Abstract:
:Amnesia is a deficit in memory caused by brain damage, disease, or trauma. Until now, there are no successful medications on the drug market available to treat amnesia. Short analogs and mimetics of human urocortin 3 (Ucn 3) tripeptide were synthetized and tested for their action against amnesia induced by eletroconvulsion in mice. Among the 16 investigated derivatives of Ucn 3 tripeptide, eight compounds displayed antiamnesic effect. Our results proved that the configuration of chiral center of glutamine does not affect the antiamnesic properties. Alkyl amide or isoleucyl amide at the C-terminus may lead to antiamnesic compounds. As concerned the N-terminus, acetyl, Boc, and alkyl ureido moieties were found among the active analogs, but the free amino function at the N-terminus usually led to an inactive derivatives. These observations may lead to the design and synthesis of small peptidomimetics and amino acid derivatives as antiamnesic drug candidates, although the elucidation of the mechanism of the action requires further investigations.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Telegdy G,Kovács AK,Rákosi K,Zarándi M,Tóth GKdoi
10.1007/s00726-016-2268-2subject
Has Abstractpub_date
2016-09-01 00:00:00pages
2261-6issue
9eissn
0939-4451issn
1438-2199pii
10.1007/s00726-016-2268-2journal_volume
48pub_type
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