The construction of an amino acid network for understanding protein structure and function.

abstract：:Some of the chemistry of amino acids going on in our laboratory (Laboratoire des Amino acides Peptides et Protéines) is described as well as some mass spectrometry methodology for their characterization particularly on solid supports. Several aspects are presented including: (i) the stereoselective synthesis of natura...

journal_title：Amino acids

authors： Bouifraden S,Drouot C,el Hadrami M,Guenoun F,Lecointe L,Mai N,Paris M,Pothion C,Sadoune M,Sauvagnat B,Amblard M,Aubagnac JL,Calmes M,Chevallet P,Daunis J,Enjalbal C,Fehrentz JA,Lamaty F,Lavergne JP,Lazaro R,Rollan

更新日期：1999-01-01 00:00:00

abstract：:Mitochondria are essential cell organelles of eukaryotes. Hence, it is vitally important to develop an automated and reliable method for timely identification of novel mitochondrial proteins. In this study, mitochondrial proteins were encoded by dipeptide composition technology; then, the genetic algorithm-partial lea...

journal_title：Amino acids

authors： Tan F,Feng X,Fang Z,Li M,Guo Y,Jiang L

更新日期：2007-11-01 00:00:00

abstract：:Branched Chain Amino Acids (BCAAs) are related to different aspects of diseases like pathogenesis, diagnosis and even prognosis. While in some diseases, levels of all the BCAAs are perturbed; in some cases, perturbation occurs in one or two while the rest remain unaltered. In case of ischemic heart disease, there is a...

journal_title：Amino acids

authors： Ghosh S,Sengupta A,Chandra K

更新日期：2015-10-01 00:00:00

abstract：:Treatment of developing rats with monosodium glutamate (MSG) produces an increase of glutamate levels in the brain, being this elevation dependent on both route of administration and animal's age. The capacity of exogenous MSG to induce convulsions seems to be related to the rate of glutamate elevation in the brain, r...

journal_title：Amino acids

authors： Peñafiel R,Cremades A,Monserrat F,Puelles L

更新日期：1991-02-01 00:00:00

abstract：:Breast cancer susceptibility gene 2 (BRCA2) is an important tumor suppressor, which is participated in repair of damaged DNA by its highly conserved BRC repeat motifs regulating RAD51 protein homologous recombination and thereby preventing cell carcinogenesis. In this study, the BRCA2(1524-1548)-RAD51(241-260) complex...

journal_title：Amino acids

authors： Li J,Lu K,Lv M,Liu G,Ma L,Qi J

更新日期：2020-03-01 00:00:00

abstract：:The high efficiency of protein deposition during the neonatal period is driven by high rates of protein synthesis, which are maximally stimulated after feeding. In the current study, we examined the individual roles of amino acids and insulin in the regulation of protein synthesis in peripheral and visceral tissues of...

journal_title：Amino acids

authors： Suryawan A,O'Connor PM,Bush JA,Nguyen HV,Davis TA

更新日期：2009-05-01 00:00:00

abstract：:An immunocytochemical investigation of the expression of alpha(1), alpha(6), beta(2/3), gamma(2) and delta subunits was performed on rat cerebellum granule cells in culture by the two photon microscopy technique. The first four subunits appear to be expressed abundantly in these cells, whereas the delta one seems to b...

journal_title：Amino acids

authors： Merlo F,Balduzzi R,Cupello A,Robello M

更新日期：2004-02-01 00:00:00

abstract：:Relapse and metastasis are the main causes of unfavorable outcome in head and neck cancers. Whereas, understanding of the molecular background of these processes is far from being complete. Therefore, in this study we aimed to identify potential biomarker candidates of relapse and metastasis in laryngeal squamous cell...

journal_title：Amino acids

authors： Bodnar M,Luczak M,Bednarek K,Szylberg L,Marszalek A,Grenman R,Szyfter K,Jarmuz-Szymczak M,Giefing M

更新日期：2016-06-01 00:00:00

abstract：:Arginine is a precursor of proteins and employed in urea synthesis. It is also the precursor of many other compounds, such as creatine, nitric oxide, polyamines, agmatine, proline. In this review, its transport and that of other basic amino acids are examined, along with its transformation into nitric oxide, agmatine ...

journal_title：Amino acids

authors： Grillo MA,Colombatto S

更新日期：2004-07-01 00:00:00

abstract：:Placental vascular formation and blood flow are crucial for fetal survival, growth and development, and arginine regulates vascular development and function. This study determined the effects of dietary arginine or N-carbamylglutamate (NCG) supplementation during late gestation of sows on the microRNAs, vascular endot...

