generatio...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Liu N,Dai Z,Zhang Y,Jia H,Chen J,Sun S,Wu G,Wu Z

    更新日期:2019-05-01 00:00:00

  • Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity.

    abstract::High-protein diets have been shown to alleviate detrimental effects of high-fat diets and this effect can be partially mimicked by dietary L-leucine supplementation. Here, we aimed to elucidate the early mechanisms and the specificity of leucine effects. We performed a 1-week trial with male C57BL/6 mice fed ad libitu...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Freudenberg A,Petzke KJ,Klaus S

    更新日期:2013-02-01 00:00:00

  • On the segregation of protein ionic residues by charge type.

    abstract::Based on ubiquitous presence of large ionic motifs and clusters in proteins involved in gene transcription and protein synthesis, we analyzed the distribution of ionizable sidechains in a broad selection of proteins with regulatory, metabolic, structural and adhesive functions, in agonist, antagonist, toxin and antimi...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Parker MS,Balasubramaniam A,Parker SL

    更新日期:2012-12-01 00:00:00

  • Intramuscular adaptations to eccentric exercise and antioxidant supplementation.

    abstract::Prophylactic supplementation of N-acetyl-cysteine (NAC) and epigallocatechin gallate (EGCG) was studied for physiological and cellular changes in skeletal muscle after eccentric muscle contractions. Thirty healthy, active males (20.0 +/- 1.8 years, 160 +/- 7.1 cm, 76.1 +/- 17.0 kg) ingested for 14 days either 1,800 mg...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Kerksick CM,Kreider RB,Willoughby DS

    更新日期:2010-06-01 00:00:00

  • Synthesis of medicinally useful lipidicα-amino acids, 2-amino alcohols and diamines.

    abstract::The lipidicα-amino acids (LAAs) are non-naturalα-amino acids with saturated or unsaturated long aliphatic side chains. LAAs and their derivatives (lipid mimetics) together with the lipidic peptides represent a class of compounds which combine structural features of lipids with those of amino acids and peptides. Racemi...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Kokotos G,Martin V,Constantinou-Kokotou V,Gibbons WA

    更新日期:1996-09-01 00:00:00

  • Insilico study of the A(2A)R-D (2)R kinetics and interfacial contact surface for heteromerization.

    abstract::G-protein-coupled receptors (GPCRs) are cell surface receptors. The dynamic property of receptor-receptor interactions in GPCRs modulates the kinetics of G-protein signaling and stability. In the present work, the structural and dynamic study of A(2A)R-D(2)R interactions was carried to acquire the understanding of the...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Prakash A,Luthra PM

    更新日期:2012-10-01 00:00:00

  • Synthesis, protonation constants and biological activity determination of amino acid-salicylaldehyde-derived Schiff bases.

    abstract::Schiff bases represent a class of molecules widely studied for their importance in organic and coordination chemistry. Despite the large amount of studies on the chemical and biological properties of the Schiff bases, the different experimental conditions prevent a useful comparison to search for a correlation structu...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Fattuoni C,Vascellari S,Pivetta T

    更新日期:2020-03-01 00:00:00

  • Lysine transporters in human trypanosomatid pathogens.

    abstract::In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters ...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Inbar E,Canepa GE,Carrillo C,Glaser F,Suter Grotemeyer M,Rentsch D,Zilberstein D,Pereira CA

    更新日期:2012-01-01 00:00:00

  • Principal component analysis of the relationship between the D-amino acid concentrations and the taste of the sake.

    abstract::We performed sensory evaluations on 141 bottles of sake and analyzed the relationship between the D-amino acid concentrations, and the taste of the sake using principal component analysis, which yielded seven principal components (PC1-7) that explained 100 % of the total variance in the data. PC1, which explains 33.6 ...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Okada K,Gogami Y,Oikawa T

    更新日期:2013-02-01 00:00:00

  • Arginine protects muscle cells from wasting in vitro in an mTORC1-dependent and NO-independent manner.

    abstract::Amino acids are potent regulators of muscle protein synthesis and breakdown and have received considerable attention for the treatment of muscle wasting conditions. Arginine is critically involved in numerous physiological functions including providing substrate for the production of creatine, urea and nitric oxide (N...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Ham DJ,Caldow MK,Lynch GS,Koopman R

    更新日期:2014-12-01 00:00:00

  • Functional significance of eIF5A and its hypusine modification in eukaryotes.

