当前位置： SCI文献检索 > AMINO ACIDS期刊下所有文献 > The postprandial use of dietary amino acids as an energy substrate is delayed after the deamination process in rats adapted for 2 weeks to a high protein diet.

The postprandial use of dietary amino acids as an energy substrate is delayed after the deamination process in rats adapted for 2 weeks to a high protein diet.

Abstract：

:The aim of this study was to determine the contribution of dietary amino acids (AA) to energy metabolism under high protein (HP) diets, using a double tracer method to follow simultaneously the metabolic fate of α-amino groups and carbon skeletons. Sixty-seven male Wistar rats were fed a normal (NP) or HP diet for 14 days. Fifteen of them were equipped with a permanent catheter. On day 15, after fasting overnight, they received a 4-g meal extrinsically labeled with a mixture of 20 U-[(15)N]-[(13)C] AA. Energy metabolism, dietary AA deamination and oxidation and their transfer to plasma glucose were measured kinetically for 4 h in the catheterized rats. The transfer of dietary AA to liver glycogen was determined at 4 h. The digestive kinetics of dietary AA, their transfer into liver AA and proteins and the liver glycogen content were measured in the 52 other rats that were killed sequentially hourly over a 4-h period. [(15)N] and [(13)C] kinetics in the splanchnic protein pools were perfectly similar. Deamination increased fivefold in HP rats compared to NP rats. In the latter, all deaminated AA were oxidized. In HP rats, the oxidation rate was slower than deamination, so that half of the deaminated AA was non-oxidized within 4 h. Non-oxidized carbon skeletons were poorly sequestrated in glycogen, although there was a significant postprandial production of hepatic glycogen. Our results strongly suggest that excess dietary AA-derived carbon skeletons above the ATP production capacity, are temporarily retained in intermediate metabolic pools until the oxidative capacities of the liver are no longer overwhelmed by an excess of substrates.

journal_name

Amino Acids

journal_title

Amino acids

authors

Fromentin C,Azzout-Marniche D,Tomé D,Even P,Luengo C,Piedcoq J,Fromentin G,Gaudichon C

doi

10.1007/s00726-010-0756-3

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

1461-72

issue

5

eissn

0939-4451

issn

1438-2199

journal_volume

40

pub_type

杂志文章

相关文献

AMINO ACIDS文献大全
  • Functional aspects of the ventral pallidum.

    abstract：:The ventral pallidum is part of the corticoaccumbo-thalamocortical loop of the basal ganglia. In the past the function of this structure was discussed as a pure relay station in the process of limbic-motor integration. Some recent studies, however, underline that on the level of the ventral pallidum motor behavior can...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s007260070050

    authors： Kretschmer BD

    更新日期：2000-01-01 00:00:00

  • Prediction of mitochondrial proteins based on genetic algorithm - partial least squares and support vector machine.

    abstract：:Mitochondria are essential cell organelles of eukaryotes. Hence, it is vitally important to develop an automated and reliable method for timely identification of novel mitochondrial proteins. In this study, mitochondrial proteins were encoded by dipeptide composition technology; then, the genetic algorithm-partial lea...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-006-0465-0

    authors： Tan F,Feng X,Fang Z,Li M,Guo Y,Jiang L

    更新日期：2007-11-01 00:00:00

  • Enhancement of cysteine catabolism into taurine impacts glutathione homeostasis in rats challenged with ethanol.

    abstract：:We determined the alterations in metabolic conversion of cysteine into glutathione and taurine in liver of rats treated with ethanol acutely. Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were s...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-015-1969-2

    authors： Ahn CW,Kwon DY,Jun DS,Lee YM,Kim YC

    更新日期：2015-06-01 00:00:00

  • Effect of tryptophan on rat hepatic nuclear poly(A)polymerase activity.

    abstract：:Addition of poly(A) to hnRNA in the cell nucleus is a post-transcriptional event and is presumed to be brought about by a specific poly(A)polymerase. Since it is known that tryptophan rapidly increases the cytoplasmic levels of polyadenylated mRNA, it was of interest to investigate whether the essential amino acid, tr...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF00805989

    authors： Kurl RN,Verney E,Sidransky H

    更新日期：1993-06-01 00:00:00

  • Glycine metabolism in animals and humans: implications for nutrition and health.

