Abstract:
:We present an optimized procedure for the synthesis of (S)-vinylglycine from (S)-methionine. The key step is a solvent free pyrolysis of an intermediate sulfoxide at high temperature. Using our optimized reaction conditions, Cbz-protected vinylglycine was obtained in high yield and with almost no side products. The protocol is scalable, fast and avoids the use of poisonous reagents.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Küchenthal CH,Migenda J,Polednia M,Maison Wdoi
10.1007/s00726-009-0460-3subject
Has Abstractpub_date
2010-07-01 00:00:00pages
443-8issue
2eissn
0939-4451issn
1438-2199journal_volume
39pub_type
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