The effect of tryptophan administration on ileum contractility and oxidant status in mice.


:L-tryptophan (TRP) is the precursor amino acid for the synthesis of serotonin (5-HT). 5-HT is effective both on the food intake and gastrointestinal system contractility. The aim of this study was to search the effects of systemic TRP treatment on 5-HT levels of ileum and searching the effect of ileal contractility and oxidant status. Swiss-albino mice were divided into two groups: 1. Control, 2. TRP-treated (100 mg/kg/24 h, i.p., for 7 days). Body weights were recorded at the beginning and at the end of experiments. Acetylcholine-induced contractile responses in the isolated ileum were recorded on polygraph. Ileal tissue malondialdehyde and glutathione levels determined by spectrophotometric and ileal tissue 5-HT levels were measured by immunohistochemical methods. TRP treatment decreased body weight and increased ileal contractile response. In the TRP-treated group, ileum malondialdehyde levels increased and glutathione levels decreased. Immunohistochemical detection showed that ileal 5-HT levels were increased by TRP treatment. There is a relationship between increased oxidative stress and increased contractility in the ileal tissue of the TRP-treated animals. These effects may be related to increased ileal 5-HT synthesis.


Amino Acids


Amino acids


Ozer C,Gönül B,Ercan ZS,Take G,Erdoğan D




Has Abstract


2007-01-01 00:00:00












  • Impaired energy metabolism of the taurine‑deficient heart.

    abstract::Taurine is a β-amino acid found in high concentrations in excitable tissues, including the heart. A significant reduction in myocardial taurine content leads to the development of a unique dilated, atrophic cardiomyopathy. One of the major functions of taurine in the heart is the regulation of the respiratory chain. H...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Schaffer SW,Shimada-Takaura K,Jong CJ,Ito T,Takahashi K

    更新日期:2016-02-01 00:00:00

  • Cerebral organic acid disorders induce neuronal damage via excitotoxic organic acids in vitro.

    abstract::Glutaryl-CoA dehydrogenase deficiency (GDD), which is one of the most frequent organic acid disorders, is characterized by a specific age- and regional-dependent neuropathology. We hypothesized that the distinct brain damage in GDD could be caused by the main pathologic metabolites, the organic acids glutaric (GA) and...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Kölker S,Ahlemeyer B,Krieglstein J,Hoffmann GF

    更新日期:2000-01-01 00:00:00

  • A mechanistic role for polypeptide hormone receptor lateral mobility in signal transduction.

    abstract::Lateral diffusion of membrane-integral receptors within the plane of the membrane has been postulated to be mechanistically important for signal transduction. Direct measurement of polypeptide hormone receptor lateral mobility using fluorescence photobleaching recovery techniques indicates that tyrosine kinase recepto...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Jans DA,Pavo I

    更新日期:1995-06-01 00:00:00

  • Solution structure of a novel α-conotoxin with a distinctive loop spacing pattern.

    abstract::α-Pharmacological conotoxins are among the most selective ligands of nicotinic acetylcholine receptors with typical cysteine frameworks. They are characterized by the intercysteine loop and classified into various subfamilies, such as α3/5 and α4/7 conotoxins. A novel α-conotoxin, Pu14a (DCPPHPVPGMHKCVCLKTC), with a d...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Zhang B,Huang F,Du W

    更新日期:2012-07-01 00:00:00

  • Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry.

    abstract::Sensitivity to pharmacological challenges has been reported in patients with panic disorder. We have previously validated transgenic mice overexpressing the neurotrophin-3 (NT-3) receptor, TrkC (TgNTRK3), as an engineered murine model of panic disorder. We could determine that TgNTRK3 mice presented increased cellular...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Sahún I,Gallego X,Gratacòs M,Murtra P,Trullás R,Maldonado R,Estivill X,Dierssen M

    更新日期:2007-11-01 00:00:00

  • Changes in plasma phenylalanine, isoleucine, leucine, and valine are associated with significant changes in intracranial pressure and jugular venous oxygen saturation in patients with severe traumatic brain injury.

