Abstract:
:Green tea which is widely consumed in China, Japan and India, contains polyphenolic compounds, which account for 30% of the dry weight of the leaves. Most of the polyphenols are flavanols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant. Epidemiological studies revealed that the incidences of stomach and prostate cancers are the lowest in the world among a population that consumes green tea on a regular basis. It has also been reported that the quantity of green tea consumed, plays an important role in reducing cancer risk and in delaying cancer outbreak and recurrence. Various systems were used to confirm anti-cancer activities of green tea and/or EGCG. These included experimental animals in which cancer was induced chemically. Cultured cells transformed chemically or by oncogenes were also used. These studies clearly demonstrated that green tea or EGCG have anticancer and cancer preventive properties. The mechanisms of these activities have also been studied in details. It has been shown that green tea and its active components interfere with signal transduction pathways. Thus the activities of various protein kinases are inhibited, the expression of nuclear proto-oncogenes declines and the activity of ornithine decarboxylase (ODC) is reduced. ODC, which catalyzes the rate-limiting step in the biosynthesis of polyamines is closely linked with cellular proliferation and carcinogenesis. Inhibitors of ODC, like alpha-difluoromethylornithine (DFMO) have long been used for cancer prevention and therapy. It has been suggested that polyamine depletion by green tea could offer one explanation for its anti-cancer activities.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Bachrach U,Wang YCdoi
10.1007/s726-002-8197-9subject
Has Abstractpub_date
2002-01-01 00:00:00pages
1-13issue
1eissn
0939-4451issn
1438-2199journal_volume
22pub_type
杂志文章,评审相关文献
AMINO ACIDS文献大全abstract::Glutamate dehydrogenase (GDH) plays a crucial role in amino acid deamination and has been used as an inductor of nutrients metabolism. In this study, we cloned and analyzed the GDH cDNAs in diploids (red crucian carp), triploids and tetraploids and characterized their expression profiles upon dietary treatments. Resul...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1313-z
更新日期:2012-12-01 00:00:00
abstract::The effect of dietary amino acid taurine on the liver function of chronic hepatitis patients was investigated. The 24 chronic hepatitis patients with 2-5 times over normal activities of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) were selected and equally divided into taurine treatment and contr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-007-0565-5
更新日期:2008-08-01 00:00:00
abstract::The Disrupted-in-schizophrenia 1 (DISC1) gene is involved in vulnerability to neuropsychiatric disorders. Naples high-excitability (NHE) rat model neuropsychiatric problems characterized by an unbalanced mesocortical dopamine system. Here, we assessed behavioral and neurochemical effects of immunization against multim...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1897-6
更新日期:2015-03-01 00:00:00
abstract::This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise...
journal_title:Amino acids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00726-018-2655-y
更新日期:2019-02-01 00:00:00
abstract::The streptococcal enzyme that catalyzes the last step in proline biosynthesis was heterologously expressed and the recombinant protein was purified to electrophoretic homogeneity and characterized thoroughly. As for δ1-pyrroline-5-carboxylate reductases from other sources, it was able to use either NADH or NADPH as th...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1077-x
更新日期:2012-07-01 00:00:00
abstract::By application with 2-aminoethanol (2-AE) and choline chloride (CC) in pot experiments the effect of drought stress on barley plants was diminished. In treated plants an increase of the grain yield by 14% (2-AE) and 40% (CC) and a decrease of the stress metabolites glycine betaine and trigonelline was observed. Additi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00807708
更新日期:1994-10-01 00:00:00
abstract::A series of hydroxypyrroloindoline (Hpi) containing dipeptides along with the corresponding monomeric Hpi-α-amino acid (Hpi-2-carboxylate), were prepared by reacting a series of N α-protected-tryptophans in aqueous or biphasic [water/cyclopentyl methyl ether (CPME)] solutions containing Oxone® (potassium peroxymonosul...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2364-3
更新日期:2017-02-01 00:00:00
