Maternal L-proline supplementation during gestation alters amino acid and polyamine metabolism in the first generation female offspring of C57BL/6J mice.

abstract：:The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protei...

journal_title：Amino acids

authors： Olma A,Lasota A,Kudaj A

更新日期：2012-06-01 00:00:00

abstract：:Relaxin family peptides perform a variety of biological functions by binding and activating relaxin family peptide receptor 1-4 (RXFP1-4), four A-class G protein-coupled receptors. In the present work, we developed a novel ligand binding assay for RXFP3 and RXFP4 based on NanoLuc complementation technology (NanoBiT). ...

journal_title：Amino acids

authors： Hu MJ,Shao XX,Li HZ,Nie WH,Wang JH,Liu YL,Xu ZG,Guo ZY

更新日期：2018-08-01 00:00:00

abstract：:When a V3 sequence obtained on the n-th year after infection with human immunodeficiency virus type 1 (HIV-1) was supposed to change into a V3 sequence on the n + 1-th year, the variation between the above two sequences was analyzed by means of entropic chaos degree. The entropic chaos degree measures chaotic aspects ...

journal_title：Amino acids

authors： Sato K,Ohya M

更新日期：2001-01-01 00:00:00

abstract：:Glutamate dehydrogenase (GDH) plays a crucial role in amino acid deamination and has been used as an inductor of nutrients metabolism. In this study, we cloned and analyzed the GDH cDNAs in diploids (red crucian carp), triploids and tetraploids and characterized their expression profiles upon dietary treatments. Resul...

journal_title：Amino acids

authors： Liu Z,Zhou Y,Liu S,Zhong H,Zhang C,kang X,Liu Y

更新日期：2012-12-01 00:00:00

abstract：:The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine} is a chiral compound with valuable synthetic interest. An update on the different routes for its synthesis is reviewed and discussed. ...

journal_title：Amino acids

authors： Benfodda Z,Bénimélis D,Reginato G,Meffre P

更新日期：2015-02-01 00:00:00

abstract：:Effects of taurine on the delayed rectifier K(+) channel in isolated 10-day-old embryonic chick ventricular cardiomyocytes were examined at different intracellular Ca(2+) concentrations ([Ca]i), using whole-cell voltage and current clamp techniques. Experiments were performed at room temperature (22°C). Test pulses we...

journal_title：Amino acids

authors： Satoh H

更新日期：1995-09-01 00:00:00

abstract：:Glutamine and leucine are abundant constituents of plant and animal proteins, whereas the content of arginine in foods and physiological fluids varies greatly. Besides their role in protein synthesis, these three amino acids individually activate signaling pathway to promote protein synthesis and possibly inhibit auto...

journal_title：Amino acids

authors： Marc Rhoads J,Wu G

更新日期：2009-05-01 00:00:00

abstract：:The kidney plays a key role in arginine metabolism. Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which ...

journal_title：Amino acids

authors： Levillain O

更新日期：2012-04-01 00:00:00

abstract：:We studied the non-specific interactions of two azo compounds: biebrich scarlet (BS) and naphthochrome green (NG), with four model proteins: bovine serum albumin, ovalbumin, poly-L-lysine and hemoglobin by UV-VIS spectrometry, fluorophotometry and circular dichroism melting technique. The optimal acidities of NG and B...

journal_title：Amino acids

authors： Gao HW,Liu XH,Qiu Z,Tan L

更新日期：2009-02-01 00:00:00

abstract：:An aromatic chiral diacid monomer, 5-[4-(2-phthalimidiylpropanoylamino)-benzoylamino]isophthalic acid was synthesized in five steps under conventional heating in high yield and purity. A series of soluble, thermally stable and optically active polyamides (PA)s containing pendent groups made of phthalimide, flexible L:...

journal_title：Amino acids

authors： Mallakpour S,Rafiee Z

更新日期：2009-10-01 00:00:00

abstract：:Polyamines have been related to the "Crassulacean Acid Metabolism" (CAM) in higher plants. Such relationship was however observed in plants where CAM activity is inducible by external factors. Results presented here indicate that, inOpuntia F. indica, cladodes where onset of CAM is dependent on internal conditions, i....

