A rapid and efficient method for the synthesis of selectively S-Trt or S-Mmt protected Cys-containing peptides.

abstract：:The nature of the products arising from a 10 days, sterile incubation at 37°C and pH 7.2 of a 1:1 mixture of N-α-(p-tosyl)-lysine-methylesterhydrochloride and anhydrous D-glucose was investigated by fast atom bombardment mass spectrometry and(1)H and(13)C nuclear magnetic resonance spectroscopies. Differently to the r...

journal_title：Amino acids

authors： Lapolla A,Gerhardinger C,Baldo L,Fedele D,Bertani R,Facchin G,Rizzi E,Catinella S,Seraglia R,Traldi P

更新日期：1993-10-01 00:00:00

abstract：:Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide generation. These defects can fundamentally alter cardiomyocyte function and if left unchanged can result in cell death. To protect against these stresses, cardiomyocytes possess quality contr...

journal_title：Amino acids

authors： Jong CJ,Ito T,Schaffer SW

更新日期：2015-12-01 00:00:00

abstract：:α-Pharmacological conotoxins are among the most selective ligands of nicotinic acetylcholine receptors with typical cysteine frameworks. They are characterized by the intercysteine loop and classified into various subfamilies, such as α3/5 and α4/7 conotoxins. A novel α-conotoxin, Pu14a (DCPPHPVPGMHKCVCLKTC), with a d...

journal_title：Amino acids

authors： Zhang B,Huang F,Du W

更新日期：2012-07-01 00:00:00

abstract：:We studied the non-specific interactions of two azo compounds: biebrich scarlet (BS) and naphthochrome green (NG), with four model proteins: bovine serum albumin, ovalbumin, poly-L-lysine and hemoglobin by UV-VIS spectrometry, fluorophotometry and circular dichroism melting technique. The optimal acidities of NG and B...

journal_title：Amino acids

authors： Gao HW,Liu XH,Qiu Z,Tan L

更新日期：2009-02-01 00:00:00

abstract：:On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting metabolism. Strategies directed at modulating glutamatergic transmission may overcome the ...

journal_title：Amino acids

authors： Skolnick P

更新日期：2002-01-01 00:00:00

abstract：:Two experiments were conducted to evaluate the effects of dietary supplementation with Astragalus polysaccharide (APS) on growth performance, apparent ileal digestibilities (AID) of amino acids (AA), and their serum concentrations in early weaned piglets. In Exp. 1, 60 pigs were weaned at 21 days of age (BW 7.35 +/- 0...

journal_title：Amino acids

authors： Yin FG,Liu YL,Yin YL,Kong XF,Huang RL,Li TJ,Wu GY,Hou Y

更新日期：2009-07-01 00:00:00

abstract：:Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes, and plasmodia, as well as human blood and cancer cells. In analysing the cytolytic activity of synthesised all-D: - and all-L: -cupiennin 1a towards pro- and e...

journal_title：Amino acids

authors： Kuhn-Nentwig L,Willems J,Seebeck T,Shalaby T,Kaiser M,Nentwig W

更新日期：2011-01-01 00:00:00

abstract：:Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a...

journal_title：Amino acids

authors： Golubnitschaja O,Filep N,Yeghiazaryan K,Blom HJ,Hofmann-Apitius M,Kuhn W

更新日期：2018-04-01 00:00:00

abstract：:We recently reported that dietary supplementation with L-proline (proline) during gestation improved embryonic survival in C57BL/6J mice. The objective of the present study was to test the hypothesis that the effect of maternal proline supplementation on embryonic survival can be carried forward to the first generatio...

journal_title：Amino acids

authors： Liu N,Dai Z,Zhang Y,Jia H,Chen J,Sun S,Wu G,Wu Z

更新日期：2019-05-01 00:00:00

abstract：:The enhancing effect on the water structure has been confirmed for most of the osmolytes exhibiting both stabilizing and destabilizing properties in regard to proteins. The presented work concerns osmolytes, which should be classified as "structure breaking" solutes: taurine and N,N,N-trimethyltaurine (TMT). Here, we ...

journal_title：Amino acids

authors： Bruździak P,Panuszko A,Kaczkowska E,Piotrowski B,Daghir A,Demkowicz S,Stangret J

更新日期：2018-01-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress, implicated in various neurodegenerative processes, increases the level of intracellular Ca(2+) and leads to activation of calpain, a Ca(2+)-dependent cysteine protease. We have shown previously that S-allyl-L-cysteine (SAC) in aged garlic extracts significantly protects cultured rat ...

