Abstract:
:The efficient synthesis ofδ-hydroxy-β,γ-dehydroα-amino acids (1) was achieved by the hybrid process, in which the Pd(II)-assisted rear-rangement ofβ-acetoxyallylglycine ester (6) afforded the corresponding (E)-δ-acetoxyvinylglycine derivatives (7) in a moderate yield. The chemo- and stereo-selective hydrolysis of7 was accomplished by the use of microbial lipase (Amano PS) to afford the allylic alcohol (8), which was transformed into1 in two step sequence.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Kirihata M,Fukuari M,Izukawa T,Ichimoto Idoi
10.1007/BF00807269subject
Has Abstractpub_date
1995-12-01 00:00:00pages
317-25issue
4eissn
0939-4451issn
1438-2199journal_volume
9pub_type
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