Evidences for a role of protein cross-links in transglutaminase-related disease.

abstract：:The cellular amino acid composition of plant cells was analyzed. The callus of carrot (Daucus carota), leaves of Torenia fournieri and protocomb-like body of Cymbidium, s.p. were examined as examples of plant cells. The cellular amino acid compositions differed in the plant cells, but their basic patterns were quite s...

journal_title：Amino acids

authors： Sorimachi K,Okayasu T,Akimoto K,Niwa A

更新日期：2000-01-01 00:00:00

abstract：:Protein and peptide oxidation is a key feature in the progression of a variety of disease states and in the poor performance of protein-based products. The present work demonstrates a mass spectrometry-based approach to profiling degradation at the amino acid residue level. Synthetic peptides containing the photosensi...

journal_title：Amino acids

authors： Grosvenor AJ,Morton JD,Dyer JM

更新日期：2010-06-01 00:00:00

abstract：:This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson's disease. A...

journal_title：Amino acids

authors： Fisher A,Biggs CS,Starr MS

更新日期：1998-01-01 00:00:00

abstract：:Polyamines are small organic polycations essential for cell proliferation and survival. Antizymes (AZs) are small proteins regulated by polyamines that inhibit polyamine biosynthesis and uptake in mammalian cells. In addition, antizyme functions are also regulated by antizyme inhibitors, homologue proteins of ornithin...

journal_title：Amino acids

authors： López-Contreras AJ,Ramos-Molina B,Cremades A,Peñafiel R

更新日期：2010-02-01 00:00:00

abstract：:This investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protoco...

journal_title：Amino acids

authors： Foster EB,Fisher G,Sartin JL,Elsasser TH,Wu G,Cowan W,Pascoe DD

更新日期：2012-04-01 00:00:00

abstract：:Selective removal of protecting groups under different cleavage mechanisms could be an asset in peptide synthesis, since it provides the feasibility to incorporate different functional groups in similar reactive centres. However, selective protection/deprotection of orthogonal protecting groups in peptides is still ch...

journal_title：Amino acids

authors： Stathopoulos P,Papas S,Sakka M,Tzakos AG,Tsikaris V

更新日期：2014-05-01 00:00:00

abstract：:A fast and efficient microwave-assisted solid phase peptide synthesis (MW-SPPS) of a 51mer peptide, the main heparin-binding site (60-110) of human pleiotrophin (hPTN), using 2-chlorotrityl chloride resin (CLTR-Cl) following the 9-fluorenylmethyloxycarbonyl/tert-butyl (Fmoc/tBu) methodology and with the standard N,N'-...

journal_title：Amino acids

authors： Friligou I,Papadimitriou E,Gatos D,Matsoukas J,Tselios T

更新日期：2011-05-01 00:00:00

abstract：:The lens transparency depends on higher concentration of lens proteins and their interactions. α-Crystallin is one of the predominant lens proteins, responsible for proper structural and functional architecture of the lens microenvironment, and any alteration of which results in cataract formation. The R12C, R21L, R49...

journal_title：Amino acids

authors： Ramkumar S,Fujii N,Sakaue H,Fujii N,Thankappan B,kumari RP,Natarajaseenivasan K,Anbarasu K

更新日期：2015-05-01 00:00:00

abstract：:The streptococcal enzyme that catalyzes the last step in proline biosynthesis was heterologously expressed and the recombinant protein was purified to electrophoretic homogeneity and characterized thoroughly. As for δ1-pyrroline-5-carboxylate reductases from other sources, it was able to use either NADH or NADPH as th...

journal_title：Amino acids

authors： Petrollino D,Forlani G

更新日期：2012-07-01 00:00:00

abstract：:Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO). Conversely, nitric oxide (NO) has exclusively inhibitory effects on rat SFO-neurons and on SFO-mediated water-intake. Extracellular and patch-clamp recordings from freshly dissociated...

journal_title：Amino acids

authors： Schmid HA

更新日期：1998-01-01 00:00:00

abstract：:The interaction of antitumor drug, cisplatin (cis-[PtCl2(NH3)2], CDDP) with insulin from porcine pancreas has been investigated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and high resolution hybrid ion trap/time-of-flight mass spectrometry (MALIDI-TOF/TOF-MS and ESI-IT/TOF MS). The...

