Changes in neutral amino acid efflux and membrane potential associated with the expression of CFTR protein.

abstract：:This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson's disease. A...

journal_title：Amino acids

authors： Fisher A,Biggs CS,Starr MS

更新日期：1998-01-01 00:00:00

abstract：:Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined b...

journal_title：Amino acids

authors： Wei S,Fan L,Wu W,Ji Z

更新日期：2012-11-01 00:00:00

abstract：:Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport chain (ETC), we investigated whether there was a direct relationship bet...

journal_title：Amino acids

authors： Hancock CN,Liu W,Alvord WG,Phang JM

更新日期：2016-03-01 00:00:00

abstract：:A novel recombinant disintegrin, vicrostatin (VCN), displays high binding affinity to a broad range of human integrins in substantial competitive biological advantage over other integrin-based antagonists. In this study, we synthesized a new 64Cu-labeled VCN probe and evaluated its imaging properties for prostate canc...

journal_title：Amino acids

authors： Jadvar H,Chen K,Park R,Yap LP,Vorobyova I,Swenson S,Markland FS

更新日期：2019-11-01 00:00:00

abstract：:Excitotoxicity induced by NMDA receptor stimulation is able to increase the activity of many enzymes involved in neuronal cell death. Primary cultures of rat cerebellar granule cells were used to elucidate the role of transglutaminase reaction in the excitotoxic cell response, and to evaluate the role of glutamate rec...

journal_title：Amino acids

authors： Caccamo D,Currò M,Cusumano G,Crisafulli G,Ientile R

更新日期：2004-03-01 00:00:00

abstract：:Among the available protocols, chemically driven approaches to oxidize cysteine may not be required for molecules that, under the native-like conditions, naturally fold in conformations ensuring an effective pairing of the right disulfide bridge pattern. In this contest, we successfully prepared the distinctin, a natu...

journal_title：Amino acids

authors： Calce E,Vitale RM,Scaloni A,Amodeo P,De Luca S

更新日期：2015-08-01 00:00:00

abstract：:The focus has been on the development of methodology for stereoselective preparation of spiroannulated intermediates of the Schöllkopf chiron and further transformations to cyclic alpha-amino acids. The spiroannulations are effected by Ru(II)-catalysed ring-closing metathesis reactions, by Ru(II)- and Pd(0)-catalysed ...

journal_title：Amino acids

authors： Undheim K

更新日期：2008-04-01 00:00:00

abstract：:The increased protein requirement of endurance athletes may be related to the need to replace exercise-induced oxidative losses, especially of the branched-chain amino acids (BCAA). However, it is unknown if non-essential amino acids (NEAA) influence the requirement for essential amino acids (EAA) during post-exercise...

journal_title：Amino acids

authors： Kato H,Volterman KA,West DWD,Suzuki K,Moore DR

更新日期：2018-12-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (ischemic disease, such as stroke and myocardial infarction, and arterial and venous thrombotic events) in the general population. We can assume that the association is causal, based on the example of homocystinuria, and on the evidence put ...

journal_title：Amino acids

authors： Perna AF,Ingrosso D,De Santo NG

更新日期：2003-12-01 00:00:00

abstract：:Transglutaminases are a family of enzymes which show the common capacity to catalyse the cross-linking of protein substrates. Some members of this family of enzymes are also capable to catalyse other chemical reactions for the cell life. The distribution and the role of these enzymes have been studied in numerous cell...

journal_title：Amino acids

authors： Pepe I,Occhino E,Cella G,Luongo A,Guardascione F,Gentile V

更新日期：2004-07-01 00:00:00

abstract：:The relative amounts of free D-amino acids (D-AA) in the urine of seven healthy volunteers (age 27 to 49 years) were determined using chiral phase (Chirasil-L-Val) capillary gas chromatography in conjunction with selected ion monitoring mass spectrometry. The absolute amounts of free D-AA were determined by pre-column...