    abstract::Changes in plasma aromatic amino acids (AAA = phenylalanine, tryptophan, tyrosine) and branched chain amino acids (BCAA = isoleucine, leucine, valine) levels possibly influencing intracranial pressure (ICP) and cerebral oxygen consumption (SjvO(2)) were investigated in 19 sedated patients up to 14 days following sever...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Vuille-Dit-Bille RN,Ha-Huy R,Stover JF

    更新日期:2012-09-01 00:00:00

  • Quantitative metabolic profiling of NMR spectral signatures of branched chain amino acids in blood serum.

    abstract::Branched Chain Amino Acids (BCAAs) are related to different aspects of diseases like pathogenesis, diagnosis and even prognosis. While in some diseases, levels of all the BCAAs are perturbed; in some cases, perturbation occurs in one or two while the rest remain unaltered. In case of ischemic heart disease, there is a...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Ghosh S,Sengupta A,Chandra K

    更新日期:2015-10-01 00:00:00

  • The ubiquitin-proteasome system and autophagy are defective in the taurine-deficient heart.

    abstract::Taurine depletion leads to impaired mitochondrial function, as characterized by reduced ATP production and elevated superoxide generation. These defects can fundamentally alter cardiomyocyte function and if left unchanged can result in cell death. To protect against these stresses, cardiomyocytes possess quality contr...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Jong CJ,Ito T,Schaffer SW

    更新日期:2015-12-01 00:00:00

  • Oxidative degradation of N(ε)-fructosylamine-substituted peptides in heated aqueous systems.

    abstract::Glycation, or non-enzymatic glycosylation, is a common protein modification formed by reactions between reducing sugars (i.e. aldoses and ketoses) with protein amino groups. Resulting Amadori and Heyns compounds, respectively, can be oxidatively degraded yielding a structurally heterogeneous group of advanced glycatio...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Greifenhagen U,Frolov A,Hoffmann R

    更新日期:2015-05-01 00:00:00

  • Enzyme promiscuity in earthworm serine protease: substrate versatility and therapeutic potential.

    abstract::Enzymes are the most versatile molecules in the biological world. These amazing molecules play an integral role in the regulation of various metabolic pathways and physiology subsequently. Promiscuity of an enzyme is the capacity to catalyze additional biochemical reactions besides their native one. Catalytic promiscu...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Verma MK,Pulicherla KK

    更新日期:2016-04-01 00:00:00

  • Cis-trans isomerization of omega dihedrals in proteins.

    abstract::Peptide bonds in protein structures are mainly found in trans conformation with a torsion angle ω close to 180°. Only a very low proportion is observed in cis conformation with ω angle around 0°. Cis-trans isomerization leads to local conformation changes which play an important role in many biological processes. In t...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Craveur P,Joseph AP,Poulain P,de Brevern AG,Rebehmed J

    更新日期:2013-08-01 00:00:00

  • The non-protein amino acid β-N-methylamino-L-alanine in Portuguese cyanobacterial isolates.

    abstract::The tailor made amino acid β-N-methyl-amino-L-alanine (BMAA) is a neurotoxin produced by cyanobacteria. It has been associated with certain forms of progressive neurodegenerative disease, including sporadic Amyotrophic Lateral Sclerosis and Alzheimer's disease. Some different reports of BMAA in cyanobacterial blooms f...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Cervantes Cianca RC,Baptista MS,Lopes VR,Vasconcelos VM

    更新日期:2012-06-01 00:00:00

  • Antiviral activity of oxidized polyamines.

    abstract::Polyamines, oxidized by serum amine oxidase, yield aminoaldehydes and hydrogen peroxide. Acrolein may be formed from the aminoaldehydes by a spontaneous beta-elimination process. These oxidation products "oxidized polyamines" inhibit bacterial growth and exhibit anticancer activity. The antimicrobial activity of oxidi...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Bachrach U

