当前位置： SCI文献检索 > AMINO ACIDS期刊下所有文献 > Protective effect of S-allyl-L-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain.

Protective effect of S-allyl-L-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain.

Abstract：

:Endoplasmic reticulum (ER) stress, implicated in various neurodegenerative processes, increases the level of intracellular Ca(2+) and leads to activation of calpain, a Ca(2+)-dependent cysteine protease. We have shown previously that S-allyl-L-cysteine (SAC) in aged garlic extracts significantly protects cultured rat hippocampal neurons (HPNs) against ER stress-induced neurotoxicity. The neuroprotective effect of SAC was compared with those of the related antioxidant compounds, L-cysteine (CYS) and N-acetylcysteine (NAC), on calpain activity in HPNs and also in vitro. SAC, but not CYS or NAC, reversibly restored the survival of HPNs and increased the degradation of α-spectrin, a substrate for calpain, induced by tunicamycin, a typical ER stress inducer. Activities of μ- and m-calpains in vitro were also concentration dependently suppressed by SAC, but not by CYS or NAC. At submaximal concentration, although ALLN (5 pM), which blocks the active site of calpain, and calpastatin (100 pM), an endogenous calpain-inhibitor protein, additively inhibited μ-calpain activity in vitro in combination with SAC, the effect of PD150606 (25 μM), which prevents interaction of Ca(2+) with the Ca(2+)-binding site of calpain, was unaffected by SAC. In contrast, SAC (1 mM) significantly reversed the effect of PD150606 at a concentration that elicited supramaximal inhibition (100 μM), but did not affect ALLN (1 nM)- and calpastatin (100 nM)-induced inhibition of μ-calpain activity. These results suggest that the protective effects of SAC against ER stress-induced neuronal cell death are not attributable to antioxidant activity, but to suppression of calpain through interaction with its Ca(2+)-binding site.

journal_name

Amino Acids

journal_title

Amino acids

authors

Imai T,Kosuge Y,Endo-Umeda K,Miyagishi H,Ishige K,Makishima M,Ito Y

doi

10.1007/s00726-013-1628-4

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

385-93

issue

2

eissn

0939-4451

issn

1438-2199

journal_volume

46

pub_type

杂志文章

相关文献

AMINO ACIDS文献大全
  • Oxidative degradation of N(ε)-fructosylamine-substituted peptides in heated aqueous systems.

    abstract：:Glycation, or non-enzymatic glycosylation, is a common protein modification formed by reactions between reducing sugars (i.e. aldoses and ketoses) with protein amino groups. Resulting Amadori and Heyns compounds, respectively, can be oxidatively degraded yielding a structurally heterogeneous group of advanced glycatio...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-015-1940-2

    authors： Greifenhagen U,Frolov A,Hoffmann R

    更新日期：2015-05-01 00:00:00

  • A mechanistic role for polypeptide hormone receptor lateral mobility in signal transduction.

    abstract：:Lateral diffusion of membrane-integral receptors within the plane of the membrane has been postulated to be mechanistically important for signal transduction. Direct measurement of polypeptide hormone receptor lateral mobility using fluorescence photobleaching recovery techniques indicates that tyrosine kinase recepto...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF00805831

    authors： Jans DA,Pavo I

    更新日期：1995-06-01 00:00:00

  • A new method to synthesize creatine derivatives.

    abstract：:Creatine is an amino acid that has a pivotal role in energy metabolism of cells. Creatine acts as an "ATP shuttle", carrying ATP to the sites where it is utilized, through its reversible phosphorylation by creatine kinase. Moreover, the creatine-phosphocreatine system delays ATP depletion during anoxia or ischemia, th...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-013-1525-x

    authors： Garbati P,Salis A,Adriano E,Galatini A,Damonte G,Balestrino M,Millo E

    更新日期：2013-10-01 00:00:00

  • Synthesis of a cyclic isostere of α-methyl homoserine by a stereoselective acylation-alkylation sequence of a chiral γ-lactam.

    abstract：:Starting from a chiral 4-hydroxymethyl pyrrolidin-2-one, an isostere of α-methyl homoserine tethered on a γ-lactam ring was prepared exploiting a stereoselective acylation-methylation sequence, followed by Curtius rearrangement, and structural assignment was confirmed by n.O.e. experiments. By reverting the sequence, ...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-014-1671-9

    authors： Civitavecchia A,Martelli G,Orena M,Rinaldi S

    更新日期：2014-04-01 00:00:00

  • Mechanistic details of amino acid catalyzed two-component Mannich reaction: experimental study backed by density functional calculations.

