Intracellular sources of ornithine for polyamine synthesis in endothelial cells.

abstract：:The effects of Red Bull Energy Drink, which includes taurine, glucuronolactone, and caffeine amongst the ingredients, were examined over 3 studies in a total of 36 volunteers. Assessments included psychomotor performance (reaction time, concentration, memory), subjective alertness and physical endurance. When compared...

journal_title：Amino acids

authors： Alford C,Cox H,Wescott R

更新日期：2001-01-01 00:00:00

abstract：:The human endothelin converting enzyme-1 (hECE-1) is a homodimer linked by a single disulfide bridge and has been identified as an important target for Alzheimer's disease. Structural analysis of hECE-1 dimer could lead to design specific and effective therapies against Alzheimer's disease. Hence, in the present study...

journal_title：Amino acids

authors： Sonawane KD,Barage SH

更新日期：2015-03-01 00:00:00

abstract：:Knowing the key features of the structure and the biochemistry of proteins is crucial to improving enzymes of industrial interest like β-fructofuranosidase. Gene sacA from Bacillus licheniformis ATCC 14580 codifies a sucrose-6-phosphate hydrolase, a β-fructofuranosidase (E.C. 3.1.2.26, protein BlsacA), which has no cr...

journal_title：Amino acids

authors： Mera A,de Lima MZT,Bernardes A,Garcia W,Muniz JRC

更新日期：2019-04-01 00:00:00

abstract：:In living cells, the N-terminal tails of core histones, the proteinaceous component of nucleosomes, are subjected to a range of covalent post-translational modifications (PTMs), which have specific roles in modulating chromatin structure and function. A growing body of evidence suggests that deregulation of histone mo...

journal_title：Amino acids

authors： Cuomo A,Moretti S,Minucci S,Bonaldi T

更新日期：2011-07-01 00:00:00

abstract：:This work proposes a strategy that uses solid-phase peptide synthesis associated with copper(I)-catalyzed azide alkyne cycloaddition reaction to promote the glycosylation of an antimicrobial peptide (HSP1) containing a carboxyamidated C-terminus (HSP1-NH2). Two glycotriazole-peptides, namely [p-Glc-trz-G1]HSP1-NH2 and...

journal_title：Amino acids

authors： Junior EFC,Guimarães CFRC,Franco LL,Alves RJ,Kato KC,Martins HR,de Souza Filho JD,Bemquerer MP,Munhoz VHO,Resende JM,Verly RM

更新日期：2017-08-01 00:00:00

abstract：:Extracellular peptide ligand binding sites, which bind the N-termini of angiotensin II (AngII) and bradykinin (BK) peptides, are located on the N-terminal and extracellular loop 3 regions of the AT(1)R and BKRB(1) or BKRB(2) G-protein-coupled receptors (GPCRs). Here we synthesized peptides P15 and P13 corresponding to...

journal_title：Amino acids

authors： Lopes DD,Vieira RF,Malavolta L,Poletti EF,Shimuta SI,Paiva AC,Schreier S,Oliveira L,Nakaie CR

更新日期：2013-03-01 00:00:00

abstract：:This study investigated the effect of agmatine (Agm) in proliferation of ovine trophecdoderm cells (oTr1) as well as the importance of the arginine decarboxylase (ADC) and agmatinase (AGMAT) alternative pathway for synthesis of polyamines in ovine conceptuses during the peri-implantation period of pregnancy. Morpholin...

journal_title：Amino acids

authors： Lenis YY,Elmetwally MA,Tang W,Satterfield C,Dunlap K,Wu G,Bazer FW

更新日期：2018-02-01 00:00:00

abstract：:Formalin-fixed paraffin-embedded (FFPE) tissues are a real treasure for retrospective analysis considering the amount of samples present in hospital archives, combined with pathological, clinical, and outcome information available for every sample. Although unlocking the proteome of these tissues is still a challenge,...

journal_title：Amino acids

authors： Maes E,Broeckx V,Mertens I,Sagaert X,Prenen H,Landuyt B,Schoofs L

更新日期：2013-08-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is a methylated form of arginine and an endogenous nitric oxide synthase inhibitor. Renal function decline is associated with increase of plasma ADMA in chronic kidney disease populations. It is yet unknown how isolated renal function impairment affects ADMA homeostasis in healthy hu...

journal_title：Amino acids

authors： Said MY,Douwes RM,van Londen M,Minović I,Frenay AR,de Borst MH,van den Berg E,Heiner-Fokkema MR,Kayacelebi AA,Bollenbach A,van Goor H,Navis G,Tsikas D,Bakker SJL

