Abstract:
:The relative amounts of free D-amino acids (D-AA) in the urine of seven healthy volunteers (age 27 to 49 years) were determined using chiral phase (Chirasil-L-Val) capillary gas chromatography in conjunction with selected ion monitoring mass spectrometry. The absolute amounts of free D-AA were determined by pre-column derivatization of the amino acids witho-phthaldialdehyde andN-isobutyryl-L-cysteine followed by high-performance liquid chromatographic separation and fluorescence detection of the isoindol derivatives formed. The following most abundant D-AA were found (highest and lowest absolute and relative amounts): D-Ser (379.8 - 30.1µMol/L; 56.5 - 19.0%), D-Ala (53.8 - 7.6µMol/L; 19.6 - 5.7%), D-Thr (5.8 - 0.25µMol/L; 3.4 - 1.0%), D-Val (3.7 - 0µMol/L; 4.2 - 0%), and D-Phe (3.5 - 0.35µMol/L; 4.8 - 1.4%).
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Brückner H,Haasmann S,Friedrich Adoi
10.1007/BF00805848subject
Has Abstractpub_date
1994-06-01 00:00:00pages
205-11issue
2eissn
0939-4451issn
1438-2199journal_volume
6pub_type
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