Low-resolution structure, oligomerization and its role on the enzymatic activity of a sucrose-6-phosphate hydrolase from Bacillus licheniformis.

abstract：:Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling....

journal_title：Amino acids

authors： Sivaramakrishnan M,Shooter GK,Upton Z,Croll TI

更新日期：2013-01-01 00:00:00

abstract：:Dopa and related catecholamines and their degradation products have been demonstrated to have neurotoxic potential in a number of cellular and in vivo experiments. Several mechanisms have been hypothesized to be involved including generation of prooxidant products that subsequently oxidize membrane lipids and exposed ...

journal_title：Amino acids

authors： VonVoigtlander PF,Fici GJ,Althaus JS

更新日期：1998-01-01 00:00:00

abstract：:The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-o...

journal_title：Amino acids

authors： Declerck V,Aitken DJ

更新日期：2011-08-01 00:00:00

abstract：:This is the third special issue focused on "Transglutaminases" that is now available on this journal and dedicated to one of the pioneers of these enzymes, John Edward Folk, who died December 2010 [see in this issue Beninati et al. 2012a]. The first edition, "Polyamines and Transglutaminases" was published in Amino Ac...

journal_title：Amino acids

authors： Beninati S,Facchiano F,Piacentini M

更新日期：2013-01-01 00:00:00

abstract：:Based on previous research with bovine peadipocytes, we hypothesized that infusion of arginine into the abomasum of Angus steers stimulates stearoyl-CoA desaturase (SCD) gene expression in bovine subcutaneous (s.c.) adipose tissue, and that this would be attenuated by conjugated linoleic acid (CLA). Growing Angus stee...

journal_title：Amino acids

authors： Choi SH,Wickersham TA,Wu G,Gilmore LA,Edwards HD,Park SK,Kim KH,Smith SB

更新日期：2014-02-01 00:00:00

abstract：:The isolated single organotypic slice model allows to investigate the effects of drugs and toxins on the expression of transcription factors in the striatum without dopaminergic and glutamatergic interactions. In this study the effects of margatoxin and iberiotoxin on the expression of c-fos mRNA by in situ hybridizat...

journal_title：Amino acids

authors： Saria A,Fischer HS,Humpel C,Pfattner A,Schatz DS,Schuligoi R

更新日期：2000-01-01 00:00:00

abstract：:The effects of metabotropic glutamate receptor (mGluR) activation were studied in medium spiny neurons and large aspiny (LA) interneurons by means of electrophysiological and optical recordings. DCG-IV and L-SOP, agonists for group II and III mGluRs, respectively, produced a presynaptic inhibitory effect on corticostr...

journal_title：Amino acids

authors： Pisani A,Bernardi G,Bonsi P,Centonze D,Giacomini P,Calabresi P

更新日期：2000-01-01 00:00:00

abstract：:Recovery of amino acid (AA) metabolism and the associated clinical implications in chronic hepatitis C (CHC) patients with sustained virological response (SVR) following anti-hepatitis C virus (HCV) therapy remains elusive. A prospective cohort study was conducted on 222 CHC patients with SVR. Eighty-two age-matched m...

journal_title：Amino acids

authors： Chang ML,Cheng ML,Chang SW,Tang HY,Chiu CT,Yeh CT,Shiao MS

更新日期：2017-02-01 00:00:00

abstract：:Enzymes are the most versatile molecules in the biological world. These amazing molecules play an integral role in the regulation of various metabolic pathways and physiology subsequently. Promiscuity of an enzyme is the capacity to catalyze additional biochemical reactions besides their native one. Catalytic promiscu...

journal_title：Amino acids

authors： Verma MK,Pulicherla KK

更新日期：2016-04-01 00:00:00

abstract：:L-tryptophan (TRP) is the precursor amino acid for the synthesis of serotonin (5-HT). 5-HT is effective both on the food intake and gastrointestinal system contractility. The aim of this study was to search the effects of systemic TRP treatment on 5-HT levels of ileum and searching the effect of ileal contractility an...

journal_title：Amino acids

authors： Ozer C,Gönül B,Ercan ZS,Take G,Erdoğan D

更新日期：2007-01-01 00:00:00

abstract：:Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic chan...

