Antiviral activity of oxidized polyamines.

Abstract:

:Polyamines, oxidized by serum amine oxidase, yield aminoaldehydes and hydrogen peroxide. Acrolein may be formed from the aminoaldehydes by a spontaneous beta-elimination process. These oxidation products "oxidized polyamines" inhibit bacterial growth and exhibit anticancer activity. The antimicrobial activity of oxidized polyamines is not limited to bacteria; and the inactivation of bacterial viruses, plant viruses and animal viruses, was also reported. Bacteriophages of the T-odd series are permeable and were inactivated by oxidized polyamines. The inactive phages absorb to their bacterial host and injected their DNA, which formed a stable inactive complex with the aminoaldehydes. Aminoaldehydes, synthesized chemically, also inactivated viruses. The growth of the plant viruses: Tobacco mosaic virus, Potato virus X and Alfalfa mosaic virus was also inhibited by oxidized polyamines. The animal viruses, which were inactivated by oxidized polyamines included Myxoviruses (influenza and Newcastle disease viruses), West Nile, vaccinia and Sindbis viruses. These findings may have practical implications.

journal_name

Amino Acids

journal_title

Amino acids

authors

Bachrach U

doi

10.1007/s00726-007-0535-y

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

267-72

issue

2

eissn

0939-4451

issn

1438-2199

journal_volume

33

pub_type

杂志文章,评审
  • Cancer therapy and prevention by green tea: role of ornithine decarboxylase.

    abstract::Green tea which is widely consumed in China, Japan and India, contains polyphenolic compounds, which account for 30% of the dry weight of the leaves. Most of the polyphenols are flavanols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant. Epidemiological studies revealed that the incidences of stomach a...

    journal_title:Amino acids

    pub_type: 杂志文章,评审

    doi:10.1007/s726-002-8197-9

    authors: Bachrach U,Wang YC

    更新日期:2002-01-01 00:00:00

  • Quantification of D-amino acids in human urine using GC-MS and HPLC.

    abstract::The relative amounts of free D-amino acids (D-AA) in the urine of seven healthy volunteers (age 27 to 49 years) were determined using chiral phase (Chirasil-L-Val) capillary gas chromatography in conjunction with selected ion monitoring mass spectrometry. The absolute amounts of free D-AA were determined by pre-column...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/BF00805848

    authors: Brückner H,Haasmann S,Friedrich A

    更新日期:1994-06-01 00:00:00

  • Metabolism and function in animal tissues of agmatine, a biogenic amine formed from arginine.

    abstract::Recently agmatine, decarboxylated arginine, has been shown to be an important biological compound in several animal tissues. This paper summarizes the known information regarding the transport of arginine, its decarboxylation and the effects of the agmatine formed mainly on NO and polyamine synthesis. ...

    journal_title:Amino acids

    pub_type: 杂志文章,评审

    doi:10.1007/s00726-003-0030-z

    authors: Grillo MA,Colombatto S

    更新日期:2004-02-01 00:00:00

  • Synthesis of medicinally useful lipidicα-amino acids, 2-amino alcohols and diamines.

    abstract::The lipidicα-amino acids (LAAs) are non-naturalα-amino acids with saturated or unsaturated long aliphatic side chains. LAAs and their derivatives (lipid mimetics) together with the lipidic peptides represent a class of compounds which combine structural features of lipids with those of amino acids and peptides. Racemi...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/BF00807940

    authors: Kokotos G,Martin V,Constantinou-Kokotou V,Gibbons WA

    更新日期:1996-09-01 00:00:00

  • Effect of glutamate and angiotensin II on whole cell currents and release of nitric oxide in the rat subfornical organ.

    abstract::Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO). Conversely, nitric oxide (NO) has exclusively inhibitory effects on rat SFO-neurons and on SFO-mediated water-intake. Extracellular and patch-clamp recordings from freshly dissociated...

    journal_title:Amino acids

    pub_type: 杂志文章,评审

    doi:10.1007/BF01345251

    authors: Schmid HA

    更新日期:1998-01-01 00:00:00

  • Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

    abstract::Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we applied a non-biase...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-016-2236-x

    authors: Zervou S,Yin X,Nabeebaccus AA,O'Brien BA,Cross RL,McAndrew DJ,Atkinson RA,Eykyn TR,Mayr M,Neubauer S,Lygate CA

