Prediction and analysis of cell-penetrating peptides using pseudo-amino acid composition and random forest models.

abstract：:No systematic approach to detect expression of differentiation-related elements was published so far. The undifferentiated N1E-115 neuroblastoma cell line was switched into a neuronal phenotype by DMSO treatment and used for proteomic experiments. We used two-dimensional gel electrophoresis followed by unambiguous mas...

journal_title：Amino acids

authors： Oh JE,Karlmark Raja K,Shin JH,Pollak A,Hengstschläger M,Lubec G

更新日期：2006-10-01 00:00:00

abstract：:In living cells, the N-terminal tails of core histones, the proteinaceous component of nucleosomes, are subjected to a range of covalent post-translational modifications (PTMs), which have specific roles in modulating chromatin structure and function. A growing body of evidence suggests that deregulation of histone mo...

journal_title：Amino acids

authors： Cuomo A,Moretti S,Minucci S,Bonaldi T

更新日期：2011-07-01 00:00:00

abstract：:Lateral diffusion of membrane-integral receptors within the plane of the membrane has been postulated to be mechanistically important for signal transduction. Direct measurement of polypeptide hormone receptor lateral mobility using fluorescence photobleaching recovery techniques indicates that tyrosine kinase recepto...

journal_title：Amino acids

authors： Jans DA,Pavo I

更新日期：1995-06-01 00:00:00

abstract：:A subline growing in medium without arginine and ornithine was established from a rat Reuber hepatoma cell line (R-Y121B·cho). The subline designated R-Y117B·cho was able to grow in glutamine, arginine and ornithine-free, glutamate-supplemented medium. Arginine synthesis from glutamate requires four urea cycle enzymes...

journal_title：Amino acids

authors： Yamamoto K,Niwa A

更新日期：1996-09-01 00:00:00

abstract：:Our observations on the growth stimulatory nature of mimosine, (beta-(3-hydroxy-4-pyridon-1-yl)-L-alanine), the toxic non-protein plant amino acid, in some model experimental systems, warranted sensitive and selective routine estimations. For the determination of both mimosine and DHP, an indirect spectrophotometric m...

journal_title：Amino acids

authors： Lalitha K,Rajendra Kulothungan S

更新日期：2006-10-01 00:00:00

abstract：:Factor VIII, the plasma protein deficient or defective in individuals with hemophilia A, is a critical member of the blood coagulation cascade. Recent studies have identified the FVIII light chain region Glu1811-Lys1818 as being involved in FIXa binding and in the assembly of the FX-activating FIXaz-FVIIIa complex. Ba...

journal_title：Amino acids

authors： Patsialas K,Koutsas C,Makris P,Liakopoulou-Kyriakides M

更新日期：2010-07-01 00:00:00

abstract：:The ventral pallidum is part of the corticoaccumbo-thalamocortical loop of the basal ganglia. In the past the function of this structure was discussed as a pure relay station in the process of limbic-motor integration. Some recent studies, however, underline that on the level of the ventral pallidum motor behavior can...

journal_title：Amino acids

authors： Kretschmer BD

更新日期：2000-01-01 00:00:00

abstract：:Transglutaminases (TGs) are a large family of related and ubiquitous enzymes that catalyze the cross-linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a protein/peptide co-substrate. Considerable and intense progress has been made in the understanding of the chemistry, molecular biol...

journal_title：Amino acids

authors： Tabolacci C,Lentini A,Provenzano B,Beninati S

更新日期：2012-02-01 00:00:00

abstract：:A series of hydroxypyrroloindoline (Hpi) containing dipeptides along with the corresponding monomeric Hpi-α-amino acid (Hpi-2-carboxylate), were prepared by reacting a series of N α-protected-tryptophans in aqueous or biphasic [water/cyclopentyl methyl ether (CPME)] solutions containing Oxone® (potassium peroxymonosul...

journal_title：Amino acids

authors： Blanc A,Xia F,Todorovic M,Perrin DM

更新日期：2017-02-01 00:00:00

abstract：:Protooncogenes (PO) play a crucial role for brain biology and pathology. Only the concerted action of protooncogenes enables normal brain development. The reliable and sensitive quantification of brain PO is still holding centre stage in neurobiological research. The aim of our study was therefore the determination of...