    abstract::The unusual basic amino acid, hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)-lysine], is a modified lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This naturally occurring amino acid is a product of a unique posttranslational modification that occurs in only one cellular protein, euk...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Park MH,Nishimura K,Zanelli CF,Valentini SR

    更新日期:2010-02-01 00:00:00

  • Synthesis and characterization of aspartic acid complexes of antimony and bismuth triiodide.

    abstract::New bioinorganic complexes of the aspartic acid with the antimony or bismuth triiodide were synthesized by a direct solid-solid reaction at room temperature. The formula of the complex is MI(3)[OOCCH(2)CH(NH(2))CO](2.5) x 2.5H(2)O (M = Sb, Bi). The complex may be a dimer with bridge structure. The crystal structure of...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Jia RR,Wu CP,Wu S,Yang YX,Chen YR,Jia YQ

    更新日期:2006-07-01 00:00:00

  • Quantitative proteome analysis of the 20S proteasome of apoptotic Jurkat T cells.

    abstract::Regulated proteolysis plays important roles in cell biology and pathological conditions. A crosstalk exists between apoptosis and the ubiquitin-proteasome system, two pathways responsible for regulated proteolysis executed by different proteases. To investigate whether the apoptotic process also affects the 20S protea...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Schmidt F,Dahlmann B,Hustoft HK,Koehler CJ,Strozynski M,Kloss A,Zimny-Arndt U,Jungblut PR,Thiede B

    更新日期:2011-07-01 00:00:00

  • Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat.

    abstract::We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activitie...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Delwing D,Chiarani F,Wannmacher CM,Wajner M,Wyse AT

    更新日期:2005-05-01 00:00:00

  • Enhanced osteoblast adhesion on transglutaminase 2-crosslinked fibronectin.

    abstract::Fibronectin (FN) is a cell adhesion protein that binds integrins in a process also involving the protein-crosslinking enzyme transglutaminase 2 (TG2) as a co-receptor. The cell-adhesive property of TG2 has been linked to a complex formation with FN and to its ability to crosslink and polymerize FN on the cell surface....

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Forsprecher J,Wang Z,Nelea V,Kaartinen MT

    更新日期:2009-04-01 00:00:00

  • The role of dietary creatine.

    abstract::The daily requirement of a 70-kg male for creatine is about 2 g; up to half of this may be obtained from a typical omnivorous diet, with the remainder being synthesized in the body Creatine is a carninutrient, which means that it is only available to adults via animal foodstuffs, principally skeletal muscle, or via su...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Brosnan ME,Brosnan JT

    更新日期:2016-08-01 00:00:00

  • Adaptative response of nitrogen metabolism in early endotoxemia: role of ornithine aminotransferase.

    abstract::Arginine (Arg) and glutamine (Gln) utilization is greatly increased during catabolic stress. While the supply of both amino acids has been advocated in this situation, arginine administration is possibly associated with deleterious effects. From a metabolic point of view, these two amino acids are reciprocal precursor...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Ventura G,Moinard C,Segaud F,Le Plenier S,Cynober L,De Bandt JP

    更新日期:2010-11-01 00:00:00

  • Volatile constituents of glutathione--ribose model system and its antioxidant activity.

    abstract::Reaction between glutathione and ribose was carried out to study the volatiles formed via Maillard reaction and their antioxidant activity as well as their role in inhibition of LDL oxidation. The simultaneous distillation-extraction technique was used for trapping the volatile components followed by GC-MS analysis. T...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: El-massry K,Farouk A,El-Ghorab A

    更新日期:2003-01-01 00:00:00

  • Cysteine enhances activity and stability of immobilized papain.

    abstract::Immobilization of papain on Sepharose 6B in the presence of different concentrations of cysteine affected the enzyme activity depending on cysteine concentration. The maximum specific activity was observed when papain was immobilized with 200 mM cysteine. The immobilization process brought significant enhancement of s...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Homaei AA,Sajedi RH,Sariri R,Seyfzadeh S,Stevanato R

    更新日期:2010-03-01 00:00:00

  • The relationship between albumin, other plasma proteins and variables, and age in the acute phase response after liver resection in man.

    abstract::A large series of plasma albumin (ALB, g/dl) and simultaneous blood and clinical measurements were prospectively performed on 92 liver resection patients, and processed to assess the correlations between ALB, other plasma proteins, additional variables and clinical events. The measurements were performed preoperativel...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Giovannini I,Chiarla C,Giuliante F,Vellone M,Ardito F,Nuzzo G

