当前位置： SCI文献检索 > AMINO ACIDS期刊下所有文献 > Enhancing effect of macroporous adsorption resin on gamma-aminobutyric acid production by Enterococcus faecium in whole-cell biotransformation system.

Enhancing effect of macroporous adsorption resin on gamma-aminobutyric acid production by Enterococcus faecium in whole-cell biotransformation system.

Abstract：

:Gamma-aminobutyric acid (GABA) biosynthesis depended to a great extent on the biotransformation characterization of glutamate decarboxylase (GAD) and process conditions. In this paper, the enhancing effect of D101 macroporous adsorption resin (MAR) on the GABA production was investigated based on the whole-cell biotransformation characterization of Enterococcus faecium and adsorption characteristics of D101 MAR. The results indicated that the optimal pH for reaction activity of whole-cell GAD and pure GAD was 4.4 and 5.0, respectively, and the pH range retained at least 50% of GAD activity was from 4.8 to 5.6 and 4.0-4.8, respectively. No substrate inhibition effect was observed on both pure GAD and whole-cell GAD, and the maximum activity could be obtained when the initial L-glutamic acid (L-Glu) concentration exceeded 57.6 mmol/L and 96.0 mmol/L, respectively. Besides, GABA could significantly inhibit the activity of whole-cell GAD rather than pure GAD. When the initial GABA concentration of the reaction solution remained 100 mmol/L, 33.51 ± 9.11% of the whole-cell GAD activity was inhibited. D101 MAR exhibited excellent properties in stabilizing the pH of the conversion reaction system, supplementing free L-Glu and removing excess GABA. Comparison of the biotransformation only in acetate buffer, the GABA production, with 50 g/100 mL of D101 MAR, was significantly increased by 138.71 ± 5.73%. D101 MAR with pre-adsorbed L-Glu could significantly enhance the production of GABA by gradual replenishment of free L-Glu, removing GABA and maintaining the pH of the reaction system, which would eventually make the GABA production more economical and eco-friendly.

journal_name

Amino Acids

journal_title

Amino acids

authors

Yang SY,Liu SM,Jiang M,Wang BS,Peng LH,Zeng C

doi

10.1007/s00726-020-02850-3

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

771-780

issue

5

eissn

0939-4451

issn

1438-2199

pii

10.1007/s00726-020-02850-3

journal_volume

52

pub_type

杂志文章

相关文献

AMINO ACIDS文献大全
  • Evolutionary relationships between seryl-histidine dipeptide and modern serine proteases from the analysis based on mass spectrometry and bioinformatics.

    abstract：:Seryl-histidine dipeptide (Ser-His) has been recognized as the shortest peptide with hydrolysis cleavage activity; however, its protein cleavage spectrum has not yet been fully explored. Here, four differently folded proteins were treated with Ser-His, and the digestion products were evaluated with high-resolution mas...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-017-2487-1

    authors： Liu Y,Li YB,Gao X,Yu YF,Liu XX,Ji ZL,Ma Y,Li YM,Zhao YF

    更新日期：2018-01-01 00:00:00

  • Folding properties of the hepatitis B core as a carrier protein for vaccination research.

    abstract：:The hepatitis B core (HBc) protein has been used successfully in numerous experiments as a carrier for heterologous peptides. Folding and capsid formation of the chimeric proteins is not always achieved easily. In silico analyses were performed to provide further comprehension of the feasibility for predicting success...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-009-0365-1

    authors： Janssens ME,Geysen D,Broos K,De Goeyse I,Robbens J,Van Petegem F,Timmermans JP,Guisez Y

    更新日期：2010-05-01 00:00:00

  • Development of a novel ligand binding assay for relaxin family peptide receptor 3 and 4 using NanoLuc complementation.

    abstract：:Relaxin family peptides perform a variety of biological functions by binding and activating relaxin family peptide receptor 1-4 (RXFP1-4), four A-class G protein-coupled receptors. In the present work, we developed a novel ligand binding assay for RXFP3 and RXFP4 based on NanoLuc complementation technology (NanoBiT). ...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-018-2588-5

    authors： Hu MJ,Shao XX,Li HZ,Nie WH,Wang JH,Liu YL,Xu ZG,Guo ZY

    更新日期：2018-08-01 00:00:00

  • Curcin C, a novel type I ribosome-inactivating protein from the post-germinating cotyledons of Jatropha curcas.

    abstract：:A novel type I ribosome-inactivating protein (RIP), designated as curcin C, was purified from Jatropha curcas, an important feedback source of bio-fuel. Molecular mass and isoelectric point of curcin C were 31.398 kDa and 7.12 as detected by MALTI-TOF assay and capillary electrophoresis assay, respectively. N-terminal...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-017-2456-8

    authors： Zhang Y,Yang Q,Li C,Ding M,Lv X,Tao C,Yu H,Chen F,Xu Y

    更新日期：2017-09-01 00:00:00

  • Uncovering protein polyamination by the spermine-specific antiserum and mass spectrometric analysis.

