Mass spectrometric studies on the interaction of cisplatin and insulin.

abstract：:Ocular ischemia resulting from perfusion disturbances may play a major role in initiation of glaucoma. Possibly secondary to ischemia autoimmunogenic events are activated in glaucoma patients with increased prevalence of systemic autoimmune diseases. The determination of potential molecular markers in blood leukocytes...

journal_title：Amino acids

authors： Golubnitschaja O,Wunderlich K,Decker C,Mönkemann H,Schild HH,Flammer J

更新日期：2002-01-01 00:00:00

abstract：:The role of pH-dependent ionic structures of L-amino acids in catalysis has been investigated for the two-component Mannich reactions between dimethyl malonate (DMM)/ethyl acetoacetate (EAA) and imines. As catalysts, L-amino acids performed well, even better than corresponding base catalysts and provided the β-amino c...

journal_title：Amino acids

authors： Rani D,Thakur L,Khera M,Goel N,Agarwal J

更新日期：2019-11-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress, implicated in various neurodegenerative processes, increases the level of intracellular Ca(2+) and leads to activation of calpain, a Ca(2+)-dependent cysteine protease. We have shown previously that S-allyl-L-cysteine (SAC) in aged garlic extracts significantly protects cultured rat ...

journal_title：Amino acids

authors： Imai T,Kosuge Y,Endo-Umeda K,Miyagishi H,Ishige K,Makishima M,Ito Y

更新日期：2014-02-01 00:00:00

abstract：:The present research has been carried out to elicit the mechanism of antiangiogenic activity of a fusion peptide P2. Peptide P2 was designed by the connection of a heptapeptide MMP inhibitor to ES-2, a fragment of Endostatin. In a previous study, P2 demonstrated strong antiangiogenic and antitumor effect, and the curr...

journal_title：Amino acids

authors： Xu Y,Qiang X,Xing L,Wang H,Zhang J,Zhang F,Caliskan B,Wang M,Qiu Z

更新日期：2018-08-01 00:00:00

abstract：:The study was designed to investigate the effects of NMDA receptor agonist on the behavioral activity in rats with experimental hyperammonemia. The experiments were performed on adult male Wistar rats. Experimental hyperammonemia was induced by intraperitoneal injections of tioacetamide (TAA, 200 mg/kg) for three cons...

journal_title：Amino acids

authors： Fedosiewicz-Wasiluk M,Hoły ZZ,Wiśniewska RJ,Wiśniewski K

更新日期：2005-02-01 00:00:00

abstract：:This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of a heteroaromatic compound denominated by us T(2)CO, comprising two thymine moieties anchored to a 2-propanonic unit, the spectroscopic properties of which wer...

journal_title：Amino acids

authors： Roviello GN,Roviello G,Musumeci D,Bucci EM,Pedone C

更新日期：2012-10-01 00:00:00

abstract：:This study aimed to investigate the ability of curcumin to convert asparagine into acrylamide during heating at different temperatures. Binary and ternary model systems of asparagine-curcumin and asparagine-curcumin-fructose were used to determine the role of curcumin on acrylamide formation in competitive and uncompe...

journal_title：Amino acids

authors： Hamzalıoğlu A,Mogol BA,Lumaga RB,Fogliano V,Gökmen V

更新日期：2013-06-01 00:00:00

abstract：:Dopa and related catecholamines and their degradation products have been demonstrated to have neurotoxic potential in a number of cellular and in vivo experiments. Several mechanisms have been hypothesized to be involved including generation of prooxidant products that subsequently oxidize membrane lipids and exposed ...

journal_title：Amino acids

authors： VonVoigtlander PF,Fici GJ,Althaus JS

更新日期：1998-01-01 00:00:00

abstract：:Mitochondria are essential cell organelles of eukaryotes. Hence, it is vitally important to develop an automated and reliable method for timely identification of novel mitochondrial proteins. In this study, mitochondrial proteins were encoded by dipeptide composition technology; then, the genetic algorithm-partial lea...

journal_title：Amino acids

authors： Tan F,Feng X,Fang Z,Li M,Guo Y,Jiang L

更新日期：2007-11-01 00:00:00

abstract：:Chemically defined amino acid diets have been developed for most laboratory and meat-producing animal species as well as for humans. In many cases, growth performance of animals fed these diets equals that obtained with standard intact-protein diets. The pattern of both essential and nonessential amino acids is critic...