abstract::Excitotoxicity induced by NMDA receptor stimulation is able to increase the activity of many enzymes involved in neuronal cell death. Primary cultures of rat cerebellar granule cells were used to elucidate the role of transglutaminase reaction in the excitotoxic cell response, and to evaluate the role of glutamate rec...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-003-0007-y
更新日期:2004-03-01 00:00:00
abstract::Effects of taurine on the delayed rectifier K(+) channel in isolated 10-day-old embryonic chick ventricular cardiomyocytes were examined at different intracellular Ca(2+) concentrations ([Ca]i), using whole-cell voltage and current clamp techniques. Experiments were performed at room temperature (22°C). Test pulses we...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00805955
更新日期:1995-09-01 00:00:00
abstract::Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide generation. These defects can fundamentally alter cardiomyocyte function and if left unchanged can result in cell death. To protect against these stresses, cardiomyocytes possess quality contr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-015-2053-7
更新日期:2015-12-01 00:00:00
abstract::The efficient synthesis ofδ-hydroxy-β,γ-dehydroα-amino acids (1) was achieved by the hybrid process, in which the Pd(II)-assisted rear-rangement ofβ-acetoxyallylglycine ester (6) afforded the corresponding (E)-δ-acetoxyvinylglycine derivatives (7) in a moderate yield. The chemo- and stereo-selective hydrolysis of7 was...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00807269
更新日期:1995-12-01 00:00:00
abstract::Ornithine decarboxylase antizyme 1 (AZ1) is a major regulatory protein responsible for the regulation and degradation of ornithine decarboxylase (ODC). To better understand the role of AZ1 in polyamine metabolism and in modulating the response to anticancer polyamine analogues, a small interfering RNA strategy was use...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1030-z
更新日期:2012-02-01 00:00:00
abstract::Methionine (Met) is an essential amino acid for all organisms. In plants, Met also functions as a precursor of plant hormones, polyamines, and defense metabolites. The regulatory mechanism of Met biosynthesis is highly complex and, despite its great importance, remains unclear. To investigate how accumulation of Met i...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0562-y
更新日期:2010-10-01 00:00:00
abstract::Starting from a chiral 4-hydroxymethyl pyrrolidin-2-one, an isostere of α-methyl homoserine tethered on a γ-lactam ring was prepared exploiting a stereoselective acylation-methylation sequence, followed by Curtius rearrangement, and structural assignment was confirmed by n.O.e. experiments. By reverting the sequence, ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1671-9
更新日期:2014-04-01 00:00:00
abstract::Due to the obvious advantages of long-acting peptide and protein drugs, strategies to prolong plasma half life time of such compounds are highly on demand. Short plasma half life times are commonly due to fast renal clearance as well as to enzymatic degradation occurring during systemic circulation. Modifications of t...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-005-0289-3
更新日期:2006-06-01 00:00:00
abstract::The daily requirement of a 70-kg male for creatine is about 2 g; up to half of this may be obtained from a typical omnivorous diet, with the remainder being synthesized in the body Creatine is a carninutrient, which means that it is only available to adults via animal foodstuffs, principally skeletal muscle, or via su...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-016-2188-1
更新日期:2016-08-01 00:00:00
abstract::Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first discovered in 1910, but its physiological significance was disregarded for a century. The recent rediscovery of agmatine as an endogenous ligand for α2-adrenergic and imidazoline receptors in the mammalian brain suggests that thi...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-019-02720-7
更新日期:2020-02-01 00:00:00
abstract::As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on diet...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1583-0
更新日期:2013-11-01 00:00:00
abstract::Synthesis and properties of a new fluorescent/fluorogenic substrate Ac-DEVD-AMAC for caspase-3 are reported. The substrate is obtained by conventional Fmoc-based solid phase peptide synthesis and its properties are investigated with regard to fluorescence, sensitivity, applicability and kinetic constants. A non-tradit...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0136-4
更新日期:2009-03-01 00:00:00
