Abstract：
:Interplay between proteins, nucleic acids, carbohydrates and/or lipids is involved in almost every process in life on earth. As a consequence, a wide range of diseases results from abnormal interactions of such biomolecules. The main motivation of foldamer science is the development of scaffolds that are capable of adopting defined structures, mimicking parts of biological protagonists in their function. Among the most fundamental interactions in living beings are those between proteins, the so called protein--protein interactions (PPIs). Therefore, peptidic foldamers bear the promise to be an important tool for the inhibition of PPIs, as they are structurally most similar to the original proteins. The great number of possible permutations given by the combination of proteinogenic α-amino acid residues along with β-amino acids opens the door for a larger pool of accessible structures with potential applications. Despite the increasing amount of new secondary structure motifs, only few examples for tertiary and quaternary structure design, as well as inhibition of PPIs, have been realized so far. In this review, we summarize the current knowledge and recent progress made in the field of α/β-peptide foldamers beginning from secondary structure design up to highly sophisticated biological applications, such as protein surface recognition and inhibition of HIV cell entry.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Pilsl LK,Reiser Odoi
10.1007/s00726-011-0894-2subject
Has Abstractpub_date
2011-08-01 00:00:00pages
709-18issue
3eissn
0939-4451issn
1438-2199journal_volume
41pub_type
杂志文章,评审相关文献
AMINO ACIDS文献大全abstract：:This study investigated the effect of taurine and β-alanine supplementation on muscle function and muscle taurine transporter (TauT) protein expression in mdx mice. Wild-type (WT) and mdx mice (5 months) were supplemented with taurine or β-alanine for 4 weeks, after which in vitro contractile properties, fatigue resis...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-016-2292-2
更新日期：2016-11-01 00:00:00
abstract：:Numerous indolyl amino acids and their derivatives inhibited arginase activity. The inhibition was found to be non-competitive, - at least partly - allosteric, and independent on manganese ions in the active site, and it cannot be explained by the dissociation of arginase homotrimers. Indole alone is weakly inhibitory...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-006-0470-3
更新日期：2008-02-01 00:00:00
abstract：:As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on diet...
journal_title：Amino acids
pub_type： 杂志文章,评审
doi：10.1007/s00726-013-1583-0
更新日期：2013-11-01 00:00:00
abstract：:The chemical modification of protein by nonenzymatic browning or Maillard reactions increases with age and in disease. Maillard products are formed by reactions of both carbohydrate- and lipid-derived intermediates with proteins, leading to formation of advanced glycation and lipoxidation end-products (AGE/ALEs). Thes...
journal_title：Amino acids
pub_type： 杂志文章,评审
doi：10.1007/s00726-003-0017-9
更新日期：2003-12-01 00:00:00
abstract：:Zinc exhibits antidepressant-like activity in preclinical tests/models. Moreover, zinc homeostasis is implicated in the pathophysiology of affective disorders. The aim of the present study was to examine the effect of chronic zinc, citalopram and imipramine intraperitoneal administration on the presynaptic and extrace...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-010-0641-0
更新日期：2011-01-01 00:00:00
abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease (ischemic disease, such as stroke and myocardial infarction, and arterial and venous thrombotic events) in the general population. We can assume that the association is causal, based on the example of homocystinuria, and on the evidence put ...
