Abstract:
:We have developed the first operationally simple and environmentally benign protocol for the aqueous asymmetric Michael addition reaction of chiral nickel(II) glycinate with nitroalkenes. The reactions proceeded smoothly in the presence of TBAB (tetrabutyl ammonium bromide) in neat water at room temperature and provided good yields of β-substituted α,γ-diaminobutyric acid derivatives with excellent diastereoselectivities.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Wang J,Ji X,Shi J,Sun H,Jiang H,Liu Hdoi
10.1007/s00726-011-0870-xsubject
Has Abstractpub_date
2012-05-01 00:00:00pages
1685-94issue
5eissn
0939-4451issn
1438-2199journal_volume
42pub_type
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