Abstract:
:This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of a heteroaromatic compound denominated by us T(2)CO, comprising two thymine moieties anchored to a 2-propanonic unit, the spectroscopic properties of which were studied by UV as a function of temperature and ionic strength. Preliminary binding-studies with molecules of biomedical interest such as nucleic acids and proteins, performed on samples containing T(2)CO, suggested that this molecule is able to interact very weakly with double-stranded RNA, whereas it does not seem to bind other nucleic acids or proteins. Moreover, by studies with fresh human serum we found that T(2)CO is resistant to enzymatic degradation till 24 h, whereas UV metal binding-studies, performed using solutions of copper (II) chloride dihydrate and nickel (II) chloride hexahydrate, revealed a certain ability of T(2)CO to bind copper (II) cation. Finally, by CD spectroscopy we investigated the influence of T(2)CO on the already described supramolecular networks based on L-serine-containing nucleopeptides. More particularly, we found that T(2)CO is able to increase the level of structuration of the non-covalent supramolecular assembly of the chiral nucleopeptides, which is a feature of remarkable interest for the development of innovative drug delivery tools.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Roviello GN,Roviello G,Musumeci D,Bucci EM,Pedone Cdoi
10.1007/s00726-012-1237-7subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1615-23issue
4eissn
0939-4451issn
1438-2199journal_volume
43pub_type
杂志文章相关文献
AMINO ACIDS文献大全abstract::Two experiments were conducted to evaluate the effects of dietary supplementation with Astragalus polysaccharide (APS) on growth performance, apparent ileal digestibilities (AID) of amino acids (AA), and their serum concentrations in early weaned piglets. In Exp. 1, 60 pigs were weaned at 21 days of age (BW 7.35 +/- 0...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0142-6
更新日期:2009-07-01 00:00:00
abstract::Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2524-0
更新日期:2018-04-01 00:00:00
abstract::A subline growing in medium without arginine and ornithine was established from a rat Reuber hepatoma cell line (R-Y121B·cho). The subline designated R-Y117B·cho was able to grow in glutamine, arginine and ornithine-free, glutamate-supplemented medium. Arginine synthesis from glutamate requires four urea cycle enzymes...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00807328
更新日期:1996-09-01 00:00:00
abstract::Glycine is a major amino acid in mammals and other animals. It is synthesized from serine, threonine, choline, and hydroxyproline via inter-organ metabolism involving primarily the liver and kidneys. Under normal feeding conditions, glycine is not adequately synthesized in birds or in other animals, particularly in a ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1493-1
更新日期:2013-09-01 00:00:00
abstract::On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting metabolism. Strategies directed at modulating glutamatergic transmission may overcome the ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-001-0121-7
更新日期:2002-01-01 00:00:00
abstract::Animals at the neonatal stage have to eat more to support better growth and health. However, it is difficult to understand the mechanism of feeding during an early stage of life in the brain of the rodent model. Chickens are precocial and they can look for their food by themselves right after hatching. Neonatal chicks...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-019-02762-x
更新日期:2019-08-01 00:00:00
abstract::In a previous research, we have shown that adequate levels of polyamines are required in transformed mouse fibroblasts for the correlated activations of MAPK subtypes (ERK and JNK) and caspases induced by etoposide and leading to apoptosis. We report now that the treatment of fibroblasts with etoposide also elicited a...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-004-0101-9
更新日期:2004-10-01 00:00:00
abstract::A series of hydroxypyrroloindoline (Hpi) containing dipeptides along with the corresponding monomeric Hpi-α-amino acid (Hpi-2-carboxylate), were prepared by reacting a series of N α-protected-tryptophans in aqueous or biphasic [water/cyclopentyl methyl ether (CPME)] solutions containing Oxone® (potassium peroxymonosul...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2364-3
更新日期:2017-02-01 00:00:00
abstract::When a V3 sequence obtained on the n-th year after infection with human immunodeficiency virus type 1 (HIV-1) was supposed to change into a V3 sequence on the n + 1-th year, the variation between the above two sequences was analyzed by means of entropic chaos degree. The entropic chaos degree measures chaotic aspects ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s007260170056
更新日期:2001-01-01 00:00:00
abstract::Protein and peptide oxidation is a key feature in the progression of a variety of disease states and in the poor performance of protein-based products. The present work demonstrates a mass spectrometry-based approach to profiling degradation at the amino acid residue level. Synthetic peptides containing the photosensi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0440-7
更新日期:2010-06-01 00:00:00
abstract::The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the inhibitors of apoptosis proteins (IAP), particularly XIAP and eliminating their inhibitory activit...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2637-0
更新日期:2018-11-01 00:00:00
abstract::The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine} is a chiral compound with valuable synthetic interest. An update on the different routes for its synthesis is reviewed and discussed. ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-014-1902-0
更新日期:2015-02-01 00:00:00
abstract::We present an optimized procedure for the synthesis of (S)-vinylglycine from (S)-methionine. The key step is a solvent free pyrolysis of an intermediate sulfoxide at high temperature. Using our optimized reaction conditions, Cbz-protected vinylglycine was obtained in high yield and with almost no side products. The pr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0460-3
更新日期:2010-07-01 00:00:00
