Design of substrates and inhibitors of G protein-coupled receptor kinase 2 (GRK2) based on its phosphorylation reaction.

abstract：:The focus has been on the development of methodology for stereoselective preparation of spiroannulated intermediates of the Schöllkopf chiron and further transformations to cyclic alpha-amino acids. The spiroannulations are effected by Ru(II)-catalysed ring-closing metathesis reactions, by Ru(II)- and Pd(0)-catalysed ...

journal_title：Amino acids

authors： Undheim K

更新日期：2008-04-01 00:00:00

abstract：:Short CCK peptides elicit panic attacks in humans and anxiogenic-like effects in some animal models, but CCK receptor antagonists have not been found clinically effective. Yet CCK overactivity appears to be involved in submissive behaviour, and CCKB receptor expression and binding are increased in suicide victims and ...

journal_title：Amino acids

authors： Harro J

更新日期：2006-10-01 00:00:00

abstract：:The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [(3)H]taurine release...

journal_title：Amino acids

authors： Saransaari P,Oja SS

更新日期：2010-05-01 00:00:00

abstract：:The chemical modification of protein by nonenzymatic browning or Maillard reactions increases with age and in disease. Maillard products are formed by reactions of both carbohydrate- and lipid-derived intermediates with proteins, leading to formation of advanced glycation and lipoxidation end-products (AGE/ALEs). Thes...

journal_title：Amino acids

authors： Thorpe SR,Baynes JW

更新日期：2003-12-01 00:00:00

abstract：:The human endothelin converting enzyme-1 (hECE-1) is a homodimer linked by a single disulfide bridge and has been identified as an important target for Alzheimer's disease. Structural analysis of hECE-1 dimer could lead to design specific and effective therapies against Alzheimer's disease. Hence, in the present study...

journal_title：Amino acids

authors： Sonawane KD,Barage SH

更新日期：2015-03-01 00:00:00

abstract：:Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were found in various clinical settings including coronary heart disease. To assess ADMA and SDMA diagnostic validity in patients with different stages of ischemic heart disease, we studied these markers in patie...

journal_title：Amino acids

authors： Djordjević BV,Pavlović R,Ćosić V,Deljanin-Ilić M,Ristić T,Krstić N,Jevtović-Stoimenov T

更新日期：2012-12-01 00:00:00

abstract：:Free D-aspartate (D-Asp) occurs in substantial amounts in the brain at the embryonic phase and in the first few postnatal days, and strongly decreases in adulthood. Temporal reduction of D-Asp levels depends on the postnatal onset of D-aspartate oxidase (DDO) activity, the only enzyme able to selectively degrade this ...

journal_title：Amino acids

authors： Errico F,Napolitano F,Nisticò R,Usiello A

更新日期：2012-11-01 00:00:00

abstract：:Nitric oxide (NO) is a free radical gas synthesised from arginine and oxygen by enzymes of the family of the nitric oxide synthase. In particular, the neuronal nitric oxide synthase (nNOS) is highly expressed by cells of the hypothalamic paraventricular nucleus, where the sympatho-adrenal system, the hypothalamic-pitu...

journal_title：Amino acids

authors： Orlando GF,Wolf G,Engelmann M

更新日期：2008-06-01 00:00:00

abstract：:The relative amounts of free D-amino acids (D-AA) in the urine of seven healthy volunteers (age 27 to 49 years) were determined using chiral phase (Chirasil-L-Val) capillary gas chromatography in conjunction with selected ion monitoring mass spectrometry. The absolute amounts of free D-AA were determined by pre-column...

journal_title：Amino acids

authors： Brückner H,Haasmann S,Friedrich A

更新日期：1994-06-01 00:00:00

abstract：:This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson's disease. A...

journal_title：Amino acids

authors： Fisher A,Biggs CS,Starr MS

更新日期：1998-01-01 00:00:00

abstract：:Increased intracellular cysteine poses a potential danger to cells due to the high ability of cysteine to reduce free iron and promote the Fenton reaction. Here, we studied ways to maintain cysteine homeostasis in E. coli cells while inhibiting protein synthesis with valine or chloramphenicol. When growing wild-type b...

journal_title：Amino acids

authors： Smirnova GV,Tyulenev AV,Bezmaternykh KV,Muzyka NG,Ushakov VY,Oktyabrsky ON