journal_title：Amino acids

authors： Deidda P,Tekle Z,Nieddu G,Pintus G,Pinna GG,Sisini A

更新日期：1994-06-01 00:00:00

abstract：:A growing body of evidence implicates endoplasmic reticulum (ER)-induced cellular dysfunction and apoptosis as important factors to a variety of diseases. In endothelial cells (ECs), the sulfur-containing amino acid homocysteine (Hcy) causes EC apoptosis and reactive oxygen species (ROS) generation through induction o...

journal_title：Amino acids

authors： Kil JS,Jeong SO,Chung HT,Pae HO

更新日期：2017-04-01 00:00:00

abstract：:This study tested the hypothesis that L-arginine (Arg) may stimulate cell proliferation and prevent lipopolysaccharide (LPS)-induced death of intestinal cells. Intestinal porcine epithelial cells (IPEC-1) were cultured for 4 days in Arg-free Dulbecco's modified Eagle's-F12 Ham medium (DMEM-F12) containing 10, 100 or 3...

journal_title：Amino acids

authors： Tan B,Yin Y,Kong X,Li P,Li X,Gao H,Li X,Huang R,Wu G

更新日期：2010-04-01 00:00:00

abstract：:We determined the alterations in metabolic conversion of cysteine into glutathione and taurine in liver of rats treated with ethanol acutely. Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were s...

journal_title：Amino acids

authors： Ahn CW,Kwon DY,Jun DS,Lee YM,Kim YC

更新日期：2015-06-01 00:00:00

abstract：:The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis). This has been assigned to the known bioenergetic, anti-apoptotic, anti-excitotoxic and anti-oxidant properties of creatine....

journal_title：Amino acids

authors： Klopstock T,Elstner M,Bender A

更新日期：2011-05-01 00:00:00

abstract：:Taurine (TAU) has been shown to improve exercise time to exhaustion and 3-km running performance; however, no studies have considered the effect of acute TAU ingestion on short duration cycling time trial (TT) performance. The aim of this study was to determine the effects of a single oral acute dose of 1000 mg of TAU...

journal_title：Amino acids

authors： Ward R,Bridge CA,McNaughton LR,Sparks SA

更新日期：2016-11-01 00:00:00

abstract：:Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance were studied using a polyamine biosynthesis and uptake deficient Escherichia coli KK3131 transformed with pACYC184 containing potFGHI or puuP. Putrescine uptake activity of E. coli KK3131 transformed with pACYC184-PotFGHI was high...

journal_title：Amino acids

authors： Terui Y,Saroj SD,Sakamoto A,Yoshida T,Higashi K,Kurihara S,Suzuki H,Toida T,Kashiwagi K,Igarashi K

更新日期：2014-03-01 00:00:00

abstract：:Branched Chain Amino Acids (BCAAs) are related to different aspects of diseases like pathogenesis, diagnosis and even prognosis. While in some diseases, levels of all the BCAAs are perturbed; in some cases, perturbation occurs in one or two while the rest remain unaltered. In case of ischemic heart disease, there is a...

journal_title：Amino acids

authors： Ghosh S,Sengupta A,Chandra K

更新日期：2015-10-01 00:00:00

abstract：:Among many actions assigned to taurine (Tau), the most abundant amino acid in numerous mammalian tissues, it prevents high-fat diet-induced obesity with increasing resting energy expenditure. To sustain this Tau action, the goal of the present study was to explore the acute effects of Tau on baseline and on adrenaline...

journal_title：Amino acids

authors： Piña-Zentella G,de la Rosa-Cuevas G,Vázquez-Meza H,Piña E,de Piña MZ

更新日期：2012-05-01 00:00:00

abstract：:The regulation of the expression of indoleamine 2,3-dioxygenase (IDO) was studied in cloned murine macrophages (MT2) and microglial (N11) cells. Both cell lines express IDO and inducible nitric oxide synthase activity after interferon-gamma (IFN-gamma) stimulation. The regulation of IDO expression appears to differ in...

journal_title：Amino acids

authors： Alberati-Giani D,Cesura AM

更新日期：1998-01-01 00:00:00

abstract：:Minerals more readily adsorb amino acids with charged R groups than uncharged R groups, so that the incorporation of amino acids with charged R groups into peptides would be more frequent than for amino acids with uncharged R groups. However, 74% of the amino acids in the proteins of modern organisms contain uncharged...