journal_title：Amino acids

authors： Li J,Yue L,Liu Y,Yin X,Yin Q,Pan Y,Yang L

更新日期：2016-04-01 00:00:00

abstract：:Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic chan...

journal_title：Amino acids

authors： Li Y,Zhang B,Wang X,Yan H,Chen G,Zhang X

更新日期：2011-10-01 00:00:00

abstract：:Nitric oxide is a small potentially toxic molecule and a diatomic free radical. We report the interaction of L-arginine, oxygen and calcium with the synthesis of nitric oxide in heart mitochondria. Nitric oxide synthesis is increased in broken rat heart mitochondria compared with intact and permeabilized mitochondria....

journal_title：Amino acids

authors： Saavedra-Molina A,Ramírez-Emiliano J,Clemente-Guerrero M,Pérez-Vázquez V,Aguilera-Aguirre L,González-Hernández JC

更新日期：2003-01-01 00:00:00

abstract：:D-Asp-containing proteins have been implicated in many aging-related diseases. To clarify the role of D-Asp-containing proteins in such diseases, we developed a screening system for these proteins using a D-aspartyl endopeptidase that specifically cleaves the proteins at the C-terminus. The digested proteins were dete...

journal_title：Amino acids

authors： Sakai-Kato K,Kinouchi T,Fujii N,Imai K,Utsunomiya-Tate N

更新日期：2009-01-01 00:00:00

abstract：:When a V3 sequence obtained on the n-th year after infection with human immunodeficiency virus type 1 (HIV-1) was supposed to change into a V3 sequence on the n + 1-th year, the variation between the above two sequences was analyzed by means of entropic chaos degree. The entropic chaos degree measures chaotic aspects ...

journal_title：Amino acids

authors： Sato K,Ohya M

更新日期：2001-01-01 00:00:00

abstract：:Changes in plasma aromatic amino acids (AAA = phenylalanine, tryptophan, tyrosine) and branched chain amino acids (BCAA = isoleucine, leucine, valine) levels possibly influencing intracranial pressure (ICP) and cerebral oxygen consumption (SjvO(2)) were investigated in 19 sedated patients up to 14 days following sever...

journal_title：Amino acids

authors： Vuille-Dit-Bille RN,Ha-Huy R,Stover JF

更新日期：2012-09-01 00:00:00

abstract：:The relative amounts of free D-amino acids (D-AA) in the urine of seven healthy volunteers (age 27 to 49 years) were determined using chiral phase (Chirasil-L-Val) capillary gas chromatography in conjunction with selected ion monitoring mass spectrometry. The absolute amounts of free D-AA were determined by pre-column...

journal_title：Amino acids

authors： Brückner H,Haasmann S,Friedrich A

更新日期：1994-06-01 00:00:00

abstract：:Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were found in various clinical settings including coronary heart disease. To assess ADMA and SDMA diagnostic validity in patients with different stages of ischemic heart disease, we studied these markers in patie...

journal_title：Amino acids

authors： Djordjević BV,Pavlović R,Ćosić V,Deljanin-Ilić M,Ristić T,Krstić N,Jevtović-Stoimenov T

更新日期：2012-12-01 00:00:00

abstract：:Pyridoxamine (PM) has long been known to inhibit protein glycation via various mechanisms of action. One such mechanism involves the scavenging of carbonyl compounds with glycating ability. Despite the abundant literature on this topic, few quantitative kinetic studies on the processes involved have been reported. In ...

journal_title：Amino acids

authors： Adrover M,Vilanova B,Frau J,Muñoz F,Donoso J

更新日期：2009-03-01 00:00:00

abstract：:Interferon tau (IFNT) was discovered as the pregnancy recognition signal in ruminants, but is now known to have a plethora of physiological functions in the mammalian uterus. The mammalian uterus includes, from the outer surface to the lumen, the serosa, myometrium and endometrium. The endometrium consists of the lumi...

journal_title：Amino acids

authors： Bazer FW,Ying W,Wang X,Dunlap KA,Zhou B,Johnson GA,Wu G

更新日期：2015-03-01 00:00:00

abstract：:The mitochondrial branched chain aminotransferase-deficient mouse model (BCATm KO), which exhibits elevated plasma and tissue branched chain amino acids (BCAAs), was used to study the effect of BCAAs on mammalian target of rapamycin complex 1 (mTORC1) regulation of organ size. BCATm is the first enzyme in the BCAA cat...