    更新日期:2016-08-01 00:00:00

  • Synthesis of N-quinonyltaurines.

    abstract::Both 1,4-benzoquinones and 1,4-naphthoquinones were attached to the non-proteinogenic amino acid taurine to form N-quinonyl taurine derivatives. The products were formed via the direct Michael-like addition or by substitution of a good leaving group. An attempt to bridge the two moieties via an ureido spacer resulted ...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-002-0407-4

    authors: Gorohovsky S,Temtsin-Krayz G,Bittner S

    更新日期:2003-04-01 00:00:00

  • Mechanistic details of amino acid catalyzed two-component Mannich reaction: experimental study backed by density functional calculations.

    abstract::The role of pH-dependent ionic structures of L-amino acids in catalysis has been investigated for the two-component Mannich reactions between dimethyl malonate (DMM)/ethyl acetoacetate (EAA) and imines. As catalysts, L-amino acids performed well, even better than corresponding base catalysts and provided the β-amino c...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-019-02798-z

    authors: Rani D,Thakur L,Khera M,Goel N,Agarwal J

    更新日期:2019-11-01 00:00:00

  • Recovery of pan-genotypic and genotype-specific amino acid alterations in chronic hepatitis C after viral clearance: transition at the crossroad of metabolism and immunity.

    abstract::Recovery of amino acid (AA) metabolism and the associated clinical implications in chronic hepatitis C (CHC) patients with sustained virological response (SVR) following anti-hepatitis C virus (HCV) therapy remains elusive. A prospective cohort study was conducted on 222 CHC patients with SVR. Eighty-two age-matched m...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-016-2360-7

    authors: Chang ML,Cheng ML,Chang SW,Tang HY,Chiu CT,Yeh CT,Shiao MS

    更新日期:2017-02-01 00:00:00

  • Synthesis and structural studies of new analogues of PTH(1-11) containing Cα-tetra-substituted amino acids in position 8.

    abstract::The N-terminal 1-34 fragment of parathyroid hormone (PTH) is fully active in vitro and in vivo and it can reproduce all biological responses characteristic of the native intact PTH. Recently, analogues of PTH(1-11) fragments with helicity-enhancing substitutions have been demonstrated to yield potent analogues of PTH(...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-010-0591-6

    authors: Caporale A,Sturlese M,Schievano E,Mammi S,Peggion E

    更新日期:2010-11-01 00:00:00

  • High clinical accuracy of asymmetric dimethylarginine and symmetric dimethylarginine in patients with ischemic heart disease.

    abstract::Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were found in various clinical settings including coronary heart disease. To assess ADMA and SDMA diagnostic validity in patients with different stages of ischemic heart disease, we studied these markers in patie...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-012-1307-x

    authors: Djordjević BV,Pavlović R,Ćosić V,Deljanin-Ilić M,Ristić T,Krstić N,Jevtović-Stoimenov T

    更新日期:2012-12-01 00:00:00

  • Microglial self-defence mediated through GLT-1 and glutathione.

    abstract::Glutamate is stored in synaptic vesicles in presynaptic neurons. It is released into the synaptic cleft to provide signalling to postsynaptic neurons. Normally, the astroglial glutamate transporters GLT-1 and GLAST take up glutamate to mediate a high signal-to-noise ratio in the synaptic signalling, and also to preven...

    journal_title:Amino acids

    pub_type: 杂志文章,评审

    doi:10.1007/s00726-011-0865-7

    authors: Persson M,Rönnbäck L

    更新日期:2012-01-01 00:00:00

  • Some of the amino acid chemistry going on in the Laboratory of Amino Acids, Peptides and Proteins.

    abstract::Some of the chemistry of amino acids going on in our laboratory (Laboratoire des Amino acides Peptides et Protéines) is described as well as some mass spectrometry methodology for their characterization particularly on solid supports. Several aspects are presented including: (i) the stereoselective synthesis of natura...

    journal_title:Amino acids

    pub_type: 杂志文章,评审

    doi:10.1007/BF01388176

    authors: Bouifraden S,Drouot C,el Hadrami M,Guenoun F,Lecointe L,Mai N,Paris M,Pothion C,Sadoune M,Sauvagnat B,Amblard M,Aubagnac JL,Calmes M,Chevallet P,Daunis J,Enjalbal C,Fehrentz JA,Lamaty F,Lavergne JP,Lazaro R,Rollan

