CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies.


:Short CCK peptides elicit panic attacks in humans and anxiogenic-like effects in some animal models, but CCK receptor antagonists have not been found clinically effective. Yet CCK overactivity appears to be involved in submissive behaviour, and CCKB receptor expression and binding are increased in suicide victims and animal models of anxiety. Preliminary data suggest that involvement of CCK and its receptor subtypes in anxiety can be better described when focusing on distinct endophenotypes, and considering environmental contingencies and confounds originating from interactions with dopamin-, opioid- and glutamatergic neurotransmission. In contrast, NPY is an anti-anxiety peptide with robust effects in various animal models when administrated into several brain regions. Studies with non-peptide antagonists selective for receptor subtypes have revealed the role of endogenous NPY in active coping. At least Y1, Y2 and Y5 receptors in various brain regions are involved, with the strongest evidence for contribution of Y1.


Amino Acids


Amino acids


Harro J




Has Abstract


2006-10-01 00:00:00












  • Free amino acids and biogenic amines in red and white muscle of tuna stored in controlled atmospheres.

    abstract::This paper analyses the presence of and changes in free amino acids and biogenic amines in red and white muscle of bigeye tuna during storage in controlled atmospheres with 2 gas mixes containing different concentrations of CO(2) and O(2). Levels of amines were generally higher in white than in red muscle, with the ex...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Ruiz-Capillas C,Moral A

    更新日期:2004-03-01 00:00:00

  • Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings.

    abstract::Over the last few years, consistent data have demonstrated that creatine (Cr) supplementation prevents the accumulation of fat in rat liver as well as the progression of fatty liver disease in different situations. Studies have demonstrated that Cr is effective and prevents fatty liver in high-fat and choline-deficien...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Deminice R,de Castro GS,Brosnan ME,Brosnan JT

    更新日期:2016-08-01 00:00:00

  • Mitomycin C modulates DNA-double strand break repair genes in cervical carcinoma cells.

    abstract::In a previous study, we elucidated the apoptotic mechanism mediated via Fas/FasL-dependent pathway in mitomycin C-treated cervical carcinoma cells. In this study, 2-D and MALDI-TOF analyses were performed in order to search mitomycin C-induced modulators in cervical carcinoma cells. Some protein spots down- or up-regu...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Kang YH,Lee KA,Kim JH,Park SG,Yoon DY

    更新日期:2010-11-01 00:00:00

  • Effect of taurine chloramine, the product of activated neutrophils, on the development of collagen-induced arthritis in DBA 1/J mice.

    abstract::Taurine chloramine (TauCl), a product of neutrophil myeloperoxidase - halide system, formed by a reaction of taurine with HOCl, is known as an anti-microbial and anti-inflammatory long-lived oxidant. We previously reported that TauCl inhibits in vitro the production of proinflammatory cytokines (IL-6, IL-8) by RA syno...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Kwaśny-Krochin B,Bobek M,Kontny E,Gluszko P,Biedroń R,Chain BM,Maśliński W,Marcinkiewicz J

    更新日期:2002-01-01 00:00:00

  • The many faces of interferon tau.

    abstract::Interferon tau (IFNT) was discovered as the pregnancy recognition signal in ruminants, but is now known to have a plethora of physiological functions in the mammalian uterus. The mammalian uterus includes, from the outer surface to the lumen, the serosa, myometrium and endometrium. The endometrium consists of the lumi...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Bazer FW,Ying W,Wang X,Dunlap KA,Zhou B,Johnson GA,Wu G

    更新日期:2015-03-01 00:00:00

  • Intramuscular adaptations to eccentric exercise and antioxidant supplementation.

    abstract::Prophylactic supplementation of N-acetyl-cysteine (NAC) and epigallocatechin gallate (EGCG) was studied for physiological and cellular changes in skeletal muscle after eccentric muscle contractions. Thirty healthy, active males (20.0 +/- 1.8 years, 160 +/- 7.1 cm, 76.1 +/- 17.0 kg) ingested for 14 days either 1,800 mg...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Kerksick CM,Kreider RB,Willoughby DS