journal_title：Amino acids

authors： Neishabouri SH,Hutson SM,Davoodi J

更新日期：2015-06-01 00:00:00

abstract：:This work proposes a strategy that uses solid-phase peptide synthesis associated with copper(I)-catalyzed azide alkyne cycloaddition reaction to promote the glycosylation of an antimicrobial peptide (HSP1) containing a carboxyamidated C-terminus (HSP1-NH2). Two glycotriazole-peptides, namely [p-Glc-trz-G1]HSP1-NH2 and...

journal_title：Amino acids

authors： Junior EFC,Guimarães CFRC,Franco LL,Alves RJ,Kato KC,Martins HR,de Souza Filho JD,Bemquerer MP,Munhoz VHO,Resende JM,Verly RM

更新日期：2017-08-01 00:00:00

abstract：:Among the large family of cyclodepsipeptides, the simplest members are the cyclodidepsipeptides which have an ester group and an amide group in the same six-membered ring. To point out the pharmacological potential of this class of compounds, the present article reviews structure, isolation, synthesis and biological p...

journal_title：Amino acids

authors： Smelcerovic A,Dzodic P,Pavlovic V,Cherneva E,Yancheva D

更新日期：2014-04-01 00:00:00

abstract：:This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of a heteroaromatic compound denominated by us T(2)CO, comprising two thymine moieties anchored to a 2-propanonic unit, the spectroscopic properties of which wer...

journal_title：Amino acids

authors： Roviello GN,Roviello G,Musumeci D,Bucci EM,Pedone C

更新日期：2012-10-01 00:00:00

abstract：:A variety of alpha-amino acids are enantioresolved for the first time on naphthylethylcarbamate-beta-cyclodextrin bonded phases (i.e., SN- and RN-beta-CD) using the acetonitrile-based mobile phase after their pre-column derivatization with phenyl isothiocyanate in alkaline medium. The resolution is better obtained on ...

journal_title：Amino acids

authors： Chen S

更新日期：2004-06-01 00:00:00

abstract：:The article traces the development of research on the naturally occurring amino acid L-3,4-dihydroxyphenylalanine (L-dopa), from the first synthesis of its D,L racemate in 1911, and the isolation of its L-isomer from seedling of Vicia faba beans to the amino acid's successful application, from 1961 onward, as the most...

journal_title：Amino acids

authors： Hornykiewicz O

更新日期：2002-01-01 00:00:00

abstract：:In a previous study, we elucidated the apoptotic mechanism mediated via Fas/FasL-dependent pathway in mitomycin C-treated cervical carcinoma cells. In this study, 2-D and MALDI-TOF analyses were performed in order to search mitomycin C-induced modulators in cervical carcinoma cells. Some protein spots down- or up-regu...

journal_title：Amino acids

authors： Kang YH,Lee KA,Kim JH,Park SG,Yoon DY

更新日期：2010-11-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) with amphipathic β-hairpin structures have been demonstrated to possess potent antimicrobial activities and great cell selectivities. However, our understanding of β-hairpin antimicrobial peptides lags behind that of α-helices, mainly because it is difficult for short peptides to form rob...

journal_title：Amino acids

authors： Xu L,Chou S,Wang J,Shao C,Li W,Zhu X,Shan A

更新日期：2015-11-01 00:00:00

abstract：:The enhancing effect on the water structure has been confirmed for most of the osmolytes exhibiting both stabilizing and destabilizing properties in regard to proteins. The presented work concerns osmolytes, which should be classified as "structure breaking" solutes: taurine and N,N,N-trimethyltaurine (TMT). Here, we ...

journal_title：Amino acids

authors： Bruździak P,Panuszko A,Kaczkowska E,Piotrowski B,Daghir A,Demkowicz S,Stangret J

更新日期：2018-01-01 00:00:00

abstract：:Taurine is known to increase ATP-dependent calcium ion (Ca2+) uptake in retinal membrane preparations and in isolated rod outer segments (ROS) under low calcium conditions (10 microM) (Pasantes-Morales and Ordóñez, 1982; Lombardini, 1991). In this report, ATP-dependent Ca2+ uptake in retinal membrane preparations was ...

journal_title：Amino acids

authors： Militante JD,Lombardini JB

更新日期：1998-01-01 00:00:00