Hydration of amino acids: FTIR spectra and molecular dynamics studies.

abstract：:Identifying protein-protein interactions (PPIs) is critical for understanding the cellular function of the proteins and the machinery of a proteome. Data of PPIs derived from high-throughput technologies are often incomplete and noisy. Therefore, it is important to develop computational methods and high-quality intera...

journal_title：Amino acids

authors： Shi MG,Xia JF,Li XL,Huang DS

更新日期：2010-03-01 00:00:00

abstract：:Endurance exercise training as well as leucine supplementation modulates glucose homeostasis and protein turnover in mammals. Here, we analyze whether leucine supplementation alters the effects of endurance exercise on these parameters in healthy mice. Mice were distributed into sedentary (C) and exercise (T) groups. ...

journal_title：Amino acids

authors： Costa Júnior JM,Rosa MR,Protzek AO,de Paula FM,Ferreira SM,Rezende LF,Vanzela EC,Zoppi CC,Silveira LR,Kettelhut IC,Boschero AC,de Oliveira CA,Carneiro EM

更新日期：2015-04-01 00:00:00

abstract：:Phenylketonuria (PKU) is an autosomal recessive genetic disease caused by the defects in the phenylalanine hydroxylase (PAH) gene. Individuals homozygous for defective PAH alleles show elevated levels of systemic phenylalanine and should be under strict dietary control to reduce the risk of neuronal damage associated ...

journal_title：Amino acids

authors： Ikeda K,Schiltz E,Fujii T,Takahashi M,Mitsui K,Kodera Y,Matsushima A,Inada Y,Schulz GE,Nishimura H

更新日期：2005-11-01 00:00:00

abstract：:The relationship between taurine concentrations of plasma, whole blood, serum and skeletal muscle during taurine depletion and repletion was investigated in cats, to identify the most useful indicators of taurine status. Sixteen cats were fed a purified diet containing either 0 or 0.15 g/kg taurine for 5 months. Treat...

journal_title：Amino acids

authors： Pacioretty L,Hickman MA,Morris JG,Rogers QR

更新日期：2001-12-01 00:00:00

abstract：:The mitochondrial branched chain aminotransferase-deficient mouse model (BCATm KO), which exhibits elevated plasma and tissue branched chain amino acids (BCAAs), was used to study the effect of BCAAs on mammalian target of rapamycin complex 1 (mTORC1) regulation of organ size. BCATm is the first enzyme in the BCAA cat...

journal_title：Amino acids

authors： Neishabouri SH,Hutson SM,Davoodi J

更新日期：2015-06-01 00:00:00

abstract：:Polyamines have been related to the "Crassulacean Acid Metabolism" (CAM) in higher plants. Such relationship was however observed in plants where CAM activity is inducible by external factors. Results presented here indicate that, inOpuntia F. indica, cladodes where onset of CAM is dependent on internal conditions, i....

journal_title：Amino acids

authors： Deidda P,Tekle Z,Nieddu G,Pintus G,Pinna GG,Sisini A

更新日期：1994-06-01 00:00:00

abstract：:New bioinorganic complexes of the aspartic acid with the antimony or bismuth triiodide were synthesized by a direct solid-solid reaction at room temperature. The formula of the complex is MI(3)[OOCCH(2)CH(NH(2))CO](2.5) x 2.5H(2)O (M = Sb, Bi). The complex may be a dimer with bridge structure. The crystal structure of...

journal_title：Amino acids

authors： Jia RR,Wu CP,Wu S,Yang YX,Chen YR,Jia YQ

更新日期：2006-07-01 00:00:00

abstract：:The transient receptor potential channels TRPV2 and TRPV5 belong to the vanilloid TRP subfamily. TRPV2 is highly similar to TRPV1 and shares many common properties with it. TRPV5 (and also its homolog TRPV6) is a rather distinct member of the TRPV subfamily. It is distant for being strictly Ca(2+)-selective and featur...

journal_title：Amino acids

authors： Holakovska B,Grycova L,Bily J,Teisinger J

更新日期：2011-02-01 00:00:00

abstract：:Ocular ischemia resulting from perfusion disturbances may play a major role in initiation of glaucoma. Possibly secondary to ischemia autoimmunogenic events are activated in glaucoma patients with increased prevalence of systemic autoimmune diseases. The determination of potential molecular markers in blood leukocytes...