    更新日期:2010-06-01 00:00:00

  • Isozymic nature of spore coat-associated alanine racemase of Bacillus subtilis.

    abstract::Spore coat-associated alanine racemase of Bacillus subtilis, which converts L-alanine to D-alanine, that is, the germinant to the competitive inhibitor, to regulate spore germination for survival of the organism under unfavorable growth conditions, was examined. The dormant spores, L-alanine-initiated germination of w...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Kanda-Nambu K,Yasuda Y,Tochikubo K

    更新日期:2000-01-01 00:00:00

  • Lipid metabolism in pigs fed supplemental conjugated linoleic acid and/or dietary arginine.

    abstract::We proposed that the combination of conjugated linoleic acid (CLA) and arginine would decrease adiposity by depressing lipid synthesis in liver and adipose tissues of growing pigs. Pigs were allotted to treatments in a 2 × 2 factorial design with two lipids (CLA or canola oil) and two amino acids [L-arginine or L-alan...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Go G,Wu G,Silvey DT,Choi S,Li X,Smith SB

    更新日期:2012-10-01 00:00:00

  • Effect of renal function on homeostasis of asymmetric dimethylarginine (ADMA): studies in donors and recipients of renal transplants.

    abstract::Asymmetric dimethylarginine (ADMA) is a methylated form of arginine and an endogenous nitric oxide synthase inhibitor. Renal function decline is associated with increase of plasma ADMA in chronic kidney disease populations. It is yet unknown how isolated renal function impairment affects ADMA homeostasis in healthy hu...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Said MY,Douwes RM,van Londen M,Minović I,Frenay AR,de Borst MH,van den Berg E,Heiner-Fokkema MR,Kayacelebi AA,Bollenbach A,van Goor H,Navis G,Tsikas D,Bakker SJL

    更新日期:2019-03-01 00:00:00

  • The effects of red bull energy drink on human performance and mood.

    abstract::The effects of Red Bull Energy Drink, which includes taurine, glucuronolactone, and caffeine amongst the ingredients, were examined over 3 studies in a total of 36 volunteers. Assessments included psychomotor performance (reaction time, concentration, memory), subjective alertness and physical endurance. When compared...

    journal_title:Amino acids

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Alford C,Cox H,Wescott R

    更新日期:2001-01-01 00:00:00

  • In sickness and in health: the widespread application of creatine supplementation.

    abstract::There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Gualano B,Roschel H,Lancha AH Jr,Brightbill CE,Rawson ES

    更新日期:2012-08-01 00:00:00

  • Multi-omic approach decodes paradoxes of the triple-negative breast cancer: lessons for predictive, preventive and personalised medicine.

    abstract::Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Golubnitschaja O,Filep N,Yeghiazaryan K,Blom HJ,Hofmann-Apitius M,Kuhn W

    更新日期:2018-04-01 00:00:00

  • Importance of amino acid composition to improve skin collagen protein synthesis rates in UV-irradiated mice.

    abstract::Skin collagen metabolism abnormalities induced by ultraviolet (UV) radiation are the major causes of skin photoaging. It has been shown that the one-time exposure of UV irradiation decreases procollagen mRNA expression in dermis and that chronic UV irradiation decreases collagen amounts and induces wrinkle formation. ...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Murakami H,Shimbo K,Inoue Y,Takino Y,Kobayashi H

    更新日期:2012-06-01 00:00:00

  • Proteomic profiling identifies the inorganic pyrophosphatase (PPA1) protein as a potential biomarker of metastasis in laryngeal squamous cell carcinoma.

    abstract::Relapse and metastasis are the main causes of unfavorable outcome in head and neck cancers. Whereas, understanding of the molecular background of these processes is far from being complete. Therefore, in this study we aimed to identify potential biomarker candidates of relapse and metastasis in laryngeal squamous cell...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Bodnar M,Luczak M,Bednarek K,Szylberg L,Marszalek A,Grenman R,Szyfter K,Jarmuz-Szymczak M,Giefing M

