Abstract:
:Taurine is found in bone tissue, but its function in skeletal tissue is not fully understood. The present study was undertaken to investigate regulation of gene expression of connective tissue growth factor (CTGF), and the roles of mitogen-activated protein kinases (MAPKs) in murine osteoblast MC3T3-E1 cells treated with taurine. Western blot analysis showed taurine stimulated CTGF protein secretion in a dose- and time-dependent manner. Taurine induced activation of extracellular signal-regulated kinase (ERK), but not p38 and c-jun N-terminal Kinase (JNK), in osteoblasts. Furthermore, pretreatment of osteoblasts with the ERK inhibitor PD98059 abolished the taurine-induced CTGF production. These data indicate that taurine induces CTGF secretion in MC3T3-E1 cells mediated by the ERK pathway, and suggest that osteoblasts are direct targets of taurine.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Yuan LQ,Lu Y,Luo XH,Xie H,Wu XP,Liao EYdoi
10.1007/s00726-006-0380-4subject
Has Abstractpub_date
2007-01-01 00:00:00pages
425-30issue
3eissn
0939-4451issn
1438-2199journal_volume
32pub_type
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