    abstract：:The polyamines spermidine and spermine, and their precursor putrescine, have been shown to play an important role in cell migration, proliferation, and differentiation. Because of their polycationic property, polyamines are traditionally thought to be involved in DNA replication, gene expression, and protein translati...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-014-1879-8

    authors： Yu CH,Chou CC,Lee YJ,Khoo KH,Chang GD

    更新日期：2015-03-01 00:00:00

  • The designer leptin antagonist peptide Allo-aca compensates for short serum half-life with very tight binding to the receptor.

    abstract：:The leptin receptor antagonist peptide Allo-aca exhibits picomolar activities in various cellular systems and sub-mg/kg subcutaneous efficacies in animal models making it a prime drug candidate and target validation tool. Here we identified the biochemical basis for its remarkable in vivo activity. Allo-aca decomposed...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-013-1650-6

    authors： Otvos L Jr,Vetter SW,Koladia M,Knappe D,Schmidt R,Ostorhazi E,Kovalszky I,Bionda N,Cudic P,Surmacz E,Wade JD,Hoffmann R

    更新日期：2014-04-01 00:00:00

  • gamma-L-glutamyltaurine.

    abstract：:The discovery of the dipeptide gamma-glutamyltaurine (gamma-GT; glutaurine, Litoralon) in the parathyroid in 1980 and later in the brain of mammals gave rise to studies on intrinsic and synthetic taurine peptides of this type. It was suggested that gamma-glutamyltransferase (GGT; gamma-glutamyltranspeptidase) in the b...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-005-0196-7

    authors： Bittner S,Win T,Gupta R

    更新日期：2005-06-01 00:00:00

  • Phenylalanine ammonia-lyase modified with polyethylene glycol: potential therapeutic agent for phenylketonuria.

    abstract：:Phenylketonuria (PKU) is an autosomal recessive genetic disease caused by the defects in the phenylalanine hydroxylase (PAH) gene. Individuals homozygous for defective PAH alleles show elevated levels of systemic phenylalanine and should be under strict dietary control to reduce the risk of neuronal damage associated ...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-005-0218-5

    authors： Ikeda K,Schiltz E,Fujii T,Takahashi M,Mitsui K,Kodera Y,Matsushima A,Inada Y,Schulz GE,Nishimura H

    更新日期：2005-11-01 00:00:00

  • New antitumoral cyclopeptides.

    abstract：:Chlamydocin is a powerfulin vitro antitumoral agent, quickly inactivatedin vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on anε-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines. One a...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF00813752

    authors： Bernardi E,Fauchère JL,Atassi G,Viallefont P,Lazaro R

    更新日期：1994-10-01 00:00:00

  • Potent effects of amino acid scanned antimicrobial peptide Feleucin-K3 analogs against both multidrug-resistant strains and biofilms of Pseudomonas aeruginosa.

    abstract：:Pseudomonas aeruginosa is particularly difficult to treat because it possesses a variety of resistance mechanisms and because it often forms biofilms. Antimicrobial peptides represent promising candidates for future templates of antibiotic-resistant bacterial infections due to their unique mechanism of antimicrobial a...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-018-2625-4

    authors： Xie J,Li Y,Li J,Yan Z,Wang D,Guo X,Zhang J,Zhang B,Mou L,Yang W,Jiang X

    更新日期：2018-10-01 00:00:00

  • Composition of polyamines and amino acids in plant-source foods for human consumption.

    abstract：:Dietary polyamines and amino acids (AAs) are crucial for human growth, development, reproduction, and health. However, the scientific literature shows large variations in polyamine and AA concentrations among major staple foods of plant origin, and there is a scarcity of information regarding their complete compositio...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-019-02751-0

    authors： Hou Y,He W,Hu S,Wu G

    更新日期：2019-08-01 00:00:00

  • Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity.

    abstract：:High-protein diets have been shown to alleviate detrimental effects of high-fat diets and this effect can be partially mimicked by dietary L-leucine supplementation. Here, we aimed to elucidate the early mechanisms and the specificity of leucine effects. We performed a 1-week trial with male C57BL/6 mice fed ad libitu...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-012-1363-2

    authors： Freudenberg A,Petzke KJ,Klaus S

    更新日期：2013-02-01 00:00:00

  • Tryptophanase-catalysed degradation of D-tryptophan in highly concentrated diammonium hydrogen phosphate solution.

