Abstract:
:We determined the alterations in metabolic conversion of cysteine into glutathione and taurine in liver of rats treated with ethanol acutely. Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were significantly higher than those found in the saline-treated rats. It is therefore suggested that enhancement of cysteine catabolism into taurine contributes to the depletion of hepatic glutathione, which could exacerbate the ethanol-induced oxidative liver injury.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Ahn CW,Kwon DY,Jun DS,Lee YM,Kim YCdoi
10.1007/s00726-015-1969-2subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1273-7issue
6eissn
0939-4451issn
1438-2199journal_volume
47pub_type
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