Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease.

abstract：:The unusual basic amino acid, hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)-lysine], is a modified lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This naturally occurring amino acid is a product of a unique posttranslational modification that occurs in only one cellular protein, euk...

journal_title：Amino acids

authors： Park MH,Nishimura K,Zanelli CF,Valentini SR

更新日期：2010-02-01 00:00:00

abstract：:Angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone of the renin-angiotensin-aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic properties. However, the peptide's therapeutic potential is limited by the short half-life and low bioavailabili...

journal_title：Amino acids

authors： Wester A,Devocelle M,Tallant EA,Chappell MC,Gallagher PE,Paradisi F

更新日期：2017-10-01 00:00:00

abstract：:Increased intracellular cysteine poses a potential danger to cells due to the high ability of cysteine to reduce free iron and promote the Fenton reaction. Here, we studied ways to maintain cysteine homeostasis in E. coli cells while inhibiting protein synthesis with valine or chloramphenicol. When growing wild-type b...

journal_title：Amino acids

authors： Smirnova GV,Tyulenev AV,Bezmaternykh KV,Muzyka NG,Ushakov VY,Oktyabrsky ON

更新日期：2019-11-01 00:00:00

abstract：:Anticancer peptides (ACPs) are biologically anticancer active molecules that are produced by mammals, plants, insects and microorganisms. Here, a new peptide (TC22) with the amino acid sequence MTVVLLLIVLPLLGGVHSSGIL was identified and characterized from the beetle Tribolium castaneum. We found it inhibited the growth...

journal_title：Amino acids

authors： Liu XD,Zhang FX,Qin ZH,Shan H

更新日期：2019-02-01 00:00:00

abstract：:Regulated proteolysis plays important roles in cell biology and pathological conditions. A crosstalk exists between apoptosis and the ubiquitin-proteasome system, two pathways responsible for regulated proteolysis executed by different proteases. To investigate whether the apoptotic process also affects the 20S protea...

journal_title：Amino acids

authors： Schmidt F,Dahlmann B,Hustoft HK,Koehler CJ,Strozynski M,Kloss A,Zimny-Arndt U,Jungblut PR,Thiede B

更新日期：2011-07-01 00:00:00

abstract：:Obesity, type 2 diabetes (T2DM) and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. They represent major public health threat to our society. Increasing prevalence of obesity and T2DM contributes to escalating morbidity and mortality from CVD and stroke. Carnos...

journal_title：Amino acids

authors： Baye E,Ukropcova B,Ukropec J,Hipkiss A,Aldini G,de Courten B

更新日期：2016-05-01 00:00:00

abstract：:In this review, recent studies on the electrophysiological effects of de novo synthesized ("endogenous") kynurenic acid (KYNA) are discussed. Endogenous KYNA is normally formed as a byproduct of tryptophan metabolism. Evidence for a physiological role in neuronal excitability has not been strong, in part because brain...

journal_title：Amino acids

authors： Scharfman HE,Goodman JH,Schwarcz R

更新日期：2000-01-01 00:00:00

abstract：:We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activitie...

journal_title：Amino acids

authors： Delwing D,Chiarani F,Wannmacher CM,Wajner M,Wyse AT

更新日期：2005-05-01 00:00:00

abstract：:The effect of up-regulation of putrescine (Put) production by genetic manipulation on the turnover of spermidine (Spd) and spermine (Spm) was investigated in transgenic cells of poplar (Populus nigra × maximowiczii) and seedlings of Arabidopsis thaliana. Several-fold increase in Put production was achieved by expressi...

journal_title：Amino acids

authors： Shao L,Bhatnagar P,Majumdar R,Minocha R,Minocha SC

更新日期：2014-03-01 00:00:00

abstract：:Transglutaminases are a family of enzymes which show the common capacity to catalyse the cross-linking of protein substrates. Some members of this family of enzymes are also capable to catalyse other chemical reactions for the cell life. The distribution and the role of these enzymes have been studied in numerous cell...

journal_title：Amino acids

authors： Pepe I,Occhino E,Cella G,Luongo A,Guardascione F,Gentile V

更新日期：2004-07-01 00:00:00

abstract：:Formalin-fixed paraffin-embedded (FFPE) tissues are a real treasure for retrospective analysis considering the amount of samples present in hospital archives, combined with pathological, clinical, and outcome information available for every sample. Although unlocking the proteome of these tissues is still a challenge,...

