CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies.

abstract：:Fibrosis, closely related to chronic various diseases, is a pathological process characterised by the accumulation of collagen (largely collagen type I). Non-invasive methods are necessary for the diagnosis and follow-up of fibrosis. This study aimed to develop a collagen-targeted probe for the molecular imaging of fi...

journal_title：Amino acids

authors： Zheng L,Ding X,Liu K,Feng S,Tang B,Li Q,Huang D,Yang S

更新日期：2017-01-01 00:00:00

abstract：:The chemical modification of protein by nonenzymatic browning or Maillard reactions increases with age and in disease. Maillard products are formed by reactions of both carbohydrate- and lipid-derived intermediates with proteins, leading to formation of advanced glycation and lipoxidation end-products (AGE/ALEs). Thes...

journal_title：Amino acids

authors： Thorpe SR,Baynes JW

更新日期：2003-12-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition are biologic processes responsible for conversion of epithelial cells into a mesenchymal phenotype or viceversa, respectively. They occur during embryo- and foetal-development and, in adult organisms, are involved in wound healing, in the ge...

journal_title：Amino acids

authors： Compagnone A,Bandino A,Meli F,Bravoco V,Cravanzola C,Parola M,Colombatto S

更新日期：2012-02-01 00:00:00

abstract：:3-Fluorotyrosine fluorescence is quenched effectively by phosphate ions not only by a dynamic but also by a static mechanism owing to H-bond complex formation in ground state. 3-Fluorotyrosine pKa values both in the ground and first excited state (8.3 and 4, respectively) are appreciably lower than those of tyrosine, ...

journal_title：Amino acids

authors： Vdovenko SI,Kolycheva MT,Gerus II,Kukhar VP

更新日期：1993-10-01 00:00:00

abstract：:Lateral diffusion of membrane-integral receptors within the plane of the membrane has been postulated to be mechanistically important for signal transduction. Direct measurement of polypeptide hormone receptor lateral mobility using fluorescence photobleaching recovery techniques indicates that tyrosine kinase recepto...

journal_title：Amino acids

authors： Jans DA,Pavo I

更新日期：1995-06-01 00:00:00

abstract：:Peptide bonds in protein structures are mainly found in trans conformation with a torsion angle ω close to 180°. Only a very low proportion is observed in cis conformation with ω angle around 0°. Cis-trans isomerization leads to local conformation changes which play an important role in many biological processes. In t...

journal_title：Amino acids

authors： Craveur P,Joseph AP,Poulain P,de Brevern AG,Rebehmed J

更新日期：2013-08-01 00:00:00

abstract：:The presence of an enzyme activity which hydrolyzes glycyl-D-aspartate was found in the homogenates of pig kidney cortex. The activity was inhibited by metal chelating agents and cilastatin, suggesting that the enzyme was a cilastatin-sensitive metallo-peptidase. Of the two hydrolysis products,D-aspartate was found to...

journal_title：Amino acids

authors： Kera Y,Funabashi K,Matsumoto T,Watanabe T,Nagasaki H,Yamada R

更新日期：1996-06-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress, implicated in various neurodegenerative processes, increases the level of intracellular Ca(2+) and leads to activation of calpain, a Ca(2+)-dependent cysteine protease. We have shown previously that S-allyl-L-cysteine (SAC) in aged garlic extracts significantly protects cultured rat ...

journal_title：Amino acids

authors： Imai T,Kosuge Y,Endo-Umeda K,Miyagishi H,Ishige K,Makishima M,Ito Y

更新日期：2014-02-01 00:00:00

abstract：:Studies have shown that specific amino acids are required for optimal growth of leukemic versus normal cells, and it is believed that the depletion of selected amino acids can abrogate tumor growth. We have developed a technique for studying the effect of amino acid deprivation on leukemic cell proliferation. The tech...

journal_title：Amino acids

authors： Reiken SR,Briedis DM

更新日期：1992-10-01 00:00:00

abstract：:For medical use of proteins and peptide-based drugs, it is desirable to have small biologically active sequences because they improve stability, reduce side effects, and production costs. Several plant defensins have their biological activities imparted by a sequence named γ-core. Vu-Def, a Vigna unguiculata defensin,...

