Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion.

abstract：:Substance P (SP) is one of the most abundant peptides in the central nervous system and has been implicated in a variety of physiological and pathophysiological processes including stress regulation, as well as affective and anxiety-related behaviour. Consistent with these functions, SP and its preferred neurokinin 1 ...

journal_title：Amino acids

authors： Ebner K,Singewald N

更新日期：2006-10-01 00:00:00

abstract：:Isoprostanes, non-enzymatic peroxidation products of arachidonic acid, are attractive biomarkers of oxidative stress in research in biology, medicine and nutrition. For the appropriate use of biomarkers it is required that these are both biologically and technically valid. Whereas the biological validity of isoprostan...

journal_title：Amino acids

authors： Coolen SA,van Buuren B,Duchateau G,Upritchard J,Verhagen H

更新日期：2005-12-01 00:00:00

abstract：:The successful prediction of protein-folding rates based on the sequence-predicted secondary structure suggests that the folding rates might be predicted from sequence alone. To pursue this question, we directly predict the folding rates from amino acid sequences, which do not require any information on secondary or t...

journal_title：Amino acids

authors： Huang JT,Xing DJ,Huang W

更新日期：2012-08-01 00:00:00

abstract：:M33 is a branched peptide currently under preclinical characterization for the development of a new antibacterial drug against gram-negative bacteria. Here, we report its pegylation at the C-terminus of the three-lysine-branching core and the resulting increase in stability to Pseudomonas aeruginosa elastase. This pro...

journal_title：Amino acids

authors： Falciani C,Lozzi L,Scali S,Brunetti J,Bracci L,Pini A

更新日期：2014-05-01 00:00:00

abstract：:The G protein-coupled receptor kinase (GRK) family consists of seven cytosolic serine/threonine (Ser/Thr) protein kinases, and among them, GRK2 is involved in the regulation of an enormous range of both G protein-coupled receptors (GPCRs) and non-GPCR substrates that participate in or regulate many critical cellular p...

journal_title：Amino acids

authors： Kang JH,Toita R,Kawano T,Murata M,Asai D

更新日期：2020-07-01 00:00:00

abstract：:This paper analyses the presence of and changes in free amino acids and biogenic amines in red and white muscle of bigeye tuna during storage in controlled atmospheres with 2 gas mixes containing different concentrations of CO(2) and O(2). Levels of amines were generally higher in white than in red muscle, with the ex...

journal_title：Amino acids

authors： Ruiz-Capillas C,Moral A

更新日期：2004-03-01 00:00:00

abstract：:In the present study, we report the synthesis and biological evaluation of a series of new non-peptide PAR(1) mimetic receptor antagonists, based on conformational analysis of the S(42)FLLR(46) tethered ligand (TL) sequence of PAR(1). These compounds incorporate the key pharmacophore groups in the TL sequence, guanidy...

journal_title：Amino acids

authors： Androutsou ME,Saifeddine M,Hollenberg MD,Matsoukas J,Agelis G

更新日期：2010-04-01 00:00:00

abstract：:The efficient synthesis ofδ-hydroxy-β,γ-dehydroα-amino acids (1) was achieved by the hybrid process, in which the Pd(II)-assisted rear-rangement ofβ-acetoxyallylglycine ester (6) afforded the corresponding (E)-δ-acetoxyvinylglycine derivatives (7) in a moderate yield. The chemo- and stereo-selective hydrolysis of7 was...

journal_title：Amino acids

authors： Kirihata M,Fukuari M,Izukawa T,Ichimoto I

更新日期：1995-12-01 00:00:00

abstract：:Pseudomonas aeruginosa is particularly difficult to treat because it possesses a variety of resistance mechanisms and because it often forms biofilms. Antimicrobial peptides represent promising candidates for future templates of antibiotic-resistant bacterial infections due to their unique mechanism of antimicrobial a...

journal_title：Amino acids

authors： Xie J,Li Y,Li J,Yan Z,Wang D,Guo X,Zhang J,Zhang B,Mou L,Yang W,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:Identifying protein-protein interactions (PPIs) is critical for understanding the cellular function of the proteins and the machinery of a proteome. Data of PPIs derived from high-throughput technologies are often incomplete and noisy. Therefore, it is important to develop computational methods and high-quality intera...