    abstract：:Tryptophanase is and is perfectly inert to D-tryptophan under ordinary conditions. However, activity that can degrade D-tryptophan into indole is observed when tryptophanase is in highly concentrated diammoniumhydrogen phosphate solution. The reaction has been so far unknown in tryptophanase metabolic pathways. Here w...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/BF00805723

    authors： Shimada A,Shishido H,Nakamura I

    更新日期：1996-03-01 00:00:00

  • Spectroscopic and structural elucidation of amino acid derivatives and small peptides: experimental and theoretical tools.

    abstract：:This mini review deals with the modern aspects of the spectroscopy and structural elucidation of amino acid derivatives and small biologically active compounds. Free peptide bond rotation in these systems yields various conformers, which possess differing biological activities. Another phenomenon is the intermolecular...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-008-0220-9

    authors： Kolev T,Spiteller M,Koleva B

    更新日期：2010-01-01 00:00:00

  • Effect of taurine chloramine, the product of activated neutrophils, on the development of collagen-induced arthritis in DBA 1/J mice.

    abstract：:Taurine chloramine (TauCl), a product of neutrophil myeloperoxidase - halide system, formed by a reaction of taurine with HOCl, is known as an anti-microbial and anti-inflammatory long-lived oxidant. We previously reported that TauCl inhibits in vitro the production of proinflammatory cytokines (IL-6, IL-8) by RA syno...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-002-0207-x

    authors： Kwaśny-Krochin B,Bobek M,Kontny E,Gluszko P,Biedroń R,Chain BM,Maśliński W,Marcinkiewicz J

    更新日期：2002-01-01 00:00:00

  • Synthesis, protonation constants and biological activity determination of amino acid-salicylaldehyde-derived Schiff bases.

    abstract：:Schiff bases represent a class of molecules widely studied for their importance in organic and coordination chemistry. Despite the large amount of studies on the chemical and biological properties of the Schiff bases, the different experimental conditions prevent a useful comparison to search for a correlation structu...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-019-02816-0

    authors： Fattuoni C,Vascellari S,Pivetta T

    更新日期：2020-03-01 00:00:00

  • Proteome analysis of soybean hypocotyl and root under salt stress.

    abstract：:To evaluate the response of soybean to salt stress, the related changes in protein expression were investigated using the proteomic approach. Soybean plants were exposed to 0, 50, 100, and 200 mM NaCl. Especially at 200 mM, the length and fresh weight of the hypocotyl and root reduced under salt stress, while the prol...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-008-0036-7

    authors： Aghaei K,Ehsanpour AA,Shah AH,Komatsu S

    更新日期：2009-01-01 00:00:00

  • Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry.

    abstract：:Sensitivity to pharmacological challenges has been reported in patients with panic disorder. We have previously validated transgenic mice overexpressing the neurotrophin-3 (NT-3) receptor, TrkC (TgNTRK3), as an engineered murine model of panic disorder. We could determine that TgNTRK3 mice presented increased cellular...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-006-0464-1

    authors： Sahún I,Gallego X,Gratacòs M,Murtra P,Trullás R,Maldonado R,Estivill X,Dierssen M

    更新日期：2007-11-01 00:00:00

  • Possible antioxidant role of SPA therapy with chlorine-sulphur-bicarbonate mineral water.

    abstract：:The aim of our research was to analyze the antioxidant role and efficacy of thermal or salus per aquam (spa) therapy with chlorine-sulphur-bicarbonate mineral water. The study has been performed on 30 rats. The animals were randomized in three groups, each of them composed by ten animals, denominated A, B and C. The A...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-008-0032-y

    authors： Costantino M,Giuberti G,Caraglia M,Lombardi A,Misso G,Abbruzzese A,Ciani F,Lampa E

    更新日期：2009-02-01 00:00:00

  • Applications and current challenges of proteomic approaches, focusing on two-dimensional electrophoresis.

    abstract：:Since the formulation of the concept of "proteomics" in 1995, a plethora of proteomic technologies have been developed in order to study proteomes of tissues, cells and organelles. The powerful new technologies enabled by proteomic approaches have lead to the application of these methods to an exponentially increasing...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-006-0460-5

    authors： Vercauteren FG,Arckens L,Quirion R

    更新日期：2007-09-01 00:00:00

  • Polyamines modulate epithelial-to-mesenchymal transition.

    abstract：:Epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition are biologic processes responsible for conversion of epithelial cells into a mesenchymal phenotype or viceversa, respectively. They occur during embryo- and foetal-development and, in adult organisms, are involved in wound healing, in the ge...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-011-0995-y

    authors： Compagnone A,Bandino A,Meli F,Bravoco V,Cravanzola C,Parola M,Colombatto S

    更新日期：2012-02-01 00:00:00

  • Cardiovascular actions of L-cysteine and L-cysteine sulfinic acid in the nucleus tractus solitarius of the rat.