journal_title：Amino acids

authors： Baker DH

更新日期：1992-02-01 00:00:00

abstract：:The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this revie...

journal_title：Amino acids

authors： Lentini A,Provenzano B,Tabolacci C,Beninati S

更新日期：2009-04-01 00:00:00

abstract：:Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance were studied using a polyamine biosynthesis and uptake deficient Escherichia coli KK3131 transformed with pACYC184 containing potFGHI or puuP. Putrescine uptake activity of E. coli KK3131 transformed with pACYC184-PotFGHI was high...

journal_title：Amino acids

authors： Terui Y,Saroj SD,Sakamoto A,Yoshida T,Higashi K,Kurihara S,Suzuki H,Toida T,Kashiwagi K,Igarashi K

更新日期：2014-03-01 00:00:00

abstract：:A species of the poorly studied order Embioptera, the webspinner Oligotoma saundersii, is investigated for its complement of neuropeptides of the adipokinetic hormone (AKH) family. A methanolic extract of its corpora cardiaca (CC) is able to effect carbohydrate mobilization in the cockroach, Periplaneta americana, and...

journal_title：Amino acids

authors： Gäde G,Šimek P,Marco HG

更新日期：2016-07-01 00:00:00

abstract：:Carnosine is found in high concentrations in skeletal muscles, where it is involved in several physiological functions. The muscle carnosine content measured within a population can vary by a factor 4. The aim of this study was to further characterize suggested determinants of the muscle carnosine content (diet, gende...

journal_title：Amino acids

authors： Everaert I,Mooyaart A,Baguet A,Zutinic A,Baelde H,Achten E,Taes Y,De Heer E,Derave W

更新日期：2011-04-01 00:00:00

abstract：:Inhibitors of histone deacetylases (HDACs) are a promising class of anticancer agents that have an effect on gene regulation. The naturally occurring cyclic depsipeptide FK228 containing disulfide and Largazole possessing thioester functionalities act as pro-drugs and share the same HDAC inhibition mechanism in cell. ...

journal_title：Amino acids

authors： Hoque MA,Islam MS,Islam MN,Kato T,Nishino N,Ito A,Yoshida M

更新日期：2014-10-01 00:00:00

abstract：:Spore coat-associated alanine racemase of Bacillus subtilis, which converts L-alanine to D-alanine, that is, the germinant to the competitive inhibitor, to regulate spore germination for survival of the organism under unfavorable growth conditions, was examined. The dormant spores, L-alanine-initiated germination of w...

journal_title：Amino acids

authors： Kanda-Nambu K,Yasuda Y,Tochikubo K

更新日期：2000-01-01 00:00:00

abstract：:Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport chain (ETC), we investigated whether there was a direct relationship bet...

journal_title：Amino acids

authors： Hancock CN,Liu W,Alvord WG,Phang JM

更新日期：2016-03-01 00:00:00

abstract：:An immunocytochemical investigation of the expression of alpha(1), alpha(6), beta(2/3), gamma(2) and delta subunits was performed on rat cerebellum granule cells in culture by the two photon microscopy technique. The first four subunits appear to be expressed abundantly in these cells, whereas the delta one seems to b...

journal_title：Amino acids

authors： Merlo F,Balduzzi R,Cupello A,Robello M

更新日期：2004-02-01 00:00:00

abstract：:The presence of an enzyme activity which hydrolyzes glycyl-D-aspartate was found in the homogenates of pig kidney cortex. The activity was inhibited by metal chelating agents and cilastatin, suggesting that the enzyme was a cilastatin-sensitive metallo-peptidase. Of the two hydrolysis products,D-aspartate was found to...

journal_title：Amino acids

authors： Kera Y,Funabashi K,Matsumoto T,Watanabe T,Nagasaki H,Yamada R

更新日期：1996-06-01 00:00:00

abstract：:The study of nanomaterial/biomolecule interface is an important emerging field in bionanoscience, and additionally in many biological processes such as hard-tissue growth and cell-surface adhesion. To have a deeper understanding of the amino acids/gold nanoparticle assemblies, the adsorption of these amino acids on th...

journal_title：Amino acids

authors： Ramezani F,Amanlou M,Rafii-Tabar H

更新日期：2014-04-01 00:00:00

abstract：:Some of the chemistry of amino acids going on in our laboratory (Laboratoire des Amino acides Peptides et Protéines) is described as well as some mass spectrometry methodology for their characterization particularly on solid supports. Several aspects are presented including: (i) the stereoselective synthesis of natura...