journal_title：Amino acids

authors： Shi MG,Xia JF,Li XL,Huang DS

更新日期：2010-03-01 00:00:00

abstract：:Taking a minimalistic approach in efforts to lower the cost for the development of new synthetic antimicrobial peptides, ultrashort cationic lipopeptides were designed to mimic the amphiphilic nature crucial for their activity but with only a very short peptide sequence ligated to a lipidic acid. Nine ultrashort catio...

journal_title：Amino acids

authors： Domalaon R,Yang X,O'Neil J,Zhanel GG,Mookherjee N,Schweizer F

更新日期：2014-11-01 00:00:00

abstract：:Since the formulation of the concept of "proteomics" in 1995, a plethora of proteomic technologies have been developed in order to study proteomes of tissues, cells and organelles. The powerful new technologies enabled by proteomic approaches have lead to the application of these methods to an exponentially increasing...

journal_title：Amino acids

authors： Vercauteren FG,Arckens L,Quirion R

更新日期：2007-09-01 00:00:00

abstract：:The expression of pluripotent stem cell protein markers, self-renewal, the potential to differentiate in cell types of all three germlines and teratoma formation in nude mice form the spectrum of the stringent pluripotency criteria for human stem cells. Currently, intercellular variability is discussed as an additiona...

journal_title：Amino acids

authors： Rosner M,Hengstschläger M

更新日期：2013-12-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are cell surface receptors. The dynamic property of receptor-receptor interactions in GPCRs modulates the kinetics of G-protein signaling and stability. In the present work, the structural and dynamic study of A(2A)R-D(2)R interactions was carried to acquire the understanding of the...

journal_title：Amino acids

authors： Prakash A,Luthra PM

更新日期：2012-10-01 00:00:00

abstract：:Early evaluation of cancer response to a therapeutic regimen can help increase the effectiveness of treatment schemes and, by enabling early termination of ineffective treatments, minimize toxicity, and reduce expenses. Biomarkers that provide early indication of tumor therapy response are urgently needed. Solid tumor...

journal_title：Amino acids

authors： Cao Q,Liu S,Niu G,Chen K,Yan Y,Liu Z,Chen X

更新日期：2011-11-01 00:00:00

abstract：:Due to the obvious advantages of long-acting peptide and protein drugs, strategies to prolong plasma half life time of such compounds are highly on demand. Short plasma half life times are commonly due to fast renal clearance as well as to enzymatic degradation occurring during systemic circulation. Modifications of t...

journal_title：Amino acids

authors： Werle M,Bernkop-Schnürch A

更新日期：2006-06-01 00:00:00

abstract：:Vigabatrin is a GABA derivative (gamma-vinyl GABA) which inhibits irreversibly the enzyme activity of GABA transaminase and thus increased indirectly brain GABA concentrations. We have used body temperature assay to examine the effects of Vigabatrin on thermoregulation in intact rats. In order to understand the mechan...

journal_title：Amino acids

authors： Nikolov RP,Yakimova KS

更新日期：2011-05-01 00:00:00

abstract：:Taurine is found in bone tissue, but its function in skeletal tissue is not fully understood. The present study was undertaken to investigate regulation of gene expression of connective tissue growth factor (CTGF), and the roles of mitogen-activated protein kinases (MAPKs) in murine osteoblast MC3T3-E1 cells treated w...

journal_title：Amino acids

authors： Yuan LQ,Lu Y,Luo XH,Xie H,Wu XP,Liao EY

更新日期：2007-01-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition are biologic processes responsible for conversion of epithelial cells into a mesenchymal phenotype or viceversa, respectively. They occur during embryo- and foetal-development and, in adult organisms, are involved in wound healing, in the ge...

journal_title：Amino acids

authors： Compagnone A,Bandino A,Meli F,Bravoco V,Cravanzola C,Parola M,Colombatto S

