Abstract:
:The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of glycine as C-nucleophiles and (b) Ni(II)-complexes of dehydroalanine as Michael acceptors. The first group is significantly larger and consequently subdivided into four chapters based on the source of stereocontrolling element. Thus, a chiral auxiliary can be used as a part of nucleophilic glycine Ni(II) complex, Michael acceptor or both, leading to the conditions of matching vs. mismatching stereochemical preferences. The particular focus of the review is made on the practical aspects of the methodology under discussion and mechanistic considerations.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Aceña JL,Sorochinsky AE,Soloshonok Vdoi
10.1007/s00726-014-1764-5subject
Has Abstractpub_date
2014-09-01 00:00:00pages
2047-73issue
9eissn
0939-4451issn
1438-2199journal_volume
46pub_type
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