journal_title：Amino acids

authors： Souza GS,de Carvalho LP,de Melo EJT,da Silva FCV,Machado OLT,Gomes VM,de Oliveira Carvalho A

更新日期：2019-11-01 00:00:00

abstract：:Green tea which is widely consumed in China, Japan and India, contains polyphenolic compounds, which account for 30% of the dry weight of the leaves. Most of the polyphenols are flavanols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant. Epidemiological studies revealed that the incidences of stomach a...

journal_title：Amino acids

authors： Bachrach U,Wang YC

更新日期：2002-01-01 00:00:00

abstract：:Reaction between glutathione and ribose was carried out to study the volatiles formed via Maillard reaction and their antioxidant activity as well as their role in inhibition of LDL oxidation. The simultaneous distillation-extraction technique was used for trapping the volatile components followed by GC-MS analysis. T...

journal_title：Amino acids

authors： El-massry K,Farouk A,El-Ghorab A

更新日期：2003-01-01 00:00:00

abstract：:The supplementation of creatine has shown a marked neuroprotective effect in mouse models of neurodegenerative diseases (Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis). This has been assigned to the known bioenergetic, anti-apoptotic, anti-excitotoxic and anti-oxidant properties of creatine....

journal_title：Amino acids

authors： Klopstock T,Elstner M,Bender A

更新日期：2011-05-01 00:00:00

abstract：:This study aimed to investigate the ability of curcumin to convert asparagine into acrylamide during heating at different temperatures. Binary and ternary model systems of asparagine-curcumin and asparagine-curcumin-fructose were used to determine the role of curcumin on acrylamide formation in competitive and uncompe...

journal_title：Amino acids

authors： Hamzalıoğlu A,Mogol BA,Lumaga RB,Fogliano V,Gökmen V

更新日期：2013-06-01 00:00:00

abstract：:A thioalkylation procedure, which uses molecular sieves to promote the reaction, was exploited to provide peptides with useful functional groups (lipidic moieties), naturally occurring on proteins as post-translational modifications. The procedure was further implemented to synthesize tailor-made lipidated peptides, i...

journal_title：Amino acids

authors： Calce E,Leone M,Monfregola L,De Luca S

更新日期：2014-08-01 00:00:00

abstract：:The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of g...

journal_title：Amino acids

authors： Aceña JL,Sorochinsky AE,Soloshonok V

更新日期：2014-09-01 00:00:00

abstract：:Vigabatrin is a GABA derivative (gamma-vinyl GABA) which inhibits irreversibly the enzyme activity of GABA transaminase and thus increased indirectly brain GABA concentrations. We have used body temperature assay to examine the effects of Vigabatrin on thermoregulation in intact rats. In order to understand the mechan...

journal_title：Amino acids

authors： Nikolov RP,Yakimova KS

更新日期：2011-05-01 00:00:00

abstract：:The human organism is exposed to numerous processes that generate reactive oxygen species (ROS). ROS may directly or indirectly cause oxidative modification and damage of proteins. Protein oxidation is regarded as a crucial event in the pathogenesis of various diseases ranging from rheumatoid arthritis to Alzheimer's ...

journal_title：Amino acids

authors： Pietzsch J,Bergmann R,Wuest F,Pawelke B,Hultsch C,van den Hoff J

更新日期：2005-12-01 00:00:00

abstract：:Fibronectin (FN) is a cell adhesion protein that binds integrins in a process also involving the protein-crosslinking enzyme transglutaminase 2 (TG2) as a co-receptor. The cell-adhesive property of TG2 has been linked to a complex formation with FN and to its ability to crosslink and polymerize FN on the cell surface....

journal_title：Amino acids

authors： Forsprecher J,Wang Z,Nelea V,Kaartinen MT

更新日期：2009-04-01 00:00:00

abstract：:The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine} is a chiral compound with valuable synthetic interest. An update on the different routes for its synthesis is reviewed and discussed. ...

