Abstract:
:Substance P (SP) is one of the most abundant peptides in the central nervous system and has been implicated in a variety of physiological and pathophysiological processes including stress regulation, as well as affective and anxiety-related behaviour. Consistent with these functions, SP and its preferred neurokinin 1 (NK1) receptor has been found within brain areas known to be involved in the regulation of stress and anxiety responses. Aversive and stressful stimuli have been shown repeatedly to change SP brain tissue content, as well as NK1 receptor binding. More recently it has been demonstrated that emotional stressors increase SP efflux in specific limbic structures such as amygdala and septum and that the magnitude of this effect depends on the severity of the stressor. Depending on the brain area, an increase in intracerebral SP concentration (mimicked by SP microinjection) produces mainly anxiogenic-like responses in various behavioural tasks. Based on findings that SP transmission is stimulated under stressful or anxiety-provoking situations it was hypothesised that blockade of NK1 receptors may attenuate stress responses and exert anxiolytic-like effects. Preclinical and clinical studies have found evidence in favour of such an assumption. The status of this research is reviewed here.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Ebner K,Singewald Ndoi
10.1007/s00726-006-0335-9subject
Has Abstractpub_date
2006-10-01 00:00:00pages
251-72issue
3eissn
0939-4451issn
1438-2199journal_volume
31pub_type
杂志文章,评审相关文献
AMINO ACIDS文献大全abstract::We proposed that the combination of conjugated linoleic acid (CLA) and arginine would decrease adiposity by depressing lipid synthesis in liver and adipose tissues of growing pigs. Pigs were allotted to treatments in a 2 × 2 factorial design with two lipids (CLA or canola oil) and two amino acids [L-arginine or L-alan...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1255-5
更新日期:2012-10-01 00:00:00
abstract::Previous studies identified lysine- and tryptophan-rich sequences within various cationic antimicrobial peptides. In the present study, we synthesized a series of peptides composed of lysine (K)-tryptophan (W) repeats (KW)( n ) (where n equals 2, 3, 4 or 5) with amida...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-012-1388-6
更新日期:2013-02-01 00:00:00
abstract::The translation elongation factor eIF5A is conserved through evolution and is necessary to rescue the ribosome during translation elongation of polyproline-containing proteins. Although the site of eIF5A binding to the ribosome is known, no systematic analysis has been performed so far to determine the important resid...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2279-z
更新日期:2016-10-01 00:00:00
abstract::Germination ofBacillus subtilis spores was initiated by L-Ala and competitively inhibited by D-Ala, suggesting the presence of an alanine receptor. The spores showed alanine racemase activity in the spore coat. To investigate the role of alanine racemase (L → D) on germination, net racemase activity was determined usi...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00805804
更新日期:1993-02-01 00:00:00
abstract::Astrocytes are glial cells in the central nervous system (CNS) that play key roles in brain physiology, controlling processes, such as neurogenesis, brain energy metabolism and synaptic transmission. Recently, immune functions have also been demonstrated in astrocytes, influencing neuronal survival in the course of ne...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0691-3
更新日期:2011-02-01 00:00:00
abstract::L-Arginine:glycine amidinotransferase (AGAT) is the main producer of the creatine precursor, guanidinoacetate (GAA), and L-homoarginine (hArg). We and others previously reported lower levels of circulating and urinary hArg in renal transplant recipients (RTR) compared to healthy subjects. In adults, hArg emerged as a ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-019-02783-6
更新日期:2019-11-01 00:00:00
abstract::Over the last few years, consistent data have demonstrated that creatine (Cr) supplementation prevents the accumulation of fat in rat liver as well as the progression of fatty liver disease in different situations. Studies have demonstrated that Cr is effective and prevents fatty liver in high-fat and choline-deficien...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-016-2183-6
更新日期:2016-08-01 00:00:00
abstract::The high efficiency of protein deposition during the neonatal period is driven by high rates of protein synthesis, which are maximally stimulated after feeding. In the current study, we examined the individual roles of amino acids and insulin in the regulation of protein synthesis in peripheral and visceral tissues of...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-008-0149-z
更新日期:2009-05-01 00:00:00
abstract::In living cells, the N-terminal tails of core histones, the proteinaceous component of nucleosomes, are subjected to a range of covalent post-translational modifications (PTMs), which have specific roles in modulating chromatin structure and function. A growing body of evidence suggests that deregulation of histone mo...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0668-2
更新日期:2011-07-01 00:00:00
abstract::Green tea which is widely consumed in China, Japan and India, contains polyphenolic compounds, which account for 30% of the dry weight of the leaves. Most of the polyphenols are flavanols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant. Epidemiological studies revealed that the incidences of stomach a...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s726-002-8197-9
更新日期:2002-01-01 00:00:00
abstract::Knowing the key features of the structure and the biochemistry of proteins is crucial to improving enzymes of industrial interest like β-fructofuranosidase. Gene sacA from Bacillus licheniformis ATCC 14580 codifies a sucrose-6-phosphate hydrolase, a β-fructofuranosidase (E.C. 3.1.2.26, protein BlsacA), which has no cr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-02690-2
更新日期:2019-04-01 00:00:00
abstract::Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling....
