Quantitative metabolic profiling of NMR spectral signatures of branched chain amino acids in blood serum.

abstract：:Alterations in adipocyte characteristics are highly implicated in the pathology of obesity. In a recent article, we demonstrated that high-fat diet-induced obesity impairs lysosomal function, thereby suppressing autophagy in mice white adipose tissue. Taurine, an amino acid naturally contained in the normal diet and e...

journal_title：Amino acids

authors： Kaneko H,Kobayashi M,Mizunoe Y,Yoshida M,Yasukawa H,Hoshino S,Itagawa R,Furuichi T,Okita N,Sudo Y,Imae M,Higami Y

更新日期：2018-05-01 00:00:00

abstract：:The activity of lysine decarboxylase was studied in 3-day-old soybean (Glycine max (L.) Meer cv. Sakai) seedlings also in relation to light conditions. Lysine decarboxylase activity was mainly localized in the roots and to a lesser extent in the hypocotyls and was detectable in both the soluble and particulate fractio...

journal_title：Amino acids

authors： Ohe M,Scoccianti V,Bagni N,Tassoni A,Matsuzaki S

更新日期：2009-01-01 00:00:00

abstract：:Chemically defined amino acid diets have been developed for most laboratory and meat-producing animal species as well as for humans. In many cases, growth performance of animals fed these diets equals that obtained with standard intact-protein diets. The pattern of both essential and nonessential amino acids is critic...

journal_title：Amino acids

authors： Baker DH

更新日期：1992-02-01 00:00:00

abstract：:Molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression has drawn significant attention because of the unique role of the HER2 gene in diagnosis, therapy and prognosis of human breast cancer. In our previous research, a novel cyclic 2-helix small protein, MUT-DS, was discovered as an anti-...

journal_title：Amino acids

authors： Ren G,Webster JM,Liu Z,Zhang R,Miao Z,Liu H,Gambhir SS,Syud FA,Cheng Z

更新日期：2012-07-01 00:00:00

abstract：:Granulocyte-colony stimulating factor stimulates production and antibacterial function of neutrophiles. Therapy using the recombinant protein drug represents a major step forward in oncology. The protein has not been, however, completely sequenced at the protein level and this formed the rationale of the current study...

journal_title：Amino acids

authors： Ahmed KE,Chen WQ,John JP,Kang SU,Lubec G

更新日期：2010-04-01 00:00:00

abstract：:This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of a heteroaromatic compound denominated by us T(2)CO, comprising two thymine moieties anchored to a 2-propanonic unit, the spectroscopic properties of which wer...

journal_title：Amino acids

authors： Roviello GN,Roviello G,Musumeci D,Bucci EM,Pedone C

更新日期：2012-10-01 00:00:00

abstract：:D-Aspartate (D-Asp) has important physiological functions, and recent studies have shown that substantial amounts of free D-Asp are present in a wide variety of mammalian tissues and cells. Biosynthesis of D-Asp has been observed in several cultured rat cell lines, and a murine gene (glutamate-oxaloacetate transaminas...

journal_title：Amino acids

authors： Matsuda S,Katane M,Maeda K,Kaneko Y,Saitoh Y,Miyamoto T,Sekine M,Homma H

更新日期：2015-05-01 00:00:00

abstract：:Among the large family of cyclodepsipeptides, the simplest members are the cyclodidepsipeptides which have an ester group and an amide group in the same six-membered ring. To point out the pharmacological potential of this class of compounds, the present article reviews structure, isolation, synthesis and biological p...

journal_title：Amino acids

authors： Smelcerovic A,Dzodic P,Pavlovic V,Cherneva E,Yancheva D

更新日期：2014-04-01 00:00:00

abstract：:Agmatine, a metabolite generated by arginine decarboxylation, has been reported as neuromodulator and neuroactive substance. Several findings suggest that agmatine displays neuroprotective effects in several models of neurodegenerative disorders, such as Parkinson's disease (PD). It has been hypothesized that biogenic...

journal_title：Amino acids

authors： Ferlazzo N,Currò M,Giunta ML,Longo D,Rizzo V,Caccamo D,Ientile R

更新日期：2020-02-01 00:00:00

abstract：:This study aimed to evaluate the effect of taurine (tau) supplementation to low fishmeal (FM) diets on growth performance, oxidative status, and immune response of European seabass juveniles. Four isoproteic (46% crude protein) and isolipidic (19% crude lipid) diets were formulated to contain either 25 or 12.5% FM and...