journal_title：Amino acids

authors： Brückner H,Haasmann S,Friedrich A

更新日期：1994-06-01 00:00:00

abstract：:L-Arginine:glycine amidinotransferase (AGAT) is the main producer of the creatine precursor, guanidinoacetate (GAA), and L-homoarginine (hArg). We and others previously reported lower levels of circulating and urinary hArg in renal transplant recipients (RTR) compared to healthy subjects. In adults, hArg emerged as a ...

journal_title：Amino acids

authors： Hanff E,Said MY,Kayacelebi AA,Post A,Minovic I,van den Berg E,de Borst MH,van Goor H,Bakker SJL,Tsikas D

更新日期：2019-11-01 00:00:00

abstract：:The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this revie...

journal_title：Amino acids

authors： Lentini A,Provenzano B,Tabolacci C,Beninati S

更新日期：2009-04-01 00:00:00

abstract：:Fibronectin (FN) is a cell adhesion protein that binds integrins in a process also involving the protein-crosslinking enzyme transglutaminase 2 (TG2) as a co-receptor. The cell-adhesive property of TG2 has been linked to a complex formation with FN and to its ability to crosslink and polymerize FN on the cell surface....

journal_title：Amino acids

authors： Forsprecher J,Wang Z,Nelea V,Kaartinen MT

更新日期：2009-04-01 00:00:00

abstract：:We describe six children with tetrahydrobiopterin (BH(4)) responsive phenylalanine hydroxylase (PAH) deficiency. All patients carry two mutant alleles in the PAH gene. Cofactor deficiency was excluded. The effect of BH(4) administration was studied by correlating different oral BH(4) doses with plasma phenylalanine le...

journal_title：Amino acids

authors： Steinfeld R,Kohlschütter A,Ullrich K,Lukacs Z

更新日期：2003-07-01 00:00:00

abstract：:Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide generation. These defects can fundamentally alter cardiomyocyte function and if left unchanged can result in cell death. To protect against these stresses, cardiomyocytes possess quality contr...

journal_title：Amino acids

authors： Jong CJ,Ito T,Schaffer SW

更新日期：2015-12-01 00:00:00

abstract：:Amino acid and glucosinolate biosynthesis are two interdependent pathways; amino acid synthesis as a part of primary metabolism provides the precursors for glucosinolate biosynthesis in secondary metabolism. In our previous studies, the combination of coexpression analysis and metabolite profiling led to the identific...

journal_title：Amino acids

authors： Albinsky D,Sawada Y,Kuwahara A,Nagano M,Hirai A,Saito K,Hirai MY

更新日期：2010-10-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) plays a vital role in the progress of malignant disease and elevated Hsp90 expression has been reported in pancreatic cancer. In this study, we radiolabeled a dimeric Sansalvamide A derivative (Di-San A1) with 64Cu, and evaluated the feasibility of using 64Cu-Di-San A1 for PET imaging of ...

journal_title：Amino acids

authors： Wang X,Zhang J,Wu H,Li Y,Conti PS,Chen K

更新日期：2018-07-01 00:00:00

abstract：:Polyamines have been related to the "Crassulacean Acid Metabolism" (CAM) in higher plants. Such relationship was however observed in plants where CAM activity is inducible by external factors. Results presented here indicate that, inOpuntia F. indica, cladodes where onset of CAM is dependent on internal conditions, i....

journal_title：Amino acids

authors： Deidda P,Tekle Z,Nieddu G,Pintus G,Pinna GG,Sisini A

更新日期：1994-06-01 00:00:00

abstract：:A procedure for the synthesis of enantiopure beta3-amino acids from proteinogenic alpha-amino acids, developed by our group a few years ago, has been modified to enable the production of C-2 fully deuterated, C-protected beta3-amino acids and, even more important, the synthesis of valuable deuterium labelled N(Boc)-pr...

journal_title：Amino acids

authors： Caputo R,Longobardo L

更新日期：2007-01-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (TAT) protein, a member of the protein transduction domain (PTD) superfamily, can deliver heterologous proteins across most biomembranes without losing bioactivity. However, there is no report on whether the TAT core domain containing the ...