    更新日期:2006-11-01 00:00:00

  • Two piperazic acid-containing cyclic hexapeptides from Streptomyces alboflavus 313.

    abstract::Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined b...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Wei S,Fan L,Wu W,Ji Z

    更新日期:2012-11-01 00:00:00

  • Cancer therapy and prevention by green tea: role of ornithine decarboxylase.

    abstract::Green tea which is widely consumed in China, Japan and India, contains polyphenolic compounds, which account for 30% of the dry weight of the leaves. Most of the polyphenols are flavanols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant. Epidemiological studies revealed that the incidences of stomach a...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Bachrach U,Wang YC

    更新日期:2002-01-01 00:00:00

  • The plant extracellular transglutaminase: what mammal analogues tell.

    abstract::The extracellular transglutaminases (TGs) in eukaryotes are responsible for the post-translational modification of proteins through different reactions, cross-linking being the best known. In higher plants, extracellular TG appears to be involved in roles similar to those performed by the mammalian counterparties. Sin...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Del Duca S,Verderio E,Serafini-Fracassini D,Iorio R,Cai G

    更新日期:2014-03-01 00:00:00

  • Asymmetric synthesis of quaternary α-amino acid derivatives and their fluorinated analogues.

    abstract::In this work, we describe the asymmetric synthesis of a series of fluorinated and non-fluorinated quaternary α-amino acid derivatives. This methodology involves the diastereoselective addition of chiral 2-p-tolylsulfinyl benzylcarbanions to either imines containing a 2-furyl moiety or trifluoromethyl α-imino esters. S...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Fustero S,Sánchez-Roselló M,Báez C,Del Pozo C,García Ruano JL,Alemán J,Marzo L,Parra A

    更新日期:2011-08-01 00:00:00

  • L-methionine as immune supportive supplement: a clinical evaluation.

    abstract::The objective of the study was to test L-methioinine as a possible immune supportive supplement in HIV infected patients by means of a clinical study. A double-blind, placebo-controlled study was designed. The patients (n = 253) from four different trial centres were randomly divided into two groups, active and placeb...

    journal_title:Amino acids

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Van Brummelen R,du Toit D

    更新日期:2007-07-01 00:00:00

  • Effects of GABA-transaminase inhibitor Vigabatrin on thermoregulation in rats.

    abstract::Vigabatrin is a GABA derivative (gamma-vinyl GABA) which inhibits irreversibly the enzyme activity of GABA transaminase and thus increased indirectly brain GABA concentrations. We have used body temperature assay to examine the effects of Vigabatrin on thermoregulation in intact rats. In order to understand the mechan...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Nikolov RP,Yakimova KS

    更新日期:2011-05-01 00:00:00

  • Optimization of hydrolysis conditions, isolation, and identification of neuroprotective peptides derived from seahorse Hippocampus trimaculatus.

    abstract::Hippocampus trimaculatus is one of the most heavily traded seahorse species for traditional medicine purposes in many countries. In the present study, we showed neuroprotective effects of peptide derived from H. trimaculatus against amyloid-β42 (Aβ42) toxicity which are central to the pathogenesis of Alzheimer's disea...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Pangestuti R,Ryu B,Himaya S,Kim SK

    更新日期:2013-08-01 00:00:00

  • Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings.

    abstract::Over the last few years, consistent data have demonstrated that creatine (Cr) supplementation prevents the accumulation of fat in rat liver as well as the progression of fatty liver disease in different situations. Studies have demonstrated that Cr is effective and prevents fatty liver in high-fat and choline-deficien...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Deminice R,de Castro GS,Brosnan ME,Brosnan JT

    更新日期:2016-08-01 00:00:00

  • Taurine in adipocytes prevents insulin-mediated H2O2 generation and activates Pka and lipolysis.

    abstract::Among many actions assigned to taurine (Tau), the most abundant amino acid in numerous mammalian tissues, it prevents high-fat diet-induced obesity with increasing resting energy expenditure. To sustain this Tau action, the goal of the present study was to explore the acute effects of Tau on baseline and on adrenaline...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Piña-Zentella G,de la Rosa-Cuevas G,Vázquez-Meza H,Piña E,de Piña MZ

    更新日期:2012-05-01 00:00:00