abstract::Skin is made up of mainly collagen type I and its structure is stabilised by the formation of covalent immature and mature crosslinks. In this study, collagen immature crosslink hydroxylysinonorleucine (HLNL) was isolated from bovine skin in high purity using two sequential purification steps. These consisted of prepa...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02708-3
更新日期:2019-04-01 00:00:00
abstract::The hepatitis B core (HBc) protein has been used successfully in numerous experiments as a carrier for heterologous peptides. Folding and capsid formation of the chimeric proteins is not always achieved easily. In silico analyses were performed to provide further comprehension of the feasibility for predicting success...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0365-1
更新日期:2010-05-01 00:00:00
abstract::In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0812-z
更新日期:2012-01-01 00:00:00
abstract::Functionalized collagen-mimetic peptides (CMPs) have been widely used in the preparation of collagen-related biomaterials. Among the reported results, the induced noncovalent interactions between the implanted functional groups or moieties were frequently the key elements to promote the self-assembly of small CMPs. In...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2312-2
更新日期:2016-12-01 00:00:00
abstract::This investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protoco...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0837-y
更新日期:2012-04-01 00:00:00
abstract::L-Homoarginine is a cationic amino acid derivative, which is structurally related to L-arginine and lysine. Several lines of evidence point to nervous tissue as an important target of homoarginine action. In the mammalian brain homoarginine can be detected in noticeable quantities, but its origin is currently poorly e...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-015-1960-y
更新日期:2015-09-01 00:00:00
abstract::The efficient synthesis ofδ-hydroxy-β,γ-dehydroα-amino acids (1) was achieved by the hybrid process, in which the Pd(II)-assisted rear-rangement ofβ-acetoxyallylglycine ester (6) afforded the corresponding (E)-δ-acetoxyvinylglycine derivatives (7) in a moderate yield. The chemo- and stereo-selective hydrolysis of7 was...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00807269
更新日期:1995-12-01 00:00:00
abstract::Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO). Conversely, nitric oxide (NO) has exclusively inhibitory effects on rat SFO-neurons and on SFO-mediated water-intake. Extracellular and patch-clamp recordings from freshly dissociated...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/BF01345251
更新日期:1998-01-01 00:00:00
abstract::Heat shock protein 90 (Hsp90) plays a vital role in the progress of malignant disease and elevated Hsp90 expression has been reported in pancreatic cancer. In this study, we radiolabeled a dimeric Sansalvamide A derivative (Di-San A1) with 64Cu, and evaluated the feasibility of using 64Cu-Di-San A1 for PET imaging of ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2566-y
更新日期:2018-07-01 00:00:00
abstract::The enhancing effect on the water structure has been confirmed for most of the osmolytes exhibiting both stabilizing and destabilizing properties in regard to proteins. The presented work concerns osmolytes, which should be classified as "structure breaking" solutes: taurine and N,N,N-trimethyltaurine (TMT). Here, we ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2499-x
更新日期:2018-01-01 00:00:00
abstract::Spore coat-associated alanine racemase of Bacillus subtilis, which converts L-alanine to D-alanine, that is, the germinant to the competitive inhibitor, to regulate spore germination for survival of the organism under unfavorable growth conditions, was examined. The dormant spores, L-alanine-initiated germination of w...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s007260070076
更新日期:2000-01-01 00:00:00
abstract::In this work, we describe the asymmetric synthesis of a series of fluorinated and non-fluorinated quaternary α-amino acid derivatives. This methodology involves the diastereoselective addition of chiral 2-p-tolylsulfinyl benzylcarbanions to either imines containing a 2-furyl moiety or trifluoromethyl α-imino esters. S...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0881-7
更新日期:2011-08-01 00:00:00
abstract::The expression of pluripotent stem cell protein markers, self-renewal, the potential to differentiate in cell types of all three germlines and teratoma formation in nude mice form the spectrum of the stringent pluripotency criteria for human stem cells. Currently, intercellular variability is discussed as an additiona...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1599-5
更新日期:2013-12-01 00:00:00
abstract::This study determined whether N-acetylcysteine (NAC) could affect intestinal redox status, proinflammatory cytokines, epidermal growth factor (EGF), EGF receptor (EGFR), Toll-like receptor-4 (TLR4), and aquaporin-8 in a lipopolysaccharide (LPS)-challenged piglet model. Eighteen piglets (35-day-old) were randomly alloc...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1295-x
更新日期:2013-09-01 00:00:00
abstract::Protooncogenes (PO) play a crucial role for brain biology and pathology. Only the concerted action of protooncogenes enables normal brain development. The reliable and sensitive quantification of brain PO is still holding centre stage in neurobiological research. The aim of our study was therefore the determination of...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF01318881
更新日期:1999-01-01 00:00:00
abstract::Taurine is known to increase ATP-dependent calcium ion (Ca2+) uptake in retinal membrane preparations and in isolated rod outer segments (ROS) under low calcium conditions (10 microM) (Pasantes-Morales and Ordóñez, 1982; Lombardini, 1991). In this report, ATP-dependent Ca2+ uptake in retinal membrane preparations was ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF01345283
更新日期:1998-01-01 00:00:00
abstract::The successful prediction of protein-folding rates based on the sequence-predicted secondary structure suggests that the folding rates might be predicted from sequence alone. To pursue this question, we directly predict the folding rates from amino acid sequences, which do not require any information on secondary or t...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1189-3
更新日期:2012-08-01 00:00:00