journal_title：Amino acids

authors： Li Y,Zhang B,Wang X,Yan H,Chen G,Zhang X

更新日期：2011-10-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is a methylated form of arginine and an endogenous nitric oxide synthase inhibitor. Renal function decline is associated with increase of plasma ADMA in chronic kidney disease populations. It is yet unknown how isolated renal function impairment affects ADMA homeostasis in healthy hu...

journal_title：Amino acids

authors： Said MY,Douwes RM,van Londen M,Minović I,Frenay AR,de Borst MH,van den Berg E,Heiner-Fokkema MR,Kayacelebi AA,Bollenbach A,van Goor H,Navis G,Tsikas D,Bakker SJL

更新日期：2019-03-01 00:00:00

abstract：:The putative translation factor eIF5A is essential for cell viability and is highly conserved from archaebacteria to mammals. This factor is the only cellular protein that undergoes an essential posttranslational modification dependent on the polyamine spermidine, called hypusination. This review focuses on the functi...

journal_title：Amino acids

authors： Zanelli CF,Valentini SR

更新日期：2007-08-01 00:00:00

abstract：:The ventral pallidum is part of the corticoaccumbo-thalamocortical loop of the basal ganglia. In the past the function of this structure was discussed as a pure relay station in the process of limbic-motor integration. Some recent studies, however, underline that on the level of the ventral pallidum motor behavior can...

journal_title：Amino acids

authors： Kretschmer BD

更新日期：2000-01-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) represents an important molecular target for both radiotracer-based diagnostic imaging and radionuclide therapy of various cancer entities. For the delivery of radionuclides to the tumor, peptides hold great potential as a transport vehicle. With respect to EGFR, the peptide...

journal_title：Amino acids

authors： Striese F,Sihver W,Gao F,Bergmann R,Walther M,Pietzsch J,Steinbach J,Pietzsch HJ

更新日期：2018-10-01 00:00:00

abstract：:Our observations on the growth stimulatory nature of mimosine, (beta-(3-hydroxy-4-pyridon-1-yl)-L-alanine), the toxic non-protein plant amino acid, in some model experimental systems, warranted sensitive and selective routine estimations. For the determination of both mimosine and DHP, an indirect spectrophotometric m...

journal_title：Amino acids

authors： Lalitha K,Rajendra Kulothungan S

更新日期：2006-10-01 00:00:00

abstract：:Delta-amino acids are very attractive in drug discovery, especially in the peptidomimetic area, because of their capability to act as dipeptide isosteres and reverse turn mimetics. Herein we report the synthesis of a rigid delta-amino acid constrained by a 3-aza-6,8-dioxabicyclo[3.2.1]octane-based scaffold, which can ...

journal_title：Amino acids

authors： Trabocchi A,Menchi G,Danieli E,Guarna A

更新日期：2008-06-01 00:00:00

abstract：:Two synthetic routes to bis-armed-alpha-amino acid derivatives are described. The first route involves alkylation of dibromo derivatives with ethyl isocyanoacetate under phase-transfer catalysis (PTC) conditions. The second route uses a palladium-mediated Suzuki-Miyaura cross-coupling reaction between a DL-4-boronophe...

journal_title：Amino acids

authors： Kotha S,Shah VR,Halder S,Vinodkumar R,Lahiri K

更新日期：2007-01-01 00:00:00

abstract：:This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of a heteroaromatic compound denominated by us T(2)CO, comprising two thymine moieties anchored to a 2-propanonic unit, the spectroscopic properties of which wer...

journal_title：Amino acids

authors： Roviello GN,Roviello G,Musumeci D,Bucci EM,Pedone C

更新日期：2012-10-01 00:00:00

abstract：:The effect of up-regulation of putrescine (Put) production by genetic manipulation on the turnover of spermidine (Spd) and spermine (Spm) was investigated in transgenic cells of poplar (Populus nigra × maximowiczii) and seedlings of Arabidopsis thaliana. Several-fold increase in Put production was achieved by expressi...