更新日期：2012-02-01 00:00:00

abstract：:Fibronectin (FN) is a cell adhesion protein that binds integrins in a process also involving the protein-crosslinking enzyme transglutaminase 2 (TG2) as a co-receptor. The cell-adhesive property of TG2 has been linked to a complex formation with FN and to its ability to crosslink and polymerize FN on the cell surface....

journal_title：Amino acids

authors： Forsprecher J,Wang Z,Nelea V,Kaartinen MT

更新日期：2009-04-01 00:00:00

abstract：:The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [(3)H]taurine release...

journal_title：Amino acids

authors： Saransaari P,Oja SS

更新日期：2010-05-01 00:00:00

abstract：:The high efficiency of protein deposition during the neonatal period is driven by high rates of protein synthesis, which are maximally stimulated after feeding. In the current study, we examined the individual roles of amino acids and insulin in the regulation of protein synthesis in peripheral and visceral tissues of...

journal_title：Amino acids

authors： Suryawan A,O'Connor PM,Bush JA,Nguyen HV,Davis TA

更新日期：2009-05-01 00:00:00

abstract：:On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting metabolism. Strategies directed at modulating glutamatergic transmission may overcome the ...

journal_title：Amino acids

authors： Skolnick P

更新日期：2002-01-01 00:00:00

abstract：:Tryptophan is important both for protein synthesis and as a precursor of niacin, serotonin and other metabolites. Tryptophan is an unusual amino acid because of the complexity of its metabolism, the variety and importance of its metabolites, the number and diversity of the diseases it is involved in, and because of it...

journal_title：Amino acids

authors： Sainio EL,Pulkki K,Young SN

更新日期：1996-03-01 00:00:00

abstract：:Involvement of individual antioxidant proteins (AOXP) and antioxidants in the differentiation process has been already reported. A systematic search strategy for detecting differentially regulated AOXP in neuronal differentiation, however, has not been published so far. The aim of this study was to provide an analytic...

journal_title：Amino acids

authors： Oh JE,Karlmark Raja K,Shin JH,Hengstschläger M,Pollak A,Lubec G

更新日期：2005-11-01 00:00:00

abstract：:Nitrogen fixation of the nodule of soybean is highly sensitive to oxygen deficiency such as provoked by waterlogging of the root system. This study aimed to evaluate the effects of flooding on N metabolism in nodules of soybean. Flooding resulted in a marked decrease of asparagine (the most abundant amino acid) and a ...

journal_title：Amino acids

authors： Souza SC,Mazzafera P,Sodek L

更新日期：2016-05-01 00:00:00

abstract：:Lung cancer is still difficult to treat by current chemotherapeutic procedures. We recently found that MVL, an anti-HIV lectin from blue-green algae Microcystis viridis, also has antitumor activity. The objective of this study was to investigate apoptosis-inducing activity of recombinant MVL (R-MVL) and proteomic chan...

journal_title：Amino acids

authors： Li Y,Zhang B,Wang X,Yan H,Chen G,Zhang X

更新日期：2011-10-01 00:00:00

abstract：:Taurine, 2-aminoethylsulfonic acid, is one of the most abundant amino acids in the brain. It has various important physiological functions as a neuromodulator and antioxidant. Taurine is expected to be involved in depression; however, knowledge regarding its function in relation to depression is limited. In this study...

journal_title：Amino acids

authors： Iio W,Matsukawa N,Tsukahara T,Toyoda A

更新日期：2012-11-01 00:00:00

abstract：:Contemporary theoretical models used in describing electrostatic properties of amino acids in polypeptides rely usually on atomic point charges. Recently noted defects of such models in reproducing protein folding originate from the inadequate representation of the electrostatic term, in particular inability of atomic...

journal_title：Amino acids

authors： Sokalski W

更新日期：1994-02-01 00:00:00

abstract：:This study aimed to investigate the ability of curcumin to convert asparagine into acrylamide during heating at different temperatures. Binary and ternary model systems of asparagine-curcumin and asparagine-curcumin-fructose were used to determine the role of curcumin on acrylamide formation in competitive and uncompe...

journal_title：Amino acids

authors： Hamzalıoğlu A,Mogol BA,Lumaga RB,Fogliano V,Gökmen V

更新日期：2013-06-01 00:00:00