Abstract：
:Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a particularly aggressive type of breast cancer lacking clear diagnostic approach and targeted therapies. Consequently, more than 50% of the TNBC patients die of the metastatic BC within the first 6 months of the diagnosis. In the current study we have hypothesised that multi-omic approach utilising blood samples may lead to discovery of a unique molecular signature of the TNBC subtype. The results achieved demonstrate, indeed, multi-omics as highly promising approach that could be of great clinical utility for development of predictive diagnosis, targeted prevention and treatments tailored to the person-overall advancing the management of the TNBC.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Golubnitschaja O,Filep N,Yeghiazaryan K,Blom HJ,Hofmann-Apitius M,Kuhn Wdoi
10.1007/s00726-017-2524-0subject
Has Abstractpub_date
2018-04-01 00:00:00pages
383-395issue
3-4eissn
0939-4451issn
1438-2199pii
10.1007/s00726-017-2524-0journal_volume
50pub_type
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