Abstract:
:Nitric oxide is a small potentially toxic molecule and a diatomic free radical. We report the interaction of L-arginine, oxygen and calcium with the synthesis of nitric oxide in heart mitochondria. Nitric oxide synthesis is increased in broken rat heart mitochondria compared with intact and permeabilized mitochondria. Intact mitochondria subjected to hypoxia-reoxygenation conditions accumulated nitric oxide that inhibits oxygen consumption and ATP synthesis. ATPase activity is not affected during this augment of nitric oxide. Physiological free calcium concentrations protected mitochondria from the damage caused by the accumulation of nitric oxide. Higher concentrations of the divalent cation increase the damage exerted by nitric oxide.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Saavedra-Molina A,Ramírez-Emiliano J,Clemente-Guerrero M,Pérez-Vázquez V,Aguilera-Aguirre L,González-Hernández JCdoi
10.1007/s00726-002-0331-7subject
Has Abstractpub_date
2003-01-01 00:00:00pages
95-102issue
1-2eissn
0939-4451issn
1438-2199journal_volume
24pub_type
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