journal_title：Amino acids

authors： Liu XD,Wu X,Yin YL,Liu YQ,Geng MM,Yang HS,Blachier F,Wu GY

更新日期：2012-06-01 00:00:00

abstract：:One pathogenic mechanism of ethanol-induced liver injury is the excessive production of reactive oxygen species (ROS), which may result in alcoholic liver disease (ALD) characterized by cell death due to necrosis and apoptosis. Taurine was proved to protect against liver damage. However, whether taurine attenuates eth...

journal_title：Amino acids

authors： Wu G,Yang J,Lv H,Jing W,Zhou J,Feng Y,Lin S,Yang Q,Hu J

更新日期：2018-07-01 00:00:00

abstract：:Amnesia is a deficit in memory caused by brain damage, disease, or trauma. Until now, there are no successful medications on the drug market available to treat amnesia. Short analogs and mimetics of human urocortin 3 (Ucn 3) tripeptide were synthetized and tested for their action against amnesia induced by eletroconvu...

journal_title：Amino acids

authors： Telegdy G,Kovács AK,Rákosi K,Zarándi M,Tóth GK

更新日期：2016-09-01 00:00:00

abstract：:Chlamydocin is a powerfulin vitro antitumoral agent, quickly inactivatedin vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on anε-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines. One a...

journal_title：Amino acids

authors： Bernardi E,Fauchère JL,Atassi G,Viallefont P,Lazaro R

更新日期：1994-10-01 00:00:00

abstract：:Factor VIII, the plasma protein deficient or defective in individuals with hemophilia A, is a critical member of the blood coagulation cascade. Recent studies have identified the FVIII light chain region Glu1811-Lys1818 as being involved in FIXa binding and in the assembly of the FX-activating FIXaz-FVIIIa complex. Ba...

journal_title：Amino acids

authors： Patsialas K,Koutsas C,Makris P,Liakopoulou-Kyriakides M

更新日期：2010-07-01 00:00:00

abstract：:The enhancing effect on the water structure has been confirmed for most of the osmolytes exhibiting both stabilizing and destabilizing properties in regard to proteins. The presented work concerns osmolytes, which should be classified as "structure breaking" solutes: taurine and N,N,N-trimethyltaurine (TMT). Here, we ...

journal_title：Amino acids

authors： Bruździak P,Panuszko A,Kaczkowska E,Piotrowski B,Daghir A,Demkowicz S,Stangret J

更新日期：2018-01-01 00:00:00

abstract：:We have been studying control mechanisms of gene expression in early embryogenesis in a South African clawed toad Xenopus laevis, especially during the period of midblastula transition (MBT), or the transition from the phase of active cell division (cleavage stage) to the phase of extensive morphogenesis (post-blastul...

journal_title：Amino acids

authors： Shiokawa K,Aso M,Kondo T,Takai J,Yoshida J,Mishina T,Fuchimukai K,Ogasawara T,Kariya T,Tashiro K,Igarashi K

更新日期：2010-02-01 00:00:00

abstract：:Polyamines are essential for proliferation of endothelial cells (EC) and angiogenesis. This study was conducted to identify the metabolic source(s) of ornithine for polyamine synthesis in EC, using N(ω)-hydroxy-nor-L-arginine (Nor-NOHA, an inhibitor of arginase) and gabaculine (an inhibitor of ornithine aminotransfera...

journal_title：Amino acids

authors： Li H,Meininger CJ,Bazer FW,Wu G

更新日期：2016-10-01 00:00:00

abstract：:Our observations on the growth stimulatory nature of mimosine, (beta-(3-hydroxy-4-pyridon-1-yl)-L-alanine), the toxic non-protein plant amino acid, in some model experimental systems, warranted sensitive and selective routine estimations. For the determination of both mimosine and DHP, an indirect spectrophotometric m...

journal_title：Amino acids

authors： Lalitha K,Rajendra Kulothungan S

更新日期：2006-10-01 00:00:00

abstract：:Taurine (TAU) has been shown to improve exercise time to exhaustion and 3-km running performance; however, no studies have considered the effect of acute TAU ingestion on short duration cycling time trial (TT) performance. The aim of this study was to determine the effects of a single oral acute dose of 1000 mg of TAU...

journal_title：Amino acids

authors： Ward R,Bridge CA,McNaughton LR,Sparks SA

更新日期：2016-11-01 00:00:00

abstract：:This study was conducted to evaluate the anti-obesity effects of long-term taurine supplementation in a mild obese ICR mouse model and to study the mechanism by which taurine induces weight loss. Three groups of male ICR mice were fed a normal chow diet, a high-fat diet (HFD), or an HFD supplemented with 2% taurine in...