journal_title：Amino acids
pub_type： 杂志文章,评审
doi：10.1007/s00726-003-0026-8
更新日期：2003-12-01 00:00:00
abstract：:Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were found in various clinical settings including coronary heart disease. To assess ADMA and SDMA diagnostic validity in patients with different stages of ischemic heart disease, we studied these markers in patie...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-012-1307-x
更新日期：2012-12-01 00:00:00
abstract：:Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-017-2524-0
更新日期：2018-04-01 00:00:00
abstract：:Taurine is found in bone tissue, but its function in skeletal tissue is not fully understood. The present study was undertaken to investigate regulation of gene expression of connective tissue growth factor (CTGF), and the roles of mitogen-activated protein kinases (MAPKs) in murine osteoblast MC3T3-E1 cells treated w...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-006-0380-4
更新日期：2007-01-01 00:00:00
abstract：:Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide's therapeutic potential is limited by the short half-life and low bioavailabili...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-017-2471-9
更新日期：2017-10-01 00:00:00
abstract：:The lipidicα-amino acids (LAAs) are non-naturalα-amino acids with saturated or unsaturated long aliphatic side chains. LAAs and their derivatives (lipid mimetics) together with the lipidic peptides represent a class of compounds which combine structural features of lipids with those of amino acids and peptides. Racemi...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/BF00807940
更新日期：1996-09-01 00:00:00
abstract：:Glutamine and leucine are abundant constituents of plant and animal proteins, whereas the content of arginine in foods and physiological fluids varies greatly. Besides their role in protein synthesis, these three amino acids individually activate signaling pathway to promote protein synthesis and possibly inhibit auto...
journal_title：Amino acids
pub_type： 杂志文章,评审
doi：10.1007/s00726-008-0225-4
更新日期：2009-05-01 00:00:00
abstract：:A fast and efficient microwave-assisted solid phase peptide synthesis (MW-SPPS) of a 51mer peptide, the main heparin-binding site (60-110) of human pleiotrophin (hPTN), using 2-chlorotrityl chloride resin (CLTR-Cl) following the 9-fluorenylmethyloxycarbonyl/tert-butyl (Fmoc/tBu) methodology and with the standard N,N'-...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-010-0753-6
更新日期：2011-05-01 00:00:00
abstract：:The effects of metabotropic glutamate receptor (mGluR) activation were studied in medium spiny neurons and large aspiny (LA) interneurons by means of electrophysiological and optical recordings. DCG-IV and L-SOP, agonists for group II and III mGluRs, respectively, produced a presynaptic inhibitory effect on corticostr...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s007260070040
更新日期：2000-01-01 00:00:00
abstract：:The streptococcal enzyme that catalyzes the last step in proline biosynthesis was heterologously expressed and the recombinant protein was purified to electrophoretic homogeneity and characterized thoroughly. As for δ1-pyrroline-5-carboxylate reductases from other sources, it was able to use either NADH or NADPH as th...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-011-1077-x
更新日期：2012-07-01 00:00:00
abstract：:Amino acid and glucosinolate biosynthesis are two interdependent pathways; amino acid synthesis as a part of primary metabolism provides the precursors for glucosinolate biosynthesis in secondary metabolism. In our previous studies, the combination of coexpression analysis and metabolite profiling led to the identific...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-010-0681-5
更新日期：2010-10-01 00:00:00
abstract：:α-Pharmacological conotoxins are among the most selective ligands of nicotinic acetylcholine receptors with typical cysteine frameworks. They are characterized by the intercysteine loop and classified into various subfamilies, such as α3/5 and α4/7 conotoxins. A novel α-conotoxin, Pu14a (DCPPHPVPGMHKCVCLKTC), with a d...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-011-1093-x
更新日期：2012-07-01 00:00:00
abstract：:Endoplasmic reticulum (ER) stress, implicated in various neurodegenerative processes, increases the level of intracellular Ca(2+) and leads to activation of calpain, a Ca(2+)-dependent cysteine protease. We have shown previously that S-allyl-L-cysteine (SAC) in aged garlic extracts significantly protects cultured rat ...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-013-1628-4
更新日期：2014-02-01 00:00:00
abstract：:Studies have shown that specific amino acids are required for optimal growth of leukemic versus normal cells, and it is believed that the depletion of selected amino acids can abrogate tumor growth. We have developed a technique for studying the effect of amino acid deprivation on leukemic cell proliferation. The tech...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/BF00805995
更新日期：1992-10-01 00:00:00
abstract：:Recently agmatine, decarboxylated arginine, has been shown to be an important biological compound in several animal tissues. This paper summarizes the known information regarding the transport of arginine, its decarboxylation and the effects of the agmatine formed mainly on NO and polyamine synthesis. ...