    abstract：:Glycine is a major amino acid in mammals and other animals. It is synthesized from serine, threonine, choline, and hydroxyproline via inter-organ metabolism involving primarily the liver and kidneys. Under normal feeding conditions, glycine is not adequately synthesized in birds or in other animals, particularly in a ...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-013-1493-1

    authors： Wang W,Wu Z,Dai Z,Yang Y,Wang J,Wu G

    更新日期：2013-09-01 00:00:00

  • Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides.

    abstract：:Previous studies identified lysine- and tryptophan-rich sequences within various cationic antimicrobial peptides. In the present study, we synthesized a series of peptides composed of lysine (K)-tryptophan (W) repeats (KW)( n ) (where n equals 2, 3, 4 or 5) with amida...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-012-1388-6

    authors： Gopal R,Seo CH,Song PI,Park Y

    更新日期：2013-02-01 00:00:00

  • Effects of phenylalanine and phenylpyruvate on ATP-ADP hydrolysis by rat blood serum.

    abstract：:The nucleotide (ATP-ADP)/nucleoside (adenosine) ratio in the circulation can modulate the processes of vasoconstriction, vasodilatation and platelet aggregation. The main objective of the present study with rat blood serum was to evaluate the possibility of changes in nucleotide hydrolysis by phenylalanine (Phe) and p...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-002-0345-1

    authors： Rücker B,Oses JP,Kirst IB,Berti SL,Bonan CD,Battastini AM,Sarkis JJ

    更新日期：2003-06-01 00:00:00

  • Hemolymph amino acid variations following behavioral and genetic changes in individual Drosophila larvae.

    abstract：:This study investigated the effect of different sampling environments on hemolymph amino acid content of individual Drosophila melanogaster larvae. Hemolymph was collected from individual third instar larvae under cold-anesthetized, awake, and stress conditions. Qualitative and quantitative hemolymph amino acid analys...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-009-0284-1

    authors： Piyankarage SC,Augustin H,Featherstone DE,Shippy SA

    更新日期：2010-03-01 00:00:00

  • Maillard reaction products in tissue proteins: new products and new perspectives.

    abstract：:The chemical modification of protein by nonenzymatic browning or Maillard reactions increases with age and in disease. Maillard products are formed by reactions of both carbohydrate- and lipid-derived intermediates with proteins, leading to formation of advanced glycation and lipoxidation end-products (AGE/ALEs). Thes...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-003-0017-9

    authors： Thorpe SR,Baynes JW

    更新日期：2003-12-01 00:00:00

  • Intramuscular adaptations to eccentric exercise and antioxidant supplementation.

    abstract：:Prophylactic supplementation of N-acetyl-cysteine (NAC) and epigallocatechin gallate (EGCG) was studied for physiological and cellular changes in skeletal muscle after eccentric muscle contractions. Thirty healthy, active males (20.0 +/- 1.8 years, 160 +/- 7.1 cm, 76.1 +/- 17.0 kg) ingested for 14 days either 1,800 mg...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-009-0432-7

    authors： Kerksick CM,Kreider RB,Willoughby DS

    更新日期：2010-06-01 00:00:00

  • Low-resolution structure, oligomerization and its role on the enzymatic activity of a sucrose-6-phosphate hydrolase from Bacillus licheniformis.

    abstract：:Knowing the key features of the structure and the biochemistry of proteins is crucial to improving enzymes of industrial interest like β-fructofuranosidase. Gene sacA from Bacillus licheniformis ATCC 14580 codifies a sucrose-6-phosphate hydrolase, a β-fructofuranosidase (E.C. 3.1.2.26, protein BlsacA), which has no cr...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-018-02690-2

    authors： Mera A,de Lima MZT,Bernardes A,Garcia W,Muniz JRC

    更新日期：2019-04-01 00:00:00

  • Ethynylglycine synthon, a useful precursor for the synthesis of biologically active compounds: an update: part I: preparations of ethynylglycine synthon.

    abstract：:The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine} is a chiral compound with valuable synthetic interest. An update on the different routes for its synthesis is reviewed and discussed. ...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-014-1902-0

    authors： Benfodda Z,Bénimélis D,Reginato G,Meffre P

    更新日期：2015-02-01 00:00:00

  • Ketimine reductase/CRYM catalyzes reductive alkylamination of α-keto acids, confirming its function as an imine reductase.

