Abstract:
:Vigabatrin is a GABA derivative (gamma-vinyl GABA) which inhibits irreversibly the enzyme activity of GABA transaminase and thus increased indirectly brain GABA concentrations. We have used body temperature assay to examine the effects of Vigabatrin on thermoregulation in intact rats. In order to understand the mechanism of thermoregulatory action of Vigabatrin at cellular level, we have investigated its effect on individual warm-sensitive preoptic area/anterior hypothalamus (PO/AH) neurons in rat brain slice preparations. The results of the present study suggest that Vigabatrin produced dose-dependent hypothermia in rats and also increased temperature sensitivity of warm-sensitive PO/AH neurons.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Nikolov RP,Yakimova KSdoi
10.1007/s00726-010-0754-5subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1441-5issue
5eissn
0939-4451issn
1438-2199journal_volume
40pub_type
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