更新日期：2019-03-01 00:00:00

abstract：:D: -Amino acid oxidase (DAAO) in mammal kidney regulates the renal reactive oxygen species (ROS) levels directly and plays a leading role in the development of ROS-mediated renal pathologic damages based on its crucial role in the oxidative deamination of D: -amino acids and the consequent generation of H(2)O(2). Quan...

journal_title：Amino acids

authors： Zhang H,Qi L,Lin Y,Mao L,Chen Y

更新日期：2012-01-01 00:00:00

abstract：:The isolated single organotypic slice model allows to investigate the effects of drugs and toxins on the expression of transcription factors in the striatum without dopaminergic and glutamatergic interactions. In this study the effects of margatoxin and iberiotoxin on the expression of c-fos mRNA by in situ hybridizat...

journal_title：Amino acids

authors： Saria A,Fischer HS,Humpel C,Pfattner A,Schatz DS,Schuligoi R

更新日期：2000-01-01 00:00:00

abstract：:In 3T3 cells temperatures higher than physiological stimulated amino acid transport activity in a dose-dependent manner up to 44 degrees C. However, the temperature increase did not induce widespread transport increase of all other nutrients tested. The activities of both amino acid transport systems A and ASC were en...

journal_title：Amino acids

authors： Petronini PG,Caccamo AE,Alfieri RR,Bonelli MA,Borghetti AF

更新日期：2001-01-01 00:00:00

abstract：:Glutamine and leucine are abundant constituents of plant and animal proteins, whereas the content of arginine in foods and physiological fluids varies greatly. Besides their role in protein synthesis, these three amino acids individually activate signaling pathway to promote protein synthesis and possibly inhibit auto...

journal_title：Amino acids

authors： Marc Rhoads J,Wu G

更新日期：2009-05-01 00:00:00

abstract：:The kidney plays a key role in arginine metabolism. Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which ...

journal_title：Amino acids

authors： Levillain O

更新日期：2012-04-01 00:00:00

abstract：:Molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression has drawn significant attention because of the unique role of the HER2 gene in diagnosis, therapy and prognosis of human breast cancer. In our previous research, a novel cyclic 2-helix small protein, MUT-DS, was discovered as an anti-...

journal_title：Amino acids

authors： Ren G,Webster JM,Liu Z,Zhang R,Miao Z,Liu H,Gambhir SS,Syud FA,Cheng Z

更新日期：2012-07-01 00:00:00

abstract：:Anticancer peptides (ACPs) are biologically anticancer active molecules that are produced by mammals, plants, insects and microorganisms. Here, a new peptide (TC22) with the amino acid sequence MTVVLLLIVLPLLGGVHSSGIL was identified and characterized from the beetle Tribolium castaneum. We found it inhibited the growth...

journal_title：Amino acids

authors： Liu XD,Zhang FX,Qin ZH,Shan H

更新日期：2019-02-01 00:00:00

abstract：:Numerous indolyl amino acids and their derivatives inhibited arginase activity. The inhibition was found to be non-competitive, - at least partly - allosteric, and independent on manganese ions in the active site, and it cannot be explained by the dissociation of arginase homotrimers. Indole alone is weakly inhibitory...

journal_title：Amino acids

authors： Hrabák A,Bajor T,Mészáros G

更新日期：2008-02-01 00:00:00

abstract：:Recovery of amino acid (AA) metabolism and the associated clinical implications in chronic hepatitis C (CHC) patients with sustained virological response (SVR) following anti-hepatitis C virus (HCV) therapy remains elusive. A prospective cohort study was conducted on 222 CHC patients with SVR. Eighty-two age-matched m...

journal_title：Amino acids

authors： Chang ML,Cheng ML,Chang SW,Tang HY,Chiu CT,Yeh CT,Shiao MS

更新日期：2017-02-01 00:00:00

abstract：:Several descriptors of protein structure at the sequence and residue levels have been recently proposed. They are widely adopted in the analysis and prediction of structural and functional characteristics of proteins. Numerous in silico methods have been developed for sequence-based prediction of these descriptors. Ho...

journal_title：Amino acids

authors： Chen K,Stach W,Homaeian L,Kurgan L

更新日期：2011-03-01 00:00:00

abstract：:New bioinorganic complexes of the aspartic acid with the antimony or bismuth triiodide were synthesized by a direct solid-solid reaction at room temperature. The formula of the complex is MI(3)[OOCCH(2)CH(NH(2))CO](2.5) x 2.5H(2)O (M = Sb, Bi). The complex may be a dimer with bridge structure. The crystal structure of...