journal_title：Amino acids

authors： Schatzmann-Turhani D,Greber-Platzer S,Cairns N,Lubec G

更新日期：1999-01-01 00:00:00

abstract：:Immobilization of papain on Sepharose 6B in the presence of different concentrations of cysteine affected the enzyme activity depending on cysteine concentration. The maximum specific activity was observed when papain was immobilized with 200 mM cysteine. The immobilization process brought significant enhancement of s...

journal_title：Amino acids

authors： Homaei AA,Sajedi RH,Sariri R,Seyfzadeh S,Stevanato R

更新日期：2010-03-01 00:00:00

abstract：:The N-terminal 1-34 fragment of parathyroid hormone (PTH) is fully active in vitro and in vivo and it can reproduce all biological responses characteristic of the native intact PTH. Recently, analogues of PTH(1-11) fragments with helicity-enhancing substitutions have been demonstrated to yield potent analogues of PTH(...

journal_title：Amino acids

authors： Caporale A,Sturlese M,Schievano E,Mammi S,Peggion E

更新日期：2010-11-01 00:00:00

abstract：:Previous studies identified lysine- and tryptophan-rich sequences within various cationic antimicrobial peptides. In the present study, we synthesized a series of peptides composed of lysine (K)-tryptophan (W) repeats (KW)( n ) (where n equals 2, 3, 4 or 5) with amida...

journal_title：Amino acids

authors： Gopal R,Seo CH,Song PI,Park Y

更新日期：2013-02-01 00:00:00

abstract：:Zinc exhibits antidepressant-like activity in preclinical tests/models. Moreover, zinc homeostasis is implicated in the pathophysiology of affective disorders. The aim of the present study was to examine the effect of chronic zinc, citalopram and imipramine intraperitoneal administration on the presynaptic and extrace...

journal_title：Amino acids

authors： Sowa-Kućma M,Kowalska M,Szlósarczyk M,Gołembiowska K,Opoka W,Baś B,Pilc A,Nowak G

更新日期：2011-01-01 00:00:00

abstract：:The leptin receptor antagonist peptide Allo-aca exhibits picomolar activities in various cellular systems and sub-mg/kg subcutaneous efficacies in animal models making it a prime drug candidate and target validation tool. Here we identified the biochemical basis for its remarkable in vivo activity. Allo-aca decomposed...

journal_title：Amino acids

authors： Otvos L Jr,Vetter SW,Koladia M,Knappe D,Schmidt R,Ostorhazi E,Kovalszky I,Bionda N,Cudic P,Surmacz E,Wade JD,Hoffmann R

更新日期：2014-04-01 00:00:00

abstract：:Molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression has drawn significant attention because of the unique role of the HER2 gene in diagnosis, therapy and prognosis of human breast cancer. In our previous research, a novel cyclic 2-helix small protein, MUT-DS, was discovered as an anti-...

journal_title：Amino acids

authors： Ren G,Webster JM,Liu Z,Zhang R,Miao Z,Liu H,Gambhir SS,Syud FA,Cheng Z

更新日期：2012-07-01 00:00:00

abstract：:The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-o...

journal_title：Amino acids

authors： Declerck V,Aitken DJ

更新日期：2011-08-01 00:00:00

abstract：:Substance P (SP) is one of the most abundant peptides in the central nervous system and has been implicated in a variety of physiological and pathophysiological processes including stress regulation, as well as affective and anxiety-related behaviour. Consistent with these functions, SP and its preferred neurokinin 1 ...

journal_title：Amino acids

authors： Ebner K,Singewald N

更新日期：2006-10-01 00:00:00

abstract：:Skin collagen metabolism abnormalities induced by ultraviolet (UV) radiation are the major causes of skin photoaging. It has been shown that the one-time exposure of UV irradiation decreases procollagen mRNA expression in dermis and that chronic UV irradiation decreases collagen amounts and induces wrinkle formation. ...

journal_title：Amino acids

authors： Murakami H,Shimbo K,Inoue Y,Takino Y,Kobayashi H

更新日期：2012-06-01 00:00:00

abstract：:Dietary polyamines and amino acids (AAs) are crucial for human growth, development, reproduction, and health. However, the scientific literature shows large variations in polyamine and AA concentrations among major staple foods of plant origin, and there is a scarcity of information regarding their complete compositio...

journal_title：Amino acids

authors： Hou Y,He W,Hu S,Wu G

更新日期：2019-08-01 00:00:00

abstract：:The focus has been on the development of methodology for stereoselective preparation of spiroannulated intermediates of the Schöllkopf chiron and further transformations to cyclic alpha-amino acids. The spiroannulations are effected by Ru(II)-catalysed ring-closing metathesis reactions, by Ru(II)- and Pd(0)-catalysed ...