journal_title：Amino acids

authors： Shao L,Bhatnagar P,Majumdar R,Minocha R,Minocha SC

更新日期：2014-03-01 00:00:00

abstract：:Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide's therapeutic potential is limited by the short half-life and low bioavailabili...

journal_title：Amino acids

authors： Wester A,Devocelle M,Tallant EA,Chappell MC,Gallagher PE,Paradisi F

更新日期：2017-10-01 00:00:00

abstract：:D-Aspartate (D-Asp) is an endogenous substance in mammals. Degradation of D-Asp is carried out only by D-aspartate oxidase (DDO). We measured DDO activity in porcine tissues, and produced an anti-porcine DDO antibody to examine the cellular localization of DDO. All the tissues examined showed DDO activities, whereas t...

journal_title：Amino acids

authors： Yamamoto A,Tanaka H,Ishida T,Horiike K

更新日期：2011-07-01 00:00:00

abstract：:The G protein-coupled receptor kinase (GRK) family consists of seven cytosolic serine/threonine (Ser/Thr) protein kinases, and among them, GRK2 is involved in the regulation of an enormous range of both G protein-coupled receptors (GPCRs) and non-GPCR substrates that participate in or regulate many critical cellular p...

journal_title：Amino acids

authors： Kang JH,Toita R,Kawano T,Murata M,Asai D

更新日期：2020-07-01 00:00:00

abstract：:Reduced glutathione (GSH) levels and glutathione reductase (GR) and glutathione S-transferase (GST) activities were investigated in the erythrocytes and lymphocytes of non-dialyzed patients with varying degrees of chronic renal insufficiency, and also of patients on regular hemodialysis treatment. GSH, GR and GST leve...

journal_title：Amino acids

authors： Mimic-Oka J,Simic T,Djukanovic L,Stefanovski J,Ramic Z

更新日期：1992-10-01 00:00:00

abstract：:The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of g...

journal_title：Amino acids

authors： Aceña JL,Sorochinsky AE,Soloshonok V

更新日期：2014-09-01 00:00:00

abstract：:Since the formulation of the concept of "proteomics" in 1995, a plethora of proteomic technologies have been developed in order to study proteomes of tissues, cells and organelles. The powerful new technologies enabled by proteomic approaches have lead to the application of these methods to an exponentially increasing...

journal_title：Amino acids

authors： Vercauteren FG,Arckens L,Quirion R

更新日期：2007-09-01 00:00:00

abstract：:The TES ether of the C6-hydroxy derivative of naturally occurring epi-jasmonic acid (epi-JA) was designed as epimerization-free equivalent of epi-JA. The TES ether was synthesized from (1R,4S)-4-hydroxycyclopent-2-enyl acetate in 13 steps. The acid part of the ether was activated with ClCO2Bui and subjected to condens...

journal_title：Amino acids

authors： Ogawa N,Kobayashi Y

更新日期：2012-05-01 00:00:00

abstract：:The successful prediction of protein-folding rates based on the sequence-predicted secondary structure suggests that the folding rates might be predicted from sequence alone. To pursue this question, we directly predict the folding rates from amino acid sequences, which do not require any information on secondary or t...

journal_title：Amino acids

authors： Huang JT,Xing DJ,Huang W

更新日期：2012-08-01 00:00:00

abstract：:By application with 2-aminoethanol (2-AE) and choline chloride (CC) in pot experiments the effect of drought stress on barley plants was diminished. In treated plants an increase of the grain yield by 14% (2-AE) and 40% (CC) and a decrease of the stress metabolites glycine betaine and trigonelline was observed. Additi...

journal_title：Amino acids

authors： Bergmann H,Machelett B,Leinhos V

更新日期：1994-10-01 00:00:00

abstract：:In this study, an optically active diamine, N,N'-(pyromellitoyl)-bis{N-[4(4-aminophenoxy)phenyl]-2-(4-methyl)pentanamide} (1) containing amino acid L-leucine was prepared in three steps. The step-growth polymerization of this chiral diamine with several diisocyanates in room temperature ionic liquid (IL), 1,3-dipropyl...

journal_title：Amino acids

authors： Mallakpour S

更新日期：2011-02-01 00:00:00