Abstract:
:A novel type I ribosome-inactivating protein (RIP), designated as curcin C, was purified from Jatropha curcas, an important feedback source of bio-fuel. Molecular mass and isoelectric point of curcin C were 31.398 kDa and 7.12 as detected by MALTI-TOF assay and capillary electrophoresis assay, respectively. N-terminal sequence and LC-MS/MS analyses confirmed that curcin C is a type I RIP having high homology, but not the exactly the same with curcin, another type 1 RIP isolated from the endosperm of J. curcas. It exhibited N-glycosidase activity and in vitro translation inhibition activity. Moreover, curcin C displayed a strong selectively anti-tumor activity on human cancer cells. Its cytotoxicity against osteosarcoma cell line U20S is even higher than that of Paclitaxel with IC50 of 0.019 μM. Purification and identification of curcin C not only suggested its potential in natural anticancer drug development, but also provide chance to understanding different cytotoxic action among different RIPs.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Zhang Y,Yang Q,Li C,Ding M,Lv X,Tao C,Yu H,Chen F,Xu Ydoi
10.1007/s00726-017-2456-8subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1619-1631issue
9eissn
0939-4451issn
1438-2199pii
10.1007/s00726-017-2456-8journal_volume
49pub_type
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