journal_title：Amino acids

authors： Undheim K

更新日期：2008-04-01 00:00:00

abstract：:This paper analyses the presence of and changes in free amino acids and biogenic amines in red and white muscle of bigeye tuna during storage in controlled atmospheres with 2 gas mixes containing different concentrations of CO(2) and O(2). Levels of amines were generally higher in white than in red muscle, with the ex...

journal_title：Amino acids

authors： Ruiz-Capillas C,Moral A

更新日期：2004-03-01 00:00:00

abstract：:The lens transparency depends on higher concentration of lens proteins and their interactions. α-Crystallin is one of the predominant lens proteins, responsible for proper structural and functional architecture of the lens microenvironment, and any alteration of which results in cataract formation. The R12C, R21L, R49...

journal_title：Amino acids

authors： Ramkumar S,Fujii N,Sakaue H,Fujii N,Thankappan B,kumari RP,Natarajaseenivasan K,Anbarasu K

更新日期：2015-05-01 00:00:00

abstract：:The reactions of phosphorus trichloride with various amino acids afford the pentacoordinated spirophosphoranes. The reaction procedures were traced by (31)P NMR spectra techniques. A new crystal structure of alanine derivative was characterized, which is a slightly distorted TBP structure. Besides, this kind of spirop...

journal_title：Amino acids

authors： Yu L,Liu Z,Fang H,Zeng QL,Zhao YF

更新日期：2005-06-01 00:00:00

abstract：:Oral β-alanine (βA) doses larger than 800 mg commonly result in unpleasant sensory symptoms (paresthesia). However, the association of form (pure vs. slow-release) with side-effects has not been fully described. The aim of this single-blinded, randomized three-arm clinical trial was to compare plasma kinetics and symp...

journal_title：Amino acids

authors： Décombaz J,Beaumont M,Vuichoud J,Bouisset F,Stellingwerff T

更新日期：2012-07-01 00:00:00

abstract：:Metformin, the drug of first choice in type 2 diabetes mellitus (T2DM), reduces cardiovascular (CV) morbidity and mortality in part independently of improved glycemic control and changes in traditional risk factors. However, there are discordant reports on the effects of metformin on endothelial function in T2DM. Our ...

journal_title：Amino acids

authors： Kruszelnicka O,Chyrchel B,Golay A,Surdacki A

更新日期：2015-09-01 00:00:00

abstract：:D: -Amino acid oxidase (DAAO) in mammal kidney regulates the renal reactive oxygen species (ROS) levels directly and plays a leading role in the development of ROS-mediated renal pathologic damages based on its crucial role in the oxidative deamination of D: -amino acids and the consequent generation of H(2)O(2). Quan...

journal_title：Amino acids

authors： Zhang H,Qi L,Lin Y,Mao L,Chen Y

更新日期：2012-01-01 00:00:00

abstract：:Ornithine decarboxylase antizyme 1 (AZ1) is a major regulatory protein responsible for the regulation and degradation of ornithine decarboxylase (ODC). To better understand the role of AZ1 in polyamine metabolism and in modulating the response to anticancer polyamine analogues, a small interfering RNA strategy was use...

journal_title：Amino acids

authors： Fraser AV,Goodwin AC,Hacker-Prietz A,Sugar E,Woster PM,Casero RA Jr

更新日期：2012-02-01 00:00:00

abstract：:eIF5A is highly conserved from archaea to mammals, essential for cell viability and the only protein known to contain the essential amino acid residue hypusine, generated by a unique posttranslational modification. eIF5A was originally identified as a translation initiation factor due to its ability to stimulate the f...

journal_title：Amino acids

authors： Dias CA,Gregio AP,Rossi D,Galvão FC,Watanabe TF,Park MH,Valentini SR,Zanelli CF

更新日期：2012-02-01 00:00:00

abstract：:Granulocyte-colony stimulating factor stimulates production and antibacterial function of neutrophiles. Therapy using the recombinant protein drug represents a major step forward in oncology. The protein has not been, however, completely sequenced at the protein level and this formed the rationale of the current study...

journal_title：Amino acids

authors： Ahmed KE,Chen WQ,John JP,Kang SU,Lubec G

更新日期：2010-04-01 00:00:00