Abstract:
:There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application of Cr supplementation is indeed exciting. Evidences of benefits from this supplement have been reported in a broad range of diseases, including myopathies, neurodegenerative disorders, cancer, rheumatic diseases, and type 2 diabetes. In addition, after hundreds of published studies and millions of exposures creatine supplementation maintains an excellent safety profile. Thus, we contend that the widespread application of this supplement may benefit athletes, elderly people and various patient populations. In this narrative review, we aimed to summarize both the ergogenic and therapeutic effects of Cr supplementation. Furthermore, we reviewed the impact of Cr supplementation on kidney function.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Gualano B,Roschel H,Lancha AH Jr,Brightbill CE,Rawson ESdoi
10.1007/s00726-011-1132-7subject
Has Abstractpub_date
2012-08-01 00:00:00pages
519-29issue
2eissn
0939-4451issn
1438-2199journal_volume
43pub_type
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