Abstract:
:The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this review, we focus our attention on the metabolic aspects of some natural compounds (methylxantines, retinoids and flavonoids) responsible of their antitumor effects exerted through the induction of TG activity in cancer cells.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Lentini A,Provenzano B,Tabolacci C,Beninati Sdoi
10.1007/s00726-008-0157-zsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
701-8issue
4eissn
0939-4451issn
1438-2199journal_volume
36pub_type
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