Abstract:
:M33 is a branched peptide currently under preclinical characterization for the development of a new antibacterial drug against gram-negative bacteria. Here, we report its pegylation at the C-terminus of the three-lysine-branching core and the resulting increase in stability to Pseudomonas aeruginosa elastase. This protease is a virulence factor that acts by destroying peptides of the native immune system. Peptide resistance to this protease is an important feature for M33-Peg activity against Pseudomonas.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Falciani C,Lozzi L,Scali S,Brunetti J,Bracci L,Pini Adoi
10.1007/s00726-014-1686-2subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1403-7issue
5eissn
0939-4451issn
1438-2199journal_volume
46pub_type
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