    abstract：:The sulfur-containing excitatory amino acid (EAA) L-cysteine sulfinic acid (CSA), a neurotransmitter candidate, is endogenously synthesized from L-cysteine (Cys). Exogenous Cys administration into the brain produces cardiovascular effects; these effects likely occur via synaptic stimulation of central nervous system (...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-014-1733-z

    authors： Takemoto Y

    更新日期：2014-07-01 00:00:00

  • Comparison of amino acids interaction with gold nanoparticle.

    abstract：:The study of nanomaterial/biomolecule interface is an important emerging field in bionanoscience, and additionally in many biological processes such as hard-tissue growth and cell-surface adhesion. To have a deeper understanding of the amino acids/gold nanoparticle assemblies, the adsorption of these amino acids on th...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-013-1642-6

    authors： Ramezani F,Amanlou M,Rafii-Tabar H

    更新日期：2014-04-01 00:00:00

  • A synthetic peptide derived of the β2-β3 loop of the plant defensin from Vigna unguiculata seeds induces Leishmania amazonensis apoptosis-like cell death.

    abstract：:For medical use of proteins and peptide-based drugs, it is desirable to have small biologically active sequences because they improve stability, reduce side effects, and production costs. Several plant defensins have their biological activities imparted by a sequence named γ-core. Vu-Def, a Vigna unguiculata defensin,...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-019-02800-8

    authors： Souza GS,de Carvalho LP,de Melo EJT,da Silva FCV,Machado OLT,Gomes VM,de Oliveira Carvalho A

    更新日期：2019-11-01 00:00:00

  • The effect of acute taurine ingestion on 4-km time trial performance in trained cyclists.

    abstract：:Taurine (TAU) has been shown to improve exercise time to exhaustion and 3-km running performance; however, no studies have considered the effect of acute TAU ingestion on short duration cycling time trial (TT) performance. The aim of this study was to determine the effects of a single oral acute dose of 1000 mg of TAU...

    journal_title：Amino acids

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00726-016-2282-4

    authors： Ward R,Bridge CA,McNaughton LR,Sparks SA

    更新日期：2016-11-01 00:00:00

  • Arginine revisited: minireview article.

    abstract：:Arginine is a precursor of proteins and employed in urea synthesis. It is also the precursor of many other compounds, such as creatine, nitric oxide, polyamines, agmatine, proline. In this review, its transport and that of other basic amino acids are examined, along with its transformation into nitric oxide, agmatine ...

    journal_title：Amino acids

    pub_type： 杂志文章,评审

    doi：10.1007/s00726-004-0081-9

    authors： Grillo MA,Colombatto S

    更新日期：2004-07-01 00:00:00

  • Prediction of mitochondrial proteins based on genetic algorithm - partial least squares and support vector machine.

    abstract：:Mitochondria are essential cell organelles of eukaryotes. Hence, it is vitally important to develop an automated and reliable method for timely identification of novel mitochondrial proteins. In this study, mitochondrial proteins were encoded by dipeptide composition technology; then, the genetic algorithm-partial lea...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-006-0465-0

    authors： Tan F,Feng X,Fang Z,Li M,Guo Y,Jiang L

    更新日期：2007-11-01 00:00:00

  • Role of curcumin in the conversion of asparagine into acrylamide during heating.

    abstract：:This study aimed to investigate the ability of curcumin to convert asparagine into acrylamide during heating at different temperatures. Binary and ternary model systems of asparagine-curcumin and asparagine-curcumin-fructose were used to determine the role of curcumin on acrylamide formation in competitive and uncompe...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-011-1179-5

    authors： Hamzalıoğlu A,Mogol BA,Lumaga RB,Fogliano V,Gökmen V

    更新日期：2013-06-01 00:00:00

  • Disturbance of erythrocyte lipid bilayer by amino acid-based surfactants.

    abstract：:In an attempt to increase our knowledge regarding the mechanisms of surfactant membrane interaction, we studied the action of several anionic and cationic amino acid-based surfactants on membrane fluidity using fluorescence anisotropy. Anisotropy measurements demonstrated that almost all of the surfactants studied dis...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-006-0447-2

    authors： Martínez V,Sánchez L,Busquets MA,Infante MR,Pilar Vinardell M,Mitjans M

    更新日期：2007-09-01 00:00:00

  • Impaired energy metabolism of the taurine‑deficient heart.

    abstract：:Taurine is a β-amino acid found in high concentrations in excitable tissues, including the heart. A significant reduction in myocardial taurine content leads to the development of a unique dilated, atrophic cardiomyopathy. One of the major functions of taurine in the heart is the regulation of the respiratory chain. H...

    journal_title：Amino acids

    pub_type： 杂志文章

    doi：10.1007/s00726-015-2110-2

    authors： Schaffer SW,Shimada-Takaura K,Jong CJ,Ito T,Takahashi K

    更新日期：2016-02-01 00:00:00