Comparison of in vitro antioxidant and antiradical activities of L-tyrosine and L-Dopa.

abstract：:Isoprostanes, non-enzymatic peroxidation products of arachidonic acid, are attractive biomarkers of oxidative stress in research in biology, medicine and nutrition. For the appropriate use of biomarkers it is required that these are both biologically and technically valid. Whereas the biological validity of isoprostan...

journal_title：Amino acids

authors： Coolen SA,van Buuren B,Duchateau G,Upritchard J,Verhagen H

更新日期：2005-12-01 00:00:00

abstract：:Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined b...

journal_title：Amino acids

authors： Wei S,Fan L,Wu W,Ji Z

更新日期：2012-11-01 00:00:00

abstract：:Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. T...

journal_title：Amino acids

authors： Le J,Perier C,Peyroche S,Rascle F,Blanchon MA,Gonthier R,Frey J,Chamson A

更新日期：1999-01-01 00:00:00

abstract：:The human organism is exposed to numerous processes that generate reactive oxygen species (ROS). ROS may directly or indirectly cause oxidative modification and damage of proteins. Protein oxidation is regarded as a crucial event in the pathogenesis of various diseases ranging from rheumatoid arthritis to Alzheimer's ...

journal_title：Amino acids

authors： Pietzsch J,Bergmann R,Wuest F,Pawelke B,Hultsch C,van den Hoff J

更新日期：2005-12-01 00:00:00

abstract：:Delta-amino acids are very attractive in drug discovery, especially in the peptidomimetic area, because of their capability to act as dipeptide isosteres and reverse turn mimetics. Herein we report the synthesis of a rigid delta-amino acid constrained by a 3-aza-6,8-dioxabicyclo[3.2.1]octane-based scaffold, which can ...

journal_title：Amino acids

authors： Trabocchi A,Menchi G,Danieli E,Guarna A

更新日期：2008-06-01 00:00:00

abstract：:In living cells, the N-terminal tails of core histones, the proteinaceous component of nucleosomes, are subjected to a range of covalent post-translational modifications (PTMs), which have specific roles in modulating chromatin structure and function. A growing body of evidence suggests that deregulation of histone mo...

journal_title：Amino acids

authors： Cuomo A,Moretti S,Minucci S,Bonaldi T

更新日期：2011-07-01 00:00:00

abstract：:The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this revie...

journal_title：Amino acids

authors： Lentini A,Provenzano B,Tabolacci C,Beninati S

更新日期：2009-04-01 00:00:00

abstract：:Protein and peptide oxidation is a key feature in the progression of a variety of disease states and in the poor performance of protein-based products. The present work demonstrates a mass spectrometry-based approach to profiling degradation at the amino acid residue level. Synthetic peptides containing the photosensi...

journal_title：Amino acids

authors： Grosvenor AJ,Morton JD,Dyer JM

更新日期：2010-06-01 00:00:00

abstract：:Studies have shown that specific amino acids are required for optimal growth of leukemic versus normal cells, and it is believed that the depletion of selected amino acids can abrogate tumor growth. We have developed a technique for studying the effect of amino acid deprivation on leukemic cell proliferation. The tech...

journal_title：Amino acids

authors： Reiken SR,Briedis DM

更新日期：1992-10-01 00:00:00

abstract：:N-Acetyl-AA(amino acid)-NHtBu derivatives of all 20 naturally occurring amino acids have been synthesized. Syntheses were performed via solution-phase methodology with yields that allow for access to gram quantities of substrates, in most cases. Syntheses include the coupling of a hindered amine, tert-butylamine, with...

journal_title：Amino acids

authors： Ekkati AR,Campanali AA,Abouelatta AI,Shamoun M,Kalapugama S,Kelley M,Kodanko JJ

更新日期：2010-03-01 00:00:00

abstract：:We proposed that the combination of conjugated linoleic acid (CLA) and arginine would decrease adiposity by depressing lipid synthesis in liver and adipose tissues of growing pigs. Pigs were allotted to treatments in a 2 × 2 factorial design with two lipids (CLA or canola oil) and two amino acids [L-arginine or L-alan...