journal_title：Amino acids

authors： Jia RR,Wu CP,Wu S,Yang YX,Chen YR,Jia YQ

更新日期：2006-07-01 00:00:00

abstract：:Amino acid networks (AANs) are undirected networks consisting of amino acid residues and their interactions in three-dimensional protein structures. The analysis of AANs provides novel insight into protein science, and several common amino acid network properties have revealed diverse classes of proteins. In this revi...

journal_title：Amino acids

authors： Yan W,Zhou J,Sun M,Chen J,Hu G,Shen B

更新日期：2014-06-01 00:00:00

abstract：:A large series of plasma albumin (ALB, g/dl) and simultaneous blood and clinical measurements were prospectively performed on 92 liver resection patients, and processed to assess the correlations between ALB, other plasma proteins, additional variables and clinical events. The measurements were performed preoperativel...

journal_title：Amino acids

authors： Giovannini I,Chiarla C,Giuliante F,Vellone M,Ardito F,Nuzzo G

更新日期：2006-11-01 00:00:00

abstract：:Sensitivity to pharmacological challenges has been reported in patients with panic disorder. We have previously validated transgenic mice overexpressing the neurotrophin-3 (NT-3) receptor, TrkC (TgNTRK3), as an engineered murine model of panic disorder. We could determine that TgNTRK3 mice presented increased cellular...

journal_title：Amino acids

authors： Sahún I,Gallego X,Gratacòs M,Murtra P,Trullás R,Maldonado R,Estivill X,Dierssen M

更新日期：2007-11-01 00:00:00

abstract：:Taurine chloramine (TauCl), a product of neutrophil myeloperoxidase - halide system, formed by a reaction of taurine with HOCl, is known as an anti-microbial and anti-inflammatory long-lived oxidant. We previously reported that TauCl inhibits in vitro the production of proinflammatory cytokines (IL-6, IL-8) by RA syno...

journal_title：Amino acids

authors： Kwaśny-Krochin B,Bobek M,Kontny E,Gluszko P,Biedroń R,Chain BM,Maśliński W,Marcinkiewicz J

更新日期：2002-01-01 00:00:00

abstract：:This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise...

journal_title：Amino acids

authors： Maroto-Sánchez B,Lopez-Torres O,Valtueña J,Benito PJ,Palacios G,Díaz-Martínez ÁE,González-Lamuño D,Zinellu A,González-Gross M,Carru C

更新日期：2019-02-01 00:00:00

abstract：:When a V3 sequence obtained on the n-th year after infection with human immunodeficiency virus type 1 (HIV-1) was supposed to change into a V3 sequence on the n + 1-th year, the variation between the above two sequences was analyzed by means of entropic chaos degree. The entropic chaos degree measures chaotic aspects ...

journal_title：Amino acids

authors： Sato K,Ohya M

更新日期：2001-01-01 00:00:00

abstract：:The effect of oxygen derived free radicals (OFR) on aromatic and sulphur containing amino acids has been investigated, both in their free form and within protein backbones. Aerated amino acids and proteins in solution were exposed to three discrete OFR generating systems; (1) gamma radiation in the presence or absence...

journal_title：Amino acids

authors： Griffiths HR,Lunec J,Blake DR

更新日期：1992-06-01 00:00:00

abstract：:N-Acetyl-AA(amino acid)-NHtBu derivatives of all 20 naturally occurring amino acids have been synthesized. Syntheses were performed via solution-phase methodology with yields that allow for access to gram quantities of substrates, in most cases. Syntheses include the coupling of a hindered amine, tert-butylamine, with...

journal_title：Amino acids

authors： Ekkati AR,Campanali AA,Abouelatta AI,Shamoun M,Kalapugama S,Kelley M,Kodanko JJ

更新日期：2010-03-01 00:00:00

abstract：:Low concentrations of L-homoarginine (hArg) in plasma or serum and urine have recently emerged as a novel cardiovascular risk factor. Previously, we reported gas chromatography-mass spectrometry (GC-MS) and GC-tandem MS (GC-MS/MS) methods for the quantitative determination of hArg and Arg in plasma, serum, urine and o...

journal_title：Amino acids

authors： Hanff E,Kayacelebi AA,Yanchev GR,Maassen N,Haghikia A,Tsikas D

更新日期：2016-03-01 00:00:00

abstract：:The presence of an enzyme activity which hydrolyzes glycyl-D-aspartate was found in the homogenates of pig kidney cortex. The activity was inhibited by metal chelating agents and cilastatin, suggesting that the enzyme was a cilastatin-sensitive metallo-peptidase. Of the two hydrolysis products,D-aspartate was found to...

journal_title：Amino acids

authors： Kera Y,Funabashi K,Matsumoto T,Watanabe T,Nagasaki H,Yamada R

更新日期：1996-06-01 00:00:00