journal_title：Amino acids

authors： Kim KS,Jang MJ,Fang S,Yoon SG,Kim IY,Seong JK,Yang HI,Hahm DH

更新日期：2019-02-01 00:00:00

abstract：:Early evaluation of cancer response to a therapeutic regimen can help increase the effectiveness of treatment schemes and, by enabling early termination of ineffective treatments, minimize toxicity, and reduce expenses. Biomarkers that provide early indication of tumor therapy response are urgently needed. Solid tumor...

journal_title：Amino acids

authors： Cao Q,Liu S,Niu G,Chen K,Yan Y,Liu Z,Chen X

更新日期：2011-11-01 00:00:00

abstract：:Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we applied a non-biase...

journal_title：Amino acids

authors： Zervou S,Yin X,Nabeebaccus AA,O'Brien BA,Cross RL,McAndrew DJ,Atkinson RA,Eykyn TR,Mayr M,Neubauer S,Lygate CA

更新日期：2016-08-01 00:00:00

abstract：:Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the...

journal_title：Amino acids

authors： Wieronska JM,Szewczyk B,Branski P,Palucha A,Pilc A

更新日期：2002-01-01 00:00:00

abstract：:We studied the non-specific interactions of two azo compounds: biebrich scarlet (BS) and naphthochrome green (NG), with four model proteins: bovine serum albumin, ovalbumin, poly-L-lysine and hemoglobin by UV-VIS spectrometry, fluorophotometry and circular dichroism melting technique. The optimal acidities of NG and B...

journal_title：Amino acids

authors： Gao HW,Liu XH,Qiu Z,Tan L

更新日期：2009-02-01 00:00:00

abstract：:Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5'-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). The limited availability and stability of the prot...

journal_title：Amino acids

authors： Castro-Oropeza R,Pino-Ángeles A,Khomutov MA,Urdiales JL,Moya-García AA,Vepsäläinen J,Persson L,Sarabia F,Khomutov A,Sánchez-Jiménez F

更新日期：2014-03-01 00:00:00

abstract：:Free D-aspartate (D-Asp) occurs in substantial amounts in the brain at the embryonic phase and in the first few postnatal days, and strongly decreases in adulthood. Temporal reduction of D-Asp levels depends on the postnatal onset of D-aspartate oxidase (DDO) activity, the only enzyme able to selectively degrade this ...

journal_title：Amino acids

authors： Errico F,Napolitano F,Nisticò R,Usiello A

更新日期：2012-11-01 00:00:00

abstract：:Beyond nigrostriatal dopaminergic system, the noradrenergic locus coeruleus (LC/NE) neurons are also degenerated in patients with Parkinson's disease (PD), the second most common neurodegenerative disorder. We previously reported that microglia-mediated neuroinflammation contributes to LC/NE neurodegeneration. The pur...

journal_title：Amino acids

authors： Hou L,Che Y,Sun F,Wang Q

更新日期：2018-05-01 00:00:00

abstract：:Arginine (Arg) and glutamine (Gln) utilization is greatly increased during catabolic stress. While the supply of both amino acids has been advocated in this situation, arginine administration is possibly associated with deleterious effects. From a metabolic point of view, these two amino acids are reciprocal precursor...

journal_title：Amino acids

authors： Ventura G,Moinard C,Segaud F,Le Plenier S,Cynober L,De Bandt JP

更新日期：2010-11-01 00:00:00

abstract：:Protooncogenes (PO) play a crucial role for brain biology and pathology. Only the concerted action of protooncogenes enables normal brain development. The reliable and sensitive quantification of brain PO is still holding centre stage in neurobiological research. The aim of our study was therefore the determination of...

journal_title：Amino acids

authors： Schatzmann-Turhani D,Greber-Platzer S,Cairns N,Lubec G

更新日期：1999-01-01 00:00:00

abstract：:Endurance exercise training as well as leucine supplementation modulates glucose homeostasis and protein turnover in mammals. Here, we analyze whether leucine supplementation alters the effects of endurance exercise on these parameters in healthy mice. Mice were distributed into sedentary (C) and exercise (T) groups. ...

journal_title：Amino acids

authors： Costa Júnior JM,Rosa MR,Protzek AO,de Paula FM,Ferreira SM,Rezende LF,Vanzela EC,Zoppi CC,Silveira LR,Kettelhut IC,Boschero AC,de Oliveira CA,Carneiro EM

更新日期：2015-04-01 00:00:00