    更新日期:1999-01-01 00:00:00

  • Polyamines modulate epithelial-to-mesenchymal transition.

    abstract::Epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition are biologic processes responsible for conversion of epithelial cells into a mesenchymal phenotype or viceversa, respectively. They occur during embryo- and foetal-development and, in adult organisms, are involved in wound healing, in the ge...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-011-0995-y

    authors: Compagnone A,Bandino A,Meli F,Bravoco V,Cravanzola C,Parola M,Colombatto S

    更新日期:2012-02-01 00:00:00

  • Asymmetric hydrogenation of dehydrodipeptides bearing different protecting groups.

    abstract::N-[(Z)-N-Benzoyl- or N-boc-(2-fluorophenyl)dehydroalanyl]-(R)- or (S)-phenyl-alanines 1,2,5 and 6 were hydrogenated in the presence of chiral and achiral rhodium complexes. The optical induction is compared to the results obtained using the corresponding esters as substrates. ...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s007260200018

    authors: Döbler C,Kreuzfeld HJ,Fischer C,Michalik M

    更新日期:2002-06-01 00:00:00

  • Effects of glutamate antagonists on the activity of aromatic L-amino acid decarboxylase.

    abstract::This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson's disease. A...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/BF01345241

    authors: Fisher A,Biggs CS,Starr MS

    更新日期:1998-01-01 00:00:00

  • How are signals transduced across the cytoplasmic membrane? Transport proteins as transmitter of information.

    abstract::In order to adapt to ever changing environmental conditions, bacteria sense environmental stimuli, and convert them into signals that are transduced intracellularly. Several mechanisms have evolved by which receptors transmit signals across the cytoplasmic membrane. Stimulus perception may trigger receptor dimerizatio...

    journal_title:Amino acids

    pub_type: 杂志文章,评审

    doi:10.1007/s00726-009-0235-x

    authors: Tetsch L,Jung K

    更新日期:2009-09-01 00:00:00

  • Literature review on the role of dietary protein and amino acids in cognitive functioning and cognitive decline.

    abstract::As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on diet...

    journal_title:Amino acids

    pub_type: 杂志文章,评审

    doi:10.1007/s00726-013-1583-0

    authors: van de Rest O,van der Zwaluw NL,de Groot LC

    更新日期:2013-11-01 00:00:00

  • Polyamine levels during the onset of "CAM" inOpuntia F. indica (Miller).

    abstract::Polyamines have been related to the "Crassulacean Acid Metabolism" (CAM) in higher plants. Such relationship was however observed in plants where CAM activity is inducible by external factors. Results presented here indicate that, inOpuntia F. indica, cladodes where onset of CAM is dependent on internal conditions, i....

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/BF00814160

    authors: Deidda P,Tekle Z,Nieddu G,Pintus G,Pinna GG,Sisini A

    更新日期:1994-06-01 00:00:00

  • Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity.

    abstract::High-protein diets have been shown to alleviate detrimental effects of high-fat diets and this effect can be partially mimicked by dietary L-leucine supplementation. Here, we aimed to elucidate the early mechanisms and the specificity of leucine effects. We performed a 1-week trial with male C57BL/6 mice fed ad libitu...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-012-1363-2

    authors: Freudenberg A,Petzke KJ,Klaus S

    更新日期:2013-02-01 00:00:00

  • Development of a novel ligand binding assay for relaxin family peptide receptor 3 and 4 using NanoLuc complementation.

    abstract::Relaxin family peptides perform a variety of biological functions by binding and activating relaxin family peptide receptor 1-4 (RXFP1-4), four A-class G protein-coupled receptors. In the present work, we developed a novel ligand binding assay for RXFP3 and RXFP4 based on NanoLuc complementation technology (NanoBiT). ...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-018-2588-5

    authors: Hu MJ,Shao XX,Li HZ,Nie WH,Wang JH,Liu YL,Xu ZG,Guo ZY

    更新日期:2018-08-01 00:00:00

  • Growth promotion by homocysteine thiolactone and its alpha-alkylated derivative - A role for excess growth in homocystinurias?

