Abstract:
:This study investigated the effect of different sampling environments on hemolymph amino acid content of individual Drosophila melanogaster larvae. Hemolymph was collected from individual third instar larvae under cold-anesthetized, awake, and stress conditions. Qualitative and quantitative hemolymph amino acid analyses were performed via capillary electrophoresis with laser-induced fluorescence detection. The hemolymph amino acid concentrations, particularly arginine, glutamate, and taurine, changed significantly depending on the prior-to-sample-collection environments. Hemolymph amino acid analyses of six different Drosophila genotypes including two control genotypes and four mutant alleles were also carried out. Two mutant genotypes with over and under expression of a putative cystine-glutamate exchanger subunit were significantly different from each other with respect to their hemolymph glutamate, glycine, lysine, and taurine levels. Hemolymph amino acid analyses of stressed larvae of two control and two mutant genotypes indicated that behavior-related hemolymph chemical changes are also genotype dependent.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Piyankarage SC,Augustin H,Featherstone DE,Shippy SAdoi
10.1007/s00726-009-0284-1subject
Has Abstractpub_date
2010-03-01 00:00:00pages
779-88issue
3eissn
0939-4451issn
1438-2199journal_volume
38pub_type
杂志文章相关文献
AMINO ACIDS文献大全abstract::Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined b...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1303-1
更新日期:2012-11-01 00:00:00
abstract::Germination ofBacillus subtilis spores was initiated by L-Ala and competitively inhibited by D-Ala, suggesting the presence of an alanine receptor. The spores showed alanine racemase activity in the spore coat. To investigate the role of alanine racemase (L → D) on germination, net racemase activity was determined usi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00805804
更新日期:1993-02-01 00:00:00
abstract::As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on diet...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1583-0
更新日期:2013-11-01 00:00:00
abstract::Taurine (TAU) has been shown to improve exercise time to exhaustion and 3-km running performance; however, no studies have considered the effect of acute TAU ingestion on short duration cycling time trial (TT) performance. The aim of this study was to determine the effects of a single oral acute dose of 1000 mg of TAU...
journal_title:Amino acids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00726-016-2282-4
更新日期:2016-11-01 00:00:00
abstract::There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-1132-7
更新日期:2012-08-01 00:00:00
abstract::Reduced glutathione (GSH) levels and glutathione reductase (GR) and glutathione S-transferase (GST) activities were investigated in the erythrocytes and lymphocytes of non-dialyzed patients with varying degrees of chronic renal insufficiency, and also of patients on regular hemodialysis treatment. GSH, GR and GST leve...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00805943
更新日期:1992-10-01 00:00:00
abstract::Emerging evidence from laboratory researches has highlighted the bioactivity of food melanoidins and melanoproteins. Whilst such studies have been carried out with different in vitro systems, information about melanoidins absorption and bio-availability are scarce. However, they are generally considered as poorly abso...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-015-1951-z
更新日期:2015-06-01 00:00:00
abstract::Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic chan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0791-0
更新日期:2011-10-01 00:00:00
abstract::The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-o...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0918-y
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:Chemo-therapeutic treatment of glioma patients has minor success. Little is known about mechanisms of a pronounced resistance of gliomas towards actual therapies, yet. ABC-1 belongs to the group of transporters known to be involved in the export of hydrophobic substances and vascular regulation. This study in...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-005-0171-3
更新日期:2005-03-01 00:00:00
abstract::The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this revie...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-008-0157-z
更新日期:2009-04-01 00:00:00
abstract::In a previous research, we have shown that adequate levels of polyamines are required in transformed mouse fibroblasts for the correlated activations of MAPK subtypes (ERK and JNK) and caspases induced by etoposide and leading to apoptosis. We report now that the treatment of fibroblasts with etoposide also elicited a...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-004-0101-9
更新日期:2004-10-01 00:00:00
abstract::Recovery of amino acid (AA) metabolism and the associated clinical implications in chronic hepatitis C (CHC) patients with sustained virological response (SVR) following anti-hepatitis C virus (HCV) therapy remains elusive. A prospective cohort study was conducted on 222 CHC patients with SVR. Eighty-two age-matched m...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2360-7
更新日期:2017-02-01 00:00:00
abstract::The TES ether of the C6-hydroxy derivative of naturally occurring epi-jasmonic acid (epi-JA) was designed as epimerization-free equivalent of epi-JA. The TES ether was synthesized from (1R,4S)-4-hydroxycyclopent-2-enyl acetate in 13 steps. The acid part of the ether was activated with ClCO2Bui and subjected to condens...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0925-z
更新日期:2012-05-01 00:00:00