journal_title：Amino acids

authors： Golubnitschaja O,Wunderlich K,Decker C,Mönkemann H,Schild HH,Flammer J

更新日期：2002-01-01 00:00:00

abstract：:The putative translation factor eIF5A is essential for cell viability and is highly conserved from archaebacteria to mammals. This factor is the only cellular protein that undergoes an essential posttranslational modification dependent on the polyamine spermidine, called hypusination. This review focuses on the functi...

journal_title：Amino acids

authors： Zanelli CF,Valentini SR

更新日期：2007-08-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress, implicated in various neurodegenerative processes, increases the level of intracellular Ca(2+) and leads to activation of calpain, a Ca(2+)-dependent cysteine protease. We have shown previously that S-allyl-L-cysteine (SAC) in aged garlic extracts significantly protects cultured rat ...

journal_title：Amino acids

authors： Imai T,Kosuge Y,Endo-Umeda K,Miyagishi H,Ishige K,Makishima M,Ito Y

更新日期：2014-02-01 00:00:00

abstract：:Carnosine is found in high concentrations in skeletal muscles, where it is involved in several physiological functions. The muscle carnosine content measured within a population can vary by a factor 4. The aim of this study was to further characterize suggested determinants of the muscle carnosine content (diet, gende...

journal_title：Amino acids

authors： Everaert I,Mooyaart A,Baguet A,Zutinic A,Baelde H,Achten E,Taes Y,De Heer E,Derave W

更新日期：2011-04-01 00:00:00

abstract：:Dopa and related catecholamines and their degradation products have been demonstrated to have neurotoxic potential in a number of cellular and in vivo experiments. Several mechanisms have been hypothesized to be involved including generation of prooxidant products that subsequently oxidize membrane lipids and exposed ...

journal_title：Amino acids

authors： VonVoigtlander PF,Fici GJ,Althaus JS

更新日期：1998-01-01 00:00:00

abstract：:Seryl-histidine dipeptide (Ser-His) has been recognized as the shortest peptide with hydrolysis cleavage activity; however, its protein cleavage spectrum has not yet been fully explored. Here, four differently folded proteins were treated with Ser-His, and the digestion products were evaluated with high-resolution mas...

journal_title：Amino acids

authors： Liu Y,Li YB,Gao X,Yu YF,Liu XX,Ji ZL,Ma Y,Li YM,Zhao YF

更新日期：2018-01-01 00:00:00

abstract：:Relaxin family peptides perform a variety of biological functions by binding and activating relaxin family peptide receptor 1-4 (RXFP1-4), four A-class G protein-coupled receptors. In the present work, we developed a novel ligand binding assay for RXFP3 and RXFP4 based on NanoLuc complementation technology (NanoBiT). ...

journal_title：Amino acids

authors： Hu MJ,Shao XX,Li HZ,Nie WH,Wang JH,Liu YL,Xu ZG,Guo ZY

更新日期：2018-08-01 00:00:00

abstract：:The release of the inhibitory amino acid taurine is markedly enhanced under ischemic conditions in both adult and developing brain stem, together with a pronounced increase in the release of the neuromodulator adenosine. We now studied the effects of adenosine receptor agonists and antagonists on [(3)H]taurine release...

journal_title：Amino acids

authors： Saransaari P,Oja SS

更新日期：2010-05-01 00:00:00

abstract：:The purpose of this study was to investigate H(e) concentration in plasma from 80 healthy donors in relation to age (6 newborns are also included), sex, daily variation (9, 11 a.m.; 2, 6, 12 p.m.) and a period of 5 subsequent months. A significant correlation (r = 0.63, p < 0.001) was observed between plasma H(e) and ...

journal_title：Amino acids

authors： Fermo I,De Vecchi E,D'Angelo SV,D'Angelo A,Paroni R

更新日期：1993-02-01 00:00:00

abstract：:Two synthetic routes to bis-armed-alpha-amino acid derivatives are described. The first route involves alkylation of dibromo derivatives with ethyl isocyanoacetate under phase-transfer catalysis (PTC) conditions. The second route uses a palladium-mediated Suzuki-Miyaura cross-coupling reaction between a DL-4-boronophe...

journal_title：Amino acids

authors： Kotha S,Shah VR,Halder S,Vinodkumar R,Lahiri K

更新日期：2007-01-01 00:00:00

abstract：:The coupling between G protein-coupled receptors (GPCRs) and guanine nucleotide-binding proteins (G proteins) regulates various signal transductions from extracellular space into the cell. However, the coupling mechanism between GPCRs and G proteins is still unknown, and experimental determination of their coupling sp...