    abstract：:The role of pH-dependent ionic structures of L-amino acids in catalysis has been investigated for the two-component Mannich reactions between dimethyl malonate (DMM)/ethyl acetoacetate (EAA) and imines. As catalysts, L-amino acids performed well, even better than corresponding base catalysts and provided the β-amino c...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-019-02798-z

    authors： Rani D,Thakur L,Khera M,Goel N,Agarwal J

    更新日期：2019-11-01 00:00:00

  • Determination of the protooncogene ets-2 gene transcript in human brain at the atto-gram-level by the use of competitive RT/PCR.

    abstract：:Protooncogenes (PO) play a crucial role for brain biology and pathology. Only the concerted action of protooncogenes enables normal brain development. The reliable and sensitive quantification of brain PO is still holding centre stage in neurobiological research. The aim of our study was therefore the determination of...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF01318881

    authors： Schatzmann-Turhani D,Greber-Platzer S,Cairns N,Lubec G

    更新日期：1999-01-01 00:00:00

  • Growth promotion by homocysteine thiolactone and its alpha-alkylated derivative - A role for excess growth in homocystinurias?

    abstract：:It is controversial whether homocysteic acid or other homocysteine derivatives show growth promoting effects. In a clonogenic assay we could show that homocysteine thiolactone and its alpha alkylated derivative increased colony formation significantly. Our work favorizes previous observations showing growth promoting ...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF00808453

    authors： Lubec B,Szekeres T

    更新日期：1994-02-01 00:00:00

  • Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides.

    abstract：:Previous studies identified lysine- and tryptophan-rich sequences within various cationic antimicrobial peptides. In the present study, we synthesized a series of peptides composed of lysine (K)-tryptophan (W) repeats (KW)( n ) (where n equals 2, 3, 4 or 5) with amida...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-012-1388-6

    authors： Gopal R,Seo CH,Song PI,Park Y

    更新日期：2013-02-01 00:00:00

  • Functional aspects of the ventral pallidum.

    abstract：:The ventral pallidum is part of the corticoaccumbo-thalamocortical loop of the basal ganglia. In the past the function of this structure was discussed as a pure relay station in the process of limbic-motor integration. Some recent studies, however, underline that on the level of the ventral pallidum motor behavior can...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s007260070050

    authors： Kretschmer BD

    更新日期：2000-01-01 00:00:00

  • SILAC-based proteomic analysis to dissect the "histone modification signature" of human breast cancer cells.

    abstract：:In living cells, the N-terminal tails of core histones, the proteinaceous component of nucleosomes, are subjected to a range of covalent post-translational modifications (PTMs), which have specific roles in modulating chromatin structure and function. A growing body of evidence suggests that deregulation of histone mo...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-010-0668-2

    authors： Cuomo A,Moretti S,Minucci S,Bonaldi T

    更新日期：2011-07-01 00:00:00

  • eIF5A interacts functionally with eEF2.

    abstract：:eIF5A is highly conserved from archaea to mammals, essential for cell viability and the only protein known to contain the essential amino acid residue hypusine, generated by a unique posttranslational modification. eIF5A was originally identified as a translation initiation factor due to its ability to stimulate the f...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-011-0985-0

    authors： Dias CA,Gregio AP,Rossi D,Galvão FC,Watanabe TF,Park MH,Valentini SR,Zanelli CF

    更新日期：2012-02-01 00:00:00

  • Taurine prevents ethanol-induced apoptosis mediated by mitochondrial or death receptor pathways in liver cells.

    abstract：:One pathogenic mechanism of ethanol-induced liver injury is the excessive production of reactive oxygen species (ROS), which may result in alcoholic liver disease (ALD) characterized by cell death due to necrosis and apoptosis. Taurine was proved to protect against liver damage. However, whether taurine attenuates eth...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-018-2561-3

    authors： Wu G,Yang J,Lv H,Jing W,Zhou J,Feng Y,Lin S,Yang Q,Hu J

    更新日期：2018-07-01 00:00:00

  • Cytotoxicity of boron containing dipeptide analogs.