journal_title：Amino acids

authors： Go G,Wu G,Silvey DT,Choi S,Li X,Smith SB

更新日期：2012-10-01 00:00:00

abstract：:Previous studies identified lysine- and tryptophan-rich sequences within various cationic antimicrobial peptides. In the present study, we synthesized a series of peptides composed of lysine (K)-tryptophan (W) repeats (KW)( n ) (where n equals 2, 3, 4 or 5) with amida...

journal_title：Amino acids

authors： Gopal R,Seo CH,Song PI,Park Y

更新日期：2013-02-01 00:00:00

abstract：:Melanoma is the most malignant type of all skin neoplasms. Its worldwide incidence has steadily increased during the past decades, suggesting a probable melanoma 'epidemic'. Although current clinical, morphologic, and histopathologic methods provide insights into disease behavior and outcome, melanoma is still an unpr...

journal_title：Amino acids

authors： Tandler N,Mosch B,Pietzsch J

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Chemo-therapeutic treatment of glioma patients has minor success. Little is known about mechanisms of a pronounced resistance of gliomas towards actual therapies, yet. ABC-1 belongs to the group of transporters known to be involved in the export of hydrophobic substances and vascular regulation. This study in...

journal_title：Amino acids

authors： Trog D,Moenkemann H,Haertel N,Schüller H,Golubnitschaja O

更新日期：2005-03-01 00:00:00

abstract：:Due to the obvious advantages of long-acting peptide and protein drugs, strategies to prolong plasma half life time of such compounds are highly on demand. Short plasma half life times are commonly due to fast renal clearance as well as to enzymatic degradation occurring during systemic circulation. Modifications of t...

journal_title：Amino acids

authors： Werle M,Bernkop-Schnürch A

更新日期：2006-06-01 00:00:00

abstract：:Changes in plasma aromatic amino acids (AAA = phenylalanine, tryptophan, tyrosine) and branched chain amino acids (BCAA = isoleucine, leucine, valine) levels possibly influencing intracranial pressure (ICP) and cerebral oxygen consumption (SjvO(2)) were investigated in 19 sedated patients up to 14 days following sever...

journal_title：Amino acids

authors： Vuille-Dit-Bille RN,Ha-Huy R,Stover JF

更新日期：2012-09-01 00:00:00

abstract：:Pseudomonas aeruginosa is particularly difficult to treat because it possesses a variety of resistance mechanisms and because it often forms biofilms. Antimicrobial peptides represent promising candidates for future templates of antibiotic-resistant bacterial infections due to their unique mechanism of antimicrobial a...

journal_title：Amino acids

authors： Xie J,Li Y,Li J,Yan Z,Wang D,Guo X,Zhang J,Zhang B,Mou L,Yang W,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:Agmatine, a metabolite generated by arginine decarboxylation, has been reported as neuromodulator and neuroactive substance. Several findings suggest that agmatine displays neuroprotective effects in several models of neurodegenerative disorders, such as Parkinson's disease (PD). It has been hypothesized that biogenic...

journal_title：Amino acids

authors： Ferlazzo N,Currò M,Giunta ML,Longo D,Rizzo V,Caccamo D,Ientile R

更新日期：2020-02-01 00:00:00

abstract：:The human endothelin converting enzyme-1 (hECE-1) is a homodimer linked by a single disulfide bridge and has been identified as an important target for Alzheimer's disease. Structural analysis of hECE-1 dimer could lead to design specific and effective therapies against Alzheimer's disease. Hence, in the present study...

journal_title：Amino acids

authors： Sonawane KD,Barage SH

更新日期：2015-03-01 00:00:00

abstract：:Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport chain (ETC), we investigated whether there was a direct relationship bet...

journal_title：Amino acids

authors： Hancock CN,Liu W,Alvord WG,Phang JM

更新日期：2016-03-01 00:00:00

abstract：:Rats were trained to perform a conditioned avoidance response to white noise in a conventional two-compartment "shuttle-box". The partition between the compartments had two openings, however, and the correct passage (leftor right) was signalled by changes in background illumination. In this situation the psychotomimet...

