Abstract:
:Placental vascular formation and blood flow are crucial for fetal survival, growth and development, and arginine regulates vascular development and function. This study determined the effects of dietary arginine or N-carbamylglutamate (NCG) supplementation during late gestation of sows on the microRNAs, vascular endothelial growth factor A (VEGFA) and endothelial nitric oxide synthase (eNOS) expression in umbilical vein. Twenty-seven landrace×large white sows at day (d) 90 of gestation were assigned randomly to three groups and fed the following diets: a control diet and the control diet supplemented with 1.0% L-arginine or 0.10% NCG. Umbilical vein of fetuses with body weight around 2.0 kg (oversized), 1.5 kg (normal) and 0.6 kg (intrauterine growth restriction, IUGR) were obtained immediately after farrowing for miR-15b, miR-16, miR-221, miR-222, VEGFA and eNOS real-time PCR analysis. Compared with the control diets, dietary Arg or NCG supplementation enhanced the reproductive performance of sows, significantly increased (P<0.05) plasma arginine and decreased plasma VEGF and eNOS (P<0.05). The miR-15b expression in the umbilical vein was higher (P<0.05) in the NCG-supplemented group than in the control group. There was a trend in that the miR-222 expression in the umbilical vein of the oversized fetuses was higher (0.05
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Liu XD,Wu X,Yin YL,Liu YQ,Geng MM,Yang HS,Blachier F,Wu GYdoi
10.1007/s00726-011-0948-5subject
Has Abstractpub_date
2012-06-01 00:00:00pages
2111-9issue
6eissn
0939-4451issn
1438-2199journal_volume
42pub_type
杂志文章相关文献
AMINO ACIDS文献大全abstract::In 3T3 cells temperatures higher than physiological stimulated amino acid transport activity in a dose-dependent manner up to 44 degrees C. However, the temperature increase did not induce widespread transport increase of all other nutrients tested. The activities of both amino acid transport systems A and ASC were en...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s007260170033
更新日期:2001-01-01 00:00:00
abstract::Glutamate dehydrogenase (GDH) plays a crucial role in amino acid deamination and has been used as an inductor of nutrients metabolism. In this study, we cloned and analyzed the GDH cDNAs in diploids (red crucian carp), triploids and tetraploids and characterized their expression profiles upon dietary treatments. Resul...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1313-z
更新日期:2012-12-01 00:00:00
abstract::Creatine is an amino acid that has a pivotal role in energy metabolism of cells. Creatine acts as an "ATP shuttle", carrying ATP to the sites where it is utilized, through its reversible phosphorylation by creatine kinase. Moreover, the creatine-phosphocreatine system delays ATP depletion during anoxia or ischemia, th...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1525-x
更新日期:2013-10-01 00:00:00
abstract::Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide,...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-006-0477-9
更新日期:2007-11-01 00:00:00
abstract::Several new beta,beta-dihalo and beta-halo-beta-substituted dehydroalanines and dehydrodipeptides were synthesized by reacting the corresponding dehydroamino acid derivative with a N-halosuccinimide or in the case of beta,beta-di-iododehydroalanines with iodine. The results obtained confirmed that the stereochemical o...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0466-x
更新日期:2010-07-01 00:00:00
abstract::The N-terminal 1-34 fragment of parathyroid hormone (PTH) is fully active in vitro and in vivo and it can reproduce all biological responses characteristic of the native intact PTH. Recently, analogues of PTH(1-11) fragments with helicity-enhancing substitutions have been demonstrated to yield potent analogues of PTH(...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0591-6
更新日期:2010-11-01 00:00:00
abstract::Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling....
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-1113-x
更新日期:2013-01-01 00:00:00
abstract::Treatment of developing rats with monosodium glutamate (MSG) produces an increase of glutamate levels in the brain, being this elevation dependent on both route of administration and animal's age. The capacity of exogenous MSG to induce convulsions seems to be related to the rate of glutamate elevation in the brain, r...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00808094
更新日期:1991-02-01 00:00:00
abstract::Recently, crystalized mouse ketimine reductase/CRYM complexed with NADPH was found to have pyruvate bound in its active site. We demonstrate that the enzyme binds α-keto acids, such as pyruvate, in solution, and catalyzes the formation of N-alkyl-amino acids from alkylamines and α-keto acids (via reduction of imine in...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2044-8
更新日期:2015-11-01 00:00:00
abstract::Early evaluation of cancer response to a therapeutic regimen can help increase the effectiveness of treatment schemes and, by enabling early termination of ineffective treatments, minimize toxicity, and reduce expenses. Biomarkers that provide early indication of tumor therapy response are urgently needed. Solid tumor...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0548-9
更新日期:2011-11-01 00:00:00
abstract::Chlamydocin is a powerfulin vitro antitumoral agent, quickly inactivatedin vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on anε-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines. One a...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00813752
更新日期:1994-10-01 00:00:00
abstract::The relationship between taurine concentrations of plasma, whole blood, serum and skeletal muscle during taurine depletion and repletion was investigated in cats, to identify the most useful indicators of taurine status. Sixteen cats were fed a purified diet containing either 0 or 0.15 g/kg taurine for 5 months. Treat...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s007260170006
更新日期:2001-12-01 00:00:00
abstract::Cell-penetrating peptides, a group of short peptides, can traverse cell membranes to enter cells and thus facilitate the uptake of various molecular cargoes. Thus, they have the potential to become powerful drug delivery systems. The correct identification of peptides as cell-penetrating or non-cell-penetrating would ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-1974-5
更新日期:2015-07-01 00:00:00