    abstract：:This work is an extension of our previous work (Hall et al., 1993) on the synthesis and cytotoxic activity of boronated peptides. The aim of this work was to carry out structural modifications of the amine terminal in compounds1 and2, to increase water solubility, and its effect on the cytotoxicity to tumor cell lines...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF00806550

    authors： Karthikeyan S,Sood A,Tomasz J,Spielvogel BF,Hall IH

    更新日期：1995-12-01 00:00:00

  • Prediction and analysis of cell-penetrating peptides using pseudo-amino acid composition and random forest models.

    abstract：:Cell-penetrating peptides, a group of short peptides, can traverse cell membranes to enter cells and thus facilitate the uptake of various molecular cargoes. Thus, they have the potential to become powerful drug delivery systems. The correct identification of peptides as cell-penetrating or non-cell-penetrating would ...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-015-1974-5

    authors： Chen L,Chu C,Huang T,Kong X,Cai YD

    更新日期：2015-07-01 00:00:00

  • Evidence for the involvement of D-aspartic acid in learning and memory of rat.

    abstract：:D-Aspartic acid (D-Asp) is an endogenous amino acid present in neuroendocrine systems. Here, we report evidence that D-Asp in the rat is involved in learning and memory processes. Oral administration of sodium D-aspartate (40 mM) for 12-16 days improved the rats' cognitive capability to find a hidden platform in the M...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-009-0369-x

    authors： Topo E,Soricelli A,Di Maio A,D'Aniello E,Di Fiore MM,D'Aniello A

    更新日期：2010-05-01 00:00:00

  • gamma-L-glutamyltaurine.

    abstract：:The discovery of the dipeptide gamma-glutamyltaurine (gamma-GT; glutaurine, Litoralon) in the parathyroid in 1980 and later in the brain of mammals gave rise to studies on intrinsic and synthetic taurine peptides of this type. It was suggested that gamma-glutamyltransferase (GGT; gamma-glutamyltranspeptidase) in the b...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-005-0196-7

    authors： Bittner S,Win T,Gupta R

    更新日期：2005-06-01 00:00:00

  • A novel method for promoting heterologous protein expression in Escherichia coli by fusion with the HIV-1 TAT core domain.

    abstract：:The human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (TAT) protein, a member of the protein transduction domain (PTD) superfamily, can deliver heterologous proteins across most biomembranes without losing bioactivity. However, there is no report on whether the TAT core domain containing the ...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-010-0534-2

    authors： Wu Y,Ren C,Gao Y,Hou B,Chen T,Zhang C

    更新日期：2010-08-01 00:00:00

  • In silico investigation of molecular mechanism of laminopathy caused by a point mutation (R482W) in lamin A/C protein.

    abstract：:Lamin A/C proteins are the major components of a thin proteinaceous filamentous meshwork, the lamina, that underlies the inner nuclear membrane. A few specific mutations in the lamin A/C gene cause a disease with remarkably different clinical features: FPLD, or familial partial lipodystrophy (Dunnigan-type), which mai...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-011-1108-7

    authors： Rajendran V,Purohit R,Sethumadhavan R

    更新日期：2012-08-01 00:00:00

  • Effects of glutamate antagonists on the activity of aromatic L-amino acid decarboxylase.

    abstract：:This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson's disease. A...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF01345241

    authors： Fisher A,Biggs CS,Starr MS

    更新日期：1998-01-01 00:00:00

  • Microwave-induced synthesis of new optically active and soluble polyamides containing pendent 4-(2-phthalimidiylpropanoylamino)benzoylamino-groups.

    abstract：:An aromatic chiral diacid monomer, 5-[4-(2-phthalimidiylpropanoylamino)-benzoylamino]isophthalic acid was synthesized in five steps under conventional heating in high yield and purity. A series of soluble, thermally stable and optically active polyamides (PA)s containing pendent groups made of phthalimide, flexible L:...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-008-0186-7

    authors： Mallakpour S,Rafiee Z

    更新日期：2009-10-01 00:00:00

  • Quantification of D-amino acids in human urine using GC-MS and HPLC.