    更新日期:2016-06-01 00:00:00

  • iFC²: an integrated web-server for improved prediction of protein structural class, fold type, and secondary structure content.

    abstract::Several descriptors of protein structure at the sequence and residue levels have been recently proposed. They are widely adopted in the analysis and prediction of structural and functional characteristics of proteins. Numerous in silico methods have been developed for sequence-based prediction of these descriptors. Ho...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Chen K,Stach W,Homaeian L,Kurgan L

    更新日期:2011-03-01 00:00:00

  • Development of a novel ligand binding assay for relaxin family peptide receptor 3 and 4 using NanoLuc complementation.

    abstract::Relaxin family peptides perform a variety of biological functions by binding and activating relaxin family peptide receptor 1-4 (RXFP1-4), four A-class G protein-coupled receptors. In the present work, we developed a novel ligand binding assay for RXFP3 and RXFP4 based on NanoLuc complementation technology (NanoBiT). ...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Hu MJ,Shao XX,Li HZ,Nie WH,Wang JH,Liu YL,Xu ZG,Guo ZY

    更新日期:2018-08-01 00:00:00

  • No peptide left behind: the "out of range" recovery in IPG-IEF fractionation.

    abstract::IEF is often used in multidimensional shotgun proteomics and the narrow range of 3.5-4.5 is the recommended pH interval for the fractionation of tryptic peptides. Usually, even if IEF is performed in IPG strip with a narrow range pH, the entire sample must be loaded onto the strip, including the "out of IPG range" pep...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Iori E,Rattazzi M,Millioni R

    更新日期:2014-05-01 00:00:00

  • Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis.

    abstract::D: -Amino acid oxidase (DAAO) in mammal kidney regulates the renal reactive oxygen species (ROS) levels directly and plays a leading role in the development of ROS-mediated renal pathologic damages based on its crucial role in the oxidative deamination of D: -amino acids and the consequent generation of H(2)O(2). Quan...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Zhang H,Qi L,Lin Y,Mao L,Chen Y

    更新日期:2012-01-01 00:00:00

  • Transglutaminases and receptor tyrosine kinases.

    abstract::Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling....

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Sivaramakrishnan M,Shooter GK,Upton Z,Croll TI

    更新日期:2013-01-01 00:00:00

  • Central regulation of feeding behavior through neuropeptides and amino acids in neonatal chicks.

    abstract::Animals at the neonatal stage have to eat more to support better growth and health. However, it is difficult to understand the mechanism of feeding during an early stage of life in the brain of the rodent model. Chickens are precocial and they can look for their food by themselves right after hatching. Neonatal chicks...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Tran PV,Chowdhury VS,Furuse M

    更新日期:2019-08-01 00:00:00

  • Immunohistochemical localization of D-aspartate oxidase in porcine peripheral tissues.

    abstract::D-Aspartate (D-Asp) is an endogenous substance in mammals. Degradation of D-Asp is carried out only by D-aspartate oxidase (DDO). We measured DDO activity in porcine tissues, and produced an anti-porcine DDO antibody to examine the cellular localization of DDO. All the tissues examined showed DDO activities, whereas t...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Yamamoto A,Tanaka H,Ishida T,Horiike K

    更新日期:2011-07-01 00:00:00

  • Antimicrobial activity and membrane-active mechanism of tryptophan zipper-like β-hairpin antimicrobial peptides.

    abstract::Antimicrobial peptides (AMPs) with amphipathic β-hairpin structures have been demonstrated to possess potent antimicrobial activities and great cell selectivities. However, our understanding of β-hairpin antimicrobial peptides lags behind that of α-helices, mainly because it is difficult for short peptides to form rob...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Xu L,Chou S,Wang J,Shao C,Li W,Zhu X,Shan A