abstract::Molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression has drawn significant attention because of the unique role of the HER2 gene in diagnosis, therapy and prognosis of human breast cancer. In our previous research, a novel cyclic 2-helix small protein, MUT-DS, was discovered as an anti-...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1096-7
更新日期:2012-07-01 00:00:00
abstract::Seryl-histidine dipeptide (Ser-His) has been recognized as the shortest peptide with hydrolysis cleavage activity; however, its protein cleavage spectrum has not yet been fully explored. Here, four differently folded proteins were treated with Ser-His, and the digestion products were evaluated with high-resolution mas...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2487-1
更新日期:2018-01-01 00:00:00
abstract::The lysine catabolism pathway differs in adult mammalian brain from that in extracerebral tissues. The saccharopine pathway is the predominant lysine degradative pathway in extracerebral tissues, whereas the pipecolate pathway predominates in adult brain. The two pathways converge at the level of ∆(1)-piperideine-6-ca...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1590-1
更新日期:2013-12-01 00:00:00
abstract::A well preserved nutritional status is beneficial in chronically uremic patients for slowing the pace of deterioration of renal function, and delaying the need for dialysis therapy. The purpose of this study was to assess the nutritional profile of 10 patients in a steady state of advanced CRF, and of 15 patients with...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00806083
更新日期:1992-02-01 00:00:00
abstract::Oxidative deamination of norepinephrine (NE) and dopamine (DA) by monoamine oxidase (MAO) generates the catecholaldehydes 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively, and H2O2. Catecholaldehydes are highly reactive electrophiles that have been implicated as cau...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2647-y
更新日期:2019-01-01 00:00:00
abstract::Several descriptors of protein structure at the sequence and residue levels have been recently proposed. They are widely adopted in the analysis and prediction of structural and functional characteristics of proteins. Numerous in silico methods have been developed for sequence-based prediction of these descriptors. Ho...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0721-1
更新日期:2011-03-01 00:00:00
abstract::Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we applied a non-biase...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2236-x
更新日期:2016-08-01 00:00:00
abstract::In order to adapt to ever changing environmental conditions, bacteria sense environmental stimuli, and convert them into signals that are transduced intracellularly. Several mechanisms have evolved by which receptors transmit signals across the cytoplasmic membrane. Stimulus perception may trigger receptor dimerizatio...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-009-0235-x
更新日期:2009-09-01 00:00:00
abstract::Granulocyte-colony stimulating factor stimulates production and antibacterial function of neutrophiles. Therapy using the recombinant protein drug represents a major step forward in oncology. The protein has not been, however, completely sequenced at the protein level and this formed the rationale of the current study...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0312-1
更新日期:2010-04-01 00:00:00
abstract::Synthesis and properties of a new fluorescent/fluorogenic substrate Ac-DEVD-AMAC for caspase-3 are reported. The substrate is obtained by conventional Fmoc-based solid phase peptide synthesis and its properties are investigated with regard to fluorescence, sensitivity, applicability and kinetic constants. A non-tradit...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0136-4
更新日期:2009-03-01 00:00:00
abstract::In the article (Romek et al. 2013) we reported the values of δ15N (‰) and δ13C (‰) obtained by. ...
journal_title:Amino acids
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00726-017-2506-2
更新日期:2018-01-01 00:00:00
abstract::Peptide bonds in protein structures are mainly found in trans conformation with a torsion angle ω close to 180°. Only a very low proportion is observed in cis conformation with ω angle around 0°. Cis-trans isomerization leads to local conformation changes which play an important role in many biological processes. In t...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1511-3
更新日期:2013-08-01 00:00:00
abstract::In the absence of exogenous Ca(2+) and Mg(2+) and in the presence of EGTA, which favours the release of endogenous Ca(2+), the polyamine spermine is able to stimulate the activity of pyruvate dehydrogenase complex (PDC) of energized rat liver mitochondria (RLM). This stimulation exhibits a gradual concentration-depend...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0099-5
更新日期:2009-03-01 00:00:00
abstract::Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes, and plasmodia, as well as human blood and cancer cells. In analysing the cytolytic activity of synthesised all-D: - and all-L: -cupiennin 1a towards pro- and e...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0471-0
更新日期:2011-01-01 00:00:00
abstract::The study of nanomaterial/biomolecule interface is an important emerging field in bionanoscience, and additionally in many biological processes such as hard-tissue growth and cell-surface adhesion. To have a deeper understanding of the amino acids/gold nanoparticle assemblies, the adsorption of these amino acids on th...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1642-6
更新日期:2014-04-01 00:00:00
abstract::This study aimed to investigate the ability of curcumin to convert asparagine into acrylamide during heating at different temperatures. Binary and ternary model systems of asparagine-curcumin and asparagine-curcumin-fructose were used to determine the role of curcumin on acrylamide formation in competitive and uncompe...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1179-5
更新日期:2013-06-01 00:00:00