journal_title：Amino acids
pub_type： 杂志文章,评审
doi：10.1007/s00726-003-0030-z
更新日期：2004-02-01 00:00:00
abstract：:In a previous research, we have shown that adequate levels of polyamines are required in transformed mouse fibroblasts for the correlated activations of MAPK subtypes (ERK and JNK) and caspases induced by etoposide and leading to apoptosis. We report now that the treatment of fibroblasts with etoposide also elicited a...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-004-0101-9
更新日期：2004-10-01 00:00:00
abstract：:BE-3-3-3-3 (1,15-(ethylamino)4,8,12-triazapentadecane) is a bis(ethyl)polyamine analogue under investigation as a therapeutic agent for breast cancer. Since estradiol (E(2)) is a critical regulatory molecule in the growth of breast cancer, we examined the effect of BE-3-3-3-3 on estrogen receptor α (ERα) positive MCF-...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-011-1005-0
更新日期：2012-02-01 00:00:00
abstract：:This study aimed to evaluate the effect of taurine (tau) supplementation to low fishmeal (FM) diets on growth performance, oxidative status, and immune response of European seabass juveniles. Four isoproteic (46% crude protein) and isolipidic (19% crude lipid) diets were formulated to contain either 25 or 12.5% FM and...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-019-02769-4
更新日期：2019-09-01 00:00:00
abstract：:Treatment of developing rats with monosodium glutamate (MSG) produces an increase of glutamate levels in the brain, being this elevation dependent on both route of administration and animal's age. The capacity of exogenous MSG to induce convulsions seems to be related to the rate of glutamate elevation in the brain, r...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/BF00808094
更新日期：1991-02-01 00:00:00
abstract：OBJECTIVE:Chemo-therapeutic treatment of glioma patients has minor success. Little is known about mechanisms of a pronounced resistance of gliomas towards actual therapies, yet. ABC-1 belongs to the group of transporters known to be involved in the export of hydrophobic substances and vascular regulation. This study in...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-005-0171-3
更新日期：2005-03-01 00:00:00
abstract：:Alterations in adipocyte characteristics are highly implicated in the pathology of obesity. In a recent article, we demonstrated that high-fat diet-induced obesity impairs lysosomal function, thereby suppressing autophagy in mice white adipose tissue. Taurine, an amino acid naturally contained in the normal diet and e...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-018-2550-6
更新日期：2018-05-01 00:00:00
abstract：:D-Amino acid oxidase cDNA was amplified by a polymerase chain reaction using RNA extracted from the mouse kidney. When digested withHindIII, the cDNAs of the BALB/c and ddY/DAO(-) mice were cleaved into two fragments whereas the cDNA of the ddY/DAO(+) mice was not. Sequencing revealed that nucleotide-471 of the cDNAs ...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/BF00806548
更新日期：1995-03-01 00:00:00
abstract：:Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-001-0131-5
更新日期：2002-01-01 00:00:00
abstract：:Fibronectin (FN) is a cell adhesion protein that binds integrins in a process also involving the protein-crosslinking enzyme transglutaminase 2 (TG2) as a co-receptor. The cell-adhesive property of TG2 has been linked to a complex formation with FN and to its ability to crosslink and polymerize FN on the cell surface....
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s00726-008-0125-7
更新日期：2009-04-01 00:00:00
abstract：:Hepatocytes were cultured for 3 days as spheroids (aggregates) or as monolayers in basal medium and in sulfur amino acid-supplemented media. Cultured hepatocytes had low levels of cysteine dioxygenase (CDO) activity and normal levels of gamma-glutamylcysteine synthetase (GCS) and cysteine-sulfinate decarboxylase (CSDC...
journal_title：Amino acids
pub_type： 杂志文章
doi：10.1007/s007260070017
更新日期：2000-01-01 00:00:00