journal_title：Amino acids

authors： Martins N,Magalhães R,Castro C,Couto A,Díaz-Rosales P,Oliva-Teles A,Peres H

更新日期：2019-09-01 00:00:00

abstract：:Phenylketonuria (PKU) is an autosomal recessive genetic disease caused by the defects in the phenylalanine hydroxylase (PAH) gene. Individuals homozygous for defective PAH alleles show elevated levels of systemic phenylalanine and should be under strict dietary control to reduce the risk of neuronal damage associated ...

journal_title：Amino acids

authors： Ikeda K,Schiltz E,Fujii T,Takahashi M,Mitsui K,Kodera Y,Matsushima A,Inada Y,Schulz GE,Nishimura H

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:Chemo-therapeutic treatment of glioma patients has minor success. Little is known about mechanisms of a pronounced resistance of gliomas towards actual therapies, yet. ABC-1 belongs to the group of transporters known to be involved in the export of hydrophobic substances and vascular regulation. This study in...

journal_title：Amino acids

authors： Trog D,Moenkemann H,Haertel N,Schüller H,Golubnitschaja O

更新日期：2005-03-01 00:00:00

abstract：:The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of g...

journal_title：Amino acids

authors： Aceña JL,Sorochinsky AE,Soloshonok V

更新日期：2014-09-01 00:00:00

abstract：:α-Pharmacological conotoxins are among the most selective ligands of nicotinic acetylcholine receptors with typical cysteine frameworks. They are characterized by the intercysteine loop and classified into various subfamilies, such as α3/5 and α4/7 conotoxins. A novel α-conotoxin, Pu14a (DCPPHPVPGMHKCVCLKTC), with a d...

journal_title：Amino acids

authors： Zhang B,Huang F,Du W

更新日期：2012-07-01 00:00:00

abstract：:N-acetylaspartate (NAA), an acetylated derivative of L-aspartate (Asp), and N-acetylaspartylglutamate (NAAG), a derivative of NAA and L-glutamate (Glu), are synthesized by neurons in brain. However, neurons cannot catabolize either of these substances, and so their metabolism requires the participation of two other ce...

journal_title：Amino acids

authors： Baslow MH

更新日期：2010-11-01 00:00:00

abstract：:N, N'-Ethylene-bridged bis-(S)-methionine[(2S, 7S)-2, 7-bis(2-methyl-thioethyl)-3,6-diazaoctanedioic acid] derived from (S)-methionine and 1,2-dibromoethane was cyclized and esterified simultaneously in boiling ethanol in the presence of an appropriate amount of strong acid such asp-toluenesulfonic acid, affording a c...

journal_title：Amino acids

authors： Yamashita T,Takenaka H,Kojima Y

更新日期：1993-02-01 00:00:00

abstract：:Glutamine is the most abundant amino acid in the body. It is an important fuel for some key cells of the immune system. Both the plasma concentration of glutamine and the functional ability of immune cells in the blood are decreased after prolonged, exhaustive exercise. Glutamine feeding has had beneficial effects in ...

journal_title：Amino acids

authors： Castell LM,Newsholme EA

更新日期：2001-01-01 00:00:00

abstract：:The intestine is not only critical for the absorption of nutrients, but also interacts with a complex external milieu. Most foreign antigens enter the body through the digestive tract. Dietary amino acids are major fuels for the small intestinal mucosa, as well as important substrates for syntheses of intestinal prote...

journal_title：Amino acids

authors： Wang WW,Qiao SY,Li DF

更新日期：2009-05-01 00:00:00

abstract：:The mitochondrial branched chain aminotransferase-deficient mouse model (BCATm KO), which exhibits elevated plasma and tissue branched chain amino acids (BCAAs), was used to study the effect of BCAAs on mammalian target of rapamycin complex 1 (mTORC1) regulation of organ size. BCATm is the first enzyme in the BCAA cat...

journal_title：Amino acids

authors： Neishabouri SH,Hutson SM,Davoodi J

更新日期：2015-06-01 00:00:00

abstract：:Reduced glutathione (GSH) levels and glutathione reductase (GR) and glutathione S-transferase (GST) activities were investigated in the erythrocytes and lymphocytes of non-dialyzed patients with varying degrees of chronic renal insufficiency, and also of patients on regular hemodialysis treatment. GSH, GR and GST leve...