journal_title：Amino acids

authors： Maes E,Broeckx V,Mertens I,Sagaert X,Prenen H,Landuyt B,Schoofs L

更新日期：2013-08-01 00:00:00

abstract：:The human organism is exposed to numerous processes that generate reactive oxygen species (ROS). ROS may directly or indirectly cause oxidative modification and damage of proteins. Protein oxidation is regarded as a crucial event in the pathogenesis of various diseases ranging from rheumatoid arthritis to Alzheimer's ...

journal_title：Amino acids

authors： Pietzsch J,Bergmann R,Wuest F,Pawelke B,Hultsch C,van den Hoff J

更新日期：2005-12-01 00:00:00

abstract：:Peptide bonds in protein structures are mainly found in trans conformation with a torsion angle ω close to 180°. Only a very low proportion is observed in cis conformation with ω angle around 0°. Cis-trans isomerization leads to local conformation changes which play an important role in many biological processes. In t...

journal_title：Amino acids

authors： Craveur P,Joseph AP,Poulain P,de Brevern AG,Rebehmed J

更新日期：2013-08-01 00:00:00

abstract：:It is controversial whether homocysteic acid or other homocysteine derivatives show growth promoting effects. In a clonogenic assay we could show that homocysteine thiolactone and its alpha alkylated derivative increased colony formation significantly. Our work favorizes previous observations showing growth promoting ...

journal_title：Amino acids

authors： Lubec B,Szekeres T

更新日期：1994-02-01 00:00:00

abstract：:We examined the effects of DON [glutamine-analogue and inhibitor of glutamine-requiring enzymes], alanyl-glutamine (regarding its role in neutrophil immunonutrition) and alanyl-glutamine combined with L-NAME, SNAP, DON, beta-alanine and DFMO on neutrophil amino and alpha-keto acid concentrations or important neutrophi...

journal_title：Amino acids

authors： Mühling J,Burchert D,Langefeld TW,Matejec R,Harbach H,Engel J,Wolff M,Welters ID,Fuchs M,Menges T,Krüll M,Hempelmann G

更新日期：2007-09-01 00:00:00

abstract：:This investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protoco...

journal_title：Amino acids

authors： Foster EB,Fisher G,Sartin JL,Elsasser TH,Wu G,Cowan W,Pascoe DD

更新日期：2012-04-01 00:00:00

abstract：:L-Homoarginine is a cationic amino acid derivative, which is structurally related to L-arginine and lysine. Several lines of evidence point to nervous tissue as an important target of homoarginine action. In the mammalian brain homoarginine can be detected in noticeable quantities, but its origin is currently poorly e...

journal_title：Amino acids

authors： Bernstein HG,Jäger K,Dobrowolny H,Steiner J,Keilhoff G,Bogerts B,Laube G

更新日期：2015-09-01 00:00:00

abstract：:The successful prediction of protein-folding rates based on the sequence-predicted secondary structure suggests that the folding rates might be predicted from sequence alone. To pursue this question, we directly predict the folding rates from amino acid sequences, which do not require any information on secondary or t...

journal_title：Amino acids

authors： Huang JT,Xing DJ,Huang W

更新日期：2012-08-01 00:00:00

abstract：:Agmatine, a metabolite generated by arginine decarboxylation, has been reported as neuromodulator and neuroactive substance. Several findings suggest that agmatine displays neuroprotective effects in several models of neurodegenerative disorders, such as Parkinson's disease (PD). It has been hypothesized that biogenic...

journal_title：Amino acids

authors： Ferlazzo N,Currò M,Giunta ML,Longo D,Rizzo V,Caccamo D,Ientile R

更新日期：2020-02-01 00:00:00

abstract：:The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this revie...

journal_title：Amino acids

authors： Lentini A,Provenzano B,Tabolacci C,Beninati S

更新日期：2009-04-01 00:00:00

abstract：:The lysine catabolism pathway differs in adult mammalian brain from that in extracerebral tissues. The saccharopine pathway is the predominant lysine degradative pathway in extracerebral tissues, whereas the pipecolate pathway predominates in adult brain. The two pathways converge at the level of ∆(1)-piperideine-6-ca...

