Ethynylglycine synthon, a useful precursor for the synthesis of biologically active compounds: an update: part I: preparations of ethynylglycine synthon.

abstract：:Creatine is an amino acid that has a pivotal role in energy metabolism of cells. Creatine acts as an "ATP shuttle", carrying ATP to the sites where it is utilized, through its reversible phosphorylation by creatine kinase. Moreover, the creatine-phosphocreatine system delays ATP depletion during anoxia or ischemia, th...

journal_title：Amino acids

authors： Garbati P,Salis A,Adriano E,Galatini A,Damonte G,Balestrino M,Millo E

更新日期：2013-10-01 00:00:00

abstract：:Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with magnesium-ammonium ph...

journal_title：Amino acids

authors： Atanassova SS,Panchev P,Ivanova M

更新日期：2010-05-01 00:00:00

abstract：:We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activitie...

journal_title：Amino acids

authors： Delwing D,Chiarani F,Wannmacher CM,Wajner M,Wyse AT

更新日期：2005-05-01 00:00:00

abstract：:This study investigated the effect of agmatine (Agm) in proliferation of ovine trophecdoderm cells (oTr1) as well as the importance of the arginine decarboxylase (ADC) and agmatinase (AGMAT) alternative pathway for synthesis of polyamines in ovine conceptuses during the peri-implantation period of pregnancy. Morpholin...

journal_title：Amino acids

authors： Lenis YY,Elmetwally MA,Tang W,Satterfield C,Dunlap K,Wu G,Bazer FW

更新日期：2018-02-01 00:00:00

abstract：:Our observations on the growth stimulatory nature of mimosine, (beta-(3-hydroxy-4-pyridon-1-yl)-L-alanine), the toxic non-protein plant amino acid, in some model experimental systems, warranted sensitive and selective routine estimations. For the determination of both mimosine and DHP, an indirect spectrophotometric m...

journal_title：Amino acids

authors： Lalitha K,Rajendra Kulothungan S

更新日期：2006-10-01 00:00:00

abstract：:Early evaluation of cancer response to a therapeutic regimen can help increase the effectiveness of treatment schemes and, by enabling early termination of ineffective treatments, minimize toxicity, and reduce expenses. Biomarkers that provide early indication of tumor therapy response are urgently needed. Solid tumor...

journal_title：Amino acids

authors： Cao Q,Liu S,Niu G,Chen K,Yan Y,Liu Z,Chen X

更新日期：2011-11-01 00:00:00

abstract：:Numerous indolyl amino acids and their derivatives inhibited arginase activity. The inhibition was found to be non-competitive, - at least partly - allosteric, and independent on manganese ions in the active site, and it cannot be explained by the dissociation of arginase homotrimers. Indole alone is weakly inhibitory...

journal_title：Amino acids

authors： Hrabák A,Bajor T,Mészáros G

更新日期：2008-02-01 00:00:00

abstract：:Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling....

journal_title：Amino acids

authors： Sivaramakrishnan M,Shooter GK,Upton Z,Croll TI

更新日期：2013-01-01 00:00:00

abstract：:The tailor made amino acid β-N-methyl-amino-L-alanine (BMAA) is a neurotoxin produced by cyanobacteria. It has been associated with certain forms of progressive neurodegenerative disease, including sporadic Amyotrophic Lateral Sclerosis and Alzheimer's disease. Some different reports of BMAA in cyanobacterial blooms f...

journal_title：Amino acids

authors： Cervantes Cianca RC,Baptista MS,Lopes VR,Vasconcelos VM

更新日期：2012-06-01 00:00:00

abstract：:The human endothelin converting enzyme-1 (hECE-1) is a homodimer linked by a single disulfide bridge and has been identified as an important target for Alzheimer's disease. Structural analysis of hECE-1 dimer could lead to design specific and effective therapies against Alzheimer's disease. Hence, in the present study...

journal_title：Amino acids

authors： Sonawane KD,Barage SH

更新日期：2015-03-01 00:00:00

abstract：:The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this revie...