journal_title：Amino acids

authors： Mimic-Oka J,Simic T,Djukanovic L,Stefanovski J,Ramic Z

更新日期：1992-10-01 00:00:00

abstract：:Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a...

journal_title：Amino acids

authors： Golubnitschaja O,Filep N,Yeghiazaryan K,Blom HJ,Hofmann-Apitius M,Kuhn W

更新日期：2018-04-01 00:00:00

abstract：:The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the inhibitors of apoptosis proteins (IAP), particularly XIAP and eliminating their inhibitory activit...

journal_title：Amino acids

authors： Khalily MP,Gerekçi S,Güleç EA,Özen C,Özçubukçu S

更新日期：2018-11-01 00:00:00

abstract：:The effects of metabotropic glutamate receptor (mGluR) activation were studied in medium spiny neurons and large aspiny (LA) interneurons by means of electrophysiological and optical recordings. DCG-IV and L-SOP, agonists for group II and III mGluRs, respectively, produced a presynaptic inhibitory effect on corticostr...

journal_title：Amino acids

authors： Pisani A,Bernardi G,Bonsi P,Centonze D,Giacomini P,Calabresi P

更新日期：2000-01-01 00:00:00

abstract：:The leptin receptor antagonist peptide Allo-aca exhibits picomolar activities in various cellular systems and sub-mg/kg subcutaneous efficacies in animal models making it a prime drug candidate and target validation tool. Here we identified the biochemical basis for its remarkable in vivo activity. Allo-aca decomposed...

journal_title：Amino acids

authors： Otvos L Jr,Vetter SW,Koladia M,Knappe D,Schmidt R,Ostorhazi E,Kovalszky I,Bionda N,Cudic P,Surmacz E,Wade JD,Hoffmann R

更新日期：2014-04-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are cell surface receptors. The dynamic property of receptor-receptor interactions in GPCRs modulates the kinetics of G-protein signaling and stability. In the present work, the structural and dynamic study of A(2A)R-D(2)R interactions was carried to acquire the understanding of the...

journal_title：Amino acids

authors： Prakash A,Luthra PM

更新日期：2012-10-01 00:00:00

abstract：:Tryptophan is important both for protein synthesis and as a precursor of niacin, serotonin and other metabolites. Tryptophan is an unusual amino acid because of the complexity of its metabolism, the variety and importance of its metabolites, the number and diversity of the diseases it is involved in, and because of it...

journal_title：Amino acids

authors： Sainio EL,Pulkki K,Young SN

更新日期：1996-03-01 00:00:00

abstract：:Prophylactic supplementation of N-acetyl-cysteine (NAC) and epigallocatechin gallate (EGCG) was studied for physiological and cellular changes in skeletal muscle after eccentric muscle contractions. Thirty healthy, active males (20.0 +/- 1.8 years, 160 +/- 7.1 cm, 76.1 +/- 17.0 kg) ingested for 14 days either 1,800 mg...

journal_title：Amino acids

authors： Kerksick CM,Kreider RB,Willoughby DS

更新日期：2010-06-01 00:00:00

abstract：:Predicting the three-dimensional structure of proteins is a long-standing challenge of computational biology, as the structure (or lack of a rigid structure) is well known to determine a protein's function. Predicting relative solvent accessibility (RSA) of amino acids within a protein is a significant step towards re...

journal_title：Amino acids

authors： Kaleel M,Torrisi M,Mooney C,Pollastri G

更新日期：2019-09-01 00:00:00

abstract：:Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5'-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). The limited availability and stability of the prot...

journal_title：Amino acids

authors： Castro-Oropeza R,Pino-Ángeles A,Khomutov MA,Urdiales JL,Moya-García AA,Vepsäläinen J,Persson L,Sarabia F,Khomutov A,Sánchez-Jiménez F

更新日期：2014-03-01 00:00:00

abstract：:We report the solid phase synthesis and some pharmacological properties of 24 oxytocin (OT) analogues. Basic modifications at position 9 (introduction of L- or D-beta-(2-thienyl)-alanine [L- or D-Thi], or L- or D-3-Pyridylalanine [L- or D-3-Pal]) were combined with D-tyrosine(OEthyl) [D-Tyr(Et)] or D-1-naphthylalanine...

journal_title：Amino acids

authors： Magafa V,Borovicková L,Slaninová J,Cordopatis P

更新日期：2010-05-01 00:00:00