journal_title：Amino acids

authors： Benfodda Z,Bénimélis D,Reginato G,Meffre P

更新日期：2015-02-01 00:00:00

abstract：:Delta-amino acids are very attractive in drug discovery, especially in the peptidomimetic area, because of their capability to act as dipeptide isosteres and reverse turn mimetics. Herein we report the synthesis of a rigid delta-amino acid constrained by a 3-aza-6,8-dioxabicyclo[3.2.1]octane-based scaffold, which can ...

journal_title：Amino acids

authors： Trabocchi A,Menchi G,Danieli E,Guarna A

更新日期：2008-06-01 00:00:00

abstract：:This study investigated the effect of different sampling environments on hemolymph amino acid content of individual Drosophila melanogaster larvae. Hemolymph was collected from individual third instar larvae under cold-anesthetized, awake, and stress conditions. Qualitative and quantitative hemolymph amino acid analys...

journal_title：Amino acids

authors： Piyankarage SC,Augustin H,Featherstone DE,Shippy SA

更新日期：2010-03-01 00:00:00

abstract：:Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5'-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). The limited availability and stability of the prot...

journal_title：Amino acids

authors： Castro-Oropeza R,Pino-Ángeles A,Khomutov MA,Urdiales JL,Moya-García AA,Vepsäläinen J,Persson L,Sarabia F,Khomutov A,Sánchez-Jiménez F

更新日期：2014-03-01 00:00:00

abstract：:Lamin A/C proteins are the major components of a thin proteinaceous filamentous meshwork, the lamina, that underlies the inner nuclear membrane. A few specific mutations in the lamin A/C gene cause a disease with remarkably different clinical features: FPLD, or familial partial lipodystrophy (Dunnigan-type), which mai...

journal_title：Amino acids

authors： Rajendran V,Purohit R,Sethumadhavan R

更新日期：2012-08-01 00:00:00

abstract：:Starting from a chiral 4-hydroxymethyl pyrrolidin-2-one, an isostere of α-methyl homoserine tethered on a γ-lactam ring was prepared exploiting a stereoselective acylation-methylation sequence, followed by Curtius rearrangement, and structural assignment was confirmed by n.O.e. experiments. By reverting the sequence, ...

journal_title：Amino acids

authors： Civitavecchia A,Martelli G,Orena M,Rinaldi S

更新日期：2014-04-01 00:00:00

abstract：:Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we applied a non-biase...

journal_title：Amino acids

authors： Zervou S,Yin X,Nabeebaccus AA,O'Brien BA,Cross RL,McAndrew DJ,Atkinson RA,Eykyn TR,Mayr M,Neubauer S,Lygate CA

更新日期：2016-08-01 00:00:00

abstract：:The streptococcal enzyme that catalyzes the last step in proline biosynthesis was heterologously expressed and the recombinant protein was purified to electrophoretic homogeneity and characterized thoroughly. As for δ1-pyrroline-5-carboxylate reductases from other sources, it was able to use either NADH or NADPH as th...

journal_title：Amino acids

authors： Petrollino D,Forlani G

更新日期：2012-07-01 00:00:00

abstract：:N, N'-Ethylene-bridged bis-(S)-methionine[(2S, 7S)-2, 7-bis(2-methyl-thioethyl)-3,6-diazaoctanedioic acid] derived from (S)-methionine and 1,2-dibromoethane was cyclized and esterified simultaneously in boiling ethanol in the presence of an appropriate amount of strong acid such asp-toluenesulfonic acid, affording a c...

journal_title：Amino acids

authors： Yamashita T,Takenaka H,Kojima Y

更新日期：1993-02-01 00:00:00

abstract：:We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activitie...

journal_title：Amino acids

authors： Delwing D,Chiarani F,Wannmacher CM,Wajner M,Wyse AT

更新日期：2005-05-01 00:00:00

abstract：:Relapse and metastasis are the main causes of unfavorable outcome in head and neck cancers. Whereas, understanding of the molecular background of these processes is far from being complete. Therefore, in this study we aimed to identify potential biomarker candidates of relapse and metastasis in laryngeal squamous cell...

journal_title：Amino acids

authors： Bodnar M,Luczak M,Bednarek K,Szylberg L,Marszalek A,Grenman R,Szyfter K,Jarmuz-Szymczak M,Giefing M

更新日期：2016-06-01 00:00:00