    更新日期:2007-08-01 00:00:00

  • Mapping surface residues of eIF5A that are important for binding to the ribosome using alanine scanning mutagenesis.

    abstract::The translation elongation factor eIF5A is conserved through evolution and is necessary to rescue the ribosome during translation elongation of polyproline-containing proteins. Although the site of eIF5A binding to the ribosome is known, no systematic analysis has been performed so far to determine the important resid...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Barbosa NM,Boldrin PE,Rossi D,Yamamoto PA,Watanabe TF,Serrão VH,Hershey JW,Fraser CS,Valentini SR,Zanelli CF

    更新日期:2016-10-01 00:00:00

  • Cysteine enhances activity and stability of immobilized papain.

    abstract::Immobilization of papain on Sepharose 6B in the presence of different concentrations of cysteine affected the enzyme activity depending on cysteine concentration. The maximum specific activity was observed when papain was immobilized with 200 mM cysteine. The immobilization process brought significant enhancement of s...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Homaei AA,Sajedi RH,Sariri R,Seyfzadeh S,Stevanato R

    更新日期:2010-03-01 00:00:00

  • Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides.

    abstract::Previous studies identified lysine- and tryptophan-rich sequences within various cationic antimicrobial peptides. In the present study, we synthesized a series of peptides composed of lysine (K)-tryptophan (W) repeats (KW)( n ) (where n equals 2, 3, 4 or 5) with amida...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Gopal R,Seo CH,Song PI,Park Y

    更新日期:2013-02-01 00:00:00

  • Cardiovascular actions of L-cysteine and L-cysteine sulfinic acid in the nucleus tractus solitarius of the rat.

    abstract::The sulfur-containing excitatory amino acid (EAA) L-cysteine sulfinic acid (CSA), a neurotransmitter candidate, is endogenously synthesized from L-cysteine (Cys). Exogenous Cys administration into the brain produces cardiovascular effects; these effects likely occur via synaptic stimulation of central nervous system (...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Takemoto Y

    更新日期:2014-07-01 00:00:00

  • The influence of NMDA, a potent agonist of glutamate receptor, on behavioral activity of rats with experimental hyperammonemia evoked by liver failure.

    abstract::The study was designed to investigate the effects of NMDA receptor agonist on the behavioral activity in rats with experimental hyperammonemia. The experiments were performed on adult male Wistar rats. Experimental hyperammonemia was induced by intraperitoneal injections of tioacetamide (TAA, 200 mg/kg) for three cons...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Fedosiewicz-Wasiluk M,Hoły ZZ,Wiśniewska RJ,Wiśniewski K

    更新日期:2005-02-01 00:00:00

  • Expression of the kynurenine enzymes in macrophages and microglial cells: regulation by immune modulators.

    abstract::The regulation of the expression of indoleamine 2,3-dioxygenase (IDO) was studied in cloned murine macrophages (MT2) and microglial (N11) cells. Both cell lines express IDO and inducible nitric oxide synthase activity after interferon-gamma (IFN-gamma) stimulation. The regulation of IDO expression appears to differ in...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Alberati-Giani D,Cesura AM

    更新日期:1998-01-01 00:00:00

  • Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis.

    abstract::D: -Amino acid oxidase (DAAO) in mammal kidney regulates the renal reactive oxygen species (ROS) levels directly and plays a leading role in the development of ROS-mediated renal pathologic damages based on its crucial role in the oxidative deamination of D: -amino acids and the consequent generation of H(2)O(2). Quan...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Zhang H,Qi L,Lin Y,Mao L,Chen Y

    更新日期:2012-01-01 00:00:00

  • How are signals transduced across the cytoplasmic membrane? Transport proteins as transmitter of information.

    abstract::In order to adapt to ever changing environmental conditions, bacteria sense environmental stimuli, and convert them into signals that are transduced intracellularly. Several mechanisms have evolved by which receptors transmit signals across the cytoplasmic membrane. Stimulus perception may trigger receptor dimerizatio...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Tetsch L,Jung K