journal_title：Amino acids

authors： Imai T,Kosuge Y,Endo-Umeda K,Miyagishi H,Ishige K,Makishima M,Ito Y

更新日期：2014-02-01 00:00:00

abstract：:An aromatic chiral diacid monomer, 5-[4-(2-phthalimidiylpropanoylamino)-benzoylamino]isophthalic acid was synthesized in five steps under conventional heating in high yield and purity. A series of soluble, thermally stable and optically active polyamides (PA)s containing pendent groups made of phthalimide, flexible L:...

journal_title：Amino acids

authors： Mallakpour S,Rafiee Z

更新日期：2009-10-01 00:00:00

abstract：:A subline growing in medium without arginine and ornithine was established from a rat Reuber hepatoma cell line (R-Y121B·cho). The subline designated R-Y117B·cho was able to grow in glutamine, arginine and ornithine-free, glutamate-supplemented medium. Arginine synthesis from glutamate requires four urea cycle enzymes...

journal_title：Amino acids

authors： Yamamoto K,Niwa A

更新日期：1996-09-01 00:00:00

abstract：:A large series of plasma albumin (ALB, g/dl) and simultaneous blood and clinical measurements were prospectively performed on 92 liver resection patients, and processed to assess the correlations between ALB, other plasma proteins, additional variables and clinical events. The measurements were performed preoperativel...

journal_title：Amino acids

authors： Giovannini I,Chiarla C,Giuliante F,Vellone M,Ardito F,Nuzzo G

更新日期：2006-11-01 00:00:00

abstract：:This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of a heteroaromatic compound denominated by us T(2)CO, comprising two thymine moieties anchored to a 2-propanonic unit, the spectroscopic properties of which wer...

journal_title：Amino acids

authors： Roviello GN,Roviello G,Musumeci D,Bucci EM,Pedone C

更新日期：2012-10-01 00:00:00

abstract：:There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application...

journal_title：Amino acids

authors： Gualano B,Roschel H,Lancha AH Jr,Brightbill CE,Rawson ES

更新日期：2012-08-01 00:00:00

abstract：:Predicting the three-dimensional structure of proteins is a long-standing challenge of computational biology, as the structure (or lack of a rigid structure) is well known to determine a protein's function. Predicting relative solvent accessibility (RSA) of amino acids within a protein is a significant step towards re...

journal_title：Amino acids

authors： Kaleel M,Torrisi M,Mooney C,Pollastri G

更新日期：2019-09-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) plays a vital role in the progress of malignant disease and elevated Hsp90 expression has been reported in pancreatic cancer. In this study, we radiolabeled a dimeric Sansalvamide A derivative (Di-San A1) with 64Cu, and evaluated the feasibility of using 64Cu-Di-San A1 for PET imaging of ...

journal_title：Amino acids

authors： Wang X,Zhang J,Wu H,Li Y,Conti PS,Chen K

更新日期：2018-07-01 00:00:00

abstract：:Alterations in adipocyte characteristics are highly implicated in the pathology of obesity. In a recent article, we demonstrated that high-fat diet-induced obesity impairs lysosomal function, thereby suppressing autophagy in mice white adipose tissue. Taurine, an amino acid naturally contained in the normal diet and e...

journal_title：Amino acids

authors： Kaneko H,Kobayashi M,Mizunoe Y,Yoshida M,Yasukawa H,Hoshino S,Itagawa R,Furuichi T,Okita N,Sudo Y,Imae M,Higami Y

更新日期：2018-05-01 00:00:00

abstract：:The efficient synthesis ofδ-hydroxy-β,γ-dehydroα-amino acids (1) was achieved by the hybrid process, in which the Pd(II)-assisted rear-rangement ofβ-acetoxyallylglycine ester (6) afforded the corresponding (E)-δ-acetoxyvinylglycine derivatives (7) in a moderate yield. The chemo- and stereo-selective hydrolysis of7 was...

journal_title：Amino acids

authors： Kirihata M,Fukuari M,Izukawa T,Ichimoto I

更新日期：1995-12-01 00:00:00

abstract：:Recently agmatine, decarboxylated arginine, has been shown to be an important biological compound in several animal tissues. This paper summarizes the known information regarding the transport of arginine, its decarboxylation and the effects of the agmatine formed mainly on NO and polyamine synthesis. ...

