Abstract:
:The focus has been on the development of methodology for stereoselective preparation of spiroannulated intermediates of the Schöllkopf chiron and further transformations to cyclic alpha-amino acids. The spiroannulations are effected by Ru(II)-catalysed ring-closing metathesis reactions, by Ru(II)- and Pd(0)-catalysed cycloisomerisations, by Rh(II)-carbenoid cyclisation reactions and by intramolecular aldol condensations. Hydrolytic reactions of the spirane intermediates have provided several groups of highly novel and functionalised five-, six- and seven-membered cyclic alpha-quaternary-alpha-amino acid derivatives as well as alicyclic derivatives. The novel cyclic amino acid derivatives can be regarded as cyclic constrained analogues of corresponding common amino acids, or in some cases as intermediates for further preparation of such amino acids. Some emphasis has been on the preparation of cyclic serine analogues. Major efforts have been on the preparation of cyclic alpha-quaternary bis(alpha-amino acid) derivatives as conformationally constrained dicarba-analogues of cystine.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Undheim Kdoi
10.1007/s00726-007-0512-5subject
Has Abstractpub_date
2008-04-01 00:00:00pages
357-402issue
3eissn
0939-4451issn
1438-2199journal_volume
34pub_type
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