    更新日期:2015-11-01 00:00:00

  • Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity.

    abstract::Muscle carnosine synthesis is limited by the availability of beta-alanine. Thirteen male subjects were supplemented with beta-alanine (CarnoSyn) for 4 wks, 8 of these for 10 wks. A biopsy of the vastus lateralis was obtained from 6 of the 8 at 0, 4 and 10 wks. Subjects undertook a cycle capacity test to determine tota...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Hill CA,Harris RC,Kim HJ,Harris BD,Sale C,Boobis LH,Kim CK,Wise JA

    更新日期:2007-02-01 00:00:00

  • The effect of lysine deprivation on leukemic blood.

    abstract::Studies have shown that specific amino acids are required for optimal growth of leukemic versus normal cells, and it is believed that the depletion of selected amino acids can abrogate tumor growth. We have developed a technique for studying the effect of amino acid deprivation on leukemic cell proliferation. The tech...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Reiken SR,Briedis DM

    更新日期:1992-10-01 00:00:00

  • Applications and current challenges of proteomic approaches, focusing on two-dimensional electrophoresis.

    abstract::Since the formulation of the concept of "proteomics" in 1995, a plethora of proteomic technologies have been developed in order to study proteomes of tissues, cells and organelles. The powerful new technologies enabled by proteomic approaches have lead to the application of these methods to an exponentially increasing...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Vercauteren FG,Arckens L,Quirion R

    更新日期:2007-09-01 00:00:00

  • Intercellular protein expression variability as a feature of stem cell pluripotency.

    abstract::The expression of pluripotent stem cell protein markers, self-renewal, the potential to differentiate in cell types of all three germlines and teratoma formation in nude mice form the spectrum of the stringent pluripotency criteria for human stem cells. Currently, intercellular variability is discussed as an additiona...

    journal_title:Amino acids

    pub_type: 杂志文章,评审


    authors: Rosner M,Hengstschläger M

    更新日期:2013-12-01 00:00:00

  • Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers.

    abstract::The effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) in mice were evaluated. C57BL/6 female mice were given 3% DSS in drinking water for 5 d to induce acute colitis. Taurine at 2% was added to the drinking water 5 d before and during the DSS-treatment to investigate its pr...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Zhao Z,Satsu H,Fujisawa M,Hori M,Ishimoto Y,Totsuka M,Nambu A,Kakuta S,Ozaki H,Shimizu M

    更新日期:2008-06-01 00:00:00

  • Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides.

    abstract::Among the available protocols, chemically driven approaches to oxidize cysteine may not be required for molecules that, under the native-like conditions, naturally fold in conformations ensuring an effective pairing of the right disulfide bridge pattern. In this contest, we successfully prepared the distinctin, a natu...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Calce E,Vitale RM,Scaloni A,Amodeo P,De Luca S

    更新日期:2015-08-01 00:00:00

  • Polyamine depletion inhibits etoposide-induced NF-kappaB activation in transformed mouse fibroblasts.

    abstract::In a previous research, we have shown that adequate levels of polyamines are required in transformed mouse fibroblasts for the correlated activations of MAPK subtypes (ERK and JNK) and caspases induced by etoposide and leading to apoptosis. We report now that the treatment of fibroblasts with etoposide also elicited a...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Tantini B,Pignatti C,Fattori M,Fiumana E,Facchini A,Stefanelli C,Caldarera CM,Pegg AE,Flamigni F

    更新日期:2004-10-01 00:00:00

  • Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks.

    abstract::Recently, we observed that central administration of L-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of L-arginine may be due to L-arginine itself and/or its metabolites, excluding NO. To clarify the me...

    journal_title:Amino acids

    pub_type: 杂志文章


    authors: Suenaga R,Yamane H,Tomonaga S,Asechi M,Adachi N,Tsuneyoshi Y,Kurauchi I,Sato H,Denbow DM,Furuse M

    更新日期:2008-06-01 00:00:00