    abstract：:Recently, crystalized mouse ketimine reductase/CRYM complexed with NADPH was found to have pyruvate bound in its active site. We demonstrate that the enzyme binds α-keto acids, such as pyruvate, in solution, and catalyzes the formation of N-alkyl-amino acids from alkylamines and α-keto acids (via reduction of imine in...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-015-2044-8

    authors： Hallen A,Cooper AJ,Smith JR,Jamie JF,Karuso P

    更新日期：2015-11-01 00:00:00

  • The neuronal differentiation process involves a series of antioxidant proteins.

    abstract：:Involvement of individual antioxidant proteins (AOXP) and antioxidants in the differentiation process has been already reported. A systematic search strategy for detecting differentially regulated AOXP in neuronal differentiation, however, has not been published so far. The aim of this study was to provide an analytic...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-005-0214-9

    authors： Oh JE,Karlmark Raja K,Shin JH,Hengstschläger M,Pollak A,Lubec G

    更新日期：2005-11-01 00:00:00

  • Putrescine overproduction does not affect the catabolism of spermidine and spermine in poplar and Arabidopsis.

    abstract：:The effect of up-regulation of putrescine (Put) production by genetic manipulation on the turnover of spermidine (Spd) and spermine (Spm) was investigated in transgenic cells of poplar (Populus nigra × maximowiczii) and seedlings of Arabidopsis thaliana. Several-fold increase in Put production was achieved by expressi...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-013-1581-2

    authors： Shao L,Bhatnagar P,Majumdar R,Minocha R,Minocha SC

    更新日期：2014-03-01 00:00:00

  • Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats.

    abstract：:Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-001-0131-5

    authors： Wieronska JM,Szewczyk B,Branski P,Palucha A,Pilc A

    更新日期：2002-01-01 00:00:00

  • Two piperazic acid-containing cyclic hexapeptides from Streptomyces alboflavus 313.

    abstract：:Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined b...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-012-1303-1

    authors： Wei S,Fan L,Wu W,Ji Z

    更新日期：2012-11-01 00:00:00

  • Enzyme promiscuity in earthworm serine protease: substrate versatility and therapeutic potential.

    abstract：:Enzymes are the most versatile molecules in the biological world. These amazing molecules play an integral role in the regulation of various metabolic pathways and physiology subsequently. Promiscuity of an enzyme is the capacity to catalyze additional biochemical reactions besides their native one. Catalytic promiscu...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-015-2162-3

    authors： Verma MK,Pulicherla KK

    更新日期：2016-04-01 00:00:00

  • A convenient route to optically pure α-alkyl-β-(sec-amino)alanines.

    abstract：:The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protei...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-011-1055-3

    authors： Olma A,Lasota A,Kudaj A

    更新日期：2012-06-01 00:00:00

  • Synthesis of bis-armed amino acid derivatives via the alkylation of ethyl isocyanoacetate and the Suzuki-Miyaura cross-coupling reaction.

    abstract：:Two synthetic routes to bis-armed-alpha-amino acid derivatives are described. The first route involves alkylation of dibromo derivatives with ethyl isocyanoacetate under phase-transfer catalysis (PTC) conditions. The second route uses a palladium-mediated Suzuki-Miyaura cross-coupling reaction between a DL-4-boronophe...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-006-0402-2

    authors： Kotha S,Shah VR,Halder S,Vinodkumar R,Lahiri K

    更新日期：2007-01-01 00:00:00

  • Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans.

    abstract：:Carnosine is found in high concentrations in skeletal muscles, where it is involved in several physiological functions. The muscle carnosine content measured within a population can vary by a factor 4. The aim of this study was to further characterize suggested determinants of the muscle carnosine content (diet, gende...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-010-0749-2

    authors： Everaert I,Mooyaart A,Baguet A,Zutinic A,Baelde H,Achten E,Taes Y,De Heer E,Derave W

    更新日期：2011-04-01 00:00:00

  • The effect of heat shock on amino acid transport and cell volume in 3T3 cells.

    abstract：:In 3T3 cells temperatures higher than physiological stimulated amino acid transport activity in a dose-dependent manner up to 44 degrees C. However, the temperature increase did not induce widespread transport increase of all other nutrients tested. The activities of both amino acid transport systems A and ASC were en...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s007260170033

    authors： Petronini PG,Caccamo AE,Alfieri RR,Bonelli MA,Borghetti AF

    更新日期：2001-01-01 00:00:00

  • Regulation of xCT expression and system x (c) (-) function in neuronal cells.