    abstract::It is controversial whether homocysteic acid or other homocysteine derivatives show growth promoting effects. In a clonogenic assay we could show that homocysteine thiolactone and its alpha alkylated derivative increased colony formation significantly. Our work favorizes previous observations showing growth promoting ...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/BF00808453

    authors: Lubec B,Szekeres T

    更新日期:1994-02-01 00:00:00

  • A dual action of taurine on the delayed rectifier K(+) current in embryonic chick cardiomyocytes.

    abstract::Effects of taurine on the delayed rectifier K(+) channel in isolated 10-day-old embryonic chick ventricular cardiomyocytes were examined at different intracellular Ca(2+) concentrations ([Ca]i), using whole-cell voltage and current clamp techniques. Experiments were performed at room temperature (22°C). Test pulses we...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/BF00805955

    authors: Satoh H

    更新日期:1995-09-01 00:00:00

  • Ethynylglycine synthon, a useful precursor for the synthesis of biologically active compounds: an update: part I: preparations of ethynylglycine synthon.

    abstract::The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine} is a chiral compound with valuable synthetic interest. An update on the different routes for its synthesis is reviewed and discussed. ...

    journal_title:Amino acids

    pub_type: 杂志文章,评审

    doi:10.1007/s00726-014-1902-0

    authors: Benfodda Z,Bénimélis D,Reginato G,Meffre P

    更新日期:2015-02-01 00:00:00

  • Rapid, simple and effective technical procedure for the regeneration of IgG and HSA affinity columns for proteomic analysis.

    abstract::In plasma and serum, the presence of high-abundance proteins can overwhelm the signals of low-abundance proteins, which then become undetectable either by two-dimensional gels or chromatographic techniques. Therefore, depletion of abundant proteins is a prerequisite to detect low-abundance components. Furthermore, the...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-007-0556-6

    authors: Millioni R,Puricelli L,Iori E,Tessari P

    更新日期:2008-04-01 00:00:00

  • Peptides derived from Mycobacterium tuberculosis Rv2301 protein are involved in invasion to human epithelial cells and macrophages.

    abstract::The specific function of putative cut2 protein (or CFP25), encoded by the Rv2301 gene from Mycobacterium tuberculosis H37Rv, has not been identified yet. The aim of this study was to assess some of CFP25 characteristics and its possible biological role in Mycobacterium tuberculosis H37Rv invasion process to target cel...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-011-0938-7

    authors: Ocampo M,Rodríguez DM,Curtidor H,Vanegas M,Patarroyo MA,Patarroyo ME

    更新日期:2012-06-01 00:00:00

  • Transglutaminases and receptor tyrosine kinases.

    abstract::Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling....

    journal_title:Amino acids

    pub_type: 杂志文章,评审

    doi:10.1007/s00726-011-1113-x

    authors: Sivaramakrishnan M,Shooter GK,Upton Z,Croll TI

    更新日期:2013-01-01 00:00:00

  • Differential regulation of protein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigs.

    abstract::The high efficiency of protein deposition during the neonatal period is driven by high rates of protein synthesis, which are maximally stimulated after feeding. In the current study, we examined the individual roles of amino acids and insulin in the regulation of protein synthesis in peripheral and visceral tissues of...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/s00726-008-0149-z

    authors: Suryawan A,O'Connor PM,Bush JA,Nguyen HV,Davis TA

    更新日期:2009-05-01 00:00:00

  • Effect of tryptophan on rat hepatic nuclear poly(A)polymerase activity.

    abstract::Addition of poly(A) to hnRNA in the cell nucleus is a post-transcriptional event and is presumed to be brought about by a specific poly(A)polymerase. Since it is known that tryptophan rapidly increases the cytoplasmic levels of polyadenylated mRNA, it was of interest to investigate whether the essential amino acid, tr...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/BF00805989

    authors: Kurl RN,Verney E,Sidransky H

    更新日期:1993-06-01 00:00:00

  • Libraries of atomic multipole moments for precise modeling of electrostatic properties of amino acids.

    abstract::Contemporary theoretical models used in describing electrostatic properties of amino acids in polypeptides rely usually on atomic point charges. Recently noted defects of such models in reproducing protein folding originate from the inadequate representation of the electrostatic term, in particular inability of atomic...

    journal_title:Amino acids

    pub_type: 杂志文章

    doi:10.1007/BF00808443

    authors: Sokalski W

    更新日期:1994-02-01 00:00:00