journal_title：Amino acids

authors： Lentini A,Provenzano B,Tabolacci C,Beninati S

更新日期：2009-04-01 00:00:00

abstract：:This study determined whether N-acetylcysteine (NAC) could affect intestinal redox status, proinflammatory cytokines, epidermal growth factor (EGF), EGF receptor (EGFR), Toll-like receptor-4 (TLR4), and aquaporin-8 in a lipopolysaccharide (LPS)-challenged piglet model. Eighteen piglets (35-day-old) were randomly alloc...

journal_title：Amino acids

authors： Hou Y,Wang L,Yi D,Ding B,Yang Z,Li J,Chen X,Qiu Y,Wu G

更新日期：2013-09-01 00:00:00

abstract：:We have developed the first operationally simple and environmentally benign protocol for the aqueous asymmetric Michael addition reaction of chiral nickel(II) glycinate with nitroalkenes. The reactions proceeded smoothly in the presence of TBAB (tetrabutyl ammonium bromide) in neat water at room temperature and provid...

journal_title：Amino acids

authors： Wang J,Ji X,Shi J,Sun H,Jiang H,Liu H

更新日期：2012-05-01 00:00:00

abstract：:Identifying protein-protein interactions (PPIs) is critical for understanding the cellular function of the proteins and the machinery of a proteome. Data of PPIs derived from high-throughput technologies are often incomplete and noisy. Therefore, it is important to develop computational methods and high-quality intera...

journal_title：Amino acids

authors： Shi MG,Xia JF,Li XL,Huang DS

更新日期：2010-03-01 00:00:00

abstract：:3-Fluorotyrosine fluorescence is quenched effectively by phosphate ions not only by a dynamic but also by a static mechanism owing to H-bond complex formation in ground state. 3-Fluorotyrosine pKa values both in the ground and first excited state (8.3 and 4, respectively) are appreciably lower than those of tyrosine, ...

journal_title：Amino acids

authors： Vdovenko SI,Kolycheva MT,Gerus II,Kukhar VP

更新日期：1993-10-01 00:00:00

abstract：:Agmatine, a metabolite generated by arginine decarboxylation, has been reported as neuromodulator and neuroactive substance. Several findings suggest that agmatine displays neuroprotective effects in several models of neurodegenerative disorders, such as Parkinson's disease (PD). It has been hypothesized that biogenic...

journal_title：Amino acids

authors： Ferlazzo N,Currò M,Giunta ML,Longo D,Rizzo V,Caccamo D,Ientile R

更新日期：2020-02-01 00:00:00

abstract：:A procedure for the synthesis of enantiopure beta3-amino acids from proteinogenic alpha-amino acids, developed by our group a few years ago, has been modified to enable the production of C-2 fully deuterated, C-protected beta3-amino acids and, even more important, the synthesis of valuable deuterium labelled N(Boc)-pr...

journal_title：Amino acids

authors： Caputo R,Longobardo L

更新日期：2007-01-01 00:00:00

abstract：:We present an optimized procedure for the synthesis of (S)-vinylglycine from (S)-methionine. The key step is a solvent free pyrolysis of an intermediate sulfoxide at high temperature. Using our optimized reaction conditions, Cbz-protected vinylglycine was obtained in high yield and with almost no side products. The pr...

journal_title：Amino acids

authors： Küchenthal CH,Migenda J,Polednia M,Maison W

更新日期：2010-07-01 00:00:00

abstract：:This study aimed to investigate the ability of curcumin to convert asparagine into acrylamide during heating at different temperatures. Binary and ternary model systems of asparagine-curcumin and asparagine-curcumin-fructose were used to determine the role of curcumin on acrylamide formation in competitive and uncompe...

journal_title：Amino acids

authors： Hamzalıoğlu A,Mogol BA,Lumaga RB,Fogliano V,Gökmen V

更新日期：2013-06-01 00:00:00

abstract：:Taurine and glutamate were monitored by microdialysis technique during various cerebral insults: a. Application of K+ triggered a cortical spreading depression (CSD). Taurine and glutamate increased concomitantly but recovery of glutamate was faster than that of taurine. b. Application of NMDA induced also CSD but onl...

journal_title：Amino acids

authors： Scheller D,Szathmary S,Kolb J,Tegtmeier F

更新日期：2000-01-01 00:00:00

abstract：:Amnesia is a deficit in memory caused by brain damage, disease, or trauma. Until now, there are no successful medications on the drug market available to treat amnesia. Short analogs and mimetics of human urocortin 3 (Ucn 3) tripeptide were synthetized and tested for their action against amnesia induced by eletroconvu...