journal_title：Amino acids

authors： Li Z,Zhou X,Dai Z,Zou X

更新日期：2012-08-01 00:00:00

abstract：:Phenolic compounds are interesting because of their antioxidant properties. In the present study, the antioxidant properties of L-tyrosine as a monophenolic and L-Dopa as a diphenolic amino acid were investigated by using different antioxidant assays: (i) 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH*) scavenging;...

journal_title：Amino acids

authors： Gülçin I

更新日期：2007-01-01 00:00:00

abstract：:Thrombin, the most potent physiological platelet agonist interacts with cells through a specific G protein-coupled receptor which has been cloned and sequenced. Synthetic thrombin receptor peptides (TRAPs) comprising the first 5 amino acids (SFLLR and SFLLR-NH2) of the new N-terminus tethered ligand of the thrombin re...

journal_title：Amino acids

authors： Alexopoulos K,Matsoukas J,Tselios T,Roumelioti P,Mavromoustakos T,Holada K

更新日期：1998-01-01 00:00:00

abstract：:D-Amino acid oxidase cDNA was amplified by a polymerase chain reaction using RNA extracted from the mouse kidney. When digested withHindIII, the cDNAs of the BALB/c and ddY/DAO(-) mice were cleaved into two fragments whereas the cDNA of the ddY/DAO(+) mice was not. Sequencing revealed that nucleotide-471 of the cDNAs ...

journal_title：Amino acids

authors： Konno R,Sasaki M,Enami J,Niwa A

更新日期：1995-03-01 00:00:00

abstract：:Short CCK peptides elicit panic attacks in humans and anxiogenic-like effects in some animal models, but CCK receptor antagonists have not been found clinically effective. Yet CCK overactivity appears to be involved in submissive behaviour, and CCKB receptor expression and binding are increased in suicide victims and ...

journal_title：Amino acids

authors： Harro J

更新日期：2006-10-01 00:00:00

abstract：:A prior knowledge of protein structural classes can provide useful information about its overall structure, so it is very important for quick and accurate determination of protein structural class with computation method in protein science. One of the key for computation method is accurate protein sample representatio...

journal_title：Amino acids

authors： Li ZC,Zhou XB,Dai Z,Zou XY

更新日期：2009-07-01 00:00:00

abstract：:The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protei...

journal_title：Amino acids

authors： Olma A,Lasota A,Kudaj A

更新日期：2012-06-01 00:00:00

abstract：:Obesity, type 2 diabetes (T2DM) and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. They represent major public health threat to our society. Increasing prevalence of obesity and T2DM contributes to escalating morbidity and mortality from CVD and stroke. Carnos...

journal_title：Amino acids

authors： Baye E,Ukropcova B,Ukropec J,Hipkiss A,Aldini G,de Courten B

更新日期：2016-05-01 00:00:00

abstract：:Amino acid and glucosinolate biosynthesis are two interdependent pathways; amino acid synthesis as a part of primary metabolism provides the precursors for glucosinolate biosynthesis in secondary metabolism. In our previous studies, the combination of coexpression analysis and metabolite profiling led to the identific...

journal_title：Amino acids

authors： Albinsky D,Sawada Y,Kuwahara A,Nagano M,Hirai A,Saito K,Hirai MY

更新日期：2010-10-01 00:00:00

abstract：:A series of hydroxypyrroloindoline (Hpi) containing dipeptides along with the corresponding monomeric Hpi-α-amino acid (Hpi-2-carboxylate), were prepared by reacting a series of N α-protected-tryptophans in aqueous or biphasic [water/cyclopentyl methyl ether (CPME)] solutions containing Oxone® (potassium peroxymonosul...

journal_title：Amino acids

authors： Blanc A,Xia F,Todorovic M,Perrin DM

更新日期：2017-02-01 00:00:00

abstract：:Treatment of developing rats with monosodium glutamate (MSG) produces an increase of glutamate levels in the brain, being this elevation dependent on both route of administration and animal's age. The capacity of exogenous MSG to induce convulsions seems to be related to the rate of glutamate elevation in the brain, r...

journal_title：Amino acids

authors： Peñafiel R,Cremades A,Monserrat F,Puelles L

更新日期：1991-02-01 00:00:00

abstract：:Functionalized collagen-mimetic peptides (CMPs) have been widely used in the preparation of collagen-related biomaterials. Among the reported results, the induced noncovalent interactions between the implanted functional groups or moieties were frequently the key elements to promote the self-assembly of small CMPs. In...

journal_title：Amino acids

authors： Huang PW,Chang JM,Horng JC

更新日期：2016-12-01 00:00:00