journal_title：Amino acids

authors： Grillo MA,Colombatto S

更新日期：2004-02-01 00:00:00

abstract：:The article traces the development of research on the naturally occurring amino acid L-3,4-dihydroxyphenylalanine (L-dopa), from the first synthesis of its D,L racemate in 1911, and the isolation of its L-isomer from seedling of Vicia faba beans to the amino acid's successful application, from 1961 onward, as the most...

journal_title：Amino acids

authors： Hornykiewicz O

更新日期：2002-01-01 00:00:00

abstract：:The glutamate/cystine antiporter system x(c)(-) transports cystine into cells in exchange for glutamate at a ratio of 1:1. It is composed of a specific light chain, xCT, and a heavy chain, 4F2, linked by a disulfide bridge. Intracellularly, cystine is reduced into cysteine, the rate-limiting precursor of glutathione (...

journal_title：Amino acids

authors： Lewerenz J,Maher P,Methner A

更新日期：2012-01-01 00:00:00

abstract：:D-Aspartic acid (D-Asp) is an endogenous amino acid present in neuroendocrine systems. Here, we report evidence that D-Asp in the rat is involved in learning and memory processes. Oral administration of sodium D-aspartate (40 mM) for 12-16 days improved the rats' cognitive capability to find a hidden platform in the M...

journal_title：Amino acids

authors： Topo E,Soricelli A,Di Maio A,D'Aniello E,Di Fiore MM,D'Aniello A

更新日期：2010-05-01 00:00:00

abstract：:Isoprostanes, non-enzymatic peroxidation products of arachidonic acid, are attractive biomarkers of oxidative stress in research in biology, medicine and nutrition. For the appropriate use of biomarkers it is required that these are both biologically and technically valid. Whereas the biological validity of isoprostan...

journal_title：Amino acids

authors： Coolen SA,van Buuren B,Duchateau G,Upritchard J,Verhagen H

更新日期：2005-12-01 00:00:00

abstract：:The tailor made amino acid β-N-methyl-amino-L-alanine (BMAA) is a neurotoxin produced by cyanobacteria. It has been associated with certain forms of progressive neurodegenerative disease, including sporadic Amyotrophic Lateral Sclerosis and Alzheimer's disease. Some different reports of BMAA in cyanobacterial blooms f...

journal_title：Amino acids

authors： Cervantes Cianca RC,Baptista MS,Lopes VR,Vasconcelos VM

更新日期：2012-06-01 00:00:00

abstract：:The G protein-coupled receptor kinase (GRK) family consists of seven cytosolic serine/threonine (Ser/Thr) protein kinases, and among them, GRK2 is involved in the regulation of an enormous range of both G protein-coupled receptors (GPCRs) and non-GPCR substrates that participate in or regulate many critical cellular p...

journal_title：Amino acids

authors： Kang JH,Toita R,Kawano T,Murata M,Asai D

更新日期：2020-07-01 00:00:00

abstract：:Glioma is the most common type of brain tumor, and has the worst prognosis in human malignancy. Experimental evidence suggests that the use of high concentrations of various amino acids may perturb neoplastic cell growth. Thus, the aim of this study was to investigate whether essential amino acids can alter the growth...

journal_title：Amino acids

authors： Takeuchi S,Nawashiro H,Wada K,Nomura N,Toyooka T,Otani N,Osada H,Matsuo H,Shinomiya N

更新日期：2012-08-01 00:00:00

abstract：:Endurance exercise training as well as leucine supplementation modulates glucose homeostasis and protein turnover in mammals. Here, we analyze whether leucine supplementation alters the effects of endurance exercise on these parameters in healthy mice. Mice were distributed into sedentary (C) and exercise (T) groups. ...

journal_title：Amino acids

authors： Costa Júnior JM,Rosa MR,Protzek AO,de Paula FM,Ferreira SM,Rezende LF,Vanzela EC,Zoppi CC,Silveira LR,Kettelhut IC,Boschero AC,de Oliveira CA,Carneiro EM

更新日期：2015-04-01 00:00:00

abstract：:To mutant ddY/DAO(-) mice lacking D-amino-acid oxidase activity and normal ddY/DAO(+) mice, five D-amino acids (D-Asp, D-Ser, D-Ala, D-Leu and D-Pro) were orally administered for two weeks, and the D-amino acid levels were examined in seven brain regions. The levels of D-Asp markedly increased in the pituitary and pin...

journal_title：Amino acids

authors： Morikawa A,Hamase K,Inoue T,Konno R,Zaitsu K

更新日期：2007-01-01 00:00:00