journal_title：Amino acids

authors： Zaia DA

更新日期：2004-08-01 00:00:00

abstract：:The dipeptide carnosine is found in high concentrations in human skeletal muscle and shows large inter-individual differences. Sex and age are determining factors, however, systematic studies investigating the sex effects on muscle carnosine content throughout the human lifespan are lacking. Despite the large inter-in...

journal_title：Amino acids

authors： Baguet A,Everaert I,Achten E,Thomis M,Derave W

更新日期：2012-07-01 00:00:00

abstract：:L-Arginine:glycine amidinotransferase (AGAT) is the main producer of the creatine precursor, guanidinoacetate (GAA), and L-homoarginine (hArg). We and others previously reported lower levels of circulating and urinary hArg in renal transplant recipients (RTR) compared to healthy subjects. In adults, hArg emerged as a ...

journal_title：Amino acids

authors： Hanff E,Said MY,Kayacelebi AA,Post A,Minovic I,van den Berg E,de Borst MH,van Goor H,Bakker SJL,Tsikas D

更新日期：2019-11-01 00:00:00

abstract：:In this study, an optically active diamine, N,N'-(pyromellitoyl)-bis{N-[4(4-aminophenoxy)phenyl]-2-(4-methyl)pentanamide} (1) containing amino acid L-leucine was prepared in three steps. The step-growth polymerization of this chiral diamine with several diisocyanates in room temperature ionic liquid (IL), 1,3-dipropyl...

journal_title：Amino acids

authors： Mallakpour S

更新日期：2011-02-01 00:00:00

abstract：:Relapse and metastasis are the main causes of unfavorable outcome in head and neck cancers. Whereas, understanding of the molecular background of these processes is far from being complete. Therefore, in this study we aimed to identify potential biomarker candidates of relapse and metastasis in laryngeal squamous cell...

journal_title：Amino acids

authors： Bodnar M,Luczak M,Bednarek K,Szylberg L,Marszalek A,Grenman R,Szyfter K,Jarmuz-Szymczak M,Giefing M

更新日期：2016-06-01 00:00:00

abstract：:Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. T...

journal_title：Amino acids

authors： Le J,Perier C,Peyroche S,Rascle F,Blanchon MA,Gonthier R,Frey J,Chamson A

更新日期：1999-01-01 00:00:00

abstract：:Recently, crystalized mouse ketimine reductase/CRYM complexed with NADPH was found to have pyruvate bound in its active site. We demonstrate that the enzyme binds α-keto acids, such as pyruvate, in solution, and catalyzes the formation of N-alkyl-amino acids from alkylamines and α-keto acids (via reduction of imine in...

journal_title：Amino acids

authors： Hallen A,Cooper AJ,Smith JR,Jamie JF,Karuso P

更新日期：2015-11-01 00:00:00

abstract：:L-tryptophan is an essential amino acid in food, but is also widely used as a drug on the basis of several physiological actions. Lately, tryptophan's uses as a drug and as a food supplement have been discontinued in several countries due to its severe side-effects.In the present study, the distribution of tryptophan ...

journal_title：Amino acids

authors： Sainio EL,Närvänen S,Sainio P,Tuohimaa P

更新日期：1995-06-01 00:00:00

abstract：:In a previous research, we have shown that adequate levels of polyamines are required in transformed mouse fibroblasts for the correlated activations of MAPK subtypes (ERK and JNK) and caspases induced by etoposide and leading to apoptosis. We report now that the treatment of fibroblasts with etoposide also elicited a...

journal_title：Amino acids

authors： Tantini B,Pignatti C,Fattori M,Fiumana E,Facchini A,Stefanelli C,Caldarera CM,Pegg AE,Flamigni F

更新日期：2004-10-01 00:00:00

abstract：:To mutant ddY/DAO(-) mice lacking D-amino-acid oxidase activity and normal ddY/DAO(+) mice, five D-amino acids (D-Asp, D-Ser, D-Ala, D-Leu and D-Pro) were orally administered for two weeks, and the D-amino acid levels were examined in seven brain regions. The levels of D-Asp markedly increased in the pituitary and pin...

journal_title：Amino acids

authors： Morikawa A,Hamase K,Inoue T,Konno R,Zaitsu K

更新日期：2007-01-01 00:00:00