journal_title：Amino acids

authors： Telegdy G,Kovács AK,Rákosi K,Zarándi M,Tóth GK

更新日期：2016-09-01 00:00:00

abstract：:Arginine (Arg) and glutamine (Gln) utilization is greatly increased during catabolic stress. While the supply of both amino acids has been advocated in this situation, arginine administration is possibly associated with deleterious effects. From a metabolic point of view, these two amino acids are reciprocal precursor...

journal_title：Amino acids

authors： Ventura G,Moinard C,Segaud F,Le Plenier S,Cynober L,De Bandt JP

更新日期：2010-11-01 00:00:00

abstract：:Addition of poly(A) to hnRNA in the cell nucleus is a post-transcriptional event and is presumed to be brought about by a specific poly(A)polymerase. Since it is known that tryptophan rapidly increases the cytoplasmic levels of polyadenylated mRNA, it was of interest to investigate whether the essential amino acid, tr...

journal_title：Amino acids

authors： Kurl RN,Verney E,Sidransky H

更新日期：1993-06-01 00:00:00

abstract：:Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes, and plasmodia, as well as human blood and cancer cells. In analysing the cytolytic activity of synthesised all-D: - and all-L: -cupiennin 1a towards pro- and e...

journal_title：Amino acids

authors： Kuhn-Nentwig L,Willems J,Seebeck T,Shalaby T,Kaiser M,Nentwig W

更新日期：2011-01-01 00:00:00

abstract：:The extracellular transglutaminases (TGs) in eukaryotes are responsible for the post-translational modification of proteins through different reactions, cross-linking being the best known. In higher plants, extracellular TG appears to be involved in roles similar to those performed by the mammalian counterparties. Sin...

journal_title：Amino acids

authors： Del Duca S,Verderio E,Serafini-Fracassini D,Iorio R,Cai G

更新日期：2014-03-01 00:00:00

abstract：:Low concentrations of L-homoarginine (hArg) in plasma or serum and urine have recently emerged as a novel cardiovascular risk factor. Previously, we reported gas chromatography-mass spectrometry (GC-MS) and GC-tandem MS (GC-MS/MS) methods for the quantitative determination of hArg and Arg in plasma, serum, urine and o...

journal_title：Amino acids

authors： Hanff E,Kayacelebi AA,Yanchev GR,Maassen N,Haghikia A,Tsikas D

更新日期：2016-03-01 00:00:00

abstract：:Animals at the neonatal stage have to eat more to support better growth and health. However, it is difficult to understand the mechanism of feeding during an early stage of life in the brain of the rodent model. Chickens are precocial and they can look for their food by themselves right after hatching. Neonatal chicks...

journal_title：Amino acids

authors： Tran PV,Chowdhury VS,Furuse M

更新日期：2019-08-01 00:00:00

abstract：:Germination ofBacillus subtilis spores was initiated by L-Ala and competitively inhibited by D-Ala, suggesting the presence of an alanine receptor. The spores showed alanine racemase activity in the spore coat. To investigate the role of alanine racemase (L → D) on germination, net racemase activity was determined usi...

journal_title：Amino acids

authors： Yasuda Y,Kanda K,Nishioka S,Tanimoto Y,Kato C,Saito A,Fukuchi S,Nakanishi Y,Tochikubo K

更新日期：1993-02-01 00:00:00

abstract：:Over the last few years, consistent data have demonstrated that creatine (Cr) supplementation prevents the accumulation of fat in rat liver as well as the progression of fatty liver disease in different situations. Studies have demonstrated that Cr is effective and prevents fatty liver in high-fat and choline-deficien...

journal_title：Amino acids

authors： Deminice R,de Castro GS,Brosnan ME,Brosnan JT

更新日期：2016-08-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) constitute a diverse class of naturally occurring or synthetic antimicrobial molecules that have potential for use in the treatment of drug-resistant infections. Several undesirable properties of AMPs, however, may ultimately hinder their development as antimicrobial agents. Thus, new syn...

journal_title：Amino acids

authors： Dong N,Zhu X,Lv YF,Ma QQ,Jiang JG,Shan AS

更新日期：2014-09-01 00:00:00