Abstract:
:Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO). Conversely, nitric oxide (NO) has exclusively inhibitory effects on rat SFO-neurons and on SFO-mediated water-intake. Extracellular and patch-clamp recordings from freshly dissociated rat SFO-neurons showed that glutamate activates AngII-sensitive SFO-neurons by opening ligand-gated cation channels. An immunocytochemical study showed that activation of glutamate receptors increased the concentration of the inhibitory second messenger cGMP in the SFO. A model is proposed suggesting that NO protects SFO-neurons from overexcitability by excitatory neurotransmitters.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Schmid HAdoi
10.1007/BF01345251subject
Has Abstractpub_date
1998-01-01 00:00:00pages
113-9issue
1-3eissn
0939-4451issn
1438-2199journal_volume
14pub_type
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