    abstract：:The glutamate/cystine antiporter system x(c)(-) transports cystine into cells in exchange for glutamate at a ratio of 1:1. It is composed of a specific light chain, xCT, and a heavy chain, 4F2, linked by a disulfide bridge. Intracellularly, cystine is reduced into cysteine, the rate-limiting precursor of glutathione (...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-011-0862-x

    authors： Lewerenz J,Maher P,Methner A

    更新日期：2012-01-01 00:00:00

  • Non-covalent binding of azo compound to peptide chain: interactions of biebrich scarlet and naphthochrome green with four model proteins.

    abstract：:We studied the non-specific interactions of two azo compounds: biebrich scarlet (BS) and naphthochrome green (NG), with four model proteins: bovine serum albumin, ovalbumin, poly-L-lysine and hemoglobin by UV-VIS spectrometry, fluorophotometry and circular dichroism melting technique. The optimal acidities of NG and B...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-008-0058-1

    authors： Gao HW,Liu XH,Qiu Z,Tan L

    更新日期：2009-02-01 00:00:00

  • Disturbance of erythrocyte lipid bilayer by amino acid-based surfactants.

    abstract：:In an attempt to increase our knowledge regarding the mechanisms of surfactant membrane interaction, we studied the action of several anionic and cationic amino acid-based surfactants on membrane fluidity using fluorescence anisotropy. Anisotropy measurements demonstrated that almost all of the surfactants studied dis...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-006-0447-2

    authors： Martínez V,Sánchez L,Busquets MA,Infante MR,Pilar Vinardell M,Mitjans M

    更新日期：2007-09-01 00:00:00

  • Anti-tissue transglutaminase antibodies activate intracellular tissue transglutaminase by modulating cytosolic Ca2+ homeostasis.

    abstract：:Anti-tissue transglutaminase (tTG) antibodies are specifically produced in the small-intestinal mucosa of celiac disease (CD) patients. It is now recognized that these antibodies, acting on cell-surface tTG, may play an active role in CD pathogenesis triggering an intracellular response via the activation of different...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-011-1120-y

    authors： Caputo I,Lepretti M,Secondo A,Martucciello S,Paolella G,Sblattero D,Barone MV,Esposito C

    更新日期：2013-01-01 00:00:00

  • Expression of the kynurenine enzymes in macrophages and microglial cells: regulation by immune modulators.

    abstract：:The regulation of the expression of indoleamine 2,3-dioxygenase (IDO) was studied in cloned murine macrophages (MT2) and microglial (N11) cells. Both cell lines express IDO and inducible nitric oxide synthase activity after interferon-gamma (IFN-gamma) stimulation. The regulation of IDO expression appears to differ in...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF01345271

    authors： Alberati-Giani D,Cesura AM

    更新日期：1998-01-01 00:00:00

  • The construction of an amino acid network for understanding protein structure and function.

    abstract：:Amino acid networks (AANs) are undirected networks consisting of amino acid residues and their interactions in three-dimensional protein structures. The analysis of AANs provides novel insight into protein science, and several common amino acid network properties have revealed diverse classes of proteins. In this revi...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-014-1710-6

    authors： Yan W,Zhou J,Sun M,Chen J,Hu G,Shen B

    更新日期：2014-06-01 00:00:00

  • iFC²: an integrated web-server for improved prediction of protein structural class, fold type, and secondary structure content.

    abstract：:Several descriptors of protein structure at the sequence and residue levels have been recently proposed. They are widely adopted in the analysis and prediction of structural and functional characteristics of proteins. Numerous in silico methods have been developed for sequence-based prediction of these descriptors. Ho...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-010-0721-1

    authors： Chen K,Stach W,Homaeian L,Kurgan L

    更新日期：2011-03-01 00:00:00

  • Synthesis of a bicyclic delta-amino acid as a constrained Gly-Asn dipeptide isostere.

    abstract：:Delta-amino acids are very attractive in drug discovery, especially in the peptidomimetic area, because of their capability to act as dipeptide isosteres and reverse turn mimetics. Herein we report the synthesis of a rigid delta-amino acid constrained by a 3-aza-6,8-dioxabicyclo[3.2.1]octane-based scaffold, which can ...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-007-0636-7

    authors： Trabocchi A,Menchi G,Danieli E,Guarna A

    更新日期：2008-06-01 00:00:00