Abstract:
:Transglutaminases are a family of enzymes which show the common capacity to catalyse the cross-linking of protein substrates. Some members of this family of enzymes are also capable to catalyse other chemical reactions for the cell life. The distribution and the role of these enzymes have been studied in numerous cell types and tissues, but only recently their expression and functions started to be investigated in the Nervous System. One of the main biochemical properties of the Transglutaminase enzymes is to form large protein aggregates that are insoluble in all known protein detergents. Recently, the Transglutaminase activity has been hypothesised to be involved in the pathogenetic mechanisms responsible for the formation of cellular inclusions present in the Corea Major and in other polyglutamine diseases. In this review we describe the biochemical mechanisms by which the Transglutaminases could play a critical role in the physiopathology of the polyglutamine diseases.
journal_name
Amino Acidsjournal_title
Amino acidsauthors
Pepe I,Occhino E,Cella G,Luongo A,Guardascione F,Gentile Vdoi
10.1007/s00726-004-0089-1subject
Has Abstractpub_date
2004-07-01 00:00:00pages
431-4issue
4eissn
0939-4451issn
1438-2199journal_volume
26pub_type
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