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-1113-x
更新日期:2013-01-01 00:00:00
abstract::In previous studies we characterized arginine transporter genes from Trypanosoma cruzi and Leishmania donovani, the etiological agents of chagas disease and kala azar, respectively, both fatal diseases in humans. Unlike arginine transporters in higher eukaryotes that transport also lysine, these parasite transporters ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0812-z
更新日期:2012-01-01 00:00:00
abstract::Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide's therapeutic potential is limited by the short half-life and low bioavailabili...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2471-9
更新日期:2017-10-01 00:00:00
abstract::Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide,...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-006-0477-9
更新日期:2007-11-01 00:00:00
abstract::Recovery of amino acid (AA) metabolism and the associated clinical implications in chronic hepatitis C (CHC) patients with sustained virological response (SVR) following anti-hepatitis C virus (HCV) therapy remains elusive. A prospective cohort study was conducted on 222 CHC patients with SVR. Eighty-two age-matched m...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-016-2360-7
更新日期:2017-02-01 00:00:00
abstract::In this paper we report the complete separation of amino acids as DABS-derivatives using a 3µm Supelcosil LC-18 (25 cm × 2.1 mm I.D.) narrowbore column. The system described makes it possible to perform the analysis of DABS-amino acids with a sensitivity to the femtomole level. We have also studied the conditions nece...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00806005
更新日期:1992-10-01 00:00:00
abstract::N, N'-Ethylene-bridged bis-(S)-methionine[(2S, 7S)-2, 7-bis(2-methyl-thioethyl)-3,6-diazaoctanedioic acid] derived from (S)-methionine and 1,2-dibromoethane was cyclized and esterified simultaneously in boiling ethanol in the presence of an appropriate amount of strong acid such asp-toluenesulfonic acid, affording a c...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00805814
更新日期:1993-02-01 00:00:00
abstract::The effect of dietary amino acid taurine on the liver function of chronic hepatitis patients was investigated. The 24 chronic hepatitis patients with 2-5 times over normal activities of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) were selected and equally divided into taurine treatment and contr...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-007-0565-5
更新日期:2008-08-01 00:00:00
abstract::The cross-linking of protein molecules to form stable supramolecular aggregates capable of acting as protective and supporting structures is a common feature of organisms coping with the stresses of life. These new polymeric forms range from thick rigid structures to thin flexible membranes. The formation of such cros...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/BF00813999
更新日期:1991-10-01 00:00:00
abstract::The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine} is a chiral compound with valuable synthetic interest. An update on the different routes for its synthesis is reviewed and discussed. ...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-014-1902-0
更新日期:2015-02-01 00:00:00
abstract::As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on diet...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-013-1583-0
更新日期:2013-11-01 00:00:00
abstract::In this study, we investigated the activating role of Mcm1p at ARG1 during arginine starvation. Our results showed that two Mcm1p binding sites positively contribute to ARG1 transcription and cell growth. Especially, we provide strong evidence that the Mcm1p binding sites play a positive role in ARG1 transcription to ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0687-z
更新日期:2011-02-01 00:00:00
abstract::Muscle carnosine synthesis is limited by the availability of beta-alanine. Thirteen male subjects were supplemented with beta-alanine (CarnoSyn) for 4 wks, 8 of these for 10 wks. A biopsy of the vastus lateralis was obtained from 6 of the 8 at 0, 4 and 10 wks. Subjects undertook a cycle capacity test to determine tota...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-006-0364-4
更新日期:2007-02-01 00:00:00
abstract::Inhibitors of histone deacetylases (HDACs) are a promising class of anticancer agents that have an effect on gene regulation. The naturally occurring cyclic depsipeptide FK228 containing disulfide and Largazole possessing thioester functionalities act as pro-drugs and share the same HDAC inhibition mechanism in cell. ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-014-1800-5
更新日期:2014-10-01 00:00:00
abstract::The enhancing effect on the water structure has been confirmed for most of the osmolytes exhibiting both stabilizing and destabilizing properties in regard to proteins. The presented work concerns osmolytes, which should be classified as "structure breaking" solutes: taurine and N,N,N-trimethyltaurine (TMT). Here, we ...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-017-2499-x
更新日期:2018-01-01 00:00:00
abstract::Oxidative deamination of norepinephrine (NE) and dopamine (DA) by monoamine oxidase (MAO) generates the catecholaldehydes 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively, and H2O2. Catecholaldehydes are highly reactive electrophiles that have been implicated as cau...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-018-2647-y
更新日期:2019-01-01 00:00:00
abstract::The hepatitis B core (HBc) protein has been used successfully in numerous experiments as a carrier for heterologous peptides. Folding and capsid formation of the chimeric proteins is not always achieved easily. In silico analyses were performed to provide further comprehension of the feasibility for predicting success...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-009-0365-1
更新日期:2010-05-01 00:00:00
abstract::Glutamate is stored in synaptic vesicles in presynaptic neurons. It is released into the synaptic cleft to provide signalling to postsynaptic neurons. Normally, the astroglial glutamate transporters GLT-1 and GLAST take up glutamate to mediate a high signal-to-noise ratio in the synaptic signalling, and also to preven...
journal_title:Amino acids
pub_type: 杂志文章,评审
doi:10.1007/s00726-011-0865-7
更新日期:2012-01-01 00:00:00
abstract::Carnosine is found in high concentrations in skeletal muscles, where it is involved in several physiological functions. The muscle carnosine content measured within a population can vary by a factor 4. The aim of this study was to further characterize suggested determinants of the muscle carnosine content (diet, gende...
journal_title:Amino acids
pub_type: 杂志文章
doi:10.1007/s00726-010-0749-2
更新日期:2011-04-01 00:00:00