journal_title：Amino acids

authors： Wu Y,Ren C,Gao Y,Hou B,Chen T,Zhang C

更新日期：2010-08-01 00:00:00

abstract：:Prophylactic supplementation of N-acetyl-cysteine (NAC) and epigallocatechin gallate (EGCG) was studied for physiological and cellular changes in skeletal muscle after eccentric muscle contractions. Thirty healthy, active males (20.0 +/- 1.8 years, 160 +/- 7.1 cm, 76.1 +/- 17.0 kg) ingested for 14 days either 1,800 mg...

journal_title：Amino acids

authors： Kerksick CM,Kreider RB,Willoughby DS

更新日期：2010-06-01 00:00:00

abstract：:Transglutaminases (TGs) are a large family of related and ubiquitous enzymes that catalyze the cross-linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a protein/peptide co-substrate. Considerable and intense progress has been made in the understanding of the chemistry, molecular biol...

journal_title：Amino acids

authors： Tabolacci C,Lentini A,Provenzano B,Beninati S

更新日期：2012-02-01 00:00:00

abstract：:Dietary polyamines and amino acids (AAs) are crucial for human growth, development, reproduction, and health. However, the scientific literature shows large variations in polyamine and AA concentrations among major staple foods of plant origin, and there is a scarcity of information regarding their complete compositio...

journal_title：Amino acids

authors： Hou Y,He W,Hu S,Wu G

更新日期：2019-08-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) biosynthesis depended to a great extent on the biotransformation characterization of glutamate decarboxylase (GAD) and process conditions. In this paper, the enhancing effect of D101 macroporous adsorption resin (MAR) on the GABA production was investigated based on the whole-cell biotra...

journal_title：Amino acids

authors： Yang SY,Liu SM,Jiang M,Wang BS,Peng LH,Zeng C

更新日期：2020-05-01 00:00:00

abstract：:L-tryptophan (TRP) is the precursor amino acid for the synthesis of serotonin (5-HT). 5-HT is effective both on the food intake and gastrointestinal system contractility. The aim of this study was to search the effects of systemic TRP treatment on 5-HT levels of ileum and searching the effect of ileal contractility an...

journal_title：Amino acids

authors： Ozer C,Gönül B,Ercan ZS,Take G,Erdoğan D

更新日期：2007-01-01 00:00:00

abstract：:The effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) in mice were evaluated. C57BL/6 female mice were given 3% DSS in drinking water for 5 d to induce acute colitis. Taurine at 2% was added to the drinking water 5 d before and during the DSS-treatment to investigate its pr...

journal_title：Amino acids

authors： Zhao Z,Satsu H,Fujisawa M,Hori M,Ishimoto Y,Totsuka M,Nambu A,Kakuta S,Ozaki H,Shimizu M

更新日期：2008-06-01 00:00:00

abstract：:An immunocytochemical investigation of the expression of alpha(1), alpha(6), beta(2/3), gamma(2) and delta subunits was performed on rat cerebellum granule cells in culture by the two photon microscopy technique. The first four subunits appear to be expressed abundantly in these cells, whereas the delta one seems to b...

journal_title：Amino acids

authors： Merlo F,Balduzzi R,Cupello A,Robello M

更新日期：2004-02-01 00:00:00

abstract：:Arginine (Arg) and glutamine (Gln) utilization is greatly increased during catabolic stress. While the supply of both amino acids has been advocated in this situation, arginine administration is possibly associated with deleterious effects. From a metabolic point of view, these two amino acids are reciprocal precursor...

journal_title：Amino acids

authors： Ventura G,Moinard C,Segaud F,Le Plenier S,Cynober L,De Bandt JP

更新日期：2010-11-01 00:00:00

abstract：:In the postgenomic era new technologies are emerging for global analysis of protein function. The introduction of active site-directed chemical probes for enzymatic activity profiling in complex mixtures, known as activity-based proteomics has greatly accelerated functional annotation of proteins. Here we review probe...

journal_title：Amino acids

authors： Schmidinger H,Hermetter A,Birner-Gruenberger R

更新日期：2006-06-01 00:00:00