    abstract：:The relative amounts of free D-amino acids (D-AA) in the urine of seven healthy volunteers (age 27 to 49 years) were determined using chiral phase (Chirasil-L-Val) capillary gas chromatography in conjunction with selected ion monitoring mass spectrometry. The absolute amounts of free D-AA were determined by pre-column...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF00805848

    authors： Brückner H,Haasmann S,Friedrich A

    更新日期：1994-06-01 00:00:00

  • Hypotaurine disproportionation reaction: identification of products.

    abstract：:Hypotaurine, concentrated under reduced pressure in HCl solution, partially (30-40%) degrades into taurine (about 30%), 2-aminoethyl-2-aminoethanethiolsulfonate (about 10%) and ethanolamine. The degradation products were identified using LC/APCI-MS, NMR, amino acid analysis and various chromatographies. The identities...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF01320900

    authors： Duprè S,Spirito A,Pinnen F,Sugahara K,Kodama H

    更新日期：1998-01-01 00:00:00

  • A refined synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids.

    abstract：:The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-o...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-011-0918-y

    authors： Declerck V,Aitken DJ

    更新日期：2011-08-01 00:00:00

  • Expression and function of arginine-producing and consuming-enzymes in the kidney.

    abstract：:The kidney plays a key role in arginine metabolism. Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which ...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-011-0897-z

    authors： Levillain O

    更新日期：2012-04-01 00:00:00

  • Changes in neutral amino acid efflux and membrane potential associated with the expression of CFTR protein.

    abstract：:The expression of wild type CFTR facilitates the efflux of neutral amino acids (Rotoli et al., Biochem. Biophys. Res. Commun. 204: 653-658, 1994); as a result, after an extensive depletion of intracellular amino acid pool obtained through an incubation in saline solution, the intracellular leucine levels were lower in...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF00813863

    authors： Rotoli BM,Bussolati O,Cabrini G,Gazzola GC

    更新日期：1996-06-01 00:00:00

  • Structure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity.

    abstract：:Taking a minimalistic approach in efforts to lower the cost for the development of new synthetic antimicrobial peptides, ultrashort cationic lipopeptides were designed to mimic the amphiphilic nature crucial for their activity but with only a very short peptide sequence ligated to a lipidic acid. Nine ultrashort catio...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-014-1806-z

    authors： Domalaon R,Yang X,O'Neil J,Zhanel GG,Mookherjee N,Schweizer F

    更新日期：2014-11-01 00:00:00

  • Identification and bioactivity evaluation of the first neuropeptide from the lesser-known insect order Embioptera (webspinner).

    abstract：:A species of the poorly studied order Embioptera, the webspinner Oligotoma saundersii, is investigated for its complement of neuropeptides of the adipokinetic hormone (AKH) family. A methanolic extract of its corpora cardiaca (CC) is able to effect carbohydrate mobilization in the cockroach, Periplaneta americana, and...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-016-2229-9

    authors： Gäde G,Šimek P,Marco HG

    更新日期：2016-07-01 00:00:00

  • Hydration of amino acids: FTIR spectra and molecular dynamics studies.

    abstract：:The hydration of selected amino acids, alanine, glycine, proline, valine, isoleucine and phenylalanine, has been studied in aqueous solutions by means of FTIR spectra of HDO isotopically diluted in H2O. The difference spectra procedure and the chemometric method have been applied to remove the contribution of bulk wat...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-015-2005-2

    authors： Panuszko A,Adamczak B,Czub J,Gojło E,Stangret J

    更新日期：2015-11-01 00:00:00

  • Taurine protected myocardial mitochondria injury induced by hyperhomocysteinemia in rats.

    abstract：:Taurine can protect against cardiovascular diseases, whereas elevated levels of plasma homocysteine are associated with atherosclerotic and thromboembolic cardiovascular diseases. To illustrate the effects of taurine on hyperhomocysteinemia, we observed the myocardial mitochondria dysfunction in the rats with hyperhom...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-004-0096-2

    authors： Chang L,Xu J,Yu F,Zhao J,Tang X,Tang C

    更新日期：2004-08-01 00:00:00

  • Glutamine, arginine, and leucine signaling in the intestine.

    abstract：:Glutamine and leucine are abundant constituents of plant and animal proteins, whereas the content of arginine in foods and physiological fluids varies greatly. Besides their role in protein synthesis, these three amino acids individually activate signaling pathway to promote protein synthesis and possibly inhibit auto...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-008-0225-4

    authors： Marc Rhoads J,Wu G

    更新日期：2009-05-01 00:00:00