abstract::Nitric oxide synthase (NOS) activities are responsible for the enzymatic conversion of L-arginine into NO and L-citrulline. Relatively low amounts of NO are produced in intestinal epithelial cells or are released from nerve endings. The effects of NO production are related to the maintenance of epithelial integrity an...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s007260050020
更新日期:2000-01-01 00:00:00
abstract::The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-o...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0918-y
更新日期:2011-08-01 00:00:00
abstract::Among many actions assigned to taurine (Tau), the most abundant amino acid in numerous mammalian tissues, it prevents high-fat diet-induced obesity with increasing resting energy expenditure. To sustain this Tau action, the goal of the present study was to explore the acute effects of Tau on baseline and on adrenaline...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0919-x
更新日期:2012-05-01 00:00:00
abstract::Inhibitors of histone deacetylases (HDACs) are a promising class of anticancer agents that have an effect on gene regulation. The naturally occurring cyclic depsipeptide FK228 containing disulfide and Largazole possessing thioester functionalities act as pro-drugs and share the same HDAC inhibition mechanism in cell. ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1800-5
更新日期:2014-10-01 00:00:00
abstract::The sulfur-containing excitatory amino acid (EAA) L-cysteine sulfinic acid (CSA), a neurotransmitter candidate, is endogenously synthesized from L-cysteine (Cys). Exogenous Cys administration into the brain produces cardiovascular effects; these effects likely occur via synaptic stimulation of central nervous system (...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1733-z
更新日期:2014-07-01 00:00:00
abstract::The TES ether of the C6-hydroxy derivative of naturally occurring epi-jasmonic acid (epi-JA) was designed as epimerization-free equivalent of epi-JA. The TES ether was synthesized from (1R,4S)-4-hydroxycyclopent-2-enyl acetate in 13 steps. The acid part of the ether was activated with ClCO2Bui and subjected to condens...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-0925-z
更新日期:2012-05-01 00:00:00
abstract::The lipidicα-amino acids (LAAs) are non-naturalα-amino acids with saturated or unsaturated long aliphatic side chains. LAAs and their derivatives (lipid mimetics) together with the lipidic peptides represent a class of compounds which combine structural features of lipids with those of amino acids and peptides. Racemi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00807940
更新日期:1996-09-01 00:00:00
abstract::Glutaryl-CoA dehydrogenase deficiency (GDD), which is one of the most frequent organic acid disorders, is characterized by a specific age- and regional-dependent neuropathology. We hypothesized that the distinct brain damage in GDD could be caused by the main pathologic metabolites, the organic acids glutaric (GA) and...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s007260050003
更新日期:2000-01-01 00:00:00
abstract::D-Aspartic acid (D-Asp) is an endogenous amino acid present in neuroendocrine systems. Here, we report evidence that D-Asp in the rat is involved in learning and memory processes. Oral administration of sodium D-aspartate (40 mM) for 12-16 days improved the rats' cognitive capability to find a hidden platform in the M...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0369-x
更新日期:2010-05-01 00:00:00
abstract::The aim of our research was to analyze the antioxidant role and efficacy of thermal or salus per aquam (spa) therapy with chlorine-sulphur-bicarbonate mineral water. The study has been performed on 30 rats. The animals were randomized in three groups, each of them composed by ten animals, denominated A, B and C. The A...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0032-y
更新日期:2009-02-01 00:00:00
abstract::Interplay between proteins, nucleic acids, carbohydrates and/or lipids is involved in almost every process in life on earth. As a consequence, a wide range of diseases results from abnormal interactions of such biomolecules. The main motivation of foldamer science is the development of scaffolds that are capable of ad...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-0894-2
更新日期:2011-08-01 00:00:00
abstract::In an attempt to increase our knowledge regarding the mechanisms of surfactant membrane interaction, we studied the action of several anionic and cationic amino acid-based surfactants on membrane fluidity using fluorescence anisotropy. Anisotropy measurements demonstrated that almost all of the surfactants studied dis...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-006-0447-2
更新日期:2007-09-01 00:00:00
abstract::In plasma and serum, the presence of high-abundance proteins can overwhelm the signals of low-abundance proteins, which then become undetectable either by two-dimensional gels or chromatographic techniques. Therefore, depletion of abundant proteins is a prerequisite to detect low-abundance components. Furthermore, the...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-007-0556-6
更新日期:2008-04-01 00:00:00
abstract::We proposed that the combination of conjugated linoleic acid (CLA) and arginine would decrease adiposity by depressing lipid synthesis in liver and adipose tissues of growing pigs. Pigs were allotted to treatments in a 2 × 2 factorial design with two lipids (CLA or canola oil) and two amino acids [L-arginine or L-alan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1255-5
更新日期:2012-10-01 00:00:00
abstract::The high efficiency of protein deposition during the neonatal period is driven by high rates of protein synthesis, which are maximally stimulated after feeding. In the current study, we examined the individual roles of amino acids and insulin in the regulation of protein synthesis in peripheral and visceral tissues of...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0149-z
更新日期:2009-05-01 00:00:00
abstract::Regulated proteolysis plays important roles in cell biology and pathological conditions. A crosstalk exists between apoptosis and the ubiquitin-proteasome system, two pathways responsible for regulated proteolysis executed by different proteases. To investigate whether the apoptotic process also affects the 20S protea...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0575-6
更新日期:2011-07-01 00:00:00
abstract::The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the inhibitors of apoptosis proteins (IAP), particularly XIAP and eliminating their inhibitory activit...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2637-0
更新日期:2018-11-01 00:00:00