journal_title：Amino acids

authors： Bouifraden S,Drouot C,el Hadrami M,Guenoun F,Lecointe L,Mai N,Paris M,Pothion C,Sadoune M,Sauvagnat B,Amblard M,Aubagnac JL,Calmes M,Chevallet P,Daunis J,Enjalbal C,Fehrentz JA,Lamaty F,Lavergne JP,Lazaro R,Rollan

更新日期：1999-01-01 00:00:00

abstract：:Germination ofBacillus subtilis spores was initiated by L-Ala and competitively inhibited by D-Ala, suggesting the presence of an alanine receptor. The spores showed alanine racemase activity in the spore coat. To investigate the role of alanine racemase (L → D) on germination, net racemase activity was determined usi...

journal_title：Amino acids

authors： Yasuda Y,Kanda K,Nishioka S,Tanimoto Y,Kato C,Saito A,Fukuchi S,Nakanishi Y,Tochikubo K

更新日期：1993-02-01 00:00:00

abstract：:Amino acids are potent regulators of muscle protein synthesis and breakdown and have received considerable attention for the treatment of muscle wasting conditions. Arginine is critically involved in numerous physiological functions including providing substrate for the production of creatine, urea and nitric oxide (N...

journal_title：Amino acids

authors： Ham DJ,Caldow MK,Lynch GS,Koopman R

更新日期：2014-12-01 00:00:00

abstract：:Amino acid networks (AANs) are undirected networks consisting of amino acid residues and their interactions in three-dimensional protein structures. The analysis of AANs provides novel insight into protein science, and several common amino acid network properties have revealed diverse classes of proteins. In this revi...

journal_title：Amino acids

authors： Yan W,Zhou J,Sun M,Chen J,Hu G,Shen B

更新日期：2014-06-01 00:00:00

abstract：:Green tea which is widely consumed in China, Japan and India, contains polyphenolic compounds, which account for 30% of the dry weight of the leaves. Most of the polyphenols are flavanols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant. Epidemiological studies revealed that the incidences of stomach a...

journal_title：Amino acids

authors： Bachrach U,Wang YC

更新日期：2002-01-01 00:00:00

abstract：:Selective removal of protecting groups under different cleavage mechanisms could be an asset in peptide synthesis, since it provides the feasibility to incorporate different functional groups in similar reactive centres. However, selective protection/deprotection of orthogonal protecting groups in peptides is still ch...

journal_title：Amino acids

authors： Stathopoulos P,Papas S,Sakka M,Tzakos AG,Tsikaris V

更新日期：2014-05-01 00:00:00

abstract：:Amnesia is a deficit in memory caused by brain damage, disease, or trauma. Until now, there are no successful medications on the drug market available to treat amnesia. Short analogs and mimetics of human urocortin 3 (Ucn 3) tripeptide were synthetized and tested for their action against amnesia induced by eletroconvu...

journal_title：Amino acids

authors： Telegdy G,Kovács AK,Rákosi K,Zarándi M,Tóth GK

更新日期：2016-09-01 00:00:00

abstract：:eIF5A is highly conserved from archaea to mammals, essential for cell viability and the only protein known to contain the essential amino acid residue hypusine, generated by a unique posttranslational modification. eIF5A was originally identified as a translation initiation factor due to its ability to stimulate the f...

journal_title：Amino acids

authors： Dias CA,Gregio AP,Rossi D,Galvão FC,Watanabe TF,Park MH,Valentini SR,Zanelli CF

更新日期：2012-02-01 00:00:00

abstract：:This study investigated the effect of different sampling environments on hemolymph amino acid content of individual Drosophila melanogaster larvae. Hemolymph was collected from individual third instar larvae under cold-anesthetized, awake, and stress conditions. Qualitative and quantitative hemolymph amino acid analys...

journal_title：Amino acids

authors： Piyankarage SC,Augustin H,Featherstone DE,Shippy SA

更新日期：2010-03-01 00:00:00

abstract：:Creatine is an amino acid that has a pivotal role in energy metabolism of cells. Creatine acts as an "ATP shuttle", carrying ATP to the sites where it is utilized, through its reversible phosphorylation by creatine kinase. Moreover, the creatine-phosphocreatine system delays ATP depletion during anoxia or ischemia, th...

journal_title：Amino acids

authors： Garbati P,Salis A,Adriano E,Galatini A,Damonte G,Balestrino M,Millo E

更新日期：2013-10-01 00:00:00