    更新日期:2009-09-01 00:00:00

  • The effects of red bull energy drink on human performance and mood.

    abstract::The effects of Red Bull Energy Drink, which includes taurine, glucuronolactone, and caffeine amongst the ingredients, were examined over 3 studies in a total of 36 volunteers. Assessments included psychomotor performance (reaction time, concentration, memory), subjective alertness and physical endurance. When compared...

    journal_title:Amino acids

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Alford C,Cox H,Wescott R

    更新日期:2001-01-01 00:00:00

  • Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences.

    abstract::Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide,...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Blachier F,Mariotti F,Huneau JF,Tomé D

    更新日期:2007-11-01 00:00:00

  • The relationship between albumin, other plasma proteins and variables, and age in the acute phase response after liver resection in man.

    abstract::A large series of plasma albumin (ALB, g/dl) and simultaneous blood and clinical measurements were prospectively performed on 92 liver resection patients, and processed to assess the correlations between ALB, other plasma proteins, additional variables and clinical events. The measurements were performed preoperativel...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Giovannini I,Chiarla C,Giuliante F,Vellone M,Ardito F,Nuzzo G

    更新日期:2006-11-01 00:00:00

  • Taurine is an amino acid with the ability to activate autophagy in adipocytes.

    abstract::Alterations in adipocyte characteristics are highly implicated in the pathology of obesity. In a recent article, we demonstrated that high-fat diet-induced obesity impairs lysosomal function, thereby suppressing autophagy in mice white adipose tissue. Taurine, an amino acid naturally contained in the normal diet and e...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Kaneko H,Kobayashi M,Mizunoe Y,Yoshida M,Yasukawa H,Hoshino S,Itagawa R,Furuichi T,Okita N,Sudo Y,Imae M,Higami Y

    更新日期:2018-05-01 00:00:00

  • Molecular imaging of fibrosis using a novel collagen-binding peptide labelled with 99mTc on SPECT/CT.

    abstract::Fibrosis, closely related to chronic various diseases, is a pathological process characterised by the accumulation of collagen (largely collagen type I). Non-invasive methods are necessary for the diagnosis and follow-up of fibrosis. This study aimed to develop a collagen-targeted probe for the molecular imaging of fi...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Zheng L,Ding X,Liu K,Feng S,Tang B,Li Q,Huang D,Yang S

    更新日期:2017-01-01 00:00:00

  • A synthetic peptide derived of the β2-β3 loop of the plant defensin from Vigna unguiculata seeds induces Leishmania amazonensis apoptosis-like cell death.

    abstract::For medical use of proteins and peptide-based drugs, it is desirable to have small biologically active sequences because they improve stability, reduce side effects, and production costs. Several plant defensins have their biological activities imparted by a sequence named γ-core. Vu-Def, a Vigna unguiculata defensin,...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Souza GS,de Carvalho LP,de Melo EJT,da Silva FCV,Machado OLT,Gomes VM,de Oliveira Carvalho A

    更新日期:2019-11-01 00:00:00

  • Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid.

    abstract::Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide's therapeutic potential is limited by the short half-life and low bioavailabili...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Wester A,Devocelle M,Tallant EA,Chappell MC,Gallagher PE,Paradisi F

    更新日期:2017-10-01 00:00:00

  • Applications of chemically defined diets to the solution of nutrition problems.

    abstract::Chemically defined amino acid diets have been developed for most laboratory and meat-producing animal species as well as for humans. In many cases, growth performance of animals fed these diets equals that obtained with standard intact-protein diets. The pattern of both essential and nonessential amino acids is critic...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Baker DH

    更新日期:1992-02-01 00:00:00

  • Is there a role for eIF5A in translation?

    abstract::The putative translation factor eIF5A is essential for cell viability and is highly conserved from archaebacteria to mammals. This factor is the only cellular protein that undergoes an essential posttranslational modification dependent on the polyamine spermidine, called hypusination. This review focuses on the functi...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Zanelli CF,Valentini SR

    更新日期:2007-08-01 00:00:00