journal_title：Amino acids

authors： Hallen A,Jamie JF,Cooper AJ

更新日期：2013-12-01 00:00:00

abstract：:Knowledge of the subcellular location of a protein provides valuable information about its function, possible interaction with other proteins and drug targetability, among other things. The experimental determination of a protein's location in the cell is expensive, time consuming and open to human error. Fast and acc...

journal_title：Amino acids

authors： Mooney C,Cessieux A,Shields DC,Pollastri G

更新日期：2013-08-01 00:00:00

abstract：:Nitrogen fixation of the nodule of soybean is highly sensitive to oxygen deficiency such as provoked by waterlogging of the root system. This study aimed to evaluate the effects of flooding on N metabolism in nodules of soybean. Flooding resulted in a marked decrease of asparagine (the most abundant amino acid) and a ...

journal_title：Amino acids

authors： Souza SC,Mazzafera P,Sodek L

更新日期：2016-05-01 00:00:00

abstract：:Chiral dehydroamino acid building blocks are versatile starting materials for the preparation of optically active unusual amino acids and other compounds of pharmacological interest. Herein we disclose the expedient preparation of dehydroalanines (ΔAla) equipped with oxazolidin-2-one (Oxd) chiral auxiliaries, Ts-Oxd-Δ...

journal_title：Amino acids

authors： De Marco R,Cavina L,Greco A,Gentilucci L

更新日期：2014-12-01 00:00:00

abstract：:The cellular amino acid composition of plant cells was analyzed. The callus of carrot (Daucus carota), leaves of Torenia fournieri and protocomb-like body of Cymbidium, s.p. were examined as examples of plant cells. The cellular amino acid compositions differed in the plant cells, but their basic patterns were quite s...

journal_title：Amino acids

authors： Sorimachi K,Okayasu T,Akimoto K,Niwa A

更新日期：2000-01-01 00:00:00

abstract：:Sensitivity to pharmacological challenges has been reported in patients with panic disorder. We have previously validated transgenic mice overexpressing the neurotrophin-3 (NT-3) receptor, TrkC (TgNTRK3), as an engineered murine model of panic disorder. We could determine that TgNTRK3 mice presented increased cellular...

journal_title：Amino acids

authors： Sahún I,Gallego X,Gratacòs M,Murtra P,Trullás R,Maldonado R,Estivill X,Dierssen M

更新日期：2007-11-01 00:00:00

abstract：:eIF5A is highly conserved from archaea to mammals, essential for cell viability and the only protein known to contain the essential amino acid residue hypusine, generated by a unique posttranslational modification. eIF5A was originally identified as a translation initiation factor due to its ability to stimulate the f...

journal_title：Amino acids

authors： Dias CA,Gregio AP,Rossi D,Galvão FC,Watanabe TF,Park MH,Valentini SR,Zanelli CF

更新日期：2012-02-01 00:00:00

abstract：:The study was designed to investigate the effects of NMDA receptor agonist on the behavioral activity in rats with experimental hyperammonemia. The experiments were performed on adult male Wistar rats. Experimental hyperammonemia was induced by intraperitoneal injections of tioacetamide (TAA, 200 mg/kg) for three cons...

journal_title：Amino acids

authors： Fedosiewicz-Wasiluk M,Hoły ZZ,Wiśniewska RJ,Wiśniewski K

更新日期：2005-02-01 00:00:00

abstract：:The cross-linking of protein molecules to form stable supramolecular aggregates capable of acting as protective and supporting structures is a common feature of organisms coping with the stresses of life. These new polymeric forms range from thick rigid structures to thin flexible membranes. The formation of such cros...

journal_title：Amino acids

authors： Bailey AJ

更新日期：1991-10-01 00:00:00

abstract：:A subline growing in medium without arginine and ornithine was established from a rat Reuber hepatoma cell line (R-Y121B·cho). The subline designated R-Y117B·cho was able to grow in glutamine, arginine and ornithine-free, glutamate-supplemented medium. Arginine synthesis from glutamate requires four urea cycle enzymes...

journal_title：Amino acids

authors： Yamamoto K,Niwa A

更新日期：1996-09-01 00:00:00