journal_title：Amino acids

authors： Ahlenius S,Ericson E,Svensson TH

更新日期：1992-02-01 00:00:00

abstract：:The enzymes Akt, mTOR, p70(S6K), rpS6, GSK3, and glycogen synthase interact in the control of protein and/or glycogen synthesis in skeletal muscle, and each has been found to respond to exercise and nutrient supplementation. In the present study, we tested the hypothesis that nutrient supplementation post exercise, in...

journal_title：Amino acids

authors： Ivy JL,Ding Z,Hwang H,Cialdella-Kam LC,Morrison PJ

更新日期：2008-06-01 00:00:00

abstract：:The nature of the products arising from a 10 days, sterile incubation at 37°C and pH 7.2 of a 1:1 mixture of N-α-(p-tosyl)-lysine-methylesterhydrochloride and anhydrous D-glucose was investigated by fast atom bombardment mass spectrometry and(1)H and(13)C nuclear magnetic resonance spectroscopies. Differently to the r...

journal_title：Amino acids

authors： Lapolla A,Gerhardinger C,Baldo L,Fedele D,Bertani R,Facchin G,Rizzi E,Catinella S,Seraglia R,Traldi P

更新日期：1993-10-01 00:00:00

abstract：:Granulocyte-colony stimulating factor stimulates production and antibacterial function of neutrophiles. Therapy using the recombinant protein drug represents a major step forward in oncology. The protein has not been, however, completely sequenced at the protein level and this formed the rationale of the current study...

journal_title：Amino acids

authors： Ahmed KE,Chen WQ,John JP,Kang SU,Lubec G

更新日期：2010-04-01 00:00:00

abstract：:Astrocytes are glial cells in the central nervous system (CNS) that play key roles in brain physiology, controlling processes, such as neurogenesis, brain energy metabolism and synaptic transmission. Recently, immune functions have also been demonstrated in astrocytes, influencing neuronal survival in the course of ne...

journal_title：Amino acids

authors： Burgos M,Fradejas N,Calvo S,Kang SU,Tranque P,Lubec G

更新日期：2011-02-01 00:00:00

abstract：:The chemical modification of protein by nonenzymatic browning or Maillard reactions increases with age and in disease. Maillard products are formed by reactions of both carbohydrate- and lipid-derived intermediates with proteins, leading to formation of advanced glycation and lipoxidation end-products (AGE/ALEs). Thes...

journal_title：Amino acids

authors： Thorpe SR,Baynes JW

更新日期：2003-12-01 00:00:00

abstract：:Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes, and plasmodia, as well as human blood and cancer cells. In analysing the cytolytic activity of synthesised all-D: - and all-L: -cupiennin 1a towards pro- and e...

journal_title：Amino acids

authors： Kuhn-Nentwig L,Willems J,Seebeck T,Shalaby T,Kaiser M,Nentwig W

更新日期：2011-01-01 00:00:00

abstract：:We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activitie...

journal_title：Amino acids

authors： Delwing D,Chiarani F,Wannmacher CM,Wajner M,Wyse AT

更新日期：2005-05-01 00:00:00

abstract：:Properties of putrescine uptake by PotFGHI and PuuP and their physiological significance were studied using a polyamine biosynthesis and uptake deficient Escherichia coli KK3131 transformed with pACYC184 containing potFGHI or puuP. Putrescine uptake activity of E. coli KK3131 transformed with pACYC184-PotFGHI was high...

journal_title：Amino acids

authors： Terui Y,Saroj SD,Sakamoto A,Yoshida T,Higashi K,Kurihara S,Suzuki H,Toida T,Kashiwagi K,Igarashi K

更新日期：2014-03-01 00:00:00

abstract：:Based on ubiquitous presence of large ionic motifs and clusters in proteins involved in gene transcription and protein synthesis, we analyzed the distribution of ionizable sidechains in a broad selection of proteins with regulatory, metabolic, structural and adhesive functions, in agonist, antagonist, toxin and antimi...

journal_title：Amino acids

authors： Parker MS,Balasubramaniam A,Parker SL

更新日期：2012-12-01 00:00:00