abstract::D: -Amino acid oxidase (DAAO) in mammal kidney regulates the renal reactive oxygen species (ROS) levels directly and plays a leading role in the development of ROS-mediated renal pathologic damages based on its crucial role in the oxidative deamination of D: -amino acids and the consequent generation of H(2)O(2). Quan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0811-0
更新日期:2012-01-01 00:00:00
abstract::Factor VIII, the plasma protein deficient or defective in individuals with hemophilia A, is a critical member of the blood coagulation cascade. Recent studies have identified the FVIII light chain region Glu1811-Lys1818 as being involved in FIXa binding and in the assembly of the FX-activating FIXaz-FVIIIa complex. Ba...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0464-z
更新日期:2010-07-01 00:00:00
abstract::Contemporary theoretical models used in describing electrostatic properties of amino acids in polypeptides rely usually on atomic point charges. Recently noted defects of such models in reproducing protein folding originate from the inadequate representation of the electrostatic term, in particular inability of atomic...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00808443
更新日期:1994-02-01 00:00:00
abstract::Nitric oxide (NO) is a free radical gas synthesised from arginine and oxygen by enzymes of the family of the nitric oxide synthase. In particular, the neuronal nitric oxide synthase (nNOS) is highly expressed by cells of the hypothalamic paraventricular nucleus, where the sympatho-adrenal system, the hypothalamic-pitu...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-007-0630-0
更新日期:2008-06-01 00:00:00
abstract::Seryl-histidine dipeptide (Ser-His) has been recognized as the shortest peptide with hydrolysis cleavage activity; however, its protein cleavage spectrum has not yet been fully explored. Here, four differently folded proteins were treated with Ser-His, and the digestion products were evaluated with high-resolution mas...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2487-1
更新日期:2018-01-01 00:00:00
abstract::Anti-tissue transglutaminase (tTG) antibodies are specifically produced in the small-intestinal mucosa of celiac disease (CD) patients. It is now recognized that these antibodies, acting on cell-surface tTG, may play an active role in CD pathogenesis triggering an intracellular response via the activation of different...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-011-1120-y
更新日期:2013-01-01 00:00:00
abstract::Knowledge of the subcellular location of a protein provides valuable information about its function, possible interaction with other proteins and drug targetability, among other things. The experimental determination of a protein's location in the cell is expensive, time consuming and open to human error. Fast and acc...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-013-1491-3
更新日期:2013-08-01 00:00:00
abstract::Metformin, the drug of first choice in type 2 diabetes mellitus (T2DM), reduces cardiovascular (CV) morbidity and mortality in part independently of improved glycemic control and changes in traditional risk factors. However, there are discordant reports on the effects of metformin on endothelial function in T2DM. Our ...
journal_title:Amino acids
pub_type: 临床试验,杂志文章
doi:10.1007/s00726-015-1976-3
更新日期:2015-09-01 00:00:00
abstract::In an attempt to increase our knowledge regarding the mechanisms of surfactant membrane interaction, we studied the action of several anionic and cationic amino acid-based surfactants on membrane fluidity using fluorescence anisotropy. Anisotropy measurements demonstrated that almost all of the surfactants studied dis...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-006-0447-2
更新日期:2007-09-01 00:00:00
abstract::Amino acid and glucosinolate biosynthesis are two interdependent pathways; amino acid synthesis as a part of primary metabolism provides the precursors for glucosinolate biosynthesis in secondary metabolism. In our previous studies, the combination of coexpression analysis and metabolite profiling led to the identific...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0681-5
更新日期:2010-10-01 00:00:00
abstract::A thioalkylation procedure, which uses molecular sieves to promote the reaction, was exploited to provide peptides with useful functional groups (lipidic moieties), naturally occurring on proteins as post-translational modifications. The procedure was further implemented to synthesize tailor-made lipidated peptides, i...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1742-y
更新日期:2014-08-01 00:00:00