更新日期：2019-11-01 00:00:00

abstract：:This study investigated the effect of agmatine (Agm) in proliferation of ovine trophecdoderm cells (oTr1) as well as the importance of the arginine decarboxylase (ADC) and agmatinase (AGMAT) alternative pathway for synthesis of polyamines in ovine conceptuses during the peri-implantation period of pregnancy. Morpholin...

journal_title：Amino acids

authors： Lenis YY,Elmetwally MA,Tang W,Satterfield C,Dunlap K,Wu G,Bazer FW

更新日期：2018-02-01 00:00:00

abstract：:The effect of up-regulation of putrescine (Put) production by genetic manipulation on the turnover of spermidine (Spd) and spermine (Spm) was investigated in transgenic cells of poplar (Populus nigra × maximowiczii) and seedlings of Arabidopsis thaliana. Several-fold increase in Put production was achieved by expressi...

journal_title：Amino acids

authors： Shao L,Bhatnagar P,Majumdar R,Minocha R,Minocha SC

更新日期：2014-03-01 00:00:00

abstract：:Glucosinolates are amino acid-derived natural plant products found throughout the Capparales order. Glucosinolates and their degradation products have a wide range of biological activities, e.g. in plant defense as deterrents against insect and fungi. The conversion of amino acids to aldoximes is a key step in glucosi...

journal_title：Amino acids

authors： Mikkelsen MD,Petersen BL,Olsen CE,Halkier BA

更新日期：2002-01-01 00:00:00

abstract：:Several descriptors of protein structure at the sequence and residue levels have been recently proposed. They are widely adopted in the analysis and prediction of structural and functional characteristics of proteins. Numerous in silico methods have been developed for sequence-based prediction of these descriptors. Ho...

journal_title：Amino acids

authors： Chen K,Stach W,Homaeian L,Kurgan L

更新日期：2011-03-01 00:00:00

abstract：:Addition of poly(A) to hnRNA in the cell nucleus is a post-transcriptional event and is presumed to be brought about by a specific poly(A)polymerase. Since it is known that tryptophan rapidly increases the cytoplasmic levels of polyadenylated mRNA, it was of interest to investigate whether the essential amino acid, tr...

journal_title：Amino acids

authors： Kurl RN,Verney E,Sidransky H

更新日期：1993-06-01 00:00:00

abstract：:Recently, we observed that central administration of L-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of L-arginine may be due to L-arginine itself and/or its metabolites, excluding NO. To clarify the me...

journal_title：Amino acids

authors： Suenaga R,Yamane H,Tomonaga S,Asechi M,Adachi N,Tsuneyoshi Y,Kurauchi I,Sato H,Denbow DM,Furuse M

更新日期：2008-06-01 00:00:00

abstract：:We have been studying control mechanisms of gene expression in early embryogenesis in a South African clawed toad Xenopus laevis, especially during the period of midblastula transition (MBT), or the transition from the phase of active cell division (cleavage stage) to the phase of extensive morphogenesis (post-blastul...

journal_title：Amino acids

authors： Shiokawa K,Aso M,Kondo T,Takai J,Yoshida J,Mishina T,Fuchimukai K,Ogasawara T,Kariya T,Tashiro K,Igarashi K

更新日期：2010-02-01 00:00:00

abstract：:Some of the chemistry of amino acids going on in our laboratory (Laboratoire des Amino acides Peptides et Protéines) is described as well as some mass spectrometry methodology for their characterization particularly on solid supports. Several aspects are presented including: (i) the stereoselective synthesis of natura...

journal_title：Amino acids

authors： Bouifraden S,Drouot C,el Hadrami M,Guenoun F,Lecointe L,Mai N,Paris M,Pothion C,Sadoune M,Sauvagnat B,Amblard M,Aubagnac JL,Calmes M,Chevallet P,Daunis J,Enjalbal C,Fehrentz JA,Lamaty F,Lavergne JP,Lazaro R,Rollan

更新日期：1999-01-01 00:00:00

abstract：:The lipidicα-amino acids (LAAs) are non-naturalα-amino acids with saturated or unsaturated long aliphatic side chains. LAAs and their derivatives (lipid mimetics) together with the lipidic peptides represent a class of compounds which combine structural features of lipids with those of amino acids and peptides. Racemi...

journal_title：Amino acids

authors： Kokotos G,Martin V,Constantinou-Kokotou V,Gibbons WA

更新日期：1996-09-01 00:00:00

abstract：:Agmatine, a natural polyamine produced from arginine by arginine decarboxylase, was first discovered in 1910, but its physiological significance was disregarded for a century. The recent rediscovery of agmatine as an endogenous ligand for α2-adrenergic and imidazoline receptors in the mammalian brain suggests that thi...

journal_title：Amino acids

authors： Akasaka N,Fujiwara S

更新日期：2020-02-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing clinical significance. The pathological progression of the disease from simple steatosis to nonalcoholic steatohepatitis (NASH) has been well defined, however, the contribution of altered branched chain amino acid metabolomic profi...

journal_title：Amino acids

authors： Lake AD,Novak P,Shipkova P,Aranibar N,Robertson DG,Reily MD,Lehman-McKeeman LD,Vaillancourt RR,Cherrington NJ

更新日期：2015-03-01 00:00:00

abstract：:Prophylactic supplementation of N-acetyl-cysteine (NAC) and epigallocatechin gallate (EGCG) was studied for physiological and cellular changes in skeletal muscle after eccentric muscle contractions. Thirty healthy, active males (20.0 +/- 1.8 years, 160 +/- 7.1 cm, 76.1 +/- 17.0 kg) ingested for 14 days either 1,800 mg...

journal_title：Amino acids

authors： Kerksick CM,Kreider RB,Willoughby DS

更新日期：2010-06-01 00:00:00

abstract：:In mammals, two major routes exist for the metabolic conversion of L-glutamine to α-ketoglutarate. The most widely studied pathway involves the hydrolysis of L-glutamine to L-glutamate catalyzed by glutaminases, followed by the conversion of L-glutamate to α-ketoglutarate by the action of an L-glutamate-linked aminotr...

journal_title：Amino acids

authors： Cooper AJ,Shurubor YI,Dorai T,Pinto JT,Isakova EP,Deryabina YI,Denton TT,Krasnikov BF

更新日期：2016-01-01 00:00:00

abstract：:To evaluate the response of soybean to salt stress, the related changes in protein expression were investigated using the proteomic approach. Soybean plants were exposed to 0, 50, 100, and 200 mM NaCl. Especially at 200 mM, the length and fresh weight of the hypocotyl and root reduced under salt stress, while the prol...

journal_title：Amino acids

authors： Aghaei K,Ehsanpour AA,Shah AH,Komatsu S

更新日期：2009-01-01 00:00:00

abstract：:This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of a heteroaromatic compound denominated by us T(2)CO, comprising two thymine moieties anchored to a 2-propanonic unit, the spectroscopic properties of which wer...

journal_title：Amino acids

authors： Roviello GN,Roviello G,Musumeci D,Bucci EM,Pedone C

更新日期：2012-10-01 00:00:00

abstract：:This study determined whether N-acetylcysteine (NAC) could affect intestinal redox status, proinflammatory cytokines, epidermal growth factor (EGF), EGF receptor (EGFR), Toll-like receptor-4 (TLR4), and aquaporin-8 in a lipopolysaccharide (LPS)-challenged piglet model. Eighteen piglets (35-day-old) were randomly alloc...

journal_title：Amino acids

authors： Hou Y,Wang L,Yi D,Ding B,Yang Z,Li J,Chen X,Qiu Y,Wu G

更新日期：2013-09-01 00:00:00

abstract：:Tryptophan is important both for protein synthesis and as a precursor of niacin, serotonin and other metabolites. Tryptophan is an unusual amino acid because of the complexity of its metabolism, the variety and importance of its metabolites, the number and diversity of the diseases it is involved in, and because of it...

journal_title：Amino acids

authors： Sainio EL,Pulkki K,Young SN

更新日期：1996-03-01 00:00:00

abstract：:We have developed the first operationally simple and environmentally benign protocol for the aqueous asymmetric Michael addition reaction of chiral nickel(II) glycinate with nitroalkenes. The reactions proceeded smoothly in the presence of TBAB (tetrabutyl ammonium bromide) in neat water at room temperature and provid...

journal_title：Amino acids

authors： Wang J,Ji X,Shi J,Sun H,Jiang H,Liu H

更新日期：2012-05-01 00:00:00

abstract：:New bioinorganic complexes of the aspartic acid with the antimony or bismuth triiodide were synthesized by a direct solid-solid reaction at room temperature. The formula of the complex is MI(3)[OOCCH(2)CH(NH(2))CO](2.5) x 2.5H(2)O (M = Sb, Bi). The complex may be a dimer with bridge structure. The crystal structure of...

journal_title：Amino acids

authors： Jia RR,Wu CP,Wu S,Yang YX,